From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly.
Anumigilimab (CSL-324) is an human IgG2a mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation .
C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts .
Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM .
Sodium caseinates, the salt of casein, are the main milk protein. Sodium caseinate are able to induce proliferation and activation of granulocytes as well as increase the serum concentration of two key cytokines, GM-CSF and G-CSF. Sodium caseinate induces mouse granulopoiesis .
Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia .
Sodium caseinates, the salt of casein, are the main milk protein. Sodium caseinate are able to induce proliferation and activation of granulocytes as well as increase the serum concentration of two key cytokines, GM-CSF and G-CSF. Sodium caseinate induces mouse granulopoiesis .
Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells .
Anumigilimab (CSL-324) is an human IgG2a mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation .
Balugrastim (CG 10639) is a novel long-acting recombinant granulocyte colony-stimulating factor (G-CSF) obtained by means of a genetic fusion between recombinant human serum albumin and granulocyte colony-stimulating factor. Balugrastim can be used for the research of breast cancer .
Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia .
Galectin-9/LGALS9 Protein acts as an eosinophil chemoattractant, recruiting and migrating eosinophils, key immune cells in inflammatory responses. It also serves as an angiogenesis inhibitor, regulating blood vessel formation and impacting vascular processes. Functioning as a regulatory modulator, Galectin-9/LGALS9 suppresses interferon-gamma (IFNG) production by natural killer cells, exerting control over immune signaling pathways. Animal-Free Galectin-9/LGALS9 Protein, Human (His) is the recombinant human-derived animal-FreeGalectin-9/LGALS9 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free Galectin-9/LGALS9 Protein, Human (His) is 322 a.a., with molecular weight of ~36.7 kDa.
The G-CSF Protein, a monomeric cytokine in the granulocyte/macrophage colony-stimulating factor family, crucially regulates hematopoiesis by orchestrating the production, differentiation, and function of granulocytes and monocytes-macrophages. Its production emphasizes its significance in maintaining immune system balance and functionality. G-CSF Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of G-CSF Protein, Mouse (HEK293, His) is 178 a.a., with molecular weight of 25-27 kDa.
G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. G-CSF Protein, Human (HEK293) is the recombinant human-derived G-CSF protein, expressed by HEK293 , with tag free. The total length of G-CSF Protein, Human (HEK293) is 175 a.a., with molecular weight of ~17.8 kDa.
G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. G-CSF Protein, Human (HEK293, Fc) is the recombinant human-derived G-CSF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of G-CSF Protein, Human (HEK293, Fc) is 174 a.a., with molecular weight of 45-50 kDa.
G-CSF Protein, Rat (HEK293) is a glycoprotein, acting to stimulate granulopoiesis, the innate immunity, and the differentiation of neural progenitor cells.
G-CSFR/CD114 Protein, functioning as the receptor for granulocyte colony-stimulating factor (CSF3), plays a pivotal role in granulocyte development and function. As a homodimer, it binds two CSF3 molecules, transducing signals. G-CSFR/CD114's interaction with CEACAM1 down-regulates the CSF3R-STAT3 pathway, recruiting PTPN6 for dephosphorylation, revealing regulatory roles in modulating granulocyte colony-stimulating factor responses. These interactions emphasize G-CSFR/CD114's intricate regulatory involvement in immune responses and hematopoiesis. G-CSFR/CD114 Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSFR/CD114 protein, expressed by HEK293, with C-His labeled tag. The total length of G-CSFR/CD114 Protein, Mouse (HEK293, His) is 601 a.a., with molecular weight of 90-110 kDa.
The G-CSFR/CD114 Protein, acting as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocytic maturation, playing a pivotal role in the proliferation, differentiation, and survival of neutrophilic lineage cells. Additionally, it may participate in cell surface adhesion or recognition events. The homodimeric receptor binds two CSF3 molecules and interacts with CEACAM1, which down-regulates the CSF3R-STAT3 pathway through the recruitment of PTPN6, leading to the dephosphorylation of CSF3R. G-CSFR/CD114 Protein, Human (HEK293, His-Flag) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293, with C-6*His, C-Flag labeled tag. The total length of G-CSFR/CD114 Protein, Human (HEK293, His-Flag) is 597 a.a., with molecular weight of 69.8 kDa.
The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with tag free. The total length of G-CSFR/CD114 Protein, Human (HEK293) is 597 a.a., with molecular weight of ~85.36 kDa.
The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293, Fc) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of G-CSFR/CD114 Protein, Human (HEK293, Fc) is 603 a.a., with molecular weight of ~110.17 kDa.
The G-CSFR/CD114 Protein, acting as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocytic maturation, playing a pivotal role in the proliferation, differentiation, and survival of neutrophilic lineage cells. Additionally, it may participate in cell surface adhesion or recognition events. The homodimeric receptor binds two CSF3 molecules and interacts with CEACAM1, which down-regulates the CSF3R-STAT3 pathway through the recruitment of PTPN6, leading to the dephosphorylation of CSF3R. G-CSFR/CD114 Protein, Human (HEK293, His) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293, with C-His labeled tag. The total length of G-CSFR/CD114 Protein, Human (HEK293, His) is 603 a.a., with molecular weight of 90-110 kDa.
OLFM4 protein may promote the proliferation of pancreatic cancer cells by affecting the transition from S phase to G2/M phase, highlighting its role in cancer cell cycle dynamics. In myeloid leukemia cell lines, OLFM4 exhibits dual effects of inhibiting growth and inducing differentiation and apoptosis. OLFM4 Protein, Human (HEK293, His) is the recombinant human-derived OLFM4 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of OLFM4 Protein, Human (HEK293, His) is 490 a.a., with molecular weight of 60-90 kDa.
G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. Animal-Free G-CSF Protein, Human (His) is the recombinant human-derived animal-FreeG-CSF protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free G-CSF Protein, Human (His) is 174 a.a., with molecular weight of ~19.48 kDa.
The G-CSF Protein, a monomeric cytokine in the granulocyte/macrophage colony-stimulating factor family, crucially regulates hematopoiesis by orchestrating the production, differentiation, and function of granulocytes and monocytes-macrophages. Its production emphasizes its significance in maintaining immune system balance and functionality. Animal-Free G-CSF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeG-CSF protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free G-CSF Protein, Mouse (His) is 178 a.a., with molecular weight of ~19.76 kDa.
