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G2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (6) Aldehyde Dehydrogenase (ALDH) (2) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (6) AP-1 (1) Apoptosis (199) ATM/ATR (3) Aurora Kinase (1) AUTACs (1) Autophagy (7) Bacterial (8) Bcl-2 Family (8) Biochemical Assay Reagents (1) c-Kit (1) c-Met/HGFR (6) Calcium Channel (1) Carboxypeptidase (1) Casein Kinase (1) Caspase (12) CDK (16) Checkpoint Kinase (Chk) (4) Cholinesterase (ChE) (1) COX (3) CXCR (1) Cytochrome P450 (3) Dihydrofolate reductase (DHFR) (1) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (2) DNA Stain (1) DNA/RNA Synthesis (8) Drug Metabolite (1) E1/E2/E3 Enzyme (1) EGFR (11) Endogenous Metabolite (9) Epigenetic Reader Domain (2) ERK (2) Estrogen Receptor/ERR (1) FAK (2) Ferroptosis (1) FGFR (2) FLT3 (2) Fluorescent Dye (1) Fungal (1) Glucosidase (1) Glutaminase (1) Glutathione Peroxidase (1) GnRH Receptor (1) HBV (4) HDAC (24) Histone Acetyltransferase (1) Histone Demethylase (2) Histone Methyltransferase (1) HIV (1) HSP (2) HSV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (1) Insulin Receptor (1) Interleukin Related (1) IRAK (1) Isotope-Labeled Compounds (10) JAK (1) JNK (3) Keap1-Nrf2 (2) MDM-2/p53 (3) Microtubule/Tubulin (60) Mitochondrial Metabolism (1) MMP (1) Mps1 (1) mTOR (1) Na+/K+ ATPase (1) NEDD8-activating Enzyme (1) NF-κB (3) NO Synthase (2) Nucleoside Antimetabolite/Analog (3) Parasite (6) PARP (11) PD-1/PD-L1 (1) PDK-1 (1) Phosphatase (3) PI3K (8) Pim (1) PKC (1) Polo-like Kinase (PLK) (6) PPAR (1) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (5) Proteasome (2) Pyroptosis (1) Pyruvate Kinase (1) RAD51 (2) Raf (3) Ras (2) Reactive Oxygen Species (10) ROS Kinase (1) Ser/Thr Protease (1) Sirtuin (1) Small Interfering RNA (siRNA) (10) Sodium Channel (4) Src (1) STAT (1) TGF-beta/Smad (2) TGF-β Receptor (1) TMV (1) TNF Receptor (1) Topoisomerase (20) Trk Receptor (1) Tyrosinase (1) VEGFR (6) Wee1 (1)
By Research Areas:	Cancer (289) Cardiovascular Disease (2) Endocrinology (2) Infection (17) Inflammation/Immunology (19) Metabolic Disease (5) Neurological Disease (7)
Click Chemistry:	Alkynes (3)

338

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6698

Aflatoxin G2	Bacterial Antibiotic Parasite	Infection Cancer
Aflatoxin G2 is a major naturally produced aflatoxin. Aflatoxin G2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 .

HY-N6983

Licoricesaponin G2

Others Cancer

Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera .
HY-70003

Carboxypeptidase G2 (CPG2) Inhibitor

CPG2 Inhibitor
Carboxypeptidase Cancer

Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.

Licoricesaponin G2	Others	Cancer
Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera .

Carboxypeptidase G2 (CPG2) Inhibitor CPG2 Inhibitor	Carboxypeptidase	Cancer
Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents.

HY-P9958

Denosumab 1 Publications Verification Immunoglobulin G2; Ranmark	NF-κB	Cancer
Denosumab is a human monoclonal antibody binding to, and inhibiting, the receptor activator of RANKL (TNFSF11). Denosumab can reduce the risk of vertebral, nonvertebral and hip fractures , also has anti-cancer activity ^[2].

HY-RS05188

G2E3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G2E3 Human Pre-designed siRNA Set A contains three designed siRNAs for G2E3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G2E3 Human Pre-designed siRNA Set A G2E3 Human Pre-designed siRNA Set A

HY-N6698S

Aflatoxin G2-13C17	Isotope-Labeled Compounds	Cancer
Aflatoxin G2- ¹³C₁₇ is the ¹³C labeled Aflatoxin G2 (HY-N6698) . Aflatoxin G2 is a major naturally produced aflatoxin. Aflatoxin G2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 ^[2].

HY-125506

NP-G2-044 2 Publications Verification	Others	Cancer
NP-G2-044 is a potent, orally active fascin inhibitor, with an IC₅₀ of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response ^[2].

HY-153101

Gal-G2-CNP

Biochemical Assay Reagents Others

Gal-G2-CNP, a galactopyranosylmaltoside, can be used as substrate for the determination of novel amylase and pancreatic amylase .

Gal-G2-CNP	Biochemical Assay Reagents	Others
Gal-G2-CNP, a galactopyranosylmaltoside, can be used as substrate for the determination of novel amylase and pancreatic amylase .

HY-P4978

CBP501 Affinity Peptide	Checkpoint Kinase (Chk)	Cancer
CBP501 Affinity Peptide is a Chk kinase inhibitor that can abrogate G2 arrest induced by DNA-damaging agents. CBP501 Affinity Peptide can be used in cancer research .

HY-145290

CPT-Se3	Topoisomerase Apoptosis	Cancer
CPT-Se3, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT–Se3 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se3 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC₅₀= 2.19-4.7 μM) .

HY-145291

CPT-Se4	Topoisomerase Apoptosis	Cancer
CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC₅₀= 2.54-6.4 μM) .

HY-144666

GLS-1-IN-1

Glutaminase Cancer

GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor. GLS-1-IN-1 shows inhibitory effect against Hep G2, MCF 7, and MCF 10A cells .

GLS-1-IN-1	Glutaminase	Cancer
GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor. GLS-1-IN-1 shows inhibitory effect against Hep G2, MCF 7, and MCF 10A cells .

HY-20808

Antioxidant agent-15	COX	Cancer
Antioxidant agent-15 (Compound 4) is a potent antioxidant inhibition activity, with the IC₅₀ of 15.44 nM. Antioxidant agent-15 inhibits tumor cell growth in Hela, Hep G2 and Caco-2 cells, with the IC₅₀ of 395.26, 400.4 and 24.6 nM, respectively .

HY-N10023

Physalin O	NO Synthase	Inflammation/Immunology
Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC₅₀ values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities ^[2].

HY-138073

Cryptomoscatone D2

Others Cancer

Cryptomoscatone D2 is a potent G2 checkpoint inhibitor .

Cryptomoscatone D2	Others	Cancer
Cryptomoscatone D2 is a potent G2 checkpoint inhibitor .

HY-P4042

Hepatitis B Virus Receptor Binding Fragment hepatitis B peptide 4980	HBV	Infection Inflammation/Immunology
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization ^[2].

HY-146189

Topoisomerase II inhibitor 9	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC₅₀ of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC₅₀ of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells .

HY-115683

NUN82647

QBS
Apoptosis Cancer

NUN82647 inhibits cell cycle at G2 phase and induces apoptosis .

NUN82647 QBS	Apoptosis	Cancer
NUN82647 inhibits cell cycle at G2 phase and induces apoptosis .

HY-147054

WEE1-IN-5	Wee1 CDK	Cancer
WEE1-IN-5 is a potent WEE1 inhibitor with an IC₅₀ value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer .

HY-131143

Cadein1

Apoptosis Cancer

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53 .

Cadein1	Apoptosis	Cancer
Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53 .

HY-P99606

Cirevetmab ZTS-00521426	TGF-beta/Smad	Inflammation/Immunology
Cirevetmab (ZTS-00521426) is an immunoglobulin G2-kappa, Canis lupus familiaris TGFB1 caninized monoclonal antibody. Cirevetmab is an immunomodulator .

HY-139621

Colibactin 742	DNA Alkylator/Crosslinker	Cancer
Colibactin 742, a stable colibactin derivative, induces DNA interstrand-cross-links, activation of the Fanconi Anemia DNA repair pathway, and G2/M arrest.

HY-156183

Antiproliferative agent-37

Others Cancer

Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle .

Antiproliferative agent-37	Others	Cancer
Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle .

HY-N10670

Bursehernin Methylpluviatolide	Apoptosis	Cancer
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity ^[2].

HY-N9534

Xylopine	Reactive Oxygen Species Apoptosis	Cancer
Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells .

HY-16518

Voreloxin Hydrochloride 2 Publications Verification SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride	Topoisomerase Apoptosis	Cancer
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

HY-N8882

Oleoside 11-methyl ester

Others Cancer

Oleoside 11-methyl ester is a secoiridoid glucoside and possesses a strong cytotoxic activity against Hep-G2 cells .

Oleoside 11-methyl ester	Others	Cancer
Oleoside 11-methyl ester is a secoiridoid glucoside and possesses a strong cytotoxic activity against Hep-G2 cells .

HY-117693

Mirin 1 Publications Verification	ATM/ATR	Cancer
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC₅₀=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .

HY-16375

Ozarelix D-63153	GnRH Receptor Apoptosis	Cancer
Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer .

HY-N11110

Inuviscolide	Apoptosis	Inflammation/Immunology Cancer
Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities ^[2] .

HY-126020

Bractoppin 2 Publications Verification	DNA/RNA Synthesis RAD51	Cancer
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC₅₀: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response .

HY-N10798

Kusunokinin (-)-Kusunokinin	Apoptosis	Cancer
Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis .

HY-162108

Antitumor agent-128	Apoptosis	Cancer
Antitumor agent-128 (compound 1a) is an antitumor agent that elicits cell cycle arrest in both the G2/M and S phases, triggering apoptosis in A549 cells .

HY-163444

Apoptosis inducer 15	Apoptosis	Cancer
Apoptosis inducer 15 (Compound 3) induces cell apoptosis and cell cycle arrest at G2/M phase. Apoptosis inducer 15 is cytotoxicitic without causing DNA fragmentation .

HY-149630

VEGFR2/HDAC1-IN-1	VEGFR HDAC Apoptosis	Cancer
VEGFR2/HDAC1-IN-1 (compound 13) is a potent *VEGFR-2/HDAC* dual inhibitor, with IC₅₀s of 57.83 nM and 9.82 nM, respectively. VEGFR2/HDAC1-IN-1 arrests the cell cycle at the S and G2 phases, and induces apoptosis in HeLa cells. VEGFR2/HDAC1-IN-1 exhibits anti-angiogenic effect .

HY-146316

Topoisomerase II inhibitor 6	Topoisomerase	Cancer
Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .

HY-122496

Malvidin chloride Syringidin	Apoptosis	Cancer
Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G₂/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer .

HY-147848

Tubulin polymerization-IN-27	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-27 (compound 5j) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis .

HY-147824

Tubulin polymerization-IN-22	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-22 is a tubulin polymerization inhibitor with an IC₅₀ of 8.1 μM. Tubulin polymerization-IN-22 arrests cell cycle at G2/M phase and induces apoptosis .

HY-B0114

Oxcarbazepine GP 47680	Sodium Channel Apoptosis	Neurological Disease Cancer
Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines ^[2]. Anti-cancer and anticonvulsant effects ^[2] .

HY-100761

SS28	Microtubule/Tubulin Apoptosis	Cancer
SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin .

HY-156437

NBI-961	Ser/Thr Protease Apoptosis	Cancer
NBI-961 is a potent *NEK2* inhibitor that inhibits proteasomal degradation. NBI-961 induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells .

HY-N10394

Metachromins X

Others Cancer

Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

Metachromins X	Others	Cancer
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-157913

PKM2-IN-6	Pyruvate Kinase Apoptosis	Cancer
PKM2-IN-6 (compound 7d) is a potent and orally active *PKM2* inhibitor with an IC₅₀ value of 23 nM. PKM2-IN-6 induces apoptosis and cell cycle arrest at G2 phase. PKM2-IN-6 reduces the level of PKM1 and PKM2 at the mRNA level. PKM2-IN-6 shows anticancer activity and has the potential for the research of triple-negative breast cancer .

HY-112607

Tubulin inhibitor 1	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis .

HY-N6011

9-Methoxycamptothecin	Topoisomerase Apoptosis	Cancer
9-Methoxycamptothecin (MCPT), isolated from Camptotheca acuminata, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer ^[2].

HY-N6576

Hellebrigenin	Apoptosis	Cancer
Hellebrigenin, one of bufadienolides belonging to cardioactive steroids, is isolated from traditional Chinese medicine Venenum Bufonis. Hellebrigenin induces DNA damage and cell cycle G2/M arrest. Hellebrigenin triggers mitochondria-mediated apoptosis.

HY-N11050

Xerophilusin B	Apoptosis	Cancer
Xerophilusin B, an anticancer agent isolated from Isodon xerophilus, exhibits antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines, induces G2/M cell cycle arrest, and mediates apoptosis .

HY-18175

CCT244747 2 Publications Verification	Checkpoint Kinase (Chk)	Cancer
CCT244747 is a potent, orally bioavailable and highly selective CHK1 inhibitor, with an IC₅₀ of 7.7 nM; CCT244747 also abrogates G2 checkpoint with an IC₅₀ of 29 nM.

HY-N7152

6-Dehydrogingerdione	Apoptosis	Cancer
6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5 .

Cat. No.	Product Name	Target	Research Area

HY-P3795

G2-Peptide

Peptides Others

G2-Peptide is an peptide. G2-Peptide can be used for the research of various biochemical .

HY-P4978

CBP501 Affinity Peptide	Checkpoint Kinase (Chk)	Cancer
CBP501 Affinity Peptide is a Chk kinase inhibitor that can abrogate G2 arrest induced by DNA-damaging agents. CBP501 Affinity Peptide can be used in cancer research .

HY-P4042

Hepatitis B Virus Receptor Binding Fragment hepatitis B peptide 4980	HBV	Infection Inflammation/Immunology
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization ^[2].

HY-16375

Ozarelix D-63153	GnRH Receptor Apoptosis	Cancer
Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer .

HY-P2698

1-Alaninechlamydocin	HDAC Apoptosis	Cancer
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC₅₀=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells .

HY-P1032S1

Angiotensin I-13C5,15N (human, mouse, rat)	Isotope-Labeled Compounds Endogenous Metabolite	Others
Angiotensin I- ¹³C₅, ¹⁵N (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-144292

HDAC-IN-30	HDAC	Cancer
HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC₅₀=13.4 nM),HDAC2 (IC₅₀=28.0 nM), HDAC3 (IC₅₀=9.18 nM), HDAC6 (IC₅₀=42.7 nM), HDAC8 (IC₅₀=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy .

HY-P4459

(Des-Gly2)-Exenatide

Peptides Metabolic Disease

(Des-Gly2)-Exenatide is a potential impurity of Exenatide (HY-13443).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6698

Aflatoxin G2	Infection Microorganisms Classification of Application Fields Source classification Coumarins Phenylpropanoids Disease Research Fields Cancer	Bacterial Antibiotic Parasite
Aflatoxin G2 is a major naturally produced aflatoxin. Aflatoxin G2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 .

HY-N6983

Licoricesaponin G2	Other Terpenoids Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Others
Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera .

HY-N10023

Physalin O	Structural Classification Physalis minima Linn. Cardiacglycosides Source classification Plants Solanaceae Steroids	NO Synthase
Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC₅₀ values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities ^[2].

HY-138073

Cryptomoscatone D2	Structural Classification Cryptocarya mandioccana Meisn. Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae	Others
Cryptomoscatone D2 is a potent G2 checkpoint inhibitor .

HY-N10670

Bursehernin Methylpluviatolide	Structural Classification Hernandia sonora Linn. other families Source classification Lignans Phenylpropanoids Plants	Apoptosis
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity ^[2].

HY-N9534

Xylopine	Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis
Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells .

HY-N8882

Oleoside 11-methyl ester	Iridoids Classification of Application Fields Oleaceae Ligustrum lucidum Ait. Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Oleoside 11-methyl ester is a secoiridoid glucoside and possesses a strong cytotoxic activity against Hep-G2 cells .

HY-N11110

Inuviscolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Erythrina arborescens Roxb.	Apoptosis
Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities ^[2] .

HY-N10798

Kusunokinin (-)-Kusunokinin	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper nigrum Linn.	Apoptosis
Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis .

HY-122496

Malvidin chloride Syringidin	Structural Classification Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids other families Microorganisms Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G₂/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer .

HY-N10394

Metachromins X	Quinones Structural Classification Classification of Application Fields Animals Terpenoids Sesquiterpenes Marine natural products Benzene Quinones Sponge Disease Research Fields Cancer	Others
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-N6011

9-Methoxycamptothecin	Alkaloids Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Isoquinoline Alkaloids Disease Research Fields Cancer	Topoisomerase Apoptosis
9-Methoxycamptothecin (MCPT), isolated from Camptotheca acuminata, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer ^[2].

HY-N6576

Hellebrigenin	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis
Hellebrigenin, one of bufadienolides belonging to cardioactive steroids, is isolated from traditional Chinese medicine Venenum Bufonis. Hellebrigenin induces DNA damage and cell cycle G2/M arrest. Hellebrigenin triggers mitochondria-mediated apoptosis.

HY-N11050

Xerophilusin B	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Cosmos sulphureus Cav.	Apoptosis
Xerophilusin B, an anticancer agent isolated from Isodon xerophilus, exhibits antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines, induces G2/M cell cycle arrest, and mediates apoptosis .

HY-N7152

6-Dehydrogingerdione	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis
6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5 .

HY-N2374

Eupatorin	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Source classification Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-P2698

1-Alaninechlamydocin	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HDAC Apoptosis
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC₅₀=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells .

HY-N10188

Nidurufin	Quinones Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields Cancer	Others
Nidurufin is a potent cell cycle inhibitor with antitumor activity.Nidurufin induces in vitro cell cycle arrest at G₂/M transition in the K562 cell line in a concentration and time dependent manner(IC₅₀=12.6 μM) .

HY-126067

(-)-Pinoresinol	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Source classification Lignans Phenylpropanoids Plants	Glucosidase Apoptosis
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest .

HY-N7273

Soyasaponin III	Triterpenes Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Soyasaponin III, a monodesmodic oleanane triterpenoid, is one of the main potentially bioactive saponins found in soy (Glycine max) and related products. Soyasaponin III can induce apoptosis in Hep-G2 cells .

HY-N9968

Cucurbitacin C	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Cucumis sativus L.	Akt Apoptosis
Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling .

HY-B0011

Docetaxel Maximum Cited Publications 81 Publications Verification RP-56976	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N0421

Cinobufagin 3 Publications Verification Cinobufagine	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models ^[2] .

HY-N1428

Citric acid 3 Publications Verification	Cardiovascular Disease Structural Classification Preservatives Classification of Application Fields Anti-aging Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Food Research Infection Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Inflammation/Immunology Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Antibiotic
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice ^[2] .

HY-N3446

IVHD-valtrate	Natural Products Classification of Application Fields Source classification Valeriana officinalis Linn. Plants Valerianaceae Disease Research Fields Cancer	Apoptosis
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

HY-126566

Trichostatin C	Structural Classification Natural Products Microorganisms Source classification	Fungal HDAC Apoptosis
Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer . Trichostatin C induces differentation of Friend leukemic cells ^[2]. Trichostatin C exhibits antifungal activity .

HY-N0047

Polyphyllin I 1 Publications Verification	Structural Classification Liliaceae Classification of Application Fields Paris polyphylla Smith Plants Disease Research Fields Saccharides Steroids Cancer	JNK mTOR Akt PDK-1 Autophagy Apoptosis
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis ^[2] .

HY-B2201

Citric acid trisodium 3 Publications Verification Sodium citrate; Trisodium citrate anhydrous	Structural Classification Preservatives Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Food Research	Apoptosis Endogenous Metabolite
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice ^[2] .

HY-N2374R

Eupatorin (Standard)	Structural Classification Flavonoids Classification of Application Fields Cruciferae Source classification Phenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-B1357

Digitoxin 3 Publications Verification	Cardiovascular Disease Digitalis purpurea Linn. Structural Classification Microorganisms Classification of Application Fields Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Bcl-2 Family Caspase Apoptosis HSV Na+/K+ ATPase Calcium Channel
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure ^[2] .

HY-N2369

Chelidonine	Infection Alkaloids Structural Classification Classification of Application Fields Chelidonium majus Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Apoptosis Influenza Virus
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity ^[2] .

HY-N10018

Cimiside E 25-Anhydrocimigenol xyloside	Triterpenes Structural Classification Terpenoids Source classification Ranunculaceae Plants Cimicifuga racemosa (L.) Nutt.	Caspase
Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC₅₀ value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways ^[2].

HY-N3093

Periglaucine B (+)-Periglaucine B	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Pericampylus glaucus (Lam.) Merr. Plants Menispermaceae	HBV
Periglaucine B ((+)-Periglaucine B) is an alkaloid and an HBsAg inhibitor. Periglaucine B can be isolated from Pericampylus glaucus. Periglaucine B inhibits the secretion of hepatitis B virus (HBV) surface antigen (HBsAg) in Hep G2.2.15 cells with an IC₅₀ of 0.47 mM .

HY-N3627

Coronalolide methyl este NSC 680073	Structural Classification Natural Products Source classification Rubiaceae Plants Gardenia jasminoides Ellis	Others
Coronalolide methyl ester (NSC 680073) is a natural triterpene with anticancer effects. Coronalolide methyl ester shows moderately cytotoxic to KATO-3, SW-620, and Hep-G2 cells., with IC₅₀ values of 8.64 µg/mL, 6.19 µg/mL, and 6.8 µg/mL, respectively .

HY-N0816

Polyphyllin VI 1 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Pyroptosis
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer ^[2] .

HY-120912

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase
Gingerenone A is a *Nrf2-Gpx4* activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale ^[2].

HY-B0011R

Docetaxel (Standard) RP-56976 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N3094

Periglaucine A	Structural Classification Alkaloids Pyrrole Alkaloids Labiatae Source classification Plants Erigeron breviscapus (Vant.) Hand.-Mazz.	HBV HIV
Periglaucine A, a hasubanane-type alkaloid, can be isolated from Pericampylus glaucus. Periglaucine A can inhibits HBV surface antigen (HBsAg) secretion in Hep G2.2.15 cells. Periglaucine A also shows anti-HIV-1 activity in C8166 cells (EC₅₀: 204 μM) .

HY-N2416

Taccalonolide A	Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities ^[2]. Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-134008

Protoapigenone	Structural Classification Flavonoids Flavones Source classification Plants Macrothelypteris torresiana (Gaud.) Ching Thelypteridaceae	Others
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .

HY-N11439

Albanol B	Structural Classification Natural Products Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	CDK Akt ERK Apoptosis Bacterial
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and *ERK1/2* .

HY-N8954

Kaempferol 7-O-neohesperidoside	Structural Classification Flavonols Flavonoids Litchi Chinensis Sonn. Source classification Sapindaceae Plants	Others
Kaempferol 7-O-neohesperidoside is a ?avonoid glycoside that can be isolated from Litchi chinensis. Kaempferol 7-O-neohesperidoside exhibits significant cytotoxic activity against A549, LAC, Hep-G2, and HeLa cell lines with IC₅₀s of 0.53, 7.93, 0.020, and 0.051 μM, respectively .

HY-N2447

Amarogentin 2 Publications Verification	Structural Classification Gentiana scabra Bunge Iridoids Classification of Application Fields Terpenoids Source classification Gentianaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	AMPK Apoptosis
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK ^[2] .

HY-N2983

Cajanin	Flavonoids Classification of Application Fields Leguminosae red seaweeds Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Isoflavones	Tyrosinase
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis ^[2].

HY-N12105

Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Illicium henryi Diels.	HBV
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside is an anti-hepatitis B virus (anti-HBV) agent. Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside inhibits HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line, with IC₅₀ values of 1.67 and >2.15 mM, respectively .

HY-N6696

Aflatoxin B2	Structural Classification Classification of Application Fields Source classification Agrostidoideae Coumarins Plants Endogenous metabolite Triticum aestivum L. Infection Human Gut Microbiota Metabolites Microorganisms Phenylpropanoids Disease Research Fields	Bacterial Antibiotic Parasite
Aflatoxin B2 is a major naturally produced aflatoxin. Aflatoxin B2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 .

HY-N6700

Aflatoxin M2	Structural Classification Microorganisms Classification of Application Fields Source classification Coumarins Phenylpropanoids Disease Research Fields Cancer	Parasite
Aflatoxin M2 is a major metabolite of Aflatoxin B1. Aflatoxin M2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 .

HY-N3626

Coronalolide	Triterpenes Structural Classification Terpenoids Source classification Rubiaceae Gardenia sootepensis hutchins. Plants	Others
Coronalolide is a natural triterpene with anticancer effects. Coronalolide exhibits a broad cytotoxic activity for human breast (BT474), gastric (KATO-3), lung (CHAGO), colon (SW-620), and liver (Hep-G2) cancer cell lines, with IC₅₀ values of 6.59 µg/mL, 5.85 µg/mL, 5.42 µg/mL, 4.98 µg/mL, and 6.41 µg/mL, respectively .

HY-N4327

Eurycomalactone	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB Apoptosis Akt Bcl-2 Family
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394) ^[2] .

HY-N6699

Aflatoxin M1	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Coumarins Phenylpropanoids Endogenous metabolite Disease Research Fields	Bacterial Parasite Apoptosis
Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is an orally active mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 ^[2] .

Species:	Human (11) Virus (2) Mouse (4)
Tag:	His (14) SUMO (1) GST (6) Flag (3) Fc (1)
Source:	HEK293 (6) Sf9 insect cells (7) P. pastoris (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71401

	UBE2G2 Protein, Human (GST) Ubiquitin-Conjugating Enzyme E2 G2; Ubiquitin Carrier Protein G2; Ubiquitin-Protein Ligase G2; UBE2G2	Human	E. coli
	UBE2G2 Protein, a vital ubiquitination component, accepts ubiquitin from the E1 complex, catalyzing its covalent attachment to various proteins, with a preference for 'Lys-48'-linked polyubiquitination. Its specificity in shaping ubiquitin chains underscores its role in cellular processes. Intricately associated with endoplasmic reticulum-associated degradation (ERAD), UBE2G2 maintains cellular homeostasis by regulating protein turnover. Indispensable for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase, it facilitates subsequent proteasomal degradation. UBE2G2 Protein, Human (GST) is the recombinant human-derived UBE2G2 protein, expressed by E. coli, with N-GST labeled tag. The total length of UBE2G2 Protein, Human (GST) is 165 a.a., with molecular weight of ~43.0 kDa.

HY-P702671

	CDK1-CCNA2 Protein, Human (sf9, GST, His) CDK1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells

HY-P702673

	CDK1-CCNE1 Protein, Human (sf9, GST, His, Flag) CDK1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells

HY-P702674

	CDK1-CCNE2 Protein, Human (sf9, GST, His, Flag) CDK1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells

HY-P702736

	CDK1-CCNB1 Protein, Human (sf9, GST, Flag, His) CDK1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells

HY-P702667

CSNK1G2 Protein, Human (sf9, GST)

CSNK1G2; casein kinase 1 gamma 2; CK1G2
Human Sf9 insect cells

HY-P76577

	glycoprotein/G2 Protein, RVFV (sf9, His) Rift Valley fever virus (RVFV) (strain MP12) glycoprotein/G2 Protein	Virus	Sf9 insect cells
	RVFV is an RNA virus in the Phlebovirus genus of the Bunyaviridae family. The virus is enveloped, spherical, and has a diameter of approximately 80-120 nm. G1 is a glycoprotein that enter the viral envelope to form a ribonucleoprotein complex (RNP) with the N protein. RVFV is a high-risk pathogen that can induce fatal encephalitis and hemorrhagic fever in humans and ruminants. glycoprotein/G2 Protein, RVFV (sf9, His) is the recombinant Virus-derived glycoprotein/G2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of glycoprotein/G2 Protein, RVFV (sf9, His) is 449 a.a., with molecular weight of ~50.1 kDa.

HY-P7741

	Casein Kinase I gamma-2 Protein, Human (His) rHuCasein kinase I isoform gamma-2, His; Casein kinase I isoform gamma-2; CK1G2; CSNK1G2	Human	E. coli
	Casein kinase I gamma-2 Protein, Human (His) is an approximately 55.0 kDa human casein kinase I isoform gamma-2 protein with a His-flag expressed in E. coli. Human Casein kinase I isoform gamma-2 may exhibit overexpression during tumorigenesis and belongs to the CKI family.

HY-P72873

	Casein Kinase I gamma-2 Protein, Human (sf9, His) Casein kinase I isoform gamma-2; CKI-gamma 2; CSNK1G2; CK1G2	Human	Sf9 insect cells
	Casein kinase I gamma-2 is a serine/threonine protein kinase that targets acidic proteins and phosphorylates a variety of substrates, such as COL4A3BP/CERT, MTA1 and SMAD3, especially destabilizing SMAD3 and inhibiting TGF- beta reaction. Hyperphosphorylation of COL4A3BP/CERT disrupts ER-to-Golgi transport and affects the synthesis of ceramide and sphingomyelin. Casein Kinase I gamma-2 Protein, Human (sf9, His) is the recombinant human-derived Casein Kinase I gamma-2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Casein Kinase I gamma-2 Protein, Human (sf9, His) is 398 a.a., with molecular weight of ~48 kDa.

HY-P71653

	PLA2G2D Protein, Human (His-SUMO) 2IID; EC 3.1.1.4; GIID sPLA2; Group IID secretory phospholipase A2; Phospholipase A2 group IID ; Pla2G2d; PLA2IID; stroma-associated homolog	Human	E. coli
	PLA2G2D protein is a secreted calcium-dependent phospholipase A2 that targets extracellular lipids and has anti-inflammatory and immunosuppressive functions. It hydrolyzes the fatty acyl group at the sn-2 position, preferentially hydrolyzing phosphatidylethanolamine and phosphatidylglycerol. PLA2G2D Protein, Human (His-SUMO) is the recombinant human-derived PLA2G2D protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of PLA2G2D Protein, Human (His-SUMO) is 124 a.a., with molecular weight of ~30.5 kDa.

HY-P74628

	PLA2G2A Protein, Mouse (P.pastoris, His) 1 Publications Verification Phospholipase A2, membrane associated; EF; GIIC sPLA2	Mouse	P. pastoris
	PLA2G2A Protein, a phospholipase A2 enzyme, efficiently hydrolyzes phosphatidylethanolamines and phosphatidylglycerols, contributing to lipid membrane remodeling and generating lipid mediators crucial for pathogen clearance. PLA2G2A Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PLA2G2A protein, expressed by P. pastoris , with C-His labeled tag. The total length of PLA2G2A Protein, Mouse (P.pastoris, His) is 125 a.a., with molecular weight of ~15.3 kDa.

HY-P75195

	Fetuin B Protein, Mouse (HEK293, His) Fetuin-B; 16G2; Fetuin-Like Protein IRL685; Gugu; FETUB	Mouse	HEK293
	Fetub Protein, a glycoprotein, plays a significant role in regulating insulin sensitivity and lipid metabolism. Dysregulation of Fetub Protein has been associated with several diseases, including obesity and type 2 diabetes. Fetuin B Protein, Mouse (HEK293, His) is the recombinant mouse-derived Fetuin B protein, expressed by HEK293 , with C-His labeled tag. The total length of Fetuin B Protein, Mouse (HEK293, His) is 370 a.a., with molecular weight of 55-65 kDa.

HY-P75977

	PLA2G2A Protein, Human (HEK293, His) Phospholipase A2, membrane associated; EF; GIIC sPLA2	Human	HEK293
	The PLA2G2A protein is a secreted calcium-dependent phospholipase A2 that selectively targets extracellular phospholipids and contributes to host antimicrobial defense, inflammation, and tissue regeneration. It has phospholipase A2 activity, which preferentially hydrolyzes fatty acyl groups, phosphatidylethanolamine and phosphatidylglycerol. PLA2G2A Protein, Human (HEK293, His) is the recombinant human-derived PLA2G2A protein, expressed by HEK293 , with C-His labeled tag. The total length of PLA2G2A Protein, Human (HEK293, His) is 144 a.a., with molecular weight of ~19 kDa.

HY-P77138

	PLA2G2E Protein, Mouse (HEK293, His) Group IIE secretory phospholipase A2; GIIE sPLA2	Mouse	HEK293
	The PLA2G2E protein is a secreted calcium-dependent phospholipase A2 that targets extracellular phospholipids. It hydrolyzes the fatty acyl group at the sn-2 position, releasing unsaturated fatty acids, especially lysophosphatidylethanolamine. PLA2G2E Protein, Mouse (HEK293, His) is the recombinant mouse-derived PLA2G2E protein, expressed by HEK293 , with C-His labeled tag. The total length of PLA2G2E Protein, Mouse (HEK293, His) is 123 a.a., with molecular weight of ~18 kDa.

HY-P70930

	Fetuin B Protein, Human (367a.a, HEK293, His) Fetuin-B; 16G2; Fetuin-Like Protein IRL685; Gugu; FETUB	Human	HEK293
	Fetuin B, a vital protease inhibitor, plays a crucial role in egg fertilization by preventing premature zona pellucida hardening before fertilization. Its primary function involves inhibiting the protease activity of ASTL, preventing ZP2 cleavage and zona pellucida hardening. Fetuin B's regulatory role emphasizes its significance in creating optimal conditions for successful fertilization and subsequent embryonic development. Fetuin B Protein, Human (367a.a, HEK293, His) is the recombinant human-derived Fetuin B protein, expressed by HEK293, with C-6*His labeled tag. The total length of Fetuin B Protein, Human (367a.a, HEK293, His) is 367 a.a., with molecular weight of 53-55 kDa.

HY-P76549

	PLA2G2D Protein, Mouse (HEK293, Fc) Group IID secretory phospholipase A2; GIID sPLA2; PLA2IID; Splash	Mouse	HEK293
	PLA2G2D protein is a secreted calcium-dependent phospholipase A2 that targets extracellular lipids and has anti-inflammatory and immunosuppressive functions. It hydrolyzes the fatty acyl group at the sn-2 position, preferentially hydrolyzing phosphatidylethanolamine and phosphatidylglycerol. PLA2G2D Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PLA2G2D protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PLA2G2D Protein, Mouse (HEK293, Fc) is 125 a.a., with molecular weight of 40-50 kDa.

HY-P75032

	HA/Hemagglutinin Protein, H5N1 (G2U0T8, HEK293, His) Influenza A H5N1 (A/Hubei/1/2010) Hemagglutinin / HA Protein (HEK293, His)	Virus	HEK293
	HA/Hemagglutinin Protein binds to sialic acid receptors, initiating virus attachment to cells. Internalization occurs through clathrin-dependent or -independent pathways. HA crucially influences host range and virus virulence. As a Class I viral fusion protein, it mediates membrane fusion between the endocytosed virus particle and the endosomal membrane, enabling virus entry into the cell cytoplasm. In low pH endosomes, HA2 undergoes an irreversible conformational change, releasing the fusion hydrophobic peptide. Multiple HA trimers are necessary for a competent fusion pore. HA/Hemagglutinin Protein, H5N1 (G2U0T8, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293, with C-His labeled tag. The total length of HA/Hemagglutinin Protein, H5N1 (G2U0T8, HEK293, His) is 530 a.a., with molecular weight of 65-70 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0294S

Flubendazole-d3
Flubendazole-d₃ is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].

HY-N6698S

Aflatoxin G2-13C17
Aflatoxin G2- ¹³C₁₇ is the ¹³C labeled Aflatoxin G2 (HY-N6698) . Aflatoxin G2 is a major naturally produced aflatoxin. Aflatoxin G2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 ^[2].

HY-B0114S2

Oxcarbazepine-d8-1
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines ^[2]. Oxcarbazepine? has anti-cancer and anticonvulsant effects ^[2].

HY-B0114S1

Oxcarbazepine-d4-1
Oxcarbazepine-d₄-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-B0114S

Oxcarbazepine-D4
Oxcarbazepine-d₄ (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3].

HY-N1428S4

Citric acid-18O
Citric acid- ¹⁸O is ¹⁸O-labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N1428S6

Citric acid-d4-1
Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N1428S3

Citric acid-13C3
Citric acid- ¹³C₃ is the ¹³C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis[1][3].

HY-N0273S

Brassinolide-d5

Brassinolide-d₅ (Brassin lactone-d₅) is the deuterated labeled Brassinolide (HY-N0273). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice ^[2] .

HY-P1032S1

Angiotensin I-13C5,15N (human, mouse, rat)

Angiotensin I- ¹³C₅, ¹⁵N (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-N6700S

Aflatoxin M2-13C17
Aflatoxin M2- ¹³C₁₇ is the ¹³C labeled Aflatoxin M2 (HY-N6700) . Aflatoxin M2 is a major metabolite of Aflatoxin B1. Aflatoxin M2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 ^[2].

HY-N6699S

Aflatoxin M1-13C17
Aflatoxin M1- ¹³C₁₇ is the ¹³C labeled Aflatoxin M1 (HY-N6699) . Aflatoxin M1 is a major metabolite of Aflatoxin B1. Aflatoxin M1 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 ^[2].

HY-N6696S

Aflatoxin B2-13C17
Aflatoxin B2- ¹³C₁₇ is ¹³C- and ¹⁵N-labeled Aflatoxin B2 (HY-N6696). Aflatoxin B2 is a major naturally produced aflatoxin. Aflatoxin B2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2 ^[2].

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