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Results for "

GC-1

" in MedChemExpress (MCE) Product Catalog:

2

Inhibitors & Agonists

2

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14823
    Sobetirome
    5 Publications Verification

    GC-1; QRX-431

    		 Thyroid Hormone Receptor Metabolic Disease Endocrinology
    Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM [1].
    Sobetirome
  • HY-141513
    NH-3
    1 Publications Verification

    		 Thyroid Hormone Receptor Neurological Disease
    NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment [1] . NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NH-3

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