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Results for "

GCs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glucosylceramide Synthase (GCS) (14) Apoptosis (1) Fluorescent Dye (1) NF-κB (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (8) Neurological Disease (7)

Inhibitors & Agonists

Fluorescent Dye

Recombinant Proteins

Antibodies

Targets Recommended: Glucosylceramide Synthase (GCS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146564

R-HP210	NF-κB	Inflammation/Immunology
R-HP210 acts on the NF-κB mediated tethered transrepression function (IC₅₀=3.80 μM). R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs) .

HY-129411

Sinbaglustat ACT-519276; OGT2378	Glucosylceramide Synthase (GCS)	Metabolic Disease
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions .

HY-144266

TP-060 Glucosylceramide synthase-IN-1	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC₅₀s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research .

HY-D1573

C6 NBD Phytoceramide

Fluorescent Dye Others

C6 NBD Phytoceramide is a fluorescently labeled short-chain ceramide analog that can be recognized by mammalian GlcCer synthase (GCS) .

C6 NBD Phytoceramide	Fluorescent Dye	Others
C6 NBD Phytoceramide is a fluorescently labeled short-chain ceramide analog that can be recognized by mammalian GlcCer synthase (GCS) .

HY-116392E

D-threo-PDMP	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth .

HY-144267

Glucosylceramide synthase-IN-2	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC₅₀s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research .

HY-144270

Glucosylceramide synthase-IN-3	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC₅₀s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research .

HY-106392

Lucerastat NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin	Glucosylceramide Synthase (GCS)	Metabolic Disease
Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study .

HY-148786

Nizubaglustat	Glucosylceramide Synthase (GCS)	Neurological Disease
Nizubaglustat is an inhibitor of Ceramide Glucosyltransferase or Glucosylceramide Synthase (GCS). Nizubaglustat also inhibits GBA2, involving in neuropathological lysosomal storage disorders .

HY-116392D

PDMP hydrochloride	Glucosylceramide Synthase (GCS) Apoptosis	Cancer
PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research .

HY-116392B

DL-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase (GCS) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice .

HY-116392A

(−)-L-threo-PDMP hydrochloride	Glucosylceramide Synthase (GCS)	Cancer
(−)-L-threo-PDMP hydrochloride is the hydrochloride form of (−)-L-threo-PDMP. L-threo-PDMP is a glucosylceramide synthase (GCS) inhibitor. L-threo-PDMP stimulates the proliferation of cultured aortic smooth muscle cells, and that increases the level of LacCer in B16 melanoma cells .

HY-16743

Ibiglustat 2 Publications Verification Venglustat; SAR402671; GZ402671	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-16743B

Ibiglustat succinate 2 Publications Verification Venglustat succinate; SAR402671 succinate; GZ402671 succinate	Glucosylceramide Synthase (GCS)	Neurological Disease
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-163131

Glucosylceramide synthase-IN-4	Glucosylceramide Synthase (GCS)	Neurological Disease
Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC₅₀ of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity .

HY-16743A

Ibiglustat (L-Malic acid) 2 Publications Verification Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

Cat. No.	Product Name	Type

HY-D1573

C6 NBD Phytoceramide

Fluorescent Dyes/Probes

C6 NBD Phytoceramide is a fluorescently labeled short-chain ceramide analog that can be recognized by mammalian GlcCer synthase (GCS) .

C6 NBD Phytoceramide	Fluorescent Dyes/Probes
C6 NBD Phytoceramide is a fluorescently labeled short-chain ceramide analog that can be recognized by mammalian GlcCer synthase (GCS) .

Species:	Human (1) E.coli (1)
Tag:	His (2) SUMO (1)
Source:	E. coli Cell-free (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P702485

	UGCG Protein, Human (Cell-Free, His) Ceramide glucosyltransferase; GLCT-1; Glucosylceramide synthase; GCs; Glycosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase	Human	E. coli Cell-free
	UGCG proteins play a key role in the glucosphingolipid (GSL) synthesis pathway based on glucosylceramide in the Golgi apparatus, catalyzing the key step of transferring glucose to ceramide to form glucosylceramide (GlcCer). GSLs have effects on membrane microdomains, affecting processes such as membrane trafficking and signal transduction. UGCG Protein, Human (Cell-Free, His) is the recombinant human-derived UGCG protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGCG Protein, Human (Cell-Free, His) is 394 a.a., with molecular weight of 47.7 kDa.

HY-P71511

	*Gamma-GCS* Protein, E.coli (His-SUMO)** gshA; gsh-I; b2688; JW2663Glutamate--cysteine ligase; EC 6.3.2.2; Gamma-ECS; GCs; Gamma-glutamylcysteine synthetase	E.coli	E. coli
	Gamma-GCS protein is a key enzyme in sulfur metabolism and initiates glutathione synthesis by catalyzing the incorporation of L-cysteine and L-glutamic acid. This important molecule critical for cellular antioxidant defense is synthesized through a critical 1/2 step facilitated by γ-GCS. Gamma-GCS Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Gamma-GCS protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of Gamma-GCS Protein, E.coli (His-SUMO) is 518 a.a., with molecular weight of ~74.3 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P83192

Guanylyl Cyclase alpha 1 Antibody (YA2937)

GUCY1A3; GC-S-alpha-1; GUC1A3; GUCA3; GCs-alpha-3; GUCY1A1; GC-SA3; GCs-alpha-1; GUCSA3
WB Human
HY-P82402

Guanylyl Cyclase beta 1 Antibody (YA2147)

GCbeta1; GCs beta 1; GCs beta 3; GUC1B3; GUCSB3; GUCY1B1; Gucy1b1; GUCY1B3; SGC
WB, IHC-P Human, Mouse, Rat
HY-P83153

GCLC Antibody (YA2898)

GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCs heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase
WB Human, Mouse, Rat

HY-P81662

GCLM Antibody (YA1407) GCLM; GLCLR; Glutamate--cysteine ligase regulatory subunit; GCs light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

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