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Results for "

GDP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Biochemical Assay Reagents (1) Bombesin Receptor (1) DNA/RNA Synthesis (6) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (16) Fluorescent Dye (1) Fungal (1) Glucosylceramide Synthase (GCS) (1) Glycosyltransferase (1) Isotope-Labeled Compounds (9) Nucleoside Antimetabolite/Analog (6) Potassium Channel (7) Ras (20) SHP2 (1) Survivin (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (7) Metabolic Disease (9)
Click Chemistry:	Tetrazine (1) Alkynes (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7389A

GDP-D-mannose disodium	Endogenous Metabolite	Metabolic Disease
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (K_i 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (K_i 115 μM) .

HY-113066

Guanosine 5'-diphosphate GDP	Endogenous Metabolite Potassium Channel	Inflammation/Immunology
Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-160258

GDP-Fucose-Tz GDP-Fucose-Am-Tz	Biochemical Assay Reagents	Others
GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. GDP-fucose-Am-Tz and TCO-ssDNA were reacted at a ratio of 1:1 to obtain the final product GDP-fucose-ssDNA .

HY-160299

GDP-Fuc-Biotin

Others Others

GDP-Fuc-Biotin is a biotinylated GDP-Fucose that can be used to conjugate antibodies .

GDP-Fuc-Biotin	Others	Others
GDP-Fuc-Biotin is a biotinylated GDP-Fucose that can be used to conjugate antibodies .

HY-134433A

GDP-L-fucose disodium	Endogenous Metabolite	Metabolic Disease
GDP-L-fucose disodium is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides. GDP-L-fucose disodium provides the fucose moiety for the oligosaccharides. The formation of GDP-L-fucose disodium occurs through two pathways, the major de novo metabolic pathway and the minor remedial metabolic pathway .

HY-134433

GDP-L-fucose	Endogenous Metabolite	Metabolic Disease
GDP-L-fucose is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides, providing the fucose moiety for the oligosaccharides.The formation of GDP-L-fucose occurs through two pathways, the major ab initio metabolic pathway and the minor remedial metabolic pathway .

HY-N7389B

GDP-α-D-mannose disodium	Endogenous Metabolite	Metabolic Disease
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (K_i 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (K_i 115 μM) .

HY-U00177

GDP366 1 Publications Verification	Survivin	Cancer
GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.

HY-160297

GDP-FAzP4Biotin

Others Others

GDP-FAzP4Biotin is a biotin junction structure .
HY-D2278

GDP-Fucose-Cy5

Fluorescent Dye Others

GDP-Fucose-Cy5 is a fluorescent dye that can be used for labeling free glycans, glycoproteins and glycolipids .

GDP-FAzP4Biotin	Others	Others
GDP-FAzP4Biotin is a biotin junction structure .

GDP-Fucose-Cy5	Fluorescent Dye	Others
GDP-Fucose-Cy5 is a fluorescent dye that can be used for labeling free glycans, glycoproteins and glycolipids .

HY-113066C

Guanosine 5'-diphosphate sodium GDP sodium	Endogenous Metabolite Potassium Channel	Inflammation/Immunology
Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate sodium is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-113066A

Guanosine 5'-diphosphate disodium salt 2 Publications Verification GDP disodium salt	Endogenous Metabolite Potassium Channel	Inflammation/Immunology
Guanosine 5'-diphosphate (GDP) disodium salt is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate disodium salt can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-113066S2

Guanosine 5'-diphosphate-d13 dilithium GDP-d¹³ dilithium	Isotope-Labeled Compounds Endogenous Metabolite Potassium Channel	Inflammation/Immunology
Guanosine 5'-diphosphate-d₁₃ (GDP-d₁₃) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S1

Guanosine 5'-diphosphate-13C10 dilithium GDP-¹³C₁₀ dilithium	Isotope-Labeled Compounds Endogenous Metabolite Potassium Channel	Inflammation/Immunology
Guanosine 5'-diphosphate- ¹³C₁₀ (GDP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S

Guanosine 5'-diphosphate-15N5 dilithium GDP-¹⁵N₅ dilithium	Isotope-Labeled Compounds Endogenous Metabolite Potassium Channel	Inflammation/Immunology
Guanosine 5'-diphosphate- ¹⁵N₅ (GDP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S3

Guanosine 5'-diphosphate-13C10,15N5 dilithium GDP-¹³C₁₀,¹⁵N₅ dilithium	Isotope-Labeled Compounds Endogenous Metabolite Potassium Channel	Inflammation/Immunology
Guanosine 5'-diphosphate- ¹³C₁₀, ¹⁵N₅ (GDP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-155291

3'-Mant-GDP

Others Others

3'-Mant-GDP is a nucleoside compound and a derivative of guanosine diphosphate .

3'-Mant-GDP	Others	Others
3'-Mant-GDP is a nucleoside compound and a derivative of guanosine diphosphate .

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Endogenous Metabolite	Others
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues .

HY-151999

KRASG12C IN-1	Ras	Cancer
KRASG12C IN-1 is a potent and covalent KRAS ^G12C inhibitor that traps KRAS ^G12C in the GDP-bound state. KRASG12C IN-1 exhibits potent antitumor activity against KRAS-mutant non-small cell lung cancer .

HY-111671

SOS1 activator 1	Ras	Cancer
SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a K_d of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS .

HY-116705

2-Deoxy-2-fluoro-L-fucose	Others	Cancer
2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma .

HY-16304

Mannose 1-phosphate	Endogenous Metabolite	Metabolic Disease
Mannose 1-phosphate is an endogenous metabolite. Mannose 1-phosphate can be used to synthesize GDP-Man by the enzyme GDP-mannose pyrophosphorylase .

HY-16304A

Mannose 1-phosphate sodium	Endogenous Metabolite	Metabolic Disease
Mannose 1-phosphate sodium is an endogenous metabolite. Mannose 1-phosphate sodium can be used to synthesize GDP-Man by the enzyme GDP-mannose pyrophosphorylase .

HY-138616

dGTP 2'-Deoxyguanosine-5'-triphosphate	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP .

HY-148426

OSu-PEG4-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Others
OSu-PEG4-VC-PAB-MMAE involves in GDP-FAmP₄MMAE (Monomethylauristatin E) synthesis, which is for GDP label via site-specific conjugation .

HY-138616S3

dGTP-13C10 dilithium 2'-Deoxyguanosine-5'-triphosphate-¹³C₁₀ dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹³C₁₀ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀) dilithium is ¹³C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S

dGTP-15N5 dilithium 2'-Deoxyguanosine-5'-triphosphate-₁₅₅	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅) dilithium is ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S1

dGTP-d14 dilithium 2'-Deoxyguanosine-5'-triphosphate-d₁₄ dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP-d₁₄ (2'-Deoxyguanosine-5'-triphosphate-d₁₄) dilithium is deuterium labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S4

dGTP-13C10,15N5 dilithium 2'-Deoxyguanosine-5'-triphosphate-¹³C₁₀,¹⁵N₅ dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹³C₁₀, ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S2

dGTP-15N5,d14 dilithium 2'-Deoxyguanosine-5'-triphosphate-¹⁵N₅,d₁₄ dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹⁵N₅,d₁₄ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-117958

HJC0197 1 Publications Verification	Ras	Cardiovascular Disease Metabolic Disease Cancer
HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC₅₀=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .

HY-145962

MRTX-EX185	Ras	Cancer
MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC₅₀ of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS . MRTX-EX185 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-145962A

MRTX-EX185 formic	Ras	Cancer
MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC₅₀ of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS . MRTX-EX185 (formic) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P5072

GRP (14-27) (human, porcine, canine)	Bombesin Receptor	Metabolic Disease
GRP (14-27) (human, porcine, canine) is a bombesin receptor ligand. The specific binding of GRP (14-27) is inhibited by GTP and GDP, whereas GMP was without effect .

HY-E70160

Protein O-Fucosyltransferase 1 EC:2.4.1.221; POFUT1	Glycosyltransferase	Others
Protein O-Fucosyltransferase 1 (EC:2.4.1.221; POFUT1) is a Glycosyltransferase containing the cysteine-rich motifs as the acceptor sugar and GDP-fucose as the donor .

HY-161066

KRAS G13D-IN-1	Ras	Cancer
KRAS G13D-IN-1 (compound 41) is a selective and covalently reversible inhibitor of KRAS ^G13D (IC₅₀: 0.41 nM). The selectivity for KRAS ^G13D is 29-fold against KRAS wild type. KRAS G13D-IN-1 is an inhibitor of the GDP state and targets the SWII binding pocket of KRAS ^G13D. KRAS G13D-IN-1 inhibits KRAS binding to GDP and turns on/off downstream signaling cascades .

HY-19706

ARS-853 2 Publications Verification	Ras Apoptosis	Cancer
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC₅₀ of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation .

HY-134885

RMC-0331 1 Publications Verification RM-023	SHP2 Ras	Cancer
RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction .

HY-E70157

Fucosyltransferase 8 EC:2.4.1.68; FUT8; α1-6FucT	Glucosylceramide Synthase (GCS)	Infection
Fucosyltransferase 8 (EC:2.4.1.68; FUT8; α1-6FucT) is a glycosyl transferase and catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans .

HY-120429

SKLB-163	Apoptosis	Cancer
SKLB-163 is an orally active inhibitor for *Rho GDP-dissociation (RhoGDI). SKLB-163 inhibits highly expressed RhoGDI tumor cell proliferation and migration, and increases radiosensitivity of tumor cells. SKLB-163 induces cancer cell Apoptosis* .

HY-138188

KRA-533	Ras	Cancer
KRA-533 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.

HY-145928

Divarasib 1 Publications Verification GDC-6036	Ras	Cancer
Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC₅₀ of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.

HY-135864

KRAS inhibitor-6

Ras Cancer

KRAS inhibitor-6 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound A .
HY-135866

KRAS inhibitor-8

Ras Cancer

KRAS inhibitor-8 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound C .
HY-135865

KRAS inhibitor-7

Ras Cancer

KRAS inhibitor-7 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound B .

KRAS inhibitor-6	Ras	Cancer
KRAS inhibitor-6 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound A .

KRAS inhibitor-8	Ras	Cancer
KRAS inhibitor-8 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound C .

KRAS inhibitor-7	Ras	Cancer
KRAS inhibitor-7 is a potent KRAS G12C inhibitor, extracted from patent WO2017087528A1, compound B .

HY-156243

GDI2-IN-1	Others	Cancer
GDI2-IN-1 (compound (+)-37) is a GDP-dissociation inhibitor beta (GDI2) inhibitor with an IC₅₀ of 2.87 μM and a K_D of 36 μM. GDI2-IN-1 exhibits excellent in vivo antitumor activity in GDI2-overexpressing pancreatic xenograft models .

HY-145928B

Divarasib adipate GDC-6036 adipate	Ras	Cancer
Divarasib (GDC-6036) adipate is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC₅₀ of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state .

HY-130149

Adagrasib 15+ Cited Publications MRTX849	Ras	Cancer
Adagrasib (MRTX849) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. Adagrasib covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bound conformation, and inhibits KRAS-dependent signal transduction .

HY-145022

KRAS G12C inhibitor 25	Ras	Cancer
KRAS G12C inhibitor 25 is a KRAS G12C inhibitor. KRAS G12C inhibitor 25 inhibits SOSl-assisted GDP/GTP exchanging activity of KRAS-G12C mutant (IC₅₀=0.48 nM). From WO2021216770A1 compound 3 .

HY-114277

Sotorasib Maximum Cited Publications 44 Publications Verification AMG-510	Ras	Cancer
Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors .

Cat. No.	Product Name	Type

HY-E70031

GDP-mannose pyrophosphorylase (ManC) GDP-MP; GDPMP; GMPase	Biochemical Assay Reagents
GDP-mannose pyrophosphorylase (ManC) (GDP-MP) is a cytoplasmic protein that catalyzes the formation of GDP-mannose. GDP-mannose pyrophosphorylase (ManC) is the precursor for the mannose residues in glycoconjugates, using mannose 1-phosphate and GTP as substrates .

HY-134433A

GDP-L-fucose disodium	Biochemical Assay Reagents
GDP-L-fucose disodium is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides. GDP-L-fucose disodium provides the fucose moiety for the oligosaccharides. The formation of GDP-L-fucose disodium occurs through two pathways, the major de novo metabolic pathway and the minor remedial metabolic pathway .

HY-113066C

Guanosine 5'-diphosphate sodium

GDP sodium

Biochemical Assay Reagents

Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate sodium is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-E70026

*L-fucokinase/GDP-fucose pyrophos-phorylase (FKP)*	Biochemical Assay Reagents
L-fucokinase/GDP-fucose pyrophos-phorylase (FKP) is an enzyme that catalyzes the chemical reaction. L-fucokinase/GDP-fucose pyrophos-phorylase (FKP) has substrate of L-fucose. L-fucokinase/GDP-fucose pyrophos-phorylase (FKP) induces L-fucose phosphorylation to form L-fucose-L-phosphate .

HY-E70160

Protein O-Fucosyltransferase 1 EC:2.4.1.221; POFUT1	Enzyme Substrates
Protein O-Fucosyltransferase 1 (EC:2.4.1.221; POFUT1) is a Glycosyltransferase containing the cysteine-rich motifs as the acceptor sugar and GDP-fucose as the donor .

HY-E70157

Fucosyltransferase 8 EC:2.4.1.68; FUT8; α1-6FucT	Enzyme Substrates
Fucosyltransferase 8 (EC:2.4.1.68; FUT8; α1-6FucT) is a glycosyl transferase and catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans .

HY-E70064

alpha-1,3-Fucosyltransferase (α1,3FucT)	Biochemical Assay Reagents
alpha-1,3-Fucosyltransferase (α1,3FucT) catalyzes the transfer of L-fucose moiety from guanosine diphosphate-beta-L-fucose (GDP-Fuc) to acceptor sugars. alpha-1,3-Fucosyltransferase (α1,3FucT) is often used in biochemical studies, and it can be used to form fucoglycoconjugates .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7389A

GDP-D-mannose disodium	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (K_i 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (K_i 115 μM) .

HY-134433

GDP-L-fucose	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
GDP-L-fucose is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides, providing the fucose moiety for the oligosaccharides.The formation of GDP-L-fucose occurs through two pathways, the major ab initio metabolic pathway and the minor remedial metabolic pathway .

HY-N7389B

GDP-α-D-mannose disodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (K_i 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (K_i 115 μM) .

HY-113066

Guanosine 5'-diphosphate GDP	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-134433A

GDP-L-fucose disodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
GDP-L-fucose disodium is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides. GDP-L-fucose disodium provides the fucose moiety for the oligosaccharides. The formation of GDP-L-fucose disodium occurs through two pathways, the major de novo metabolic pathway and the minor remedial metabolic pathway .

HY-113066C

Guanosine 5'-diphosphate sodium GDP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate sodium is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-113066A

Guanosine 5'-diphosphate disodium salt 2 Publications Verification GDP disodium salt	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Potassium Channel
Guanosine 5'-diphosphate (GDP) disodium salt is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate disodium salt can be used in the research of inflammation, such as anemia of inflammation (AI) .

HY-141472

7-Methylguanosine 5'-diphosphate sodium 7-Methyl-GDP sodium; m7GDP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues .

HY-16304

Mannose 1-phosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Mannose 1-phosphate is an endogenous metabolite. Mannose 1-phosphate can be used to synthesize GDP-Man by the enzyme GDP-mannose pyrophosphorylase .

Species:	Human (2)
Tag:	His (2)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71390

	TSTA3 Protein, Human (His) GDP-L-Fucose Synthase; GDP-4-Keto-6-Deoxy-D-Mannose-3; 5-Epimerase-4-Reductase; Protein FX; Red Cell NADP(H)-Binding Protein; Short-Chain Dehydrogenase/Reductase Family 4E Member 1; TSTA3; SDR4E1	Human	E. coli
	The TSTA3 protein plays a key role in catalyzing the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose. The process involves successive epimerase and reductase reactions, ultimately leading to the biosynthesis of GDP-fucose. TSTA3 Protein, Human (His) is the recombinant human-derived TSTA3 protein, expressed by E. coli , with C-6*His labeled tag. The total length of TSTA3 Protein, Human (His) is 321 a.a., with molecular weight of ~40.0 kDa.

HY-P71737

	GDI2 Protein, Human (P.pastoris, His) GDI-2; GDP dissociation inhibitor 2; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta; RABGDIB	Human	P. pastoris
	GDI2 protein inhibits the exchange of GDP to GTP in Rab proteins and regulates intracellular membrane transport. GDI2 Protein, Human (P.pastoris, His) is the recombinant human-derived GDI2 protein, expressed by P. pastoris , with N-His labeled tag. The total length of GDI2 Protein, Human (P.pastoris, His) is 445 a.a., with molecular weight of ~52.7 kDa.

Cat. No.	Product Name	Chemical Structure

HY-113066S2

Guanosine 5'-diphosphate-d13 dilithium

Guanosine 5'-diphosphate-d₁₃ (GDP-d₁₃) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S1

Guanosine 5'-diphosphate-13C10 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀ (GDP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S

Guanosine 5'-diphosphate-15N5 dilithium

Guanosine 5'-diphosphate- ¹⁵N₅ (GDP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S3

Guanosine 5'-diphosphate-13C10,15N5 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀, ¹⁵N₅ (GDP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-138616S3

dGTP-13C10 dilithium
dGTP- ¹³C₁₀ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀) dilithium is ¹³C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S

dGTP-15N5 dilithium
dGTP- ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅) dilithium is ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S1

dGTP-d14 dilithium
dGTP-d₁₄ (2'-Deoxyguanosine-5'-triphosphate-d₁₄) dilithium is deuterium labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S4

dGTP-13C10,15N5 dilithium

dGTP- ¹³C₁₀, ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S2

dGTP-15N5,d14 dilithium

dGTP- ¹⁵N₅,d₁₄ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

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