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GLO1+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glyoxalase (GLO) (7)
By Research Areas:	Cancer (6) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

7

Inhibitors & Agonists

1

Click Chemistry

Cat. No.	Product Name	Target	Research Areas

*Glyoxalase I inhibitor* free base** 2 Publications Verification	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor (free base) is a potent Glyoxalase I *(GLO1)* inhibitor, candidate for anticancer agents.

BrBzGCp2 S-p-Bromobenzylglutathione cyclopentyl diester	Glyoxalase (GLO)	Cancer Neurological Disease
BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC₅₀ of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity.

*Glyoxalase I inhibitor* 3**	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety.

HY-146657

4BAB

Glyoxalase (GLO) Cancer

4BAB (compound 29) is an irreversible glyoxalase I (GLO1) inhibitor. 4BAB has anticancer effects.

*Glyoxalase I inhibitor* 2**	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor 2 (compound 26) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.5 µM. Glyoxalase I inhibitor 2 has the potential for the research of depression and anxiety.

*Glyoxalase I inhibitor* 1**	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor 1 (compound 23) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 26 nM. Glyoxalase I inhibitor 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Methyl gerfelin	Glyoxalase (GLO)	Others
Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: *glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1* inhibitor related to the flavonoid class.

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