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GNF-5

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15738
    GNF-5
    3 Publications Verification

    		 Bcr-Abl Cancer
    GNF-5, the N-hydroxyethyl carboxamide analog of GNF-2, is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC50 value of 0.22 µM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer .
    <em>GNF-5</em>
  • HY-111852
    GNF5-amido-Me

    PROTAC ABL binding moiety 2

    		 Ligands for Target Protein for PROTAC Cancer
    GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
    <em>GNF5</em>-amido-Me
  • HY-111860
    SNIPER(ABL)-013

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-013, conjugating GNF5 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 20 μM .
    SNIPER(ABL)-013
  • HY-111861
    SNIPER(ABL)-024

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM .
    SNIPER(ABL)-024
  • HY-111854
    SNIPER(ABL)-015

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-015, conjugating GNF5 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5 μM .
    SNIPER(ABL)-015

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