GPI

By Targets:	Biochemical Assay Reagents (1) Carboxypeptidase (1) Endogenous Metabolite (1) FKBP (1) Fungal (2) HIV (1) Mesothelin (1) Opioid Receptor (2) PARP (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3) Endocrinology (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (6)
Click Chemistry:	Azide (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2918

Phosphoglucose Isomerase, Baker's yeast (S. cerevisiae) GPI; Phosphoglucose Isomerase	Endogenous Metabolite	Others
Phosphoglucose Isomerase, Baker's yeast (S. cerevisiae) (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-124619

GPI-1046	FKBP HIV	Infection Neurological Disease
GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models . GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models . GPI-1046 improves HIV-associated injury of peripheral nerves .

HY-136424

GPI-1485 1 Publications Verification GM1485	Others	Neurological Disease
GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke .

HY-103345

2-MPPA GPI-5693	Carboxypeptidase	Neurological Disease Cancer
2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC₅₀ of 90 nM .

HY-108614

GPi688	Others	Metabolic Disease
GPi688 is a potent and orally active glycogen phosphorylase (GPa) inhibitor with IC₅₀s of 19 nM, 61 nM and 12 nM for human liver GPa, rat liver GPa and human skeletal muscle GPa, respectively . GPi688 can inhibit glucagons-mediated glucose output in rat primary hepatocytes. GPi688 can be used for researching glucagon-mediated hyperglycaemia .

HY-RS05639

GPI Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPI Human Pre-designed siRNA Set A contains three designed siRNAs for GPI gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPI Human Pre-designed siRNA Set A GPI Human Pre-designed siRNA Set A

HY-13540

E7016 GPI 21016	PARP	Cancer
E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent .

HY-108615

CP-316819 GPI 819	Others	Endocrinology
CP 316819 is a potent glycogen phosphorylase (GPase) inhibitor with antihyperglycemic effect (IC₅₀ values are 17 and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa) respectively).CP 316819 causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low.CP-316819 prevents neuronal cell death and maintains brain electrical currents .

HY-19396

Ingliforib CP 368296; GPI 296
Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC₅₀s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

HY-P99006

Amatuximab MORab-009	Mesothelin	Cancer
Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium .

HY-P3632

[DAla2, DArg6] Dynorphin A, (1-13) (porcine) DADAD	Opioid Receptor	Neurological Disease Metabolic Disease
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an opioid peptide (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .

HY-18233

Manogepix E1210; APX001A	Fungal	Infection
Manogepix (E1210) is a first-in-class, broad-spectrum and orally active antifungal. Manogepix has a mechanism of action-inhibition of fungal glycosylphosphatidylinositol (GPI) biosynthesis .

HY-P1596

Gluten Exorphin C	Opioid Receptor	Neurological Disease
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC₅₀ values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

HY-129035

PFI-653 Vanin-1-IN-1	Others	Metabolic Disease Inflammation/Immunology
PFI-653 (Vanin-1-IN-1) is an inhibitor of vanin-1 enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation .

HY-145316

Vanin-1-IN-2	Others	Metabolic Disease
Vanin-1-IN-2 is a potent vanin-1 inhibitor with an IC₅₀ of 162 nM. Vanin-1 is a cell-surface-associated, glycosylphosphatidyl inositol (GPI)-anchored protein which is expressed at high levels in the kidney, liver, and small intestine .

HY-147110

APX2039	Fungal	Infection Inflammation/Immunology
APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research .

HY-131455A

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA	Biochemical Assay Reagents	Others
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Type

HY-131455A

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA	Biochemical Assay Reagents
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA

Biochemical Assay Reagents

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Target	Research Area

HY-P1596

Gluten Exorphin C	Opioid Receptor	Neurological Disease
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC₅₀ values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

HY-P3632

[DAla2, DArg6] Dynorphin A, (1-13) (porcine) DADAD	Opioid Receptor	Neurological Disease Metabolic Disease
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an opioid peptide (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .

HY-P3809

[D-Pro2,D-Phe7,D-Trp9] Substance P	Peptides	Neurological Disease
[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly .

Cat. No.	Product Name	Target	Research Area

HY-P99006

Amatuximab MORab-009	Mesothelin	Cancer
Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium .

Species:	Human (3) Mouse (3) Cynomolgus (2)
Tag:	His (7) B2M (1) Fc (1)
Source:	HEK293 (6) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71738

	Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) GPI; GPI1Glucose-6-phosphate isomerase; GPI; AMF; Neuroleukin; NLK; PHI	Mouse	P. pastoris
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) is 557 a.a., with molecular weight of ~64.6 kDa.

HY-P70873

	GPIHBP1 Protein, Human (HEK293, Fc) glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein1; GPI anchored high density lipoprotein binding protein 1; GPI-Anchored HDL-Binding Protein 1; GPIHBP1; GPI-HBP1; GPI-HBP1LOC338328; HBP1; High density lipoprotein-binding protein 1; H	Human	HEK293
	GPIHBP1 Protein mediates lipid metabolism by transporting lipoprotein lipase LPL, anchoring it in capillaries, and safeguarding against loss of activity. It crucially contributes to chylomicron lipolysis, triglyceride metabolism, and overall lipid homeostasis. The protein binds chylomicrons, APOA5-containing phospholipid particles, and HDL, highlighting its role in lipid interactions and uptake. With predominantly monomeric states and 1:1 stoichiometry in LPL interaction, GPIHBP1 precisely orchestrates lipid processing, emphasizing its significance in vascular lipid transport. GPIHBP1 Protein, Human (HEK293, Fc) is the recombinant human-derived GPIHBP1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of GPIHBP1 Protein, Human (HEK293, Fc) is 130 a.a., with molecular weight of 50-65 kDa.

HY-P76483

	LYPD3/C4.4A Protein, Mouse (HEK293, His) Ly6/PLAUR domain-containing protein 3; GPI-anchored metastasis-associated protein C4.4A homolog	Mouse	HEK293
	The LYPD3/C4.4A protein is a multifunctional cell surface molecule that is critical for cell migration and has been implicated in potential tumor progression. It binds laminin 1 and laminin 5, emphasizing its role in extracellular matrix interactions. LYPD3/C4.4A Protein, Mouse (HEK293, His) is the recombinant mouse-derived LYPD3/C4.4A protein, expressed by HEK293 , with C-His labeled tag. The total length of LYPD3/C4.4A Protein, Mouse (HEK293, His) is 255 a.a., with molecular weight of ~45-75 kDa.

HY-P72210

	Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) GPI; GPI1Glucose-6-phosphate isomerase; GPI; EC 5.3.1.9; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI	Mouse	E. coli
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His, B2M labeled tag. The total length of Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is 557 a.a., with molecular weight of ~76.6 kDa.

HY-P70219

	LYPD3/C4.4A Protein, Human (HEK293, His) rHuLy6/PLAUR domain-containing protein 3, His; Ly6/PLAUR Domain-Containing Protein 3; GPI-Anchored Metastasis-Associated Protein C4.4A Homolog; Matrigel-Induced Gene C4 Protein; MIG-C4; LYPD3; C4.4A	Human	HEK293
	LYPD3/C4.4A protein facilitates cell migration and potentially influences urothelial cell-matrix interactions. It plays a role in tumor progression, binding to laminin-1 and laminin-5. Interactions with LGALS3, AGR2, and AGR3 emphasize its functional associations and impact in diverse biological processes. LYPD3/C4.4A Protein, Human (HEK293, His) is the recombinant human-derived LYPD3/C4.4A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LYPD3/C4.4A Protein, Human (HEK293, His) is 256 a.a., with molecular weight of 55-75 kDa.

HY-P700660

	Apolipoprotein H/APOH Protein, Cynomolgus (HEK293, His) Apo-H; B2GP1; B2G1; APOH; B2GPI; beta(2)GPI; BG; β(2)GPI;	Cynomolgus	HEK293
	Apolipoprotein H/APOH proteins have multiple functions and can bind to negatively charged substances such as heparin and phospholipids. Its diverse interactions highlight the adaptability that is critical for preventing activation of the intrinsic coagulation cascade by binding to phospholipids on the surface of damaged cells. Apolipoprotein H/APOH Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Apolipoprotein H/APOH protein, expressed by HEK293 , with C-His labeled tag. The total length of Apolipoprotein H/APOH Protein, Cynomolgus (HEK293, His) is 326 a.a., with molecular weight of 50-65 kDa.

HY-P77617

	CD55/DAF Protein, Cynomolgus (HEK293, His) DAF-GPI; CD55; Cd55a; Daf; Daf1; DAF; CR; CROM; TC	Cynomolgus	HEK293
	CD55/DAF protein does not possess the conserved residue(s) necessary for propagating feature annotation. CD55/DAF Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD55/DAF protein, expressed by HEK293 , with C-His labeled tag. The total length of CD55/DAF Protein, Cynomolgus (HEK293, His) is 315 a.a., with molecular weight of 65-70 kDa.

HY-P71045

	VNN2/Vanin-2 Protein, Human (470a.a, HEK293, His) Vascular Non-Inflammatory Molecule 2; Vanin-2; Glycosylphosphatidyl Inositol-Anchored Protein GPI-80; Protein FOAP-4; VNN2	Human	HEK293
	VNN2/Vanin-2 Proteinas, an amidohydrolase, crucially hydrolyzes D-pantetheine's carboamide linkage, recycling pantothenic acid and releasing cysteamine. Apart from its vitamin metabolism role, VNN2 is involved in thymus homing of bone marrow cells and may regulate beta-2 integrin-mediated processes, influencing neutrophil adhesion, migration, and motility. VNN2/Vanin-2 Protein, Human (470a.a, HEK293, His) is the recombinant human-derived VNN2/Vanin-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VNN2/Vanin-2 Protein, Human (470a.a, HEK293, His) is 470 a.a., with molecular weight of ~68.0 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P82032

AMF Antibody (YA1777) GPI; Glucose-6-phosphate isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36	WB, IHC-P, ICC/IF, FC	Human

HY-P81353

LYPD3 Antibody (YA1098) LYPD3; C4.4A; UNQ491/PRO1007; Ly6/PLAUR domain-containing protein 3; GPI-anchored metastasis-associated protein C4.4A homolog; Matrigel-induced gene C4 protein (MIG-C4)	IHC-P	Human

HY-P82297

ApoH Antibody (YA2042)

APC inhibitor; APOH; Apolipoprotein H; B2G1; B2GP1; B2GPI; BG
WB, ICC/IF, IP Human, Rat

Cat. No.	Product Name		Classification

HY-131455A

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA		Azide
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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