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Results for "

GSTP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (1) Glutathione S-transferase (8) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (9) Inflammation/Immunology (1)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115673

LAS17 1 Publications Verification	Glutathione S-transferase	Cancer
LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione?S-Transferase Pi (GSTP1) ^[1]. LAS17 inhibits GSTP1 activity with an IC₅₀ of 0.5 μM . LAS17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13634A

Ezatiostat 3 Publications Verification TER199(free base); TLK199	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting *GSTP1*. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment ^[1] .

HY-RS05886

GSTP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GSTP1 Human Pre-designed siRNA Set A contains three designed siRNAs for GSTP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GSTP1 Human Pre-designed siRNA Set A GSTP1 Human Pre-designed siRNA Set A

HY-160455

GSTP1-1 inhibitor 1	Glutathione S-transferase	Cancer
GSTP1-1 inhibitor 1 (compound 6b) is an irreversible, long-acting, glutathione S-transferase inhibitor with an IC₅₀ of 21 μM targeting GSTP_1-1 . GSTP_1-1 is a key tumor suppressor target, and GSTP1-1 inhibitor 1 has potential anticancer activity ^[1].

HY-13634

Ezatiostat hydrochloride TER199; TLK199 hydrochloride	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting *GSTP1*. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment ^[1] .

HY-145413

BRD2889	Glutathione S-transferase	Cancer
BRD2889 is an analog of the alkaloid piperlongumine. BRD2889 is a robust modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH) ^[1]. BRD2889 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-135318

NBDHEX 1 Publications Verification	Apoptosis Autophagy Glutathione S-transferase	Cancer
NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the *GSTP1-1* and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor ^[1] .

HY-112534

GSTO-IN-2 2 Publications Verification	Glutathione S-transferase	Cancer
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC₅₀s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.

HY-13634B

TLK117 TER117	Glutathione S-transferase	Inflammation/Immunology Cancer
TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a K_i of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a K_i of 0.56 μM.

Cat. No.	Product Name	Target	Research Area

HY-13634A

Ezatiostat 3 Publications Verification TER199(free base); TLK199	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting *GSTP1*. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment ^[1] .

HY-13634B

TLK117 TER117	Glutathione S-transferase	Inflammation/Immunology Cancer
TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a K_i of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a K_i of 0.56 μM.

HY-13634

Ezatiostat hydrochloride TER199; TLK199 hydrochloride	Glutathione S-transferase Apoptosis	Cancer
Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting *GSTP1*. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment ^[1] .

Species:	Human (3) Rat (1)
Tag:	His (5) Tag Free (1) Myc (2)
Source:	P. pastoris (1) Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P70150

	GSTP1 Protein, Human rHuGlutathione S-transferase P/GSTP1; Glutathione S-transferase P; GSTP1; GST class-pi; GSTP1-1; FAEES3; GST3;	Human	E. coli
	Glutathione S-transferase P (GSTP1) is a member of GSTs family and plays an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 enables JUN kinase binding activity; glutathione transferase activity; and kinase regulator activity and is involved in negative regulation of cell population proliferation, intracellular signal transduction and macromolecule metabolic process as well. GSTP1 Protein, Human is the recombinant human-derived GSTP1 protein, expressed by E. coli , with tag free. The total length of GSTP1 Protein, Human is 210 a.a., with molecular weight of ~23.66 kDa.

HY-P72217

	GSTP1 Protein, Rat (His) GSTP1; Glutathione S-transferase P; EC 2.5.1.18; Chain 7; GST 7-7; GST class-pi	Rat	E. coli
	GSTP1 protein conjugates reduced glutathione to hydrophobic electrophiles, forms glutathione conjugates of PGA2 and PGJ2, and contributes to hepoxilin production. It also regulates CDK5 activity by facilitating p25/p35 translocation, preventing neurodegeneration. GSTP1 Protein, Rat (His) is the recombinant rat-derived GSTP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GSTP1 Protein, Rat (His) is 209 a.a., with molecular weight of ~24 kDa.

HY-P71740

	GSTP1 Protein, Human (P.pastoris, His) Deafness; Deafness X-linked 7; DFN7; FAEES3; GSTP; GSTP1; GSTP1-1; PI; X linked 7	Human	P. pastoris
	The GSTP1 protein is critical for binding reduced glutathione to a variety of hydrophobic electrophiles, actively forming glutathione conjugates of PGA2 and PGJ2. Documented studies highlight its involvement in hepoxilin regioisomer synthesis, emphasizing the versatility of GSTP1 in processing substrates. GSTP1 Protein, Human (P.pastoris, His) is the recombinant human-derived GSTP1 protein, expressed by P. pastoris , with N-His labeled tag. The total length of GSTP1 Protein, Human (P.pastoris, His) is 209 a.a., with molecular weight of ~25.7 kDa.

HY-P72215

	GSTP1 Protein, Human (His) Deafness; Deafness X-linked 7; DFN7; FAEES3; Fatty Acid Ethyl Ester Synthase III ; Glutathione S Transferase 3; Glutathione S Transferase Pi; Glutathione S-transferase P; Glutathione S-transferase pi 1; GST class-pi; GST3; GSTP; GSTP1; GSTP1-1; GSTP1_HUMAN; PI; X linked 7	Human	E. coli
	The GSTP1 protein is critical for binding reduced glutathione to a variety of hydrophobic electrophiles, actively forming glutathione conjugates of PGA2 and PGJ2. Documented studies highlight its involvement in hepoxilin regioisomer synthesis, emphasizing the versatility of GSTP1 in processing substrates. GSTP1 Protein, Human (His) is the recombinant human-derived GSTP1 protein, expressed by E. coli , with N-10*His labeled tag. The total length of GSTP1 Protein, Human (His) is 209 a.a., with molecular weight of ~25 kDa.

HY-P72214

	GSTP1 Protein, Cricetulus longicaudatus (His-Myc) GSTP1Glutathione S-transferase P; EC 2.5.1.18; GST class-pi	Others	E. coli
	GSTP1, a key protein, aids in cellular detoxification by conjugating reduced glutathione to hydrophobic electrophiles. It also forms glutathione conjugates for PGA2 and PGJ2 and contributes to hepoxilin synthesis. Additionally, GSTP1 regulates CDK5 activity, preventing neurodegeneration. This versatile enzyme safeguards cellular homeostasis and plays a crucial role in various biochemical pathways. GSTP1 Protein, Cricetulus longicaudatus (His-Myc) is the recombinant GSTP1 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of GSTP1 Protein, Cricetulus longicaudatus (His-Myc) is 210 a.a., with molecular weight of ~28.7 kDa.

HY-P72050

	GSTP1 Protein, Cricetulus longicaudatus (Baculovirus, His-Myc) GSTP1Glutathione S-transferase P; EC 2.5.1.18; GST class-pi	Others	Sf9 insect cells
	GSTP1, a key protein, aids in cellular detoxification by conjugating reduced glutathione to hydrophobic electrophiles. It also forms glutathione conjugates for PGA2 and PGJ2 and contributes to hepoxilin synthesis. Additionally, GSTP1 regulates CDK5 activity, preventing neurodegeneration. This versatile enzyme safeguards cellular homeostasis and plays a crucial role in various biochemical pathways. GSTP1 Protein, Cricetulus longicaudatus (Baculovirus, His-Myc) is the recombinant GSTP1 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of GSTP1 Protein, Cricetulus longicaudatus (Baculovirus, His-Myc) is 210 a.a., with molecular weight of ~27.5 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81277A

GST3 Antibody (YA976)

GSTP1; FAEES3; GST3; Glutathione S-transferase P; GST class-pi; GSTP1-1
IHC-P Human
HY-P81277

GST3 Antibody (YA975)

GSTP1; FAEES3; GST3; Glutathione S-transferase P; GST class-pi; GSTP1-1
WB, IHC-F, IHC-P, ICC/IF, FC Human

Cat. No.	Product Name		Classification

HY-115673

LAS17 1 Publications Verification		Alkynes
LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione?S-Transferase Pi (GSTP1) ^[1]. LAS17 inhibits GSTP1 activity with an IC₅₀ of 0.5 μM . LAS17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132913

Cyclopropenone probe 1		Alkynes
Cyclopropenone probe 1 can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site. Cyclopropenone probe 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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