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Results for "General Inhibitors" in MCE Product Catalog:

Cat. No. Product Name Target Research Areas
  • HY-15282
    E-64

    Proteinase inhibitor E 64

    Cathepsin Autophagy Bacterial Inflammation/Immunology Cancer
    E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
  • HY-112654
    GCN2iB

    Eukaryotic Initiation Factor (eIF) Autophagy Cancer
    GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.
  • HY-100877
    GCN2-IN-1

    A-92

    Eukaryotic Initiation Factor (eIF) Cancer
    GCN2-IN-1 (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay.
  • HY-15206
    Glibenclamide

    Glyburide

    Potassium Channel Autophagy CFTR P-glycoprotein Metabolic Disease
    Glibenclamide is a high affinity P-glycoprotein inhibitor and appears to be general inhibitor of ABC transporters. Glibenclamide binds to the sulphonylurea receptor (SUR) and to the cystic fibrosis transmembrane conductance regulator proteins (CFTR) and blocks their function. Glibenclamide is a potent second-generation sulfonylurea agent that improves glucose control by acting both on insulin secretion and on insulin action..
  • HY-122198
    ML367

    Others Cancer
    ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.