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Results for "

Glioblastoma Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (2) Apoptosis (16) Atg4 (1) ATP Synthase (1) Autophagy (7) Bacterial (2) BCRP (1) Biochemical Assay Reagents (1) c-Met/HGFR (1) c-Myc (1) Caspase (1) CDK (1) Deubiquitinase (1) DNA Alkylator/Crosslinker (1) DNA-PK (1) DNA/RNA Synthesis (3) DYRK (1) EGFR (4) Endogenous Metabolite (2) Estrogen Receptor/ERR (2) FABP (1) FAK (1) Fat Mass and Obesity-associated Protein (FTO) (3) Glutaminase (1) GSK-3 (1) HDAC (2) HIV (2) HSP (3) Integrin (1) IRE1 (1) Isotope-Labeled Compounds (1) LPL Receptor (1) LXR (2) MDM-2/p53 (1) Microtubule/Tubulin (4) Mitochondrial Metabolism (2) Mitophagy (2) MMP (2) Monoamine Oxidase (2) Mps1 (1) mTOR (4) NF-κB (1) OLIG2 (1) Oxidative Phosphorylation (1) P-glycoprotein (1) p38 MAPK (1) Parasite (4) PARP (3) PD-1/PD-L1 (1) Phosphatase (2) Phospholipase (2) PI3K (1) Reactive Oxygen Species (1) SHP2 (7) Sodium Channel (4) Src (1) STAT (1) Survivin (1) Trk Receptor (1) VEGFR (2) β-catenin (1)
By Research Areas:	Cancer (78) Infection (3) Inflammation/Immunology (5) Neurological Disease (10)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147011

FTO-IN-7	Fat Mass and Obesity-associated Protein (FTO)	Cancer
FTO-IN-7 is an inhibitor of FTO. FTO-IN-7 can be used in study Alzheimer's diseases, breast cancers, small-cell lung cancers,a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma .

HY-12401A

Mps1-IN-3 hydrochloride 1 Publications Verification	Mps1	Cancer
Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC₅₀ value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model .

HY-157975

LM11

Glutaminase Cancer

LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state .

LM11	Glutaminase	Cancer
LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state .

HY-120115

PARPi-FL Olaparib-bodipy FL	PARP	Cancer
PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo .

HY-146275

LXRβ agonist-3	LXR	Cancer
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC₅₀ of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC₅₀ of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma .

HY-B0114

Oxcarbazepine GP 47680	Sodium Channel Apoptosis	Neurological Disease Cancer
Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .

HY-153773

Z4P	IRE1	Cancer
Z4P is a BBB-permeable IRE1 inhibitor (IC₅₀: 1.11 μM). Z4P inhibits Glioblastoma cell growth. Z4P prevents glioblastoma relapse when administered together with Temozolomide (HY-17364) .

HY-P4115

CooP	FABP	Cancer
CooP is a linear glioblastoma-targeting nonapeptide. CooP binds to the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) in the glioblastoma cells and its associated vasculature. CooP is used for the targeted delivery of chemotherapy and different nanoparticles .

HY-163193

MJO445

Atg4 Autophagy Cancer

MJO445 (Compound 7) is a ATG4B inhibitor, which inhibits the autophagy of glioblastoma .
HY-132865

FTO-IN-3

Fat Mass and Obesity-associated Protein (FTO) Cancer

FTO-IN-3 is a FTO inhibitor that impair self-renewal in glioblastoma stem cells.
HY-132863

FTO-IN-2

Fat Mass and Obesity-associated Protein (FTO) Cancer

FTO-IN-2 is a FTO inhibitor that impairs self-renewal in glioblastoma stem cells.
HY-N8835

Cannabisin D

p38 MAPK Neurological Disease

Cannabisin D inhibits proliferation and migration of glioblastoma cells through MAPKs signaling .

MJO445	Atg4 Autophagy	Cancer
MJO445 (Compound 7) is a ATG4B inhibitor, which inhibits the autophagy of glioblastoma .

FTO-IN-3	Fat Mass and Obesity-associated Protein (FTO)	Cancer
FTO-IN-3 is a FTO inhibitor that impair self-renewal in glioblastoma stem cells.

FTO-IN-2	Fat Mass and Obesity-associated Protein (FTO)	Cancer
FTO-IN-2 is a FTO inhibitor that impairs self-renewal in glioblastoma stem cells.

Cannabisin D	p38 MAPK	Neurological Disease
Cannabisin D inhibits proliferation and migration of glioblastoma cells through MAPKs signaling .

HY-B0114S2

Oxcarbazepine-d8-1 GP 47680-d₈	Sodium Channel Apoptosis	Neurological Disease Cancer
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Oxcarbazepine? has anti-cancer and anticonvulsant effects .

HY-N12535

Tagitinin C	Others	Cancer
Tagitinin C is a sesquiterpenoid compound isolated from the Tithonia diversifolia. Tagitinin C has anticancer activity and can inhibit the proliferation of human glioblastoma U373 cells with an IC₅₀ of 6.1 μg/mL. Tagitinin C can induce U373 cell death and be used in glioblastoma research .

HY-15735

c-Met inhibitor 1	c-Met/HGFR	Cancer
c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer.

HY-B0114S1

Oxcarbazepine-d4-1 GP 47680-d₄-1	Isotope-Labeled Compounds Sodium Channel Apoptosis	Neurological Disease Cancer
Oxcarbazepine-d₄-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-149374

Tubulin inhibitor 36	Microtubule/Tubulin	Cancer
Tubulin inhibitor 36 (Compound 10) is a novel and potent tubulin inhibitor and inhibits the polymerization of microtubular protein then induces apoptosis with an IC₅₀ value of 1.5±0.1 μM. Tubulin inhibitor 36 (Compound 10) has significant anti-mitotic effect and exhibits activities against glioblastoma cells. Tubulin inhibitor 36 (Compound 10) has anti-tumor effects and can be used for glioblastoma multiforme (GBM) research .

HY-111651

Gboxin 1 Publications Verification	Oxidative Phosphorylation ATP Synthase Mitochondrial Metabolism	Cancer
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F₀F₁ ATP synthase. Antitumour activity .

HY-111652

S-Gboxin

Others Cancer

S-Gboxin, a functional analogue of Gboxin, inhibits growth of mouse and human glioblastoma (GBM) with an IC₅₀ of 470 nM . Antitumour activity .
HY-133570

17-AEP-GA

HSP ADC Cytotoxin Cancer

17-AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. ADCs Toxin .

S-Gboxin	Others	Cancer
S-Gboxin, a functional analogue of Gboxin, inhibits growth of mouse and human glioblastoma (GBM) with an IC₅₀ of 470 nM . Antitumour activity .

17-AEP-GA	HSP ADC Cytotoxin	Cancer
17-AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. ADCs Toxin .

HY-B0114S

Oxcarbazepine-D4 GP 47680-d₄	Sodium Channel Apoptosis	Neurological Disease Cancer
Oxcarbazepine-d₄ (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-128685

FD 12-9 Ac12Az9	P-glycoprotein BCRP	Cancer
FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC₅₀s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity .

HY-125964

LLP-3	Survivin	Cancer
LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM) .

HY-155272

SHP2-IN-16

SHP2 Cancer

SHP2-IN-16 (compound 222) is a SHP2 inhibitor with an IC₅₀ value of 1 nM. SHP2-IN-16 can be used for glioblastoma research .
HY-155273

SHP2-IN-17

SHP2 Cancer

SHP2-IN-17 (compound 192) is a SHP2 inhibitor with an IC₅₀ value of 2 nM. SHP2-IN-17 can be used for glioblastoma research .
HY-155274

SHP2-IN-18

SHP2 Cancer

SHP2-IN-18 (compound 183) is a SHP2 inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-18 can be used for glioblastoma research .
HY-155275

SHP2-IN-19

SHP2 Cancer

SHP2-IN-19 (compound 183) is a SHP2 inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-19 can be used for glioblastoma research .
HY-155276

SHP2-IN-20

SHP2 Cancer

SHP2-IN-20 (compound 193) is a SHP2 inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-20 can be used for glioblastoma research .
HY-155277

SHP2-IN-21

SHP2 Cancer

SHP2-IN-21 (compound 208) is a SHP2 inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-21 can be used for glioblastoma research .

SHP2-IN-16	SHP2	Cancer
SHP2-IN-16 (compound 222) is a SHP2 inhibitor with an IC₅₀ value of 1 nM. SHP2-IN-16 can be used for glioblastoma research .

SHP2-IN-17	SHP2	Cancer
SHP2-IN-17 (compound 192) is a SHP2 inhibitor with an IC₅₀ value of 2 nM. SHP2-IN-17 can be used for glioblastoma research .

SHP2-IN-18	SHP2	Cancer
SHP2-IN-18 (compound 183) is a SHP2 inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-18 can be used for glioblastoma research .

SHP2-IN-19	SHP2	Cancer
SHP2-IN-19 (compound 183) is a SHP2 inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-19 can be used for glioblastoma research .

SHP2-IN-20	SHP2	Cancer
SHP2-IN-20 (compound 193) is a SHP2 inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-20 can be used for glioblastoma research .

SHP2-IN-21	SHP2	Cancer
SHP2-IN-21 (compound 208) is a SHP2 inhibitor with an IC₅₀ value of 3 nM. SHP2-IN-21 can be used for glioblastoma research .

HY-142682

SCP1-IN-1	Others	Neurological Disease Cancer
SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity .

HY-142683

SCP1-IN-2	Others	Neurological Disease Cancer
SCP1-IN-2 (Compound SH T-65) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-2 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-2 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity .

HY-116165

ML-298	Phospholipase	Cancer
ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC₅₀ of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells .

HY-147327

N-Formylsarcolysine	Others	Cancer
N-Formylsarcolysine has antitumor activity, and inhibits leukemia by increasing the Hb and erythrocyte levels and decreasing the number of leukocytes. N-Formylsarcolysine also involves in glioblastoma and other diseases research .

HY-125427

SKOG102	OLIG2	Cancer
SKOG102 is a potent OLIG2 inhibitor that is directly engaging OLIG2 and interferes with the ability of OLIG2 to bind DNA. SKOG102 can be used for the research of glioblastoma (GBM) .

HY-100475

KYP-2047
KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an K_i value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation .

HY-152203

Mitochondrial respiration-IN-2	Others	Cancer
Mitochondrial respiration-IN-2 is the fluorine derivative of Virginiamycin M1 (HY-N6686). Mitochondrial respiration-IN-2 can inhibit mitochondrial translation of glioblastoma stem cells .

HY-124582

NEO214	Autophagy mTOR	Cancer
NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma .

HY-161256

Tubulin inhibitor 41	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 41 (Compd D19), a promising anti-GBM (glioblastoma) lead compound and tublin inhibitor with BBB permeability, induces G2/M phase arrest, resulted in cell apoptosis and inhibits the migration of U87 cells .

HY-13703A

Nimustine hydrochloride 1 Publications Verification ACNU	DNA/RNA Synthesis DNA Alkylator/Crosslinker Apoptosis	Cancer
Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas .

HY-116273

ML299	Phospholipase	Cancer
ML299 is a selective allosteric modulator and a dual inhibitor of phospholipases D1 and D2 (IC₅₀ values are 6 and 12 nM, respectively). ML299 decreases invasive migration in U87-MG glioblastoma cells .

HY-157168

TrkA-IN-6	Trk Receptor	Neurological Disease
TrkA-IN-6 (compound R48) is a hydrazone-like, selective inhibitor of tropomyosin kinase type A receptor kinase (TrkA). TrkA-IN-6 exhibited a higher cytotoxic effect on U87 GBM cells than Temozolomide (HY-17364), with an IC₅₀ of 68.99 μM .

HY-14942

Berubicin RTA 744 free base; WP 744 free base; WP 769	Others	Cancer
Berubicin (RTA 744 free base; WP 744) is a 4'-O-benzyldoxorubicin that inhibits P-gp and MRP1-mediated efflux and has anticancer activity. Berubicin inhibits glioblastoma multiforme (GBM) and exhibits cytotoxicity. Berubicin has poor bioavailability in mice .

HY-149530

EGFR-IN-86	EGFR Apoptosis	Cancer
EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC₅₀: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase .

HY-12616

ACT-209905	LPL Receptor	Cancer
ACT-209905 is a S1P1 receptor agonist. ACT-209905 can inhibit glioblastoma (GBM) cell growth and migration. ACT-209905 also has immunomodulating activity, and can be used in research of autoimmune diseases .

HY-17595

Mebendazole 3 Publications Verification	Parasite Apoptosis Microtubule/Tubulin	Infection Cancer
Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration .

HY-P99768

Olinvacimab TTAC-0001	VEGFR	Cancer
Olinvacimab (TTAC-0001) is a fully human anti-VEGFR2 monoclonal antibody. Olinvacimab inhibits VEGF binds to KDR with a K_d value of 0.23 nM. Olinvacimab has antiangiogenic activity. Olinvacimab can be used for the research of recurrent glioblastoma and breast cancer .

HY-126771

Chrysomycin A Chr-A	Antibiotic Bacterial Akt GSK-3 β-catenin c-Myc	Infection Cancer
Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway .

HY-149515

MAO-IN-3	Monoamine Oxidase	Cancer
MAO-IN-3 (Compound 5) is a reversible and competitive MAO inhibitor (K_i: 0.6 and 0.2 μM for MAO A and MAO B). MAO-IN-3 inhibits LN-229 glioblastoma cell proliferation with an IC₅₀ of 0.8 μM. MAO-IN-3 can be used for cancer research .

HY-14590

Kaempferol 25+ Cited Publications Kempferol; Robigenin	Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite	Cancer
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .

HY-P3990

Coibamide A	VEGFR Autophagy Apoptosis	Cancer
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14590

Kaempferol Maximum Cited Publications 27 Publications Verification Kempferol; Robigenin	Flavonols Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Microorganisms Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Cancer	Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .

HY-N0421

Cinobufagin 3 Publications Verification Cinobufagine	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to apoptosis in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models .

HY-N8835

Cannabisin D	Structural Classification Anisodus tanguticus (Maxinowicz) Pascher Source classification Phenols Plants Solanaceae	p38 MAPK
Cannabisin D inhibits proliferation and migration of glioblastoma cells through MAPKs signaling .

HY-N12535

Tagitinin C	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Tithonia diversifolia A. Gray. Compositae	Others
Tagitinin C is a sesquiterpenoid compound isolated from the Tithonia diversifolia. Tagitinin C has anticancer activity and can inhibit the proliferation of human glioblastoma U373 cells with an IC₅₀ of 6.1 μg/mL. Tagitinin C can induce U373 cell death and be used in glioblastoma research .

HY-14590R

Kaempferol (Standard) Kempferol(Standard); Robigenin (Standard)	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Sunscreen Phenols Cosmetic Research Disease Research Fields Cancer	Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite
Kaempferol (Standard) is the analytical standard of Kaempferol. This product is intended for research and analytical applications. Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-19939S

VX-984 4 Publications Verification
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-B0688S

Dapsone-d8

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].