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Results for "

Glucocorticoid Receptor

" in MCE Product Catalog:

By Targets:	Glucocorticoid Receptor (79) ADC Cytotoxin (1) Androgen Receptor (3) Antibiotic (6) AP-1 (1) Apoptosis (6) Autophagy (9) Bacterial (6) Caspase (1) Complement System (6) Cytochrome P450 (2) Drug Metabolite (1) Drug-Linker Conjugates for ADC (3) Endogenous Metabolite (11) Enterovirus (3) Estrogen Receptor/ERR (1) LXR (1) Mineralocorticoid Receptor (3) Mitophagy (6) MMP (2) NF-κB (2) NO Synthase (5) Parasite (1) Phosphodiesterase (PDE) (2) PPAR (1) Progesterone Receptor (6) Reactive Oxygen Species (2) SARS-CoV (6) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (19) Cardiovascular Disease (5) Endocrinology (52) Infection (10) Inflammation/Immunology (63) Metabolic Disease (6) Neurological Disease (3)

By Targets:

Glucocorticoid Receptor (79)

ADC Cytotoxin (1)

Androgen Receptor (3)

Antibiotic (6)

AP-1 (1)

Apoptosis (6)

Autophagy (9)

Bacterial (6)

Caspase (1)

Complement System (6)

Cytochrome P450 (2)

Drug Metabolite (1)

Drug-Linker Conjugates for ADC (3)

Endogenous Metabolite (11)

Enterovirus (3)

Estrogen Receptor/ERR (1)

LXR (1)

Mineralocorticoid Receptor (3)

Mitophagy (6)

MMP (2)

NF-κB (2)

NO Synthase (5)

Parasite (1)

Phosphodiesterase (PDE) (2)

PPAR (1)

Progesterone Receptor (6)

Reactive Oxygen Species (2)

SARS-CoV (6)

Wnt (2)

β-catenin (2)

By Research Areas:

Cancer (19)

Cardiovascular Disease (5)

Endocrinology (52)

Infection (10)

Inflammation/Immunology (63)

Metabolic Disease (6)

Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Glucocorticoid Receptor SGK

Cat. No.	Product Name	Target	Research Areas

HY-14234

Glucocorticoid receptor agonist	Glucocorticoid Receptor	Endocrinology Metabolic Disease Inflammation/Immunology
Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC₅₀ values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin.

HY-148435

Glucocorticoid receptor agonist-2	Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoid receptor agonist-2 (compound 21) is an **glucocorticoid receptor agonist with an IC₅₀** value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373.

HY-152121

Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal	Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Infection Inflammation/Immunology
Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal is a **glucocorticoid receptor** agonist. Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal can be used in anti-CD40 antibody drug conjugate (ADC). Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal can be used for the research of inflammation and immune regulation.

HY-131974

Glucocorticoid receptor agonist-1	Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoid receptor agonist-1 is a potent **glucocorticoid receptor agonist with an IC₅₀** of 2.8 nM extracted from patent WO2017210471A1, compound 41.

HY-142941

Glucocorticoid receptor-IN-1	Glucocorticoid Receptor MMP	Inflammation/Immunology
Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC₅₀ of 2.11 nM against hMMP1, and transcriptional activation activity with an EC₅₀ of 5.59 nM against MMTV.

HY-142942

Glucocorticoid receptor-IN-2	Glucocorticoid Receptor MMP	Inflammation/Immunology
Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC₅₀ of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC₅₀ of 0.94 nM against MMTV.

HY-137882

Glucocorticoid receptor agonist-1 Ala-Ala-Mal	Glucocorticoid Receptor ADC Cytotoxin	Inflammation/Immunology
Glucocorticoid receptor agonist-1 Ala-Ala-Mal (compound 88) is a glucocorticosteroid, and an agonist of **glucocorticoid receptor*. Glucocorticoid* receptor agonist-1 Ala-Ala-Mal can be conjugated with Adalimumab (HY-P9908) to prepare an ADC.

HY-151876

Glucocorticoid receptor modulator 1	Glucocorticoid Receptor NF-κB AP-1	Inflammation/Immunology
Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective **glucocorticoid receptor modulator with an IC₅₀ value of 9 nM and 130 nM for NF-κB and AP-1*, respectively. Glucocorticoid* receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice.

HY-148436

Glucocorticoid receptor agonist-2 Ala-Ala-Mal	Drug-Linker Conjugates for ADC	Inflammation/Immunology
Glucocorticoid receptor agonist-2 Ala-Ala-Mal (compound 79) can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference for ABBV-3373.

HY-120273

Glucocorticoids receptor agonist 3	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology
Glucocorticoids receptor agonist 3 is a potent agonist of glucocorticoids receptor. Glucocorticoids receptor agonist 3 is useful to research diseases, such as obesity, diabetes, and inflammation (extracted from patent WO2000066522A1, compound 345).

HY-132811

Dazucorilant CORT113176	Glucocorticoid Receptor	Inflammation/Immunology Neurological Disease
Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a K_i value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders.

HY-125265

JTP-117968	Glucocorticoid Receptor	Metabolic Disease
JTP-117968, a novel selective **glucocorticoid receptor modulator (a non-steroidal SGRM, IC₅₀** of 6.8 nM), exhibits improved transrepression/transactivation dissociation.

HY-147293

Nenocorilant Relacorilant; CORT125134	Glucocorticoid Receptor Apoptosis Caspase	Cancer
Nenocorilant (Relacorilant) is a potent, orally activity glucocorticoid receptor (GR) antagonist with K_i value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research.

HY-14648

Dexamethasone Hexadecadrol; Prednisolone F	Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Cancer Infection Endocrinology Inflammation/Immunology
Dexamethasone (Hexadecadrol) is a **glucocorticoid receptor** agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648A

Dexamethasone acetate Dexamethasone 21-acetate; Hexadecadrol acetate	Glucocorticoid Receptor Autophagy Mitophagy Bacterial SARS-CoV Antibiotic Complement System	Inflammation/Immunology Endocrinology Cancer
Dexamethasone acetate (Dexamethasone 21-acetate) is a **glucocorticoid receptor** agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-121131

Deacylcortivazol
Glucocorticoid Receptor Endocrinology

Deacylcortivazol, a potent glucocorticoid, is a glucocorticoid receptor (GR) activator.

Deacylcortivazol	Glucocorticoid Receptor	Endocrinology
Deacylcortivazol, a potent glucocorticoid, is a glucocorticoid receptor (GR) activator.

HY-139709

Glucocorticoids receptor agonist 1	Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoids receptor agonist 1 is a potent anti-inflammatory, arylpyrazole-based **glucocorticoid receptor** agonist that does not impair insulin secretion.

HY-139710

Glucocorticoids receptor agonist 2	Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoids receptor agonist 2 is a potent anti-inflammatory, arylpyrazole-based **glucocorticoid receptor** agonist that does not impair insulin secretion.

HY-103548

GSK9027	Glucocorticoid Receptor	Endocrinology
GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone.

HY-B1540

Beclometasone
Beclomethasone
Glucocorticoid Receptor Inflammation/Immunology Endocrinology

Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.

Beclometasone Beclomethasone	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Beclometasone (Beclomethasone) is a prototype **glucocorticoid receptor** agonist.

HY-17461A

Cortisone acetate Cortisone 21-acetate	Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to *Glucocorticoid-receptor* at high concentrations.

HY-114154

AL-438	Glucocorticoid Receptor	Inflammation/Immunology
AL-438 is a potent, selective and orally active **glucocorticoid receptor modulator with K_i*s of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid* receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity.

HY-B1893

Fluorometholone	Glucocorticoid Receptor	Inflammation/Immunology
Fluorometholone, a synthetic glucocorticoid, is a **glucocorticoid receptor** agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used for the research of dry eye.

HY-139556

Zavacorilant
Glucocorticoid Receptor Metabolic Disease

Zavacorilant is capable of modulating glucocorticoid receptor (GR).
HY-16722

Fosdagrocorat
PF-04171327
Glucocorticoid Receptor Inflammation/Immunology Endocrinology

Fosdagrocorat (PF-04171327) is a dissociated glucocorticoid receptor agonist.
HY-14864A

(S)-Mapracorat
(S)-ZK-245186; (S)-BOL-303242X
Glucocorticoid Receptor Endocrinology

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
HY-14864

Mapracorat
ZK-245186; BOL-303242X
Glucocorticoid Receptor Endocrinology

Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist.

Zavacorilant	Glucocorticoid Receptor	Metabolic Disease
Zavacorilant is capable of modulating glucocorticoid receptor (GR).

Fosdagrocorat PF-04171327	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Fosdagrocorat (PF-04171327) is a dissociated **glucocorticoid receptor** agonist.

(S)-Mapracorat (S)-ZK-245186; (S)-BOL-303242X	Glucocorticoid Receptor	Endocrinology
(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

Mapracorat ZK-245186; BOL-303242X	Glucocorticoid Receptor	Endocrinology
Mapracorat is a novel non-steroidal selective **glucocorticoid receptor** agonist.

HY-17461

Cortisone 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E	Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to *Glucocorticoid-receptor* at high concentrations.

HY-B0469

Medroxyprogesterone acetate Medroxyprogesterone 17-acetate; Farlutin	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Cancer
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and **glucocorticoid receptors**.

HY-145351

BAY 1003803
Glucocorticoid Receptor Inflammation/Immunology

BAY 1003803 is a glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis.
HY-15709

AL 082D06
D06; D-06
Glucocorticoid Receptor Endocrinology

AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with K_i of 210 nM.

BAY 1003803	Glucocorticoid Receptor	Inflammation/Immunology
BAY 1003803 is a **glucocorticoid receptor** agonist for the topical treatment of psoriasis or severe atopic dermatitis.

AL 082D06 D06; D-06	Glucocorticoid Receptor	Endocrinology
AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with K_i of 210 nM.

HY-111490

Desisobutyryl-ciclesonide CIC-AP; Ciclesonide active principle	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the **glucocorticoid receptor**.

HY-111453

Velsecorat AZD7594; AZ13189620	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
AZD7594 is a potent selective nonsteroidal **glucocorticoid receptor modulator, with an IC₅₀** of 0.9 nM.

HY-13571B

Beclometasone dipropionate monohydrate	Glucocorticoid Receptor Reactive Oxygen Species NO Synthase	Cancer Inflammation/Immunology
Beclometasone dipropionate monohydrate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma .

HY-13571A

Beclometasone dipropionate Beclomethasone dipropionate	Glucocorticoid Receptor Reactive Oxygen Species NO Synthase	Inflammation/Immunology Endocrinology
Beclometasone dipropionate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .

HY-17461S2

Cortisone-d7	Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Cortisone-d₇ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S1

Cortisone-d8	Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Cortisone-d₈ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S

Cortisone-13C3	Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Inflammation/Immunology
Cortisone-¹³C₃ is the ¹³C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S3

Cortisone-d2 17-Hydroxy-11-dehydrocorticosterone-d₂; Kendall's compound E-d₂	Glucocorticoid Receptor Endogenous Metabolite
Cortisone-d₂ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].

HY-B1540S

Beclomethasone-d5	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Beclomethasone-d₅ is the deuterium labeled Beclometasone. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.

HY-103025

Methylprednisolone aceponate ZK 91588; MPA	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective **glucocorticoid receptor** Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders.

HY-B1832

Prednisone acetate Prednisone 21-acetate	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a **glucocorticoid receptor** agonist with anti-inflammatory and immunomodulating properties.

HY-112710

ORIC-101
Glucocorticoid Receptor Cancer Endocrinology

ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC₅₀ of 5.6 nM. Anti-cancer activity.

ORIC-101	Glucocorticoid Receptor	Cancer Endocrinology
ORIC-101 is a highly potent and selective **glucocorticoid receptor antagonist, with an EC₅₀** of 5.6 nM. Anti-cancer activity.

HY-B0469S

Medroxyprogesterone acetate-d3 Medroxyprogesterone 17-acetate-d₃; Farlutin-d₃	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor	Cancer Endocrinology
Medroxyprogesterone acetate-d₃ is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].

HY-13683

Mifepristone RU486; RU 38486	Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy	Endocrinology Cancer
Mifepristone (RU486) is a progesterone receptor (PR) and **glucocorticoid receptor (GR) antagonist with IC₅₀**s of 0.2 nM and 2.6 nM in in vitro assay.

HY-100087

Budesonide impurity C	Glucocorticoid Receptor	Cancer Inflammation/Immunology
Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist.

HY-13702

Nilutamide Nilandron; RU 23908	Androgen Receptor Parasite	Cancer Infection Endocrinology
Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties.

HY-125839

OP-3633	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC₅₀ of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism.

HY-103662

GW-870086	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
GW-870086 is a potent anti-inflammatory agent, acting as a **glucocorticoid receptor agonist, with a pIC₅₀** of 10.1 in A549 cells expressing NF-κB.

HY-13683S

Mifepristone-d3 RU486-d₃; RU 38486-d₃	Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy	Endocrinology Cancer
Mifepristone-d₃ is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

HY-B0154

Fluticasone (propionate)	Glucocorticoid Receptor Enterovirus Endogenous Metabolite	Infection Endocrinology Inflammation/Immunology
Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective **glucocorticoid receptor agonist, with an absolute affinity (K_D*) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors*. Anti-viral activity.

HY-14648G

Dexamethasone Hexadecadrol; Prednisolone F	Glucocorticoid Receptor	Cancer Infection Endocrinology Inflammation/Immunology
Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of **glucocorticoid receptor**.

HY-13693S

Mometasone furoate-d3 Sch32088-d₃	Glucocorticoid Receptor	Endocrinology Inflammation/Immunology
Mometasone furoate-d₃ is a deuterium labeled Mometasone furoate. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity[1].

HY-B1832S

Prednisone acetate-d3 Prednisone 21-acetate-d₃	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Prednisone acetate-d₃ is the deuterium labeled Prednisone acetate. Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1].

HY-B1121

Flunisolide	Glucocorticoid Receptor Apoptosis	Endocrinology Inflammation/Immunology
Flunisolide is a corticosteroid, which is an orally active **glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide can induce eosinophil apoptosis**, and is used for the research of asthma or rhinitis, and inflammation.

HY-132269

Isoflupredone	Others	Inflammation/Immunology
Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases.

HY-B1121A

Flunisolide hemihydrate	Glucocorticoid Receptor Apoptosis	Endocrinology Inflammation/Immunology
Flunisolide hemihydrate is a corticosteroid, which is an orally active **glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis**, and is used for the research of asthma or rhinitis, and inflammation.

HY-111372A

(Rac)-Finerenone (Rac)-BAY 94-8862	Mineralocorticoid Receptor	Cardiovascular Disease
(Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold).

HY-A0158

Diflorasone	Others	Inflammation/Immunology
Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis.

HY-147220

Dexamethasone oxetanone Dex-Ox	Progesterone Receptor	Endocrinology
Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms.

HY-13683S1

Mifepristone-13C,d3 RU486-¹³C,d₃; RU 38486-¹³C,d₃	Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy	Endocrinology Cancer
Mifepristone-¹³C,d₃ is the ¹³C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

HY-B1121S

Flunisolide-d6	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Flunisolide-d₆ is the deuterium labeled Flunisolide. Flunisolide is a corticosteroid often used to treat allergic rhinitis.The principal mechanism of action of Flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.

HY-136290

Mc-Dexamethasone	Drug-Linker Conjugates for ADC	Cancer
Mc-Dexamethasone is a drug-linker conjugate for ADC. Mc-Dexamethasone is made toxin Dexamethasone (HY-14648) conjugated to the non-cleavable MC linker. Dexamethasone is a glucocorticoid receptor agonist.

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis	Endocrinology Cardiovascular Disease
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and *oestrogen receptor* (ER), and is also a LXRα** inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects.

HY-108243

AZD5423	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma.

HY-B0154S1

Fluticasone propionate-d5	Glucocorticoid Receptor Enterovirus Endogenous Metabolite	Infection Endocrinology Inflammation/Immunology
Fluticasone propionate-d₅ is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

HY-B0154S

Fluticasone propionate-d3	Glucocorticoid Receptor Enterovirus Endogenous Metabolite	Infection Endocrinology Inflammation/Immunology
Fluticasone propionate-d₃ is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

HY-144397

LEO 134310	Glucocorticoid Receptor	Inflammation/Immunology
LEO 134310 is a selective, non-steroidal **glucocorticoid receptor (GR) agonist optimized for topical treatment., LEO 134310 showed high affinity (EC₅₀** of 14 nM) in a GR binding assay. LEO 134310 can be used for skin diseases.

HY-111372

Finerenone BAY 94-8862	Mineralocorticoid Receptor	Cardiovascular Disease
Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal *mineralocorticoid receptor* (MR) antagonist (IC₅₀*=18 nM). Finerenone displays excellent selectivity versus glucocorticoid* receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.

HY-13693

Mometasone furoate Sch32088	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Mometasone furoate (Sch32088) is a glucocorticoid *receptor* agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo

HY-120012

Mizacorat AZD9567	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and *selective glucocorticoid* receptor modulator (SGRM), with an IC₅₀** of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation.

HY-13580

Budesonide	Glucocorticoid Receptor	Cancer Inflammation/Immunology
Budesonide, an inhaled glucocortical steroid, is an orally active **glucocorticoid receptor** agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.

HY-123352

ZK 216348 (+)-ZK 216348	Glucocorticoid Receptor	Endocrinology Inflammation/Immunology
ZK 216348 ((+)-ZK 216348) is a nonsteroidal selective **glucocorticoid receptor agonist with an IC₅₀** of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC₅₀s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects.

HY-125096

C108297	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology
C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding K_i 0.7 nM; GR reporter gene functional K_i 0.6 nM). C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation.

HY-151963

PPARγ/GR modulator 1	PPAR Glucocorticoid Receptor	Metabolic Disease
PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with K_is of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes.

HY-13580S

Budesonide-d8	Glucocorticoid Receptor	Cancer Inflammation/Immunology
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3].

HY-B0251S

Eplerenone-d3 Epoxymexrenone-d₃	Mineralocorticoid Receptor Endogenous Metabolite	Cardiovascular Disease
Eplerenone-d₃ is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch[1][2].

HY-113854

AZD2906	Glucocorticoid Receptor	Cardiovascular Disease Endocrinology
AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC₅₀s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively.

HY-14930A

Mirodenafil dihydrochloride SK-3530 dihydrochloride	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Endocrinology Inflammation/Immunology Neurological Disease
Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).

HY-14930

Mirodenafil SK3530	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Endocrinology Inflammation/Immunology Neurological Disease
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).

HY-16718

Dagrocorat PF-00251802	Glucocorticoid Receptor Cytochrome P450	Endocrinology Inflammation/Immunology
Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the **glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A (IC₅₀=1.3 μM in human liver microsomes) and CYP2D6 (K_i**=0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis.

HY-136239

Beclomethasone 17-propionate Beclomethasone-17-monopropionate; 17-BMP	Glucocorticoid Receptor Drug Metabolite	Inflammation/Immunology
Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages.

HY-16718A

Dagrocorat hydrochloride PF-00251802 hydrochloride	Glucocorticoid Receptor Cytochrome P450	Endocrinology Inflammation/Immunology
Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the **glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC₅₀=1.3 μM in human liver microsomes) and CYP2D6 (K_i**=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis.

HY-14648S2

Dexamethasone-d4 Hexadecadrol-d₄; Prednisolone F-d₄	Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Cancer Infection Endocrinology Inflammation/Immunology
Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S1

Dexamethasone-d5-1 Hexadecadrol-d₅-1; Prednisolone F-d₅-1	Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Cancer Infection Endocrinology Inflammation/Immunology
Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-146561

S-HP210	Glucocorticoid Receptor NF-κB	Inflammation/Immunology
S-HP210 is a potent and selective glucocorticoid receptor (GR) with an IC₅₀ value of 1.92 μM for NF-κB transrepression (TR). S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells.

HY-14648S

Dexamethasone-d5 Hexadecadrol-d₅; Prednisolone F-d₅	Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Cancer Infection Endocrinology Inflammation/Immunology
Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].

HY-14648S3

Dexamethasone-4,6α,21,21-d4	Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic
Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Cat. No.	Product Name	Target	Category

HY-17461A

Cortisone acetate Cortisone 21-acetate	Glucocorticoid Receptor Endogenous Metabolite	Steroids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Endogenous metabolite
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to *Glucocorticoid-receptor* at high concentrations.

HY-17461

Cortisone 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E	Glucocorticoid Receptor Endogenous Metabolite	Steroids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Endogenous metabolite
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to *Glucocorticoid-receptor* at high concentrations.

HY-B0469

Medroxyprogesterone acetate Medroxyprogesterone 17-acetate; Farlutin	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite	Steroids Disease Research Fields Cancer Classification of Application Fields Source classification Endogenous metabolite
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and **glucocorticoid receptors**.

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants Araliaceae Panax ginseng C. A. Meyer
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and *oestrogen receptor* (ER), and is also a LXRα** inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects.

Recombinant Proteins Recommended:

Glucocorticoid Receptor

Species:	Human (2)
Tag:	Fc (2)
Source:	HEK293 (2)

Cat. No.	Product Name	Species	Source

HY-P70683

GITR Protein, Human (136a.a, HEK293, Fc) Tumor necrosis factor Receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR	Human	HEK293
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (136a.a, HEK293, Fc) is a recombinant protein with a C-terminal Fc label, It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

HY-P70822

GITR Protein, Human (T45A, HEK293, mFc) Tumor necrosis factor Receptor superfamily member 18; TNFRSF18; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR	Human	HEK293
GITR (TNFRSF18) is a member of the TNFR superfamily. GITR promotes T cell activation and proliferation and increases resistance to tumors and viral infections, and exacerbates autoimmune diseases and inflammation processes. GITR Protein, Human (T45A, HEK293, mFc) is a recombinant protein with a C-terminal Fc label and T at position 45 is mutated to A. It consists of 136 amino acids (Q26-E161) and is produced in HEK293 cells.

Cat. No.	Product Name

HY-17461S2

Cortisone-d7
Cortisone-d₇ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S1

Cortisone-d8
Cortisone-d₈ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S

Cortisone-13C3
Cortisone-¹³C₃ is the ¹³C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

HY-17461S3

Cortisone-d2
Cortisone-d₂ is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].

HY-B1540S

Beclomethasone-d5

Beclomethasone-d₅ is the deuterium labeled Beclometasone. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.

HY-B0469S

Medroxyprogesterone acetate-d3
Medroxyprogesterone acetate-d₃ is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].

HY-13683S

Mifepristone-d3
Mifepristone-d₃ is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

HY-13693S

Mometasone furoate-d3
Mometasone furoate-d₃ is a deuterium labeled Mometasone furoate. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity[1].

HY-B1832S

Prednisone acetate-d3
Prednisone acetate-d₃ is the deuterium labeled Prednisone acetate. Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1].

HY-13683S1

Mifepristone-13C,d3
Mifepristone-¹³C,d₃ is the ¹³C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

HY-B1121S

Flunisolide-d6
Flunisolide-d₆ is the deuterium labeled Flunisolide. Flunisolide is a corticosteroid often used to treat allergic rhinitis.The principal mechanism of action of Flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.

HY-B0154S1

Fluticasone propionate-d5
Fluticasone propionate-d₅ is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

HY-B0154S

Fluticasone propionate-d3
Fluticasone propionate-d₃ is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

HY-13580S

Budesonide-d8
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3].

HY-B0251S

Eplerenone-d3
Eplerenone-d₃ is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch[1][2].

HY-14648S2

Dexamethasone-d4

Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S1

Dexamethasone-d5-1

Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S

Dexamethasone-d5

Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].

HY-14648S3

Dexamethasone-4,6α,21,21-d4

Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Glucocorticoid Receptor

Inhibitors & Agonists

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Recombinant Proteins

Isotope-Labeled Compounds

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