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Isoforms Recommended: HDAC5
Results for "

HDAC5

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112719
    BRD 4354

    		HDAC Cancer
    BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.
    BRD 4354
  • HY-RS06076
    HDAC5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    HDAC5 Human Pre-designed siRNA Set A contains three designed siRNAs for HDAC5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    HDAC5 Human Pre-designed siRNA Set A
    HDAC5 Human Pre-designed siRNA Set A
  • HY-RS06077
    Hdac5 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Hdac5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Hdac5 Mouse Pre-designed siRNA Set A
    Hdac5 Mouse Pre-designed siRNA Set A
  • HY-RS06078
    Hdac5 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Hdac5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hdac5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Hdac5 Rat Pre-designed siRNA Set A
    Hdac5 Rat Pre-designed siRNA Set A
  • HY-112719B
    BRD 4354 ditrifluoroacetate

    		HDAC Cancer
    BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively .
    BRD 4354 ditrifluoroacetate
  • HY-18361
    TMP195
    10+ Cited Publications

    		 HDAC Cancer
    TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with Kis of 59, 60, 26, 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
    TMP195
  • HY-18360
    TMP269
    5+ Cited Publications

    		 HDAC Cancer
    TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC50s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
    TMP269
  • HY-18998
    LMK-235
    Maximum Cited Publications
    18 Publications Verification

    		 HDAC Cancer
    LMK-235 is a potent and selective HDAC4/5 inhibitor, inhibits HDAC5, HDAC4, HDAC6, HDAC1, HDAC2, HDAC11 and HDAC8, with IC50s of 4.22 nM, 11.9 nM, 55.7 nM, 320 nM, 881 nM, 852 nM and 1278 nM, respectively, and is used in cancer research.
    LMK-235
  • HY-12164
    Mocetinostat
    10+ Cited Publications

    MGCD0103

    		 HDAC Autophagy Apoptosis Cancer
    Mocetinostat (MGCD0103) is a potent, orally active and isotype-selective HDAC (Class I/IV) inhibitor with IC50s of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1, HDAC2, HDAC3 and HDAC11, respectively. Mocetinostat shows no inhibition on HDAC4, HDAC5, HDAC6, HDAC7, or HDAC8.
    Mocetinostat
  • HY-152226
    MC2590

    		HDAC Apoptosis Cancer
    MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2590 is a inhibitor of HDAC1-3, -6, -8, and -10 (class I/IIb-selective inhibitor) with IC50s of 0.015 μM-0.156 μM. MC2590 also inhibits HDAC isoforms HDAC4, HDAC5, HDAC7, HDAC9, HDAC11 with IC50s of 1.35 μM-3.98 μM. MC2625 induces G2/M cell cycle arrest and modulates pro- and anti-apoptotic microRNAs towards apoptosis induction .
    MC2590
  • HY-119939
    CHDI-390576

    		HDAC Cancer
    CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform .
    CHDI-390576
  • HY-143248
    KR-39038

    		G Protein-coupled Receptor Kinase (GRK) HDAC Cardiovascular Disease
    KR-39038 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 0.02 μM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression of HDAC5 pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research .
    KR-39038
  • HY-114548
    Ebselen oxide

    		Guanylate Cyclase Infection
    Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM) .
    Ebselen oxide
  • HY-152225
    MC2625

    		HDAC Apoptosis Cancer
    MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC50s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction .
    MC2625

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