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HEK293

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (4) 5-HT Receptor (16) AAK1 (1) Acyltransferase (2) Adenosine Receptor (1) Adenylate Cyclase (1) Adrenergic Receptor (3) Akt (2) AMPK (2) Amylases (1) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (2) Antibiotic (4) Apelin Receptor (APJ) (4) Apolipoprotein (1) Apoptosis (18) Arrestin (1) ASCT (3) Aurora Kinase (6) Autophagy (17) AUTOTACs (2) Bacterial (22) Bcl-2 Family (1) BCRP (2) Beta-lactamase (3) Biochemical Assay Reagents (1) BMI1 (2) c-Myc (2) Calcium Channel (6) CaMK (1) CaSR (8) CD28 (1) CD73 (1) CDK (2) Ceramidase (2) CFTR (2) CGRP Receptor (2) Chloride Channel (1) Cholinesterase (ChE) (1) COX (1) CRFR (1) CXCR (3) Cytochrome P450 (3) Deubiquitinase (1) Discoidin Domain Receptor (1) DNA Methyltransferase (1) DNA/RNA Synthesis (5) DOCK (1) Dopamine Receptor (8) Dopamine Transporter (3) Drug Isomer (1) Drug Metabolite (1) DYRK (2) EAAT (1) EGFR (2) ELOVL (1) Endogenous Metabolite (14) Epigenetic Reader Domain (4) ERK (6) Estrogen Receptor/ERR (4) FAAH (3) Ferroportin (1) FGFR (1) FKBP (6) Fluorescent Dye (1) Free Fatty Acid Receptor (1) Fungal (2) FXR (2) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (6) GHSR (1) GLP Receptor (2) Glutathione Peroxidase (2) Glycosidase (2) GnRH Receptor (1) GPR119 (1) GPR35 (1) GPR68 (1) GPR84 (2) GPR88 (2) GSK-3 (2) Guanylate Cyclase (1) HCN Channel (1) HCV (1) HDAC (8) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (3) Hippo (MST) (1) Histamine Receptor (2) Histone Methyltransferase (4) HIV (5) HMG-CoA Reductase (HMGCR) (6) HSP (2) IAP (1) IFNAR (1) IGF-1R (1) iGluR (4) Indoleamine 2,3-Dioxygenase (IDO) (6) Influenza Virus (1) Insecticide (1) Insulin Receptor (1) Interleukin Related (5) IRAK (2) IRE1 (1) Isotope-Labeled Compounds (8) JAK (4) Lactate Dehydrogenase (2) Leukotriene Receptor (1) Ligands for Target Protein for PROTAC (2) LPL Receptor (2) LRRK2 (4) mAChR (6) MAGL (4) Mas-related G-protein-coupled Receptor (MRGPR) (1) MDM-2/p53 (1) Melanocortin Receptor (1) mGluR (3) Microtubule/Tubulin (5) Mitochondrial Metabolism (1) MNK (1) Monoamine Oxidase (1) mTOR (5) nAChR (1) NADPH Oxidase (2) Neuromedin U Receptor (NMUR) (1) Neuropeptide Y Receptor (2) NF-κB (3) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (2) OAT (2) Oct3/4 (1) Opioid Receptor (10) Orexin Receptor (OX Receptor) (2) Orphan Receptor (3) P-glycoprotein (4) P2X Receptor (2) p62 (1) Parasite (13) PARP (5) PD-1/PD-L1 (2) PERK (1) Phosphatase (1) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (3) Piezo Channel (1) PIKfyve (1) PIN1 (1) Potassium Channel (12) PPAR (1) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (7) PROTACs (7) Protease Activated Receptor (PAR) (1) Proteasome (1) Pyroptosis (1) RAD51 (1) Ras (1) Reactive Oxygen Species (14) ROCK (1) ROR (3) RXFP Receptor (8) SARS-CoV (5) Serotonin Transporter (2) Sodium Channel (7) Src (1) STAT (4) Steroid Sulfatase (1) STING (1) Tau Protein (1) TNF Receptor (3) Toll-like Receptor (TLR) (7) TRP Channel (11) URAT1 (3) Urotensin Receptor (2) VEGFR (3) Virus Protease (6) Wnt (5) Xanthine Oxidase (1) α-synuclein (1) β-catenin (5) γ-secretase (1)
By Research Areas:	Cancer (129) Cardiovascular Disease (28) Endocrinology (8) Infection (44) Inflammation/Immunology (75) Metabolic Disease (52) Neurological Disease (106)
Click Chemistry:	Azide (1) Alkynes (2)
Oligonucleotides:	Aptamers (2) CpG ODNs (2)

380

Inhibitors & Agonists

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6682

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Isotope-Labeled Compounds

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100360

MS049	Histone Methyltransferase	Cancer
MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC₅₀s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells .

HY-19774

GNE-0946	ROR	Inflammation/Immunology
GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC₅₀ value of 4 nM for HEK-293 cell.

HY-136583

28-Epirapamycin	Drug Metabolite	Others
28-Epirapamycin is an impurity of Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells .

HY-169301

Gpr35 modulator 1	GPR35	Cancer
Gpr35 modulator 1 (compound 1-18) is a potent modulator of Gpr35, with the IC₅₀ of ≤ 100 nM in HEK293 cells stably transfected with human GPR35 .

HY-158422

SARS-CoV-2 Mpro-IN-16	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-16 (compound 5J) is a SARS-CoV-2 Mpro inhibitor, and inhibits HEK293 cells growth .

HY-100360A

MS049 dihydrochloride	Histone Methyltransferase	Cancer
MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC₅₀s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells .

HY-P4376

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is an agonist for calcium sensing receptor (CaSR), that activates the CaSR with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-108576

Linopirdine dihydrochloride DuP 996 dihydrochloride	TRP Channel	Neurological Disease
Linopirdine dihydrochloride is a agonist of capsaicin receptor TRPV1. Linopirdine increases the intracellular calcium concentration in HEK293 cells. Linopirdine dihydrochloride exerts an excitatory action on mammalian nociceptors .

HY-169136

U 101958	Dopamine Receptor	Neurological Disease
U 101958 is full Dopamine D4 receptor agonist, with a pEC₅₀ of 8.7 in HEK293/D₄ cells .

HY-P1168

[Orn8]-Urotensin II (human)	Urotensin Receptor	Cardiovascular Disease
[Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293 .

HY-146071

Antitrypanosomal agent 5	Parasite	Infection
Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC₅₀s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively .

HY-132934

Ac32Az19 1 Publications Verification	BCRP	Cancer
Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor with an EC₅₀ value of 13 nM in the BCRP-overexpressed HEK293/R2 cells.

HY-125717

VU0029251	mGluR	Neurological Disease
VU0029251 is a mGluR5 partial antagonist (K_i: 1.07 μM). VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC₅₀: 1.7 μM) .

HY-120538

CPG-52364	Toll-like Receptor (TLR)	Inflammation/Immunology
CPG-52364 (compound 2) is a TLR9 antagonist. CPG-52364 inhibits the HEK293-hTLR9 cell with an IC₅₀ value of 4.6 nM .

HY-170390

AB3067	PROTACs Epigenetic Reader Domain	Cancer
AB3067 is a PROTAC degrader for BET protein, that recruits two different E3 ligase Cereblon and VHL with good affinity (IC₅₀=559 nM for VHL in live HEK293; IC₅₀=190 nM for CRBN in live HEK293), and degrades BRD2, BRD3, BRD4 and CRBN with DC₅₀ of 2.1~2.3, 1.6, 15 and 75 nM, respectively. AB3067 inhibits the proliferation of RKO cell with an EC₅₀ of 111 nM . (Pink: ligand for target protein (HY-131633A); Black: linker (HY-170391); Blue: ligand for E3 ligase VHL (HY-112078) and CRBN(HY-W998346))

HY-10219

Rapamycin Maximum Cited Publications 954 Publications Verification Sirolimus; AY-22989	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial	Cancer
Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-150737

MI-1851	SARS-CoV	Infection
MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity .

HY-158758

PROTAC IRAK4 degrader-10	PROTACs IRAK	Inflammation/Immunology
PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC₅₀ of 7.68 nM in HEK293 cells (Sturcture Note:(Blue: Cereblon ligand, Black: linker；Pink: IRAK4 ligand) .

HY-163762

Antibacterial agent 226	Bacterial	Infection
Antibacterial agent 226 (Compound 7f) is an antibacterial agent, that inhibits Staphylococcus aureus strains and methicillin-resistant S. aureus strain with MIC of 2 μg/mL. Antibacterial agent 226 exhibits cytotoxicity to HEK293 with IC₅₀ of 1.9 μM .

HY-109039

Praliciguat IW-1973	Guanylate Cyclase	Cardiovascular Disease
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC₅₀ of 197 nM .

HY-19775

GNE-6468	ROR	Inflammation/Immunology
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC₅₀ value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC₅₀ of 30 nM for IL-17 PBMC .

HY-158760

PROTAC IRAK4 degrader-11	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-11 (compound 15) is PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 96.25% and the DC₅₀ of 2.29 nM in HEK293 cells(Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker；Pink: IRAK4 inhibitor) .

HY-149944

Analgesic agent-2	Sodium Channel	Inflammation/Immunology
Analgesic agent-2 is a selective and orally active NaV1.8 Channel inhibitor, with an IC₅₀ of 50.18 nM in HEK293 cells stably expressing human NaV1.8 channel. Analgesic agent-2 has analgesic activity .

HY-10219S

Rapamycin-d3 Sirolimus-d₃; AY-22989-d₃	Isotope-Labeled Compounds mTOR FKBP Autophagy	Cancer
Rapamycin-d₃ is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .

HY-160811

hVEGF-IN-3	VEGFR	Cancer
hVEGF-IN-3 (compound 9) is a potent hVEGF inhibitor. hVEGF-IN-3 inhibits HT-29, MCF-7, and HEK-293 cells proliferation with IC₅₀s of 61, 142, and 114 μM .

HY-146428

Anti-MRSA agent 4	Bacterial	Infection
Anti-MRSA agent 4 (compound 7a) is a potent and selective growth inhibitor of Gram-positive *Methicillin-resistant Staphylococcus aureus* (MRSA), with MIC** ≤ 0.26 µM. Anti-MRSA agent 4 exhibits no cytotoxic and no hemolytic activity in HEK293 cells .

HY-108682

EMPA 5+ Cited Publications	Orexin Receptor (OX Receptor)	Neurological Disease
EMPA is a high-affinity, reversible and selective orexin OX₂ receptor antagonist. [ ³H]EMPA binds to human and rat OX₂-HEK293 membranes with K_D values of 1.1 and 1.4 nM respectively .

HY-156541

RXFP1 receptor agonist-6	RXFP Receptor	Cardiovascular Disease Inflammation/Immunology
RXFP1 receptor agonist-6 (Example 7) is a RXFP1 receptor agonist. RXFP1 receptor agonist-6 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 12 nM .

HY-156538

RXFP1 receptor agonist-3	RXFP Receptor	Inflammation/Immunology
RXFP1 receptor agonist-3 (Example 223) is a RXFP1 receptor agonist. RXFP1 receptor agonist-3 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 2 nM .

HY-156537

RXFP1 receptor agonist-2	RXFP Receptor	Cardiovascular Disease Inflammation/Immunology
RXFP1 receptor agonist-2 (Example 124) is a RXFP1 receptor agonist. RXFP1 receptor agonist-2 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 1 nM .

HY-100013C

2-PCCA hydrochloride	GPR88	Neurological Disease
2-PCCA hydrochloride is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC₅₀ of 116 nM in HEK293 cells.

HY-119695B

Simvastatin acid calcium hydrate Tenivastatin calcium hydrate	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-119695A

Simvastatin acid ammonium 1 Publications Verification Tenivastatin ammonium	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-115292

Simvastatin hydroxy acid sodium Tenivastatin sodium; Simvastatin Impurity A sodium	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-169622

RAD51-IN-9	RAD51	Others
RAD51-IN-9 (Compound 3a) is a RAD51 inhibitor that can inhibit the binding of RAD51 to ssDNA with an IC₅₀ of 17.85 μM. RAD51-IN-9 has a LD₅₀ against HEK293 cells of 40.21 μM. RAD51-IN-9 can sensitize cells to Mitomycin C (HY-13316) .

HY-156543

RXFP1 receptor agonist-8	RXFP Receptor	Cardiovascular Disease Inflammation/Immunology
RXFP1 receptor agonist-8 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-8 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 1.8 nM .

HY-156539

RXFP1 receptor agonist-4	RXFP Receptor	Cardiovascular Disease Inflammation/Immunology
RXFP1 receptor agonist-4 (Example 268) is a RXFP1 receptor agonist. RXFP1 receptor agonist-4 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 4.9 nM .

HY-156540

RXFP1 receptor agonist-5	RXFP Receptor	Inflammation/Immunology
RXFP1 receptor agonist-5 (Example 98) is a RXFP1 receptor agonist. RXFP1 receptor agonist-5 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 1.3 nM .

HY-156542

RXFP1 receptor agonist-7	RXFP Receptor	Cardiovascular Disease Inflammation/Immunology
RXFP1 receptor agonist-7 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-7 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 4.2 nM .

HY-50883

BMS 299897	γ-secretase	Neurological Disease
BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC₅₀ of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

HY-156536

RXFP1 receptor agonist-1	RXFP Receptor	Cardiovascular Disease Inflammation/Immunology
RXFP1 receptor agonist-1 (Example 2 peak2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-1 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 300 nM .

HY-10219R

Rapamycin (Standard)	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial	Cancer
Rapamycin (Standard) is the analytical standard of Rapamycin. This product is intended for research and analytical applications. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-P4376A

Gamma-Glu-Abu TFA	CaSR	Neurological Disease
Gamma-Glu-Abu TFA is the TFA salt form of Gamma-Glu-Abu (HY-P4376). Gamma-Glu-Abu TFA is an agonist for calcium sensing receptor (CaSR), that activates the CaSR with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-119695

Simvastatin acid Tenivastatin	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species	Cardiovascular Disease Cancer
Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-147917

RNA polymerase II-IN-2	DNA/RNA Synthesis	Cancer
RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with K_i value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293 .

HY-16934

ML352	Cholinesterase (ChE)	Neurological Disease
ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with K_i values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively .

HY-162304

MAGL-IN-14	MAGL	Neurological Disease
MAGL-IN-14 (compound 2) is a potent inhibitor of MAGL, with IC₅₀ of 0.00289 μM and 0.002 μM in HEK293 and PC3 cells, respectively .

HY-101560

Linrodostat 5 Publications Verification BMS-986205; ONO-7701	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ value of 1.1 nM in *IDO1*-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers .

HY-164587

E197	DOCK	Metabolic Disease
E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC₅₀=3.44 μM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC₅₀ of 36 μM. E197 prevents the bone loss in mouse ovariectomized models .

HY-12805

ML171 15+ Cited Publications 2-Acetylphenothiazine; 2-APT	NADPH Oxidase	Cardiovascular Disease
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC₅₀ of 0.25 μM in HEK293-Nox1 confirmatory assay.

Cat. No.	Product Name	Type

HY-100545

BAPTA-AM 70+ Cited Publications	Chelators
BAPTA-AM is a well-known membrane permeable Ca ²⁺ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC₅₀s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P1066

Apelin-17(human, bovine)	Apelin Receptor (APJ) HIV	Infection
Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC₅₀=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P1064

Apelin-36(human)	Apelin Receptor (APJ) HIV	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC₅₀=8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P1064A

Apelin-36(human) TFA	HIV Apelin Receptor (APJ)	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC5₅₀=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P4376

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is an agonist for calcium sensing receptor (CaSR), that activates the CaSR with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-P1168

[Orn8]-Urotensin II (human)	Urotensin Receptor	Cardiovascular Disease
[Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293 .

HY-P4376A

Gamma-Glu-Abu TFA	CaSR	Neurological Disease
Gamma-Glu-Abu TFA is the TFA salt form of Gamma-Glu-Abu (HY-P4376). Gamma-Glu-Abu TFA is an agonist for calcium sensing receptor (CaSR), that activates the CaSR with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-P5372

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Protease Activated Receptor (PAR)	Others
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)

HY-P1432A

K-(D-1-Nal)-FwLL-NH2 TFA	GHSR	Cancer
K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (K_i values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

HY-P5157

BmP02	Potassium Channel	Neurological Disease
BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC₅₀ value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells .

HY-P1066A

Apelin-17(human, bovine) TFA	HIV Apelin Receptor (APJ)	Infection
Apelin-17(human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells (pIC₅₀=9.02). Apelin-17(human, bovine) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P10842

d-GLP-2 E33A	GLP Receptor Akt	Metabolic Disease Inflammation/Immunology
d-GLP-2 E33A is an agonist for the glucagon-like peptide 2 receptor (GLP-2R) with an EC₅₀ of 414 nM. d-GLP-2 E33A can activate GLP-2R and increase the phosphorylation of AKT, but has no stimulative effect on GLP-1R. d-GLP-2 E33A can be used in the study of diseases such as intestinal malabsorption and inflammatory bowel diseases .

HY-P5114A

Maurocalcine TFA	Calcium Channel	Others
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques .

HY-P5114

Maurocalcine	Calcium Channel	Others
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques .

HY-P10234

Poneratoxin	Sodium Channel	Neurological Disease
Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC₅₀ for NaV1.6 and NaV1.6 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals .

HY-P5883

TAT-M2NX tatM2NX	TRP Channel	Neurological Disease
TAT-M2NX (tatM2NX) is a TRPM2 inhibitor with specific neuroprotective activity in male mice. TAT-M2NX can be used to study ischemic neuronal damage .

HY-P10234A

Poneratoxin acetate	Sodium Channel	Neurological Disease
Poneratoxin acetate is the acetate salt form of Poneratoxin (HY-P10234). Poneratoxin acetate is the modulator for voltage-gated sodium channel (NaV, EC₅₀ for NaV1.6 and NaV1.6 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals .

HY-P5907

Helianorphin-19	Opioid Receptor	Neurological Disease
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a K_i of 21 nM and an EC₅₀ of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain .

HY-P10090

Apoptin-derived peptide	Akt PI3K Apoptosis	Cancer
Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer .

HY-P10302A

GLP-1R/GIPR agonist-1 (soduim)	GLP Receptor	Metabolic Disease
GLP-1R/GIPR agonist-1 soduim is the sodium salt form of GLP-1R/GIPR agonist-1 (HY-P10302). GLP-1R/GIPR agonist-1 soduim is a dual agonist for glucagon-like peptide-1 receptor (GLP-1R, EC₅₀ is 0.57 nM) and glucose-dependent insulin releasing peptide receptor (GIPR, EC₅₀ is 0.75 nM). GLP-1R/GIPR agonist-1 soduim lowers blood sugar by mimicking the action of endogenous hormones GLP-1 and GIP, enhancing insulin secretion while inhibiting glucagon secretion. GLP-1R/GIPR agonist-1 soduim can be used in the study of metabolic diseases such as diabetes, obesity, and non-alcoholic steatohepatitis (NASH) .

HY-105173

Teverelix EP 24332	GnRH Receptor Histamine Receptor	Endocrinology Cancer
Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer .

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs .

Cat. No.	Product Name

HY-K2014

PEI Transfection Reagent 10+ Cited Publications
MCE PEI Transfection Reagent is designed based on 25 kDa PEI. It has high-efficiency, low-toxicity, strong-stability, and is suitable for many cell types, such as HEK-293、HEK-293T、CHO-K1、COS-1、COS-7、NIH/3T3、Sf9、HepG2 and HeLa et, even some hard-to-transfect cells. It can also be applied to large-scale recombinant protein expression and virus production.

Cat. No.	Product Name	Target	Research Area

HY-P99499

Cetrelimab JNJ 63723283; JNJ 3283	PD-1/PD-L1 Interleukin Related TNF Receptor	Cancer
Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (K_d=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC₅₀s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo .

HY-P99665

Insulin efsitora alfa LY-3209590	Insulin Receptor	Metabolic Disease
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes .

HY-P99220

Tabalumab LY2127399	TNF Receptor	Inflammation/Immunology Cancer
Tabalumab (LY2127399) is a human anti-BAFF (B-cell activating factor) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus .

HY-P99115

Envafolimab ASC 22; KN 035	PD-1/PD-L1	Cancer
Envafolimab (ASC 22; KN 035) is a recombinant protein of a humanized single-domain anti- PD-L1 antibody. Envafolimab is created by a fusion of the of anti-PD-L1 domain with Fc fragment of human IgG1 antibody. Envafolimab blocks interaction between PD-L1 and PD-1 with an IC₅₀ value of 5.25?nM. Envafolimab has the potential for the research of solid tumors .

Species:	Human (3465) Rhesus Macaque (223) Rat (456) Bovine (1) Cynomolgus (498) Rabbit (19) Canine (123) Pig (4) Virus (607) Marmoset (4) Rhesus Macaque/Cynomolgus (1) Mouse (1319) Cat (1) Sheep (1) Dog (4) Staphylococcus aureus (1)
Tag:	mCherry (1) SUMO (2) GST (1) Flag (132) GFP (15) His (4756) Tag Free (300) Strep (40) Avi (829) Myc (35) HSA (1) HA (2) MBP (18) Fc (1661)
Source:	HEK293 (6676) HEK293 (1) CHO (1) Sf9 insect cells (1) E. coli (3)

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