Search Result

Results for "

HPGDS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ligands for Target Protein for PROTAC (1) PGE synthase (7) Prostaglandin Receptor (3) PROTACs (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Inflammation/Immunology (6) Metabolic Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10439

HPGDS inhibitor 1	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC₅₀s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .

HY-12791

hPGDS-IN-1 1 Publications Verification	PGE synthase	Inflammation/Immunology
hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.

HY-126134

HPGDS inhibitor 2	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC₅₀ of 9.9 nM .

HY-146662

HPGDS inhibitor 3	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 3 is an orally active and highly potent peripherally restricted hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC₅₀ value of 9.4 nM and EC₅₀ of 42 nM, respectively. HPGDS inhibitor 3 exhibits good selectivity, good pharmacokinetic parameters in mouse, rat, and dog, and no CNS toxicity. HPGDS inhibitor 3 has anti-inflammatory activity .

HY-RS06341

HPGDS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HPGDS Human Pre-designed siRNA Set A contains three designed siRNAs for HPGDS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HPGDS Human Pre-designed siRNA Set A HPGDS Human Pre-designed siRNA Set A

HY-110167

TFC 007	PGE synthase Ligands for Target Protein for PROTAC	Cancer
TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC₅₀ value of 83 nM). TFC-007 can be used for composing H-PGDS degradation inducer PROTAC(H-PGDS)-1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon) .

HY-RS06338

HPGD Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HPGD Human Pre-designed siRNA Set A contains three designed siRNAs for HPGD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HPGD Human Pre-designed siRNA Set A HPGD Human Pre-designed siRNA Set A

HY-RS06339

Hpgd Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hpgd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hpgd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hpgd Mouse Pre-designed siRNA Set A Hpgd Mouse Pre-designed siRNA Set A

HY-RS06340

Hpgd Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hpgd Rat Pre-designed siRNA Set A contains three designed siRNAs for Hpgd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hpgd Rat Pre-designed siRNA Set A Hpgd Rat Pre-designed siRNA Set A

HY-157577

*PROTAC(H-PGDS)-8*	PROTACs Prostaglandin Receptor	Cardiovascular Disease
PROTAC(H-PGDS)-8 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a IC₅₀ of 0.14 μM .

HY-139972

PROTAC(H-PGDS)-7

Prostaglandin Receptor Cardiovascular Disease

PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a DC₅₀ of 17.3 pM .

*PROTAC(H-PGDS)-7*	Prostaglandin Receptor	Cardiovascular Disease
PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a DC₅₀ of 17.3 pM .

HY-139171

F092	PGE synthase	Inflammation/Immunology
F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a K_D value of 0.14 nM. F092 can be used in the study of allergic and inflammatory responses .

HY-109134

Pizuglanstat TAS-205 free base	Prostaglandin Receptor	Metabolic Disease
Pizuglanstat (compound 3) is a prostaglandin D synthase inhibitor with an IC₅₀ of 76 nM for human hematopoietic prostaglandin D synthases (H-PGDS). Pizuglanstat can be used for myodegenerative disease research, such as muscular dystrophy .

HY-108259

HQL-79	PGE synthase	Inflammation/Immunology
HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD₂, and acts as an anti-allergic agent, with a K_d of 0.8 μM and an IC₅₀ of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS .

Cat. No.	Compare	Product Name	Species	Source

HY-P71036

	HPGDS Protein, Human Glutathione-Dependent PGD Synthase; Glutathione-Requiring Prostaglandin D Synthase; Prostaglandin-H2 D-Isomerase; HPGDS; GSTS; PGDS; PTGDS2	Human	E. coli
	HPGDS protein is a multifunctional enzyme with bifunctionality, and its C-terminal and N-terminal domains have different activities. The C terminus acts as an epoxide hydrolase, promoting xenobiotic metabolism by degrading harmful epoxides and regulating physiological mediator levels. HPGDS Protein, Human is the recombinant human-derived HPGDS protein, expressed by E. coli , with tag free. The total length of HPGDS Protein, Human is 199 a.a., with molecular weight of ~26.0 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.