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Results for "

HSP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSP (157) ADC Cytotoxin (4) Akt (2) Androgen Receptor (1) Antibiotic (13) Antifolate (4) Apoptosis (37) Aryl Hydrocarbon Receptor (1) Autophagy (22) Bacterial (17) Bcl-2 Family (1) Beta-lactamase (1) CDK (1) Deubiquitinase (1) DNA/RNA Synthesis (3) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (5) ERK (3) Estrogen Receptor/ERR (5) FAK (1) FKBP (1) Fungal (3) HDAC (5) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (2) HMG-CoA Reductase (HMGCR) (6) HSV (1) Influenza Virus (6) JNK (3) MAPKAPK2 (MK2) (2) MDM-2/p53 (3) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Mitophagy (1) Monoamine Oxidase (2) mTOR (1) Necroptosis (1) Neurokinin Receptor (4) NF-κB (1) NO Synthase (1) Orthopoxvirus (2) Oxidative Phosphorylation (1) p38 MAPK (4) Parasite (4) PDHK (2) PKC (1) Potassium Channel (9) PROTACs (3) Reactive Oxygen Species (1) RIP kinase (1) Sirtuin (3) Small Interfering RNA (siRNA) (5) Survivin (2) Topoisomerase (1) VEGFR (2)
By Research Areas:	Cancer (142) Cardiovascular Disease (11) Endocrinology (1) Infection (28) Inflammation/Immunology (20) Metabolic Disease (18) Neurological Disease (23)
Click Chemistry:	Alkynes (2)

202

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: HSP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15190

*NVP-HSP990* 2 Publications Verification HSP-990	HSP Apoptosis	Cancer
NVP-HSP990 is a potent, selective and orally active *Hsp90* inhibitor, with IC₅₀ values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively.

HY-113574

HSP90-IN-29	HSP	Cancer
HSP90-IN-29 (Compound 13), a benzoxazole derivative, is a potent and selective *HSP-90* inhibitor with an IC₅₀ value of 30 nM. HSP90-IN-29 has antitumor activity .

HY-152027

HSP90-IN-18	HSP Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-18 is an effective *heat shock protein 90 (Hsp90)* inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-152028

HSP90-IN-19	HSP	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-19 is an effective *heat shock protein 90 (Hsp90)* inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-144724

HSP90-IN-10	HSP Apoptosis	Cancer
HSP90-IN-10 (Compound 16s) is a potent inhibitor of *HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC₅₀* value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis .

HY-146325

HSP90-IN-11	HSP	Cancer
HSP90-IN-11 (Compound 12c) is a potent inhibitor of *HSP90. HSP90-IN-11 displays potent HSP90α inhibition comparable to AUY-922 (Luminespib). HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP*90-IN-11 induces significant accumulation of a sub-G1 phase population .

HY-150655

Hsp90-IN-15	HSP	Cancer
Hsp90-IN-15 is an *Hsp90* inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of *Hsp90* in Hela cell .

HY-18406

HSP70-IN-4

HSP Cancer

HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC₅₀ of 3.2 μM. HSP70-IN-4 is not BBB permeable .
HY-149531

HSP90-IN-25

HSP Cancer

HSP90-IN-25 (compound 4a) is an HSP90 inhibitor that specifically inhibits the ATPase activity of HSP90 .
HY-148963

HSP90-IN-20

HSP Cancer

HSP90-IN-20 (compound 78p) is a potent HSP90 inhibitor with an IC₅₀ of ≤10 μM. HSP90-IN-20 has the potential for cancers research .

HSP70-IN-4	HSP	Cancer
HSP70-IN-4 (Compound YM-01) is an *Hsp70* inhibitor with an IC₅₀ of 3.2 μM. HSP70-IN-4 is not BBB permeable .

HSP90-IN-25	HSP	Cancer
HSP90-IN-25 (compound 4a) is an HSP90 inhibitor that specifically inhibits the ATPase activity of HSP90 .

HSP90-IN-20	HSP	Cancer
HSP90-IN-20 (compound 78p) is a potent *HSP90* inhibitor with an IC₅₀ of ≤10 μM. HSP90-IN-20 has the potential for cancers research .

HY-145814

HSP90-IN-9	HSP Fungal	Infection
HSP90-IN-9 is a potent and selective *HSP90* inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2) .

HY-149891

HSP90-IN-23	HSP	Cancer
HSP90-IN-23 (Comp 12-1) is an inhibitor of heat shock protein 90(HSP90) with an IC₅₀ of 9 nM. HSP90-IN-23 induces apoptosis of tumor cells and arrests the tumor cell cycle in G0/G1 phase. HSP90-IN-23 can be used for cancer research .

HY-156779

HSP90-IN-27

HSP Cancer

HSP90-IN-27 (compound 19) is an HSP90 inhibitor .

HSP90-IN-27	HSP	Cancer
HSP90-IN-27 (compound 19) is an *HSP90* inhibitor .

HY-151137

HSP90/mTOR-IN-1	mTOR HSP Apoptosis Autophagy	Cancer
HSP90/mTOR-IN-1 is a potent and orally active *Hsp90* and mTOR inhibitor with IC₅₀ values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer .

HY-146228

HSP90-IN-13	HSP Apoptosis Topoisomerase EGFR VEGFR	Cancer
HSP90-IN-13 (compound 5k) is a highly potent *HSP90* pan inhibitor with an IC₅₀ value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway .

HY-148215

Hsp90-IN-17

HSP Cancer

Hsp90-IN-17 (Example 5) is an HSP90 inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases .

Hsp90-IN-17	HSP	Cancer
Hsp90-IN-17 (Example 5) is an *HSP90* inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases .

HY-148215A

Hsp90-IN-17 hydrochloride	HSP	Cancer
Hsp90-IN-17 (Example 5) hydrochloride is an *HSP90* inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases .

HY-12622

HSP70-IN-1

1 Publications Verification

HSP Cancer

HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC₅₀ of 2.3 μM.

HSP70-IN-1 1 Publications Verification	HSP	Cancer
HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC₅₀ of 2.3 μM.

HY-P1896

Hsp70-derived octapeptide	HSP	Infection Neurological Disease Cancer
Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs .

HY-144650

Hsp90-Cdc37-IN-3	Apoptosis HSP	Cancer
Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol−imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits *Hsp90−Cdc37* by covalent-binding, and induces apoptosis .

HY-143400

HSP70-IN-3	HSP Hedgehog	Cancer
HSP70-IN-3 is a potent *HSP70* inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1 .

HY-147974

HSP90-IN-14	HSP Influenza Virus	Infection
HSP90-IN-14 (compound 4) is a potent *Hsp90* (heat shock protein 90) inhibitor, with a K_d of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC₅₀ values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively .

HY-111414

Hsp90-Cdc37-IN-1

HSP Cancer

Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC₅₀ of 140 nM.

Hsp90-Cdc37-IN-1	HSP	Cancer
Hsp90-Cdc37-IN-1 is an *Hsp90-Cdc37* interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC₅₀ of 140 nM.

HY-149637

HSP70/SIRT2-IN-1	Sirtuin HSP	Cancer
HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and *HSP*70, with IC₅₀ of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity .

HY-149638

HSP70/SIRT2-IN-2	Sirtuin HSP	Cancer
HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and *HSP*70, with IC₅₀ of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity .

HY-153588

HSP90-IN-22	HSP	Cancer
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC₅₀ values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.

HY-124653

HSP27 inhibitor J2 5 Publications Verification J2	HSP	Cancer
HSP27 inhibitor J2 (J2) is a *HSP27* inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .

HY-147747

HSP90-IN-12	HSP	Cancer
Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of *hsp90* related proteins in cells and inhibited *hsp90* mediated protein refolding of luciferase in vitro.

HY-153547

HSP90-IN-21	Parasite	Infection Inflammation/Immunology
HSP90-IN-21 (5e) is an antiplasmodial agent, with IC₅₀ values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2 strains), cytotoxicity of human liver hepatocellular carcinoma cell line (HepG2), respectively .

HY-P10072A

MK2-IN-5 acetate HSP25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

HY-RS06415

HSP90AA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90AA1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90AA1 Human Pre-designed siRNA Set A HSP90AA1 Human Pre-designed siRNA Set A

HY-RS06416

Hsp90aa1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90aa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsp90aa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90aa1 Mouse Pre-designed siRNA Set A Hsp90aa1 Mouse Pre-designed siRNA Set A

HY-RS06417

Hsp90aa1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90aa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsp90aa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90aa1 Rat Pre-designed siRNA Set A Hsp90aa1 Rat Pre-designed siRNA Set A

HY-RS06418

HSP90AB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90AB1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90AB1 Human Pre-designed siRNA Set A HSP90AB1 Human Pre-designed siRNA Set A

HY-RS06419

HSP90B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90B1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90B1 Human Pre-designed siRNA Set A HSP90B1 Human Pre-designed siRNA Set A

HY-P10072

MK2-IN-5 HSP25 kinase inhibitor; Mk2 pseudosubstrate	ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)	Others
MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation .

HY-151337

*Aha1/Hsp90-IN-1*	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology
Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC₅₀ of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation .

HY-146212

*HDAC/HSP90-IN-4*	HDAC HSP	Cancer
These compounds have strong hdac and *hsp90* inhibitory activities. Compound 20 (HDAC ic₅₀   =   194   nm; Hsp90 α < b> Ic₅₀ =   153   nm) and compound 26 ((HDAC ic₅₀=   360   nm; Hsp90 α < b> Ic₅₀   =   77   nm) shows the strongest HDAC and HSP90 α Inhibitory activity. Both compounds can induce *hsp90* expression and down regulate *hsp90* client proteins, which play an important role in regulating the survival and invasion of cancer cells.

HY-163288

*EZH2/HSP90-IN-29*	Histone Methyltransferase HSP Apoptosis	Cancer
EZH2/HSP90-IN-29 is a dual inhibitor for EZH2 and *HSP90, with IC₅₀s of 6.29 nM and 60.1 nM, for EZH2 and HSP90, respectively. EZH2/HSP90-IN-29 increases apoptosis/necrosis-related gene expression, induces cell cycle arrest at M phase and inhibits reactive oxygen species (ROS) catabolism pathway. EZH2/HSP*90-IN-29 is able to cross the blood-brain-barrier (BBB) .

HY-158131

*FKBP51-Hsp90-IN-2*	FKBP HSP	Neurological Disease Cancer
FKBP51-Hsp90-IN-2 (Compound E08) is a selective *FKBP51-Hsp90* protein-protein interaction inhibitor with IC₅₀ values of 0.4 µM and 5 µM for FKBP51 and FKBP52, respectively. FKBP51-Hsp90-IN-2 also effectively stimulates cellular energy metabolism and neurite growth. FKBP51-Hsp90-IN-2 can be used in research on neurodegenerative diseases and cancer .

HY-150774

*HDAC6/HSP90-IN-2*	HDAC HSP Apoptosis	Cancer
HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and *Hsp90, with IC₅₀s of 105.7 and 61 nM, respectively. HDAC6/HSP*90-IN-2 can be used for the research of cancer .

HY-146293

*HDAC6/HSP90-IN-1*	HDAC HSP	Cancer
HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and *HSP90, with IC₅₀* values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice .

HY-115997

*PROTAC HSP90 degrader BP3*	PROTACs HSP	Cancer
PROTAC HSP90 degrader BP3 is a potent and selective degradation of *HSP90* in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain degradation effect on *HSP90* protein in MCF-7 cells (DC₅₀=0.99 μM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell . PROTAC HSP90 degrader BP3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-144694

*HDAC/HSP90-IN-3*	HSP HDAC Fungal	Infection
HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal *Hsp90* and HDAC dual inhibitor, with IC₅₀ values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1 .

HY-155577

*MAO A/HSP90-IN-1*	Monoamine Oxidase HSP	Cancer
MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC₅₀ value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research .

HY-155580

*MAO A/HSP90-IN-2*	Monoamine Oxidase HSP	Cancer
MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of *HSP90*and MAO A with the IC₅₀ values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases *HSP70* expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape ^[1].

HY-163329

*BCH-HSP-C01*	Others	Neurological Disease
BCH-HSP-C01 is a lead compound that restores AP-4-dependent protein trafficking in neuronal models of adapter protein complex 4 (AP-4)-associated hereditary spastic paraplegia. BCH-HSP-C01 can be used for the research of autophagy-associated diseases .

HY-155113

*PROTAC Hsp90α degrader 1*	PROTACs HSP	Cancer
PROTAC Hsp90α degrader 1 (Compound X10g) is a selective PROTAC *Hsp90α* degrader. PROTAC Hsp90α degrader 1 can be used for breast cancer research. PROTAC Hsp90α degrader 1 inhibits the proliferation of MDA-MB-231, MDA-MB-468, MCF-7, MX-1 cells with IC₅₀s of 51.48 μM, 16.46 μM, 8.93 μM, 11.95 μM respectively .

HY-W014102

L-Alanyl-L-glutamine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-B0779A

(5E,9E,13E)-Teprenone (5E,9E,13E)-Geranylgeranylacetone	HSP	Metabolic Disease
(5E,9E,13E)-Teprenone ((5E,9E,13E)-Geranylgeranylacetone) is an isomer of Teprenone with antiulcer activity. (5E,9E,13E)-Teprenone induces transcriptional activation of HSP genes that may increase gastric mucosal defense at conditions of stress .

Cat. No.	Product Name	Target	Research Area

HY-P1896

Hsp70-derived octapeptide	HSP	Infection Neurological Disease Cancer
Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs .

HY-P10072A

MK2-IN-5 acetate HSP25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

HY-W014102

L-Alanyl-L-glutamine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-P10072

MK2-IN-5 HSP25 kinase inhibitor; Mk2 pseudosubstrate	ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)	Others
MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation .

HY-P1750

Shepherdin (79-87)	HSP Survivin	Cancer
Shepherdin (79-87) is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity .

HY-P1750A

Shepherdin (79-87) (TFA)	HSP Survivin	Cancer
Shepherdin (79-87) TFA is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity .

HY-105063

DiaPep277	Peptides	Metabolic Disease Inflammation/Immunology
DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W014102

L-Alanyl-L-glutamine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-N0754

Eupalinolide A	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Inflammation/Immunology	HSP
Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90 .

HY-107577

Gedunin	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	HSP
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent *Hsp90* inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research .

HY-126601

Malonganenone A	Infection Structural Classification Alkaloids Classification of Application Fields Animals Other Alkaloids Source classification Disease Research Fields	Parasite HSP
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between PfHsp70-x and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x .

HY-119906

Conglobatin FW-04-806	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HSP Apoptosis
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active *Hsp90* inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-N6249

Feretoside	Cardiovascular Disease Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Disease Research Fields	HSP
Feretoside, a phenolic compound extracted from the barks of E. ulmoides, is a HSP inducer which act as cytoprotective agent.

HY-N10393

Vibsanin A	Structural Classification Natural Products Classification of Application Fields Viburnaceae Source classification Viburnum awabuki K. Koch Plants Disease Research Fields Cancer	PKC HSP
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a *HSP90* inhibitor .

HY-15230

Geldanamycin Maximum Cited Publications 21 Publications Verification	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Inflammation/Immunology Disease Research Fields	HSP Bacterial Influenza Virus Antibiotic
Geldanamycin is a *Hsp90* inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	HSP Endogenous Metabolite
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90) .

HY-B1434

7-Aminocephalosporanic acid 1 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a *HSP90β* inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

HY-113314

AFMK	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pK_a of AFMK at physiological pH is 8.7. Antioxidant capacity . AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway .

HY-119552

Acetylaszonalenin LL-S490β	Alkaloids Microorganisms Source classification Indole Alkaloids	Endogenous Metabolite Neurokinin Receptor
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-N3417

Kongensin A	Classification of Application Fields Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Croton kongensis Gagnep.	HSP RIP kinase Apoptosis Necroptosis
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent *HSP90* inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications .

HY-B0425A

Novobiocin sodium 5 Publications Verification Albamycin sodium; Cathomycin sodium	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Cancer	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-108486

Herbimycin A	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-N10502

Colletofragarone A2	Other Terpenoids Structural Classification Microorganisms Terpenoids	MDM-2/p53 HSP
Colletofragarone A2 can be be isolated from the fungus Colletotrichum sp. (13S020). Colletofragarone A2 inhibits mutant p53 and *HSP90* with anti-cancer activity. Colletofragarone A2 promotes degradation and aggregation of mutant p53 and suppressing tumor growth in vivo .

HY-N6790

Nonactin Ammonium ionophore I	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺ . Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin . Nonactin inhibits the surface expression of endogenous *HSP60* .

HY-13425

Deguelin 5 Publications Verification (-)-Deguelin; (-)-cis-Deguelin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Isoflavanones Source classification Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Akt Autophagy Apoptosis
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N6712

Thiolutin 2 Publications Verification Acetopyrrothin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic Endogenous Metabolite Deubiquitinase
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation .

HY-N6769

Radicicol 3 Publications Verification Monorden	Structural Classification Antifungal Classification of Application Fields Source classification Marine natural products Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Disease Research Fields Marine microorganism	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of *Hsp90* with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

Species:	Human (18) Mouse (8) E.coli (1)
Tag:	SUMO (1) His (20) Tag Free (3) Avi (2) GST (4)
Source:	HEK293 (2) Sf9 insect cells (5) P. pastoris (3) E. coli (16)

Cat. No.	Compare	Product Name	Species	Source

HY-P72238

	HSP90AA1 Protein, Human (His-SUMO) Heat shock 86 kDa; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein HSP 90 alpha ; Heat shock protein HSP 90 beta; Heat shock protein HSP 90-alpha; HS90A_HUMAN; HSP 84; HSP 86; HSP 90; HSP86; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPCAL1 ; HSPCAL4; Renal carcinoma antigen NY-REN-38	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HSP90AA1 Protein, Human (His-SUMO) is 224 a.a., with molecular weight of ~43 kDa.

HY-P72051

	HSP90AA1 Protein, Sus scrofa (Baculovirus, His) HSP90AA1; HSP90A; HSPCAHeat shock protein HSP 90-alpha	Others	Sf9 insect cells
	HSP90AA1 is a molecular chaperone that regulates target proteins involved in cell cycle control and signal transduction. It interacts with co-chaperones to regulate substrate recognition and chaperone function. HSP90AA1 Protein, Sus scrofa (Baculovirus, His) is the recombinant HSP90AA1 protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of HSP90AA1 Protein, Sus scrofa (Baculovirus, His) is 146 a.a., with molecular weight of ~19.7 kDa.

HY-P74878

	HSP27/HSPB1 Protein, Human (His) Heat shock protein beta-1; HSPB1; HSP 27; SRP27; HSPB1; HSP28	Human	E. coli
	The HSP27/HSPB1 protein is a small heat shock protein that acts as a molecular chaperone, possibly maintaining denatured proteins in a foldable state. In addition to its chaperone role, it crucially enhances stress resistance and contributes to actin organization. HSP27/HSPB1 Protein, Human (His) is the recombinant human-derived HSP27/HSPB1 protein, expressed by E. coli , with C-His labeled tag. The total length of HSP27/HSPB1 Protein, Human (His) is 205 a.a., with molecular weight of ~28 kDa.

HY-P701004

	HSP70/HSPA1A Protein, Human (E110D, His) HSP70-1; HSPA1A; HSP72 ; HSPA1; HSX70	Human	E. coli
	The HSP70/HSPA1A protein is an important molecular chaperone that protects proteome integrity by counteracting stress, aiding protein folding, activating misfolded proteolysis, and regulating protein complex dynamics. In protein quality control systems, it ensures accurate protein folding, controls substrate targeting for degradation through the ATP cycle, and interacts with co-chaperones such as HSP40, BAG1/2/3, HOPX, and STUB1. HSP70/HSPA1A Protein, Human (E110D, His) is the recombinant human-derived HSP70/HSPA1A protein, expressed by E. coli , with N-His labeled tag and E110D, , , , mutation. The total length of HSP70/HSPA1A Protein, Human (E110D, His) is 640 a.a., with molecular weight of 72.2 kDa.

HY-P73105

	HSP70/HSPA1B Protein, Human (SF9, His) Heat shock 70 kDa protein 1B; HSP70-2; HSPA1B; HSP72	Human	Sf9 insect cells
	HSP70/HSPA1B protein, a vital molecular chaperone, ensures proteome integrity by protecting from stress, aiding protein folding, activating proteolysis, and regulating protein complex assembly. It maintains accurate folding through ATP cycles and co-chaperones like HSP40s, BAG1/2/3, HOPX, and STUB1. Its acetylation state modulates competitive binding with HOPX and STUB1, dictating roles in protein refolding and degradation during stress. Beyond protein homeostasis, HSP70 regulates centrosome integrity, influences SMAD3 and FOXP3 degradation, and acts as a post-attachment receptor in rotavirus A infection. HSP70/HSPA1B Protein, Human (SF9, His) is the recombinant human-derived HSP70/HSPA1B protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of HSP70/HSPA1B Protein, Human (SF9, His) is 640 a.a., with molecular weight of ~72.2 kDa.

HY-P74877

	HSP70/HSPA1A Protein, Human (HEK293, His) Heat shock 70 kDa protein 1A; HSP70-1; HSPA1A; HSP72	Human	HEK293
	The HSP70/HSPA1A protein is an important molecular chaperone that protects proteome integrity by counteracting stress, aiding protein folding, activating misfolded proteolysis, and regulating protein complex dynamics. In protein quality control systems, it ensures accurate protein folding, controls substrate targeting for degradation through the ATP cycle, and interacts with co-chaperones such as HSP40, BAG1/2/3, HOPX, and STUB1. HSP70/HSPA1A Protein, Human (HEK293, His) is the recombinant human-derived HSP70/HSPA1A protein, expressed by HEK293 , with N-His labeled tag. The total length of HSP70/HSPA1A Protein, Human (HEK293, His) is 640 a.a., with molecular weight of ~85 kDa.

HY-P73916

	HSP60 Protein, Mouse (His) 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1	Mouse	E. coli
	The HSP60 protein, together with Hsp10, contributes to the import and assembly of mitochondrial proteins. It ensures correct folding and prevents incorrect folding under stressful conditions. HSP60 Protein, Mouse (His) is the recombinant mouse-derived HSP60 protein, expressed by E. coli , with N-His labeled tag. The total length of HSP60 Protein, Mouse (His) is 572 a.a., with molecular weight of ~58 kDa.

HY-P73917

	HSP60 Protein, Human (His-GST) 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1	Human	E. coli
	The HSP60 protein is a mitochondrial chaperone that facilitates protein import and assembly. HSP60 Protein, Human (His-GST) is the recombinant human-derived HSP60 protein, expressed by E. coli , with N-His, N-GST labeled tag. The total length of HSP60 Protein, Human (His-GST) is 572 a.a., with molecular weight of 52-65 kDa.

HY-P73916A

HSP60 Protein, Mouse (N-His)

60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSPD1
Mouse E. coli

HY-P701386

	HSPBP1 Protein, Human HSPBP1; HSP70-binding protein 1; HSPBP1; Heat shock protein-binding protein 1; HSP70-binding protein 2; HSPBP2; HSP70-interacting protein 1; HSP70-interacting protein 2	Human	E. coli
	HSPBP1 protein regulates HSPA1A chaperone activity by inducing conformational changes in the ATP-binding domain and disrupting ATP binding. This interference inhibits the STUB1-mediated ubiquitination process and blocks chaperone-assisted degradation of immature CFTR. HSPBP1 Protein, Human is the recombinant human-derived HSPBP1 protein, expressed by E. coli , with tag free. The total length of HSPBP1 Protein, Human is 276 a.a., .

HY-P701387

	HSPBP1 Protein, Human (His) HSPBP1; HSP70-binding protein 1; HSPBP1; Heat shock protein-binding protein 1; HSP70-binding protein 2; HSPBP2; HSP70-interacting protein 1; HSP70-interacting protein 2	Human	E. coli
	HSPBP1 protein regulates HSPA1A chaperone activity by inducing conformational changes in the ATP-binding domain and disrupting ATP binding. This interference inhibits the STUB1-mediated ubiquitination process and blocks chaperone-assisted degradation of immature CFTR. HSPBP1 Protein, Human (His) is the recombinant human-derived HSPBP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HSPBP1 Protein, Human (His) is 276 a.a., .

HY-P700699

	HSP10/EPF Protein, Human/Mouse (His-Avi) Cpn10; HSPE1; HSP10; Chaperonin 10; CPN10; EPF; GROES	Human;Mouse	E. coli
	The HSP10/EPF protein in collaboration with Hsp60 promotes the correct folding of the input protein and, under stressful conditions in the mitochondrial matrix, prevents misfolding while promoting the refolding and correct assembly of the unfolded polypeptide. The increased expression of HSP10 protein can inhibit the apoptosis of astrocytoma cells and is associated with poor prognosis. HSP10/EPF Protein, Human/Mouse (His-Avi) is the recombinant human, mouse-derived HSP10/EPF protein, expressed by E. coli , with C-Avi, N-His labeled tag. The total length of HSP10/EPF Protein, Human/Mouse (His-Avi) is 101 a.a., with molecular weight of 13.70 kDa.

HY-P71824

	HSP70/DnaK Protein, E. coli (P.pastoris, His) dnaK; HSP70; Heat shock 70kDa protein; Heat shock protein 70	E.coli	P. pastoris
	HSP70/DnaK protein, a molecular chaperone, responds primarily to stress, notably heat shock. It plays a crucial role in aiding the proper folding of proteins during cellular stress, preventing misfolding or aggregation. The chaperone activity is vital for cellular homeostasis and survival under adverse conditions, where maintaining correct protein conformation becomes challenging. HSP70/DnaK's ability to recognize and assist in refolding misfolded or denatured proteins is essential for cellular resilience, preventing proteotoxicity induced by stressors, especially elevated temperatures. HSP70/DnaK Protein, E. coli (P.pastoris, His) is the recombinant E. coli-derived HSP70/DnaK protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of HSP70/DnaK Protein, E. coli (P.pastoris, His) is 638 a.a., with molecular weight of ~71.1 kDa.

HY-P76283

	HSP10/EPF Protein, Human (His) 1 Publications Verification 10 kDa heat shock protein, mitochondrial; HSP10; Chaperonin 10; CPN10; EPF; HSPE1	Human	E. coli
	The HSP10/EPF protein is a cochaperone that plays a role in mitochondrial protein import and assembly. HSP10/EPF Protein, Human (His) is the recombinant human-derived HSP10/EPF protein, expressed by E. coli , with N-His, N-6*His labeled tag. The total length of HSP10/EPF Protein, Human (His) is 102 a.a., with molecular weight of ~13 KDa.

HY-P700698

	HSP10/EPF Protein, Human/Mouse (Biotinylated, His-Avi) Cpn10; HSPE1; HSP10; Chaperonin 10; CPN10; EPF; GROES	Human;Mouse	E. coli
	The HSP10/EPF protein in collaboration with Hsp60 promotes the correct folding of the input protein and, under stressful conditions in the mitochondrial matrix, prevents misfolding while promoting the refolding and correct assembly of the unfolded polypeptide. The increased expression of HSP10 protein can inhibit the apoptosis of astrocytoma cells and is associated with poor prognosis. HSP10/EPF Protein, Human/Mouse (Biotinylated, His-Avi) is the recombinant human, mouse-derived HSP10/EPF protein, expressed by E. coli , with C-Avi, N-His labeled tag. The total length of HSP10/EPF Protein, Human/Mouse (Biotinylated, His-Avi) is 101 a.a., with molecular weight of 13.70 kDa.

HY-P71537

	TRAP1 Protein, Human (GST) Heat shock protein 75kDa; Heat shock protein 75kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein	Human	E. coli
	As a chaperone with ATPase activity, TRAP1 protein plays a crucial role in protecting mitochondrial function and polarization, especially downstream of PINK1 and mitochondrial complex I. TRAP1 acts as a negative regulator of mitochondrial respiration, affecting the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1 Protein, Human (GST) is the recombinant human-derived TRAP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRAP1 Protein, Human (GST) is 249 a.a., with molecular weight of ~54.5 kDa.

HY-P75363

	CDC37 Protein, Mouse (sf9) HSP90 co-chaperone Cdc37; CDC37; CDC37A	Mouse	Sf9 insect cells
	CDC37 protein, a co-chaperone, binds to kinases and promotes their interaction with the Hsp90 complex, stabilizing and activating them. It inhibits HSP90AA1's ATPase activity. CDC37 likely forms a complex with HSP90, HSP70, STIP1/HOP, PPP5C, PTGES3/p23, TSC1, and TSC2. This complex may include CDK4, AKT, RAF1, and NR3C1 but lacks STIP1/HOP and PTGES3/p23. CDC37 also forms a separate complex with Hsp90/HSP90AB1 and CDK6. It interacts with HSP90AA1, AR, CDK4, CDK6, EIF2AK1, RB1, KSR1, FLCN, FNIP1, and FNIP2. CDC37 Protein, Mouse (sf9) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of CDC37 Protein, Mouse (sf9) is 379 a.a., with molecular weight of ~46 kDa.

HY-P75364

	CDC37 Protein, Human (sf9, GST) HSP90 co-chaperone Cdc37; CDC37; CDC37A	Human	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds multiple kinases and promotes their interaction with the Hsp90 complex, resulting in stability and enhanced activity. CDC37 Protein, Human (sf9, GST) is the recombinant human-derived CDC37 protein, expressed by Sf9 insect cells , with C-GST labeled tag. The total length of CDC37 Protein, Human (sf9, GST) is 378 a.a., with molecular weight of ~70.7 kDa.

HY-P70331

	HSP40/DNAJB1 Protein, Human (His) rHuDnaJ homolog subfamily B member 1/HSP40, His; DnaJ Homolog Subfamily B Member 1; DnaJ Protein Homolog 1; Heat Shock 40 kDa Protein 1; HSP40; Heat Shock Protein 40; Human DnaJ Protein 1; hDj-1; DNAJB1; DNAJ1; HDJ1; HSPF1	Human	E. coli
	HSP40/DNAJB1 protein, a key player in cellular processes, interacts with HSP70 to enhance ATPase activity and stimulate HSC70-HIP association. It negatively regulates HSF1 transcriptional activity in heat shock response recovery, and interacts with DNAJC3 and HSF1, inhibiting their transcriptional activity. These multifaceted interactions showcase HSP40/DNAJB1's intricate regulatory functions in stress responses and protein folding. HSP40/DNAJB1 Protein, Human (His) is the recombinant human-derived HSP40/DNAJB1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSP40/DNAJB1 Protein, Human (His) is 339 a.a., with molecular weight of ~38.0 kDa.

HY-P75362

	CDC37 Protein, Mouse (sf9, His-GST) HSP90 co-chaperone Cdc37; CDC37; CDC37A	Mouse	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CDC37 Protein, Mouse (sf9, His-GST) is 379 a.a., with molecular weight of ~66 kDa.

HY-P70933

	HSPB8 Protein, Human (His) Heat shock protein beta-8; HSPB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22; HSPB8; CRYAC; E2IG1; HSP22	Human	E. coli
	The HSPB8 protein exhibits temperature-dependent chaperone activity and functions as a monomer in its molecular form. It interacts with other cellular proteins to form complexes critical for cellular homeostasis. HSPB8 Protein, Human (His) is the recombinant human-derived HSPB8 protein, expressed by E. coli , with C-6*His labeled tag. The total length of HSPB8 Protein, Human (His) is 196 a.a., with molecular weight of ~23.0 kDa.

HY-P71742

	HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) HSPa5; Grp78; Endoplasmic reticulum chaperone BiP; EC 3.6.4.10; 78kDa glucose-regulated protein; GRP-78; HSP70 family protein 5	Mouse	P. pastoris
	The HSPA5/GRP-78 protein is an endoplasmic reticulum chaperone involved in protein folding and quality control. It interacts with DNAJC10/ERdj5 to fold and degrade misfolded proteins. HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived HSPA5/GRP-78 protein, expressed by P. pastoris , with N-6*His, N-His labeled tag. The total length of HSPA5/GRP-78 Protein, Mouse (P.pastoris, His) is 636 a.a., with molecular weight of ~72.5 kDa.

HY-P71742Y

	HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) HSPa5; Grp78; Endoplasmic reticulum chaperone BiP; EC 3.6.4.10; 78kDa glucose-regulated protein; GRP-78; HSP70 family protein 5	Mouse	P. pastoris
	HSPA5/GRP-78 Protein serves as a crucial endoplasmic reticulum chaperone, playing a pivotal role in protein folding and quality control within the endoplasmic reticulum lumen. It engages in correct protein folding and participates in the degradation of misfolded proteins, collaborating with DNAJC10/ERdj5 to facilitate the release of DNAJC10/ERdj5 from its substrate. Furthermore, HSPA5/GRP-78 acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, it is recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, disrupting the dimerization of ERN1/IRE1 and consequently inactivating it. The accumulation of misfolded proteins triggers the release of HSPA5/BiP from ERN1/IRE1, allowing for homodimerization and the subsequent activation of ERN1/IRE1. Additionally, HSPA5/GRP-78 plays an auxiliary role in the post-translational transport of small presecretory proteins across the endoplasmic reticulum and may function as an allosteric modulator for the SEC61 channel-forming translocon complex. It is suggested to cooperate with SEC62 to enable the productive insertion of these precursors into the SEC61 channel. The protein appears to specifically regulate the translocation of precursors with inhibitory residues in their mature region, which weaken channel gating. Beyond its role in protein folding, HSPA5/GRP-78 may also contribute to apoptosis and cell proliferation. HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) is the recombinant mouse-derived HSPA5/GRP-78 protein, expressed by P. pastoris , with N-His labeled tag. The total length of HSPA5/GRP-78 Protein, Mouse (P.pastoris, His, solution) is 636 a.a., with molecular weight of ~72.5 kDa.

HY-P71298

	Serpin H1 Protein, Human (HEK293, His) Serpin H1; 47 kDa Heat Shock Protein; Arsenic-Transactivated Protein 3; AsTP3; Cell Proliferation-Inducing Gene 14 Protein; Collagen-Binding Protein; Colligin; Rheumatoid Arthritis-Related Antigen RA-A47; SERPINH1; CBP1; CBP2; HSP47; SERPINH2	Human	HEK293
	Serpin H1 protein exhibits a specific affinity for collagen, indicating its role as a chaperone in the biosynthetic pathway of collagen. This suggests its potential contribution to collagen synthesis, emphasizing its importance in maintaining tissue integrity and modulating cellular responses related to collagen metabolism. Serpin H1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin H1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin H1 Protein, Human (HEK293, His) is 400 a.a., with molecular weight of ~51.0 kDa.

HY-P70405

	FKBP4 Protein, Human (His) rHuPeptidyl-prolyl cis-trans isomerase FKBP4/FKBP4, His; Peptidyl-prolyl cis-trans isomerase FKBP4; 51kDa FK506-binding protein; 51kDa FK506-binding protein; 59kDa immunophilin; FK506-binding protein 4; FKBP59; HSP-binding immunophilin; immunophilin FKBP52; Rotamase; FKBP4	Human	E. coli
	The FKBP4 protein is an immunophilin with peptidyl prolyl cis-trans isomerase (PPIase) and co-chaperone activity. It plays a key role in the formation of hybrids with steroid receptors, specifically by interacting with heat shock protein 90 (HSP90). FKBP4 Protein, Human (His) is the recombinant human-derived FKBP4 protein, expressed by E. coli , with C-6*His labeled tag. The total length of FKBP4 Protein, Human (His) is 459 a.a., with molecular weight of 50-60 kDa.

HY-P71340

	STUB1 Protein, Human E3 Ubiquitin-Protein Ligase CHIP; Antigen NY-CO-7; CLL-Associated Antigen KW-8; Carboxy Terminus of HSP70-Interacting Protein; STIP1 Homology and U Box-Containing Protein 1; STUB1; CHIP	Human	E. coli
	STUB1 protein is an E3 ubiquitin protein ligase that cooperates with ATXN3 to regulate ubiquitin chain length on substrates and prevent chain extension. It ubiquitinates NOS1 through Hsp70/Hsp40 and regulates chaperone complexes (Hsp70, Hsc70, Hsp90). STUB1 Protein, Human is the recombinant human-derived STUB1 protein, expressed by E. coli , with tag free. The total length of STUB1 Protein, Human is 303 a.a., with molecular weight of ~33.0 kDa.

Cat. No.	Product Name	Chemical Structure

HY-13757AS

Tamoxifen-d5
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

Cat. No.	Product Name	Application	Reactivity

HY-P80713

Hsp70 1B Antibody HSP70; HSP68; HSP70B1; HSP70-1; HSP70.1	WB, IHC-P, IP	Human, Mouse, Rat
Hsp70 1B Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 70 kDa, targeting to Hsp70 1B. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80714

Hsp90 alpha/beta Antibody HSP90AA1; HSP90A; HSPC1; HSPCA; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
Hsp90 alpha/beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Hsp90 alpha/beta. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80712

Hsp70 1A Antibody (YA727) HSP72; HSPA1; HSP70I; HSPA1B; HSP70-1; HSP70-1A.	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
Hsp70 1A Antibody (YA727) is a non-conjugated and Mouse origined monoclonal antibody about 70 kDa, targeting to Hsp70 1A (1D9). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P82880

Hsp75 Antibody (YA2625)

HSP75; HSP90L; Trap1
WB, IHC-P, ICC/IF Human
HY-P82868

Hsp110 Antibody (YA2613)

Antigen NY-CO-25; Heat shock protein 105 kDa; HS105; HSP105; HSP105A; HSP105B; HSP110; HSPH1
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

HY-P80184

HSP60 Antibody	WB, ICC, IHC-P	Human, Mouse, Rat
HSP60 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 61 kDa, targeting to HSP60. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80186

Hsp90 alpha Antibody	WB, ICC/IF, IHC-P	Human, Mouse, Monkey
Hsp90 alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Hsp90 alpha. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse, Monkey.

HY-P80187

Hsp90 beta Antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
Hsp90 beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to Hsp90 beta. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80185

Hsp70 Antibody (YA359)	WB, ICC/IF, IHC-P, FC	Human, Mouse
Hsp70 Antibody (YA359) is a non-conjugated and Rabbit origined monoclonal antibody about 70 kDa, targeting to Hsp70. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80412

HSP70 Antibody (YA728)	WB, IHC-P, IF	Human, Mouse, Rat
HSP70 Antibody (YA728) is a non-conjugated and Mouse origined monoclonal antibody about 70 kDa, targeting to HSP70. It can be used for WB,IHC-P,IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P83258

HspA14 Antibody (YA3003)

HSPA14; HSP60; HSP70L1; Heat shock 70 kDa protein 14; HSP70-like protein 1; Heat shock protein HSP60
WB, ICC/IF, IP Human, Mouse

HY-P80709

Hsp27 Antibody (YA732) HSPB1; HSP27; HSP28; Heat shock protein beta-1; HSPB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, ICC/IF	Human, Monkey
Hsp27 Antibody (YA732) is a non-conjugated and Mouse origined monoclonal antibody about 23 kDa, targeting to Hsp27 (7E5). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Monkey.

HY-P80823

*Phospho-Hsp27 (Ser78) Antibody* HSPB1; HSP27; HSP28; Heat shock protein beta-1; HSPB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P, ICC/IF	Human
Phospho-Hsp27 (Ser78) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Phospho-Hsp27 (Ser78). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80824

*Phospho-Hsp27 (Ser82) Antibody* HSPB1; HSP27; HSP28; Heat shock protein beta-1; HSPB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27	WB, IHC-P	Human
Phospho-Hsp27 (Ser82) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Phospho-Hsp27 (Ser82). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P80711

Hsp60 Antibody (YA730) HSPD1; HSP60; 60 kDa heat shock protein; mitochondrial; 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; HSP60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein	WB, ICC/IF, IP	Human, Mouse, Rat
Hsp60 Antibody (YA730) is a non-conjugated and Mouse origined monoclonal antibody about 61 kDa, targeting to Hsp60 (6C8). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83429

Hsp20 Antibody (YA3174)

HSPB6; HEL55; HSP20; Heat-shock 20 kDa like-protein p20
WB, IHC-P, FC Human, Mouse, Rat
HY-P82863

Hsp47 Antibody (YA2608)

CBP1; CBP2; OI10; gp46; AsTP3; HSP47; PIG14; PPROM; RA-A47; SERPINH2
WB, IHC-P Human, Mouse, Rat
HY-P81733

ORP150 Antibody (YA1478)

Grp170; HSP12A; Hyou1; Orp150
WB, IHC-P Human, Mouse, Rat

HY-P81306

SAFB1 Antibody (YA1042) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein	WB, ICC/IF, ChIP	Human

HY-P81306A

SAFB1 Antibody (YA1043) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse

HY-P83311

HspA2 Antibody (YA3056)

HSPA2; Heat shock 70kD protein 2; HSP70-2; HSP70-3; Heat shock 70 kDa protein 2; Heat shock 70kDa protein 2
WB, IHC-P Human, Mouse, Rat
HY-P82774

GRP94 Antibody (YA2519)

Endoplasmin; GRP-94; gp96 homolog; HSP90B1; GRP 94; TRA1
WB, IHC-P, ICC/IF Human, Mouse

HY-P82872

HspB8 Antibody (YA2617) HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HSPB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22	WB, IHC-P, ICC/IF	Human, Mouse, Rat

HY-P80710

Hsp40 Antibody DNAJB1; DNAJ1; HDJ1; HSPF1; DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; Heat shock 40 kDa protein 1; HSP40; Heat shock protein 40; Human DnaJ protein 1; hDj-1	WB	Human
Hsp40 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 38 kDa, targeting to Hsp40. It can be used for WB assays with tag free, in the background of Human.

HY-P82445

Cpn10 Antibody (YA2190)

HSPE1; 10 kDa heat shock protein; mitochondrial; HSP10; 10 kDa chaperonin; Chaperonin 10; CPN10; Early-pregnancy factor; EPF
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P83427

HspA4 Antibody (YA3172)

HSPA4; APG2; Heat shock 70 kDa protein 4; HSP70RY; Heat shock 70-related protein APG-2
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P83386

p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; HSP90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat

HY-P80465

*Phospho-Hsp27 (Ser82) Antibody (YA187)*	WB, IP	Human
Phospho-Hsp27 (Ser82) Antibody (YA187) is a non-conjugated and Rabbit origined monoclonal antibody about 23 kDa, targeting to Phospho-Hsp27(S82). It can be used for WB,IP assays with tag free, in the background of Human.

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