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Results for "

HSV-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSV (61) Acyltransferase (1) Adenosine Receptor (1) Akt (1) Androgen Receptor (1) Antibiotic (15) Apoptosis (11) Autophagy (6) Bacterial (15) CDK (2) CMV (7) COX (1) CRISPR/Cas9 (1) DNA/RNA Synthesis (2) Drug Metabolite (2) EBV (1) Endogenous Metabolite (6) Ferroptosis (2) Fungal (3) GSK-3 (2) HBV (1) HCV (1) HIV (4) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (4) Mitophagy (1) NOD-like Receptor (NLR) (1) Notch (1) Nucleoside Antimetabolite/Analog (8) Orthopoxvirus (2) Parasite (5) Phosphatase (1) Proton Pump (2) SARS-CoV (11) Ser/Thr Protease (1) STING (1) Tyrosinase (1) VSV (1) YB-1 (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (2) Infection (76) Inflammation/Immunology (8) Metabolic Disease (4) Neurological Disease (7)

By Targets:

HSV (61)

Acyltransferase (1)

Adenosine Receptor (1)

Akt (1)

Androgen Receptor (1)

Antibiotic (15)

Apoptosis (11)

Autophagy (6)

Bacterial (15)

CDK (2)

CMV (7)

COX (1)

CRISPR/Cas9 (1)

DNA/RNA Synthesis (2)

Drug Metabolite (2)

EBV (1)

Endogenous Metabolite (6)

Ferroptosis (2)

Fungal (3)

GSK-3 (2)

HBV (1)

HCV (1)

HIV (4)

Influenza Virus (2)

Interleukin Related (1)

Isotope-Labeled Compounds (4)

Mitophagy (1)

NOD-like Receptor (NLR) (1)

Notch (1)

Nucleoside Antimetabolite/Analog (8)

Orthopoxvirus (2)

Parasite (5)

Phosphatase (1)

Proton Pump (2)

SARS-CoV (11)

Ser/Thr Protease (1)

STING (1)

Tyrosinase (1)

VSV (1)

YB-1 (1)

By Research Areas:

Cancer (26)

Cardiovascular Disease (2)

Infection (76)

Inflammation/Immunology (8)

Metabolic Disease (4)

Neurological Disease (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: HSV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4773

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 ^[1].

HY-149022

HSV-1/HSV-2-IN-1	HSV Orthopoxvirus	Infection
HSV-1/HSV-2-IN-1 (compound 7d) is a *HSV-1* and *HSV-2* inhibitor, with EC₅₀s of 7.6, 7.6, 4, and 12 μM for HSV-1 (KOS), HSV-2 (G), HSV-1 TK ^- KOS ACV ^r and vaccinia virus in human embryonic lung fibroblast cell cultures ^[1].

HY-149023

HSV-1/HSV-2-IN-2	HSV	Infection
HSV-1/HSV-2-IN-2 is a *HSV-1, HSV-2* and VV inhibitor with EC₅₀ values of 6.8, 8.9 and 8.9 µM, respectively. HSV-1/HSV-2-IN-2 shows antiviral activity ^[1].

HY-N8082

Stearyl gallate	HSV	Infection
Stearyl gallate is an alkyl gallate with a long alkyl chain (carbon number of 18). Stearyl gallate has an antioxidant activity, and a weak antiviral activity against *HSV-1* ^[1] .

HY-U00124

Tromantadine

HSV Infection

Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication ^[1].

Tromantadine	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication ^[1].

HY-U00124B

Tromantadine hydrochloride 1 Publications Verification	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and *HSV-2* replication ^[1].

HY-15303

Pritelivir 3 Publications Verification AIC316; BAY 57-1293	HSV	Infection
Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV1*-2 ^[1].

HY-15303B

Pritelivir mesylate hydrate 3 Publications Verification AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate	HSV	Infection
Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV1*-2 ^[1].

HY-15303A

Pritelivir mesylate 3 Publications Verification AIC316 mesylate; BAY 57-1293 mesylate	HSV	Infection
Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV1*-2 ^[1].

HY-N1451

Betulonic acid 1 Publications Verification Betunolic acid; Liquidambaric acid; (+)-Betulonic acid	Parasite HSV	Infection Inflammation/Immunology Cancer
Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities ^[1] .

HY-18684

SIBA 5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine	Nucleoside Antimetabolite/Analog HSV Parasite	Infection Metabolic Disease Cancer
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies ^[1] .

HY-N11097

FK-3000	Apoptosis HSV HIV	Infection Cancer
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against *HSV-1* and *HIV-1* ^[1] .

HY-160222

HSV-60mer sodium	HSV STING	Infection Inflammation/Immunology
HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome ^[1]. Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR)-, DNA-dependent activator of IRFs (DAI)-, and RNA polymerase III (Pol III)-independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3)-dependent manner.

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Tyrosinase HSV Autophagy	Others
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against *HSV-1, HSV-2* and varicella-zoster virus, and has neuroprotective effects ^[1] .

HY-W004486

Gallic aldehyde

HSV Infection

Gallic aldehyde is a HSV-1 inhibitor isolated from Geum japonicum, with potent antiviral activity ^[1].
HY-100272

B220

HSV CMV Infection Cancer

B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV).
HY-P1958

Histone H4 (2-21)

HSV Infection

Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes ^[1].

Gallic aldehyde	HSV	Infection
Gallic aldehyde is a *HSV-1* inhibitor isolated from Geum japonicum, with potent antiviral activity ^[1].

B220	HSV CMV	Infection Cancer
B220 is an antiviral agent which can inhibit the growth of *HSV-1, HSV-2* and human cytomegalovirus (CMV).

Histone H4 (2-21)	HSV	Infection
Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes ^[1].

HY-15486

Salubrinal 15+ Cited Publications	Phosphatase HSV Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation ^[1]. Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis . Salubrinal has antiviral activity against *HSV-1* and inhibits dephosphorylation of eIF2α mediated by the *HSV-1* protein ICP34.5 .

HY-122920

Soyasaponin II	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1	Infection Inflammation/Immunology
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure ^[1] .

HY-W002008

5-Nitrobarbituric acid

HSV Infection Inflammation/Immunology

5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC₅₀=1.7 μM) ^[1].

5-Nitrobarbituric acid	HSV	Infection Inflammation/Immunology
5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC₅₀=1.7 μM) ^[1].

HY-113289

Brassicasterol	Akt Androgen Receptor Bacterial Drug Metabolite HSV	Infection Cardiovascular Disease Neurological Disease Cancer
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits *HSV-1* (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease ^[1] .

HY-A0181A

Adenosine 5'-monophosphate monohydrate 5+ Cited Publications 5'-AMP monohydrate	Adenosine Receptor HSV Endogenous Metabolite	Infection Neurological Disease
Adenosine 5'-monophosphate monohydrate is an adenosine A₁ receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against *HSV-1* and *HSV-2*.

HY-U00224

BRL44385	EBV HSV	Infection
BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and *HSV2*), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

HY-N1060

Yatein
Yatein is a lignan isolated from A. chilensis, with antiproliferative activity ^[1]. Yatein suppresses *herpes simplex virus type 1 (HSV-1* )** replication by interruption the immediate-early gene expression .

HY-19288

Valomaciclovir stearate ABT 606; MIV 606; A 174606.0
Valomaciclovir stearate (ABT 606), a nucleoside analog, is the Omaciclovir (HY-116174) prodrug. Valomaciclovir stearate has antiviral activity against HSV-1 and varicella zoster virus (VZV) ^[1].

HY-N2004

Isoborneol (±)-Isoborneol
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 *(HSV-1)* ^[1] .

HY-N3395

Leachianone G	HSV	Infection
Leachianone G is an antiviral flavonoid from the root bark of Morus alba L. Leachianone G shows potent antiviral activity against herpes simplex type 1 virus (HSV-1) with an IC₅₀* value of 1.6 μg/mL ^[1].*

HY-17425

Valacyclovir Valaciclovir	HSV Antibiotic Bacterial	Infection Cancer
Valacyclovir (Valaciclovir) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir is a proagent of Aciclovir (HY-17422) ^[1] .

HY-17425A

Valacyclovir hydrochloride 1 Publications Verification Valaciclovir hydrochloride	HSV Antibiotic Bacterial	Infection Cancer
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) ^[1] .

HY-131606

Cidofovir diphosphate	Others	Infection
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively ^[1] .

HY-17424

Penciclovir 1 Publications Verification BRL 39123; VSA 671	HSV	Infection
Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC₅₀ values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse ^[1] .

HY-107739

Penciclovir sodium VSA 671 sodium; BRL 39123A; BRL 39123D	HSV	Infection
Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC₅₀ values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse ^[1] .

HY-131606B

Cidofovir diphosphate tri(triethylamine)	Drug Metabolite	Infection
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively ^[1] .

HY-B0277

Vidarabine 5 Publications Verification Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine	HSV Nucleoside Antimetabolite/Analog Orthopoxvirus Antibiotic	Infection
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses ^[1] . Vidarabine has IC₅₀s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2 . Vidarabine also has anti-orthopoxvirus activity .

HY-N2011

Octyl gallate n-Octyl gallate; Stabilizer GA 8
Octyl gallate (Progallin O) is widely used as a food additive, with antimicrobial and antioxidant activity ^[1] . Octyl gallate (Progallin O) shows selective and sensitive fluorescent property . Octyl gallate shows a marked antiviral effect against *HSV-1, vesicular stomatitis virus (VSV)* and poliovirus .

HY-50735

Fiacitabine NSC 382097; FIAC; FOAC	HSV	Infection
Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively.

HY-17425AS

Valacyclovir-d8 hydrochloride	HSV Antibiotic	Infection
Valacyclovir-d₈ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) [1][2][3][4][5].

HY-17425AS1

Valacyclovir-d4 hydrochloride	Isotope-Labeled Compounds HSV Antibiotic	Infection
Valacyclovir-d₄ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422)[1][2][3][4][5].

HY-W747737

BVDU 5′-Triphosphate (E)-5-(2-Bromovinyl)-dUTP; BVdUTP	DNA/RNA Synthesis HSV	Infection
BVDU 5′-Triphosphate is an antivirus agent with 5′-Triphosphate label, targeting viral DNA polymerase. BVDU 5′-Triphosphate shows excellent selectivity against varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1), due to a specific phosphorylation by the virus-encoded thymidine kinase.

HY-N1067

Xanthohumol 5+ Cited Publications	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), *COX-1* and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-W747737A

BVDU 5′-Triphosphate ammonium (E)-5-(2-Bromovinyl)-dUTP ammonium; BVdUTP ammonium	HSV	Infection
BVDU 5′-Triphosphate ammonium is an antivirus agent with 5′-Triphosphate label, targeting viral DNA polymerase. BVDU 5′-Triphosphate ammonium shows excellent selectivity against varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1), due to a specific phosphorylation by the virus-encoded thymidine kinase.

HY-17425AR

Valacyclovir hydrochloride (Standard) Valaciclovir hydrochloride (Standard)	HSV Antibiotic Bacterial	Infection Cancer
Valacyclovir (hydrochloride) (Standard) is the analytical standard of Valacyclovir (hydrochloride). This product is intended for research and analytical applications. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) ^[1] .

HY-17422

Acyclovir 5+ Cited Publications Aciclovir; Acycloguanosine	HSV Apoptosis Antibiotic Bacterial	Infection Cancer
Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC₅₀ values of 0.85 μM and 0.86 μM for *HSV-1* and *HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis*. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia ^[1] .

HY-16592

Brefeldin A Maximum Cited Publications 62 Publications Verification BFA; Cyanein; Decumbin	Autophagy CRISPR/Cas9 Mitophagy HSV Antibiotic Bacterial	Infection Cancer
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus ^[1] . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A is a CRISPR/Cas9 activator . Brefeldin A inhibits *HSV-1* and has anti-cancer activity .

HY-17422A

Acyclovir sodium Aciclovir sodium; Acycloguanosine sodium	HSV Apoptosis Antibiotic Bacterial	Infection Cancer
Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC₅₀ values of 0.85 μM and 0.86 μM for *HSV-1* and *HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis*. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia ^[1] .

HY-P3626

Astodrimer SPL7013 free base	Bacterial HCV SARS-CoV	Infection
Astodrimer (SPL7013 free base) is a large (3-4 nm, ~ 16.5 kDa), negatively charged, highly-branched dendrimer, is a potent virucidal agent. Astodrimer shows antiviral and virucidal activity against a broad spectrum of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, HPV. Astodrimer also has antibacterial properties ^[1] .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) ^[1].

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	GSK-3 CDK Parasite Proton Pump HSV Autophagy	Infection Neurological Disease Cancer
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against *HSV-1* ^[1] .

HY-117025

Manzamine A Keramamine A	GSK-3 CDK Parasite Proton Pump HSV Autophagy	Infection Neurological Disease Cancer
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against *HSV-1* ^[1] .

HY-N8156

Soyasapogenol C

HSV Infection

Soyasapogenol C is an oleanane-type triterpenoid. Soyasapogenol C exhibits anti-HSV-1 activity, with an IC₅₀ of 18.9 μM ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1451

Betulonic acid 1 Publications Verification Betunolic acid; Liquidambaric acid; (+)-Betulonic acid	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Parasite HSV
Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities ^[1] .

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Structural Classification other families Stilbenes Classification of Application Fields Anti-aging Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against *HSV-1, HSV-2* and varicella-zoster virus, and has neuroprotective effects ^[1] .

HY-122920

Soyasaponin II	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc.	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure ^[1] .

HY-113289

Brassicasterol	Infection Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Akt Androgen Receptor Bacterial Drug Metabolite HSV
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits *HSV-1* (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease ^[1] .

HY-N11097

FK-3000	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Stephania delavayi Diels Menispermaceae	Apoptosis HSV HIV
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against *HSV-1* and *HIV-1* ^[1] .

HY-A0181A

Adenosine 5'-monophosphate monohydrate 5+ Cited Publications 5'-AMP monohydrate	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Adenosine Receptor HSV Endogenous Metabolite
Adenosine 5'-monophosphate monohydrate is an adenosine A₁ receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against *HSV-1* and *HSV-2*.

HY-N3395

Leachianone G	Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	HSV
Leachianone G is an antiviral flavonoid from the root bark of Morus alba L. Leachianone G shows potent antiviral activity against herpes simplex type 1 virus (HSV-1) with an IC₅₀* value of 1.6 μg/mL ^[1].*

HY-17425A

Valacyclovir hydrochloride 1 Publications Verification Valaciclovir hydrochloride	Infection Classification of Application Fields Disease Research Fields	HSV Antibiotic Bacterial
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) ^[1] .

HY-B0277

Vidarabine 5 Publications Verification Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine	Infection Structural Classification Microorganisms Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields	HSV Nucleoside Antimetabolite/Analog Orthopoxvirus Antibiotic
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses ^[1] . Vidarabine has IC₅₀s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2 . Vidarabine also has anti-orthopoxvirus activity .

HY-N1067

Xanthohumol 5+ Cited Publications	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), *COX-1* and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-16592

Brefeldin A Maximum Cited Publications 62 Publications Verification BFA; Cyanein; Decumbin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Disease Research Anticancer Disease Research Fields	Autophagy CRISPR/Cas9 Mitophagy HSV Antibiotic Bacterial
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus ^[1] . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A is a CRISPR/Cas9 activator . Brefeldin A inhibits *HSV-1* and has anti-cancer activity .

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	Structural Classification Neurological Disease Classification of Application Fields Source classification Marine natural products Pyridine Alkaloids Indole Alkaloids Infection Alkaloids Piperidine Alkaloids Animals Sponge Disease Research Fields	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against *HSV-1* ^[1] .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Structural Classification Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against *HSV-1* ^[1] .

HY-N8156

Soyasapogenol C	Infection Triterpenes Trifolium repens Linn. Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields	HSV
Soyasapogenol C is an oleanane-type triterpenoid. Soyasapogenol C exhibits anti-HSV-1 activity, with an IC₅₀ of 18.9 μM ^[1].

HY-N2584A

Isoxanthohumol 1 Publications Verification	Infection Flavonoids Classification of Application Fields Anti-aging Humulus lupulus L. Flavonones Source classification Plants Moraceae Disease Research Fields Cancer	HSV
Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) ^[1] .

HY-B0275

Oxytetracycline 5 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Plant agriculture research Infection Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols Disease Research Fields	Bacterial HSV Endogenous Metabolite Antibiotic
Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity ^[1] .

HY-B0275C

Oxytetracycline calcium	Infection Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity ^[1] .

HY-N10177

Peniterphenyl A	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	HSV
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits *HSV-1/2* virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 ^[1].

HY-B0222

1-Docosanol 1 Publications Verification Behenyl alcohol	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields	HSV
1-Docosanol (Behenyl alcohol) is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus (HSV) .

HY-N12191

Cangorinine E-1	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Celastraceae Plants Tripterygium wilfordii Hook. f.	HSV
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

HY-N2812

Epipodophyllotoxin acetate 4-O-Epipodophyllotoxinyl acetate	Structural Classification Cupressaceae Source classification Lignans Phenylpropanoids Plants	HSV VSV
Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits *HSV* and VSV, with IC₅₀s of 0.2 and 0.1 μg/mL, respectively ^[1].

HY-N0415

Trigonelline chloride 4 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Lactuca perennis Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0414

Trigonelline 4 Publications Verification Trigenolline	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Alkaloids other families Microorganisms Leguminosae Disease Research Fields Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N2127

Pinostrobin 1 Publications Verification	Structural Classification Monophenols Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-17425AS

Valacyclovir-d8 hydrochloride
Valacyclovir-d₈ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) [1][2][3][4][5].

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].

HY-N0415S

Trigonelline-d3 chloride
Trigonelline-d₃ (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.

HY-17425AS1

Valacyclovir-d4 hydrochloride
Valacyclovir-d₄ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422)[1][2][3][4][5].

HY-13666S

Levamisole-d5 hydrochloride
Levamisole-d₅ (hydrochloride) is the deuterium labeled Levamisole hydrochloride. Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV[1][2].

HY-13605S

Cytarabine-d2
Cytarabine-d₂ is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].

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