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Results for "

HV1

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Fluorescent Dye

2

Peptides

1

Recombinant Proteins

3

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-109024
    Balovaptan

    RG7314

    		 Vasopressin Receptor Cardiovascular Disease Neurological Disease Endocrinology
    Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
    Balovaptan
  • HY-P5142
    ω-Hexatoxin-Hv1a

    ω-ACTX-HV1; ω-Atracotoxin-HV1

    		 Insecticide Calcium Channel Apoptosis Necroptosis Cardiovascular Disease Neurological Disease Inflammation/Immunology
    ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a blocks L-type voltage-dependent Ca 2+ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons [1] .
    ω-Hexatoxin-Hv1a
  • HY-163696A
    HV1-IN-1 hydrochloride

    		Proton Pump Others Neurological Disease Cancer
    HV1-IN-1 hydrochloride is an inhibitor of the human voltage-gated proton channel (hHV1). HV1-IN-1 hydrochloride works by binding to the VSD of the HV1 channel. The VSD is a component of the HV1 channel that is responsible for detecting changes in membrane potential and triggering the opening of the channel. HV1-IN-1 hydrochloride can be used in the study of cancer, neuroinflammation and immune response [1].
    HV1-IN-1 hydrochloride
  • HY-D1560
    FG 488 DHPE

    		Fluorescent Dye Others
    FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well [1] .
    FG 488 DHPE
  • HY-175003
    HV1-IN-2

    		Proton Pump Cancer
    HV1-IN-2 (Compound 14c) is a human voltage-gated proton channel (HV1) inhibitor with an IC50 of 2.14 μM. HV1-IN-2 has a potent anticancer activity with significant antiproliferative effects against THP-1 and MCF-7 cells. HV1-IN-2 can be used for cancers research, such as colorectal tumours, leukaemia, and breast cancer [1].
    HV1-IN-2
  • HY-12981
    RG7713
    2 Publications Verification

    RO5028442

    		 Vasopressin Receptor Cardiovascular Disease Neurological Disease Metabolic Disease
    RG7713 (RO5028442) is a highly potent, selective and brain-penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
    RG7713
  • HY-P5142A
    ω-Hexatoxin-Hv1a TFA

    ω-ACTX-HV1 TFA; ω-Atracotoxin-HV1 TFA

    		 Insecticide Apoptosis Calcium Channel Necroptosis Cardiovascular Disease Neurological Disease Inflammation/Immunology
    ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a TFA blocks L-type voltage-dependent Ca 2+ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a TFA causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a TFA is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons [1] .
    ω-Hexatoxin-Hv1a TFA
  • HY-W283930
    YHV98-4

    		Tau Protein ATP Synthase Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism Neurological Disease Inflammation/Immunology
    YHV98-4 is a selective, blood-brain barrier permeable Hv1 channel inhibitor. YHV98-4 specifically inhibits Hv1 with a half-maximal inhibitory concentration of 1 µM without inhibiting other ion channels. YHV98-4 reduces the propagation of p-tau. YHV98-4 increases ATP production, and enhances microglial mitophagy. YHV98-4 attenuates inflammatory pain via inhibition of Hv1 and ROS production. YHV98-4 enhances microglia-to-neuron mitochondrial transfer, promoting the delivery of functional mitochondria to rescue neuronal damage and improve cognitive function. YHV98-4 reduces inflammation. YHV98-4 can be used in the research of Alzheimer's disease [1] .
    YHV98-4
  • HY-RS06494
    HVCN1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    HVCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for HVCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    HVCN1 Human Pre-designed siRNA Set A
    HVCN1 Human Pre-designed siRNA Set A
  • HY-168742
    V1a/V2 antagonist 1

    		Vasopressin Receptor Neurological Disease
    V1a/V2 antagonist 1 (Compound 18j) is an orally active dual V1a and V2 receptor antagonist with high binding affinity for both receptors (Ki: 0.13 nM for hV1a, 0.53 nM for hV2 and 0.5 nM for mV1a; IC50: 2.2 nM for hV1a). V1a/V2 antagonist 1 inhibits Oxytocin (HY-17571)-induced scratching behavior in mice [1].
    V1a/V2 antagonist 1
  • HY-162118
    RGH-122

    		Vasopressin Receptor Neurological Disease
    RGH-122 (compound 43) is an orally active, potent, selective, and hV1a receptor antagonist with Ki value of 0.3 nM and IC50 of 0.9 nM. RGH-122 showes microsomal stability with CLint value of 13/28/25 μL/min/mg [1].
    RGH-122
  • HY-109024R
    Balovaptan (Standard)

    RG7314 (Standard)

    		 Reference Standards Vasopressin Receptor Cardiovascular Disease Neurological Disease Endocrinology
    Balovaptan (Standard) is the analytical standard of Balovaptan (HY-109024). This product is intended for research and analytical applications. Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
    Balovaptan (Standard)
  • HY-RS22565
    Hvcn1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Hvcn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hvcn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Hvcn1 Mouse Pre-designed siRNA Set A
    Hvcn1 Mouse Pre-designed siRNA Set A

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