Search Result

Results for "

HePG2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Acetyl-CoA Carboxylase (2) Acyltransferase (2) Adrenergic Receptor (1) Akt (8) Aldehyde Dehydrogenase (ALDH) (1) AMPK (6) Amyloid-β (4) Anaplastic lymphoma kinase (ALK) (2) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (4) Apoptosis (119) Aryl Hydrocarbon Receptor (2) Atg8/LC3 (1) Aurora Kinase (1) Autophagy (19) Bacterial (21) Bcl-2 Family (13) BCRP (1) Beclin1 (2) Beta-lactamase (3) Biochemical Assay Reagents (3) c-Kit (1) c-Met/HGFR (2) c-Myc (2) Calcium Channel (4) CaMK (1) Carbonic Anhydrase (3) Casein Kinase (1) Caspase (9) CDK (9) Cholinesterase (ChE) (8) ClpP (1) COX (4) Cytochrome P450 (9) Dihydrofolate reductase (DHFR) (3) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (5) Dopamine Receptor (1) Drug Metabolite (2) E1/E2/E3 Enzyme (1) EGFR (21) Endogenous Metabolite (23) Endothelin Receptor (1) Ephrin Receptor (1) Epigenetic Reader Domain (1) Epoxide Hydrolase (1) ERK (3) Estrogen Receptor/ERR (2) FAAH (1) FBPase (1) Ferroptosis (3) FGFR (3) Fluorescent Dye (8) FOXO (1) Fungal (6) FXR (1) GABA Receptor (1) Glucocorticoid Receptor (1) Glucosidase (2) GLUT (1) GSK-3 (4) HBV (19) HCV (1) HDAC (7) HIF/HIF Prolyl-Hydroxylase (1) Hippo (MST) (1) Histone Acetyltransferase (2) Histone Demethylase (2) HIV (6) HMG-CoA Reductase (HMGCR) (7) HSP (4) Influenza Virus (3) Insulin Receptor (2) Interleukin Related (2) Isotope-Labeled Compounds (10) JAK (1) JNK (2) Keap1-Nrf2 (2) Ketohexokinase (2) Lactate Dehydrogenase (2) Liposome (1) LXR (4) LYTACs (1) mAChR (2) MAP3K (2) MDM-2/p53 (4) MetAP (1) Microtubule/Tubulin (15) Mitochondrial Metabolism (2) Mitophagy (6) MMP (1) Monoamine Oxidase (4) mTOR (2) Na+/K+ ATPase (1) NAMPT (2) Necroptosis (1) NF-κB (10) NO Synthase (4) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (2) P-glycoprotein (3) p38 MAPK (4) p62 (2) Parasite (15) PARP (3) PD-1/PD-L1 (1) PDGFR (2) PGC-1α (1) Phosphatase (2) Phosphodiesterase (PDE) (2) PI3K (4) Pim (4) PKA (3) PKC (3) Polo-like Kinase (PLK) (1) Potassium Channel (7) PPAR (3) PROTACs (1) Proteasome (2) Pyroptosis (1) Raf (3) RAR/RXR (3) Reactive Oxygen Species (14) REV-ERB (2) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (2) ROCK (3) SARS-CoV (2) Ser/Thr Protease (6) SGK (2) SHP2 (1) Sirtuin (1) SOD (1) Sodium Channel (2) Src (2) STAT (7) Stearoyl-CoA Desaturase (SCD) (3) Steroid Sulfatase (1) Survivin (1) TGF-β Receptor (1) Thyroid Hormone Receptor (3) TNF Receptor (2) Toll-like Receptor (TLR) (3) Topoisomerase (13) TrxR (1) Tyrosinase (1) ULK (1) URAT1 (1) VEGFR (21) Wnt (3) Xanthine Oxidase (1) β-catenin (3)
By Research Areas:	Cancer (291) Cardiovascular Disease (29) Endocrinology (1) Infection (70) Inflammation/Immunology (49) Metabolic Disease (72) Neurological Disease (31)
Click Chemistry:	Azide (1) Alkynes (1)

464

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

123

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0876

Arenobufagin 3 Publications Verification	Others	Cancer
Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.

HY-146465

Anticancer agent 60	Microtubule/Tubulin	Cancer
Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC₅₀ = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model .

HY-P1935

Cyclo(Ala-Pro)

Biochemical Assay Reagents Cancer

Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .
HY-149815

HBV-IN-33

HBV Infection Inflammation/Immunology

HBV-IN-33 (C-49), a HBV inhibitor, notably suppresses HBV replication in HepAD38, HepG2-HBV1.3 and HepG2-NTCP cells .

Cyclo(Ala-Pro)	Biochemical Assay Reagents	Cancer
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HBV-IN-33	HBV	Infection Inflammation/Immunology
HBV-IN-33 (C-49), a HBV inhibitor, notably suppresses HBV replication in HepAD38, HepG2-HBV1.3 and HepG2-NTCP cells .

HY-N12158

Pipermethystine	Apoptosis	Cancer
Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces apoptosis .

HY-N10089

Psiguadial D	Others	Cancer
Psiguadial D is a terpenoid that can be isolated from Psidium guajava, and it has a strong inhibitory effect on the growth of HepG2 cells, with an IC₅₀value of 128.3 nM .

HY-N11433

Celosin L

Others Others

Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

Celosin L	Others	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-115962

Anticancer agent 37	Others	Cancer
Anticancer agent 37 (compound 18), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 37 inhibits HePG2 cell growth with an IC₅₀ of 17.2 µg/mL .

HY-D1255

Sel-green	Fluorescent Dye	Cancer
Sel-green, a selective selenol fluorescent probe, is applied to quantify the Sec content in the selenoenzyme thioredoxin reductase and image endogenous Sec in live HepG2 cells .

HY-116920

Alyssin	Reactive Oxygen Species Microtubule/Tubulin	Cancer
Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .

HY-N10207

Penicitide A	Endogenous Metabolite	Infection Cancer
Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line .

HY-N12288

Wangzaozin A

Others Cancer

Wangzaozin A is an ent-kaurene diterpenoid. Wangzaozin A has cytotoxic against HepG2 cells and Tb cells with IC₅₀ of 1.41 μM and 0.32 μM, respectively .

Wangzaozin A	Others	Cancer
Wangzaozin A is an ent-kaurene diterpenoid. Wangzaozin A has cytotoxic against HepG2 cells and Tb cells with IC₅₀ of 1.41 μM and 0.32 μM, respectively .

HY-145821

Tubulin inhibitor 15	Microtubule/Tubulin	Cancer
Tubulin inhibitor 15 is a potent tubulin inhibitor. Tubulin inhibitor 15 shows antiproliferative activity. Tubulin inhibitor 15 shows cytotoxicity in HepG2 cells .

HY-145822

Tubulin inhibitor 16	Microtubule/Tubulin	Cancer
Tubulin inhibitor 16 is a potent tubulin inhibitor. Tubulin inhibitor 16 shows antiproliferative activity. Tubulin inhibitor 16 shows cytotoxicity in HepG2 cells .

HY-146082

(Z)-α-Cyanostilbene	Others	Cancer
(Z)-α-Cyanostilbene (compound 8), a dicyano substituted acrylonitrile, shows selective antiproliferative activity against HeLa and HepG2 cells, with IC₅₀s of 0.33 and 0.52 μM, respectively .

HY-147198

Antimalarial agent 13	Parasite	Infection
Antimalarial agent 13 (Compound 1) is a potent antimalarial agent. Antimalarial agent 13 shows inhibition with EC₅₀ values of 124 nM and 2.5 μM against P. falciparum parasite and HepG2, respectively .

HY-N7321

Eucomol	Others	Cancer
Eucomol has potent cytotoxicity against KKU-M156 and HepG2 cells with the IC₅₀ values of 7.12 and 25.76? μg/mL, respectively. Eucomol can be isolated from an ethanolic extract of D. cochinchinensis .

HY-N10063

Penispidin A

Others Metabolic Disease

Penispidin A inhibits hepatic lipid accumulation in HepG2 cells.

Penispidin A	Others	Metabolic Disease
Penispidin A inhibits hepatic lipid accumulation in HepG2 cells.

HY-N8361

Glycoborinine	HIV Apoptosis	Infection Cancer
Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells ^[2].

HY-144795

VEGFR-2-IN-14	VEGFR Apoptosis	Cancer
VEGFR-2-IN-14 (Compound 5) is a potent *VEGFR-2* inhibitor. VEGFR-2-IN-14 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis .

HY-P4284

Z-GGF-CMK	ClpP Proteasome	Others
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM .

HY-149061

Anticancer agent 99	Apoptosis	Cancer
Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC₅₀ value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect .

HY-10332

(Z)-Semaxanib (Z)-SU5416	c-Met/HGFR	Cancer
(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC₅₀s of 6.28 µM and 8.17 µM, respectively .

HY-144796

VEGFR-2-IN-15	VEGFR Apoptosis	Cancer
VEGFR-2-IN-15 (Compound 14b) is a potent *VEGFR-2* inhibitor. VEGFR-2-IN-15 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis .

HY-143266

Topoisomerase I inhibitor 3	Topoisomerase Apoptosis	Cancer
Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase .

HY-161171

Antimalarial agent 37	Parasite Ephrin Receptor	Cancer
Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7 .

HY-N10846

Neotriptonoterpene	Others	Others
Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC₅₀ values of 65.80, 35.45 and 64.80 µM respectively .

HY-160059

JHIT2e aptamer sodium	Others	Cancer
JHIT2e aptamer sodium is a molecular probe based on the aptamer JHIT2 of human liver cancer cell line HepG2 cells. JHIT2e aptamer sodiu retains the ability to specifically bind HepG2 and can deliver fluorescent materials or radionuclides to tumors .

HY-75564

Cyclo(Ala-Gly)	Endogenous Metabolite	Cancer
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC₅₀ values range from 9.5 to 18.1 μM .

HY-N9966

Sanggenol O	Others	Others
Sanggenol O? is an active product that can be extracted from Morus alba. Sanggenol O? has hepatoprotective and neuroprotective activities with EC₅₀s more than 80 μM in HepG2 and HT22 cells .

HY-137371

Lactonic sophorolipid	Bacterial Apoptosis Antibiotic	Infection Cancer
Lactonic sophorolipid is a natural antimicrobial surfactant for oral hygiene . Lactonic sophorolipid, a potential anticancer agent, induces apoptosis in human HepG2 cells through the caspase-3 pathway .

HY-163286

BODIQPy-TPA	Fluorescent Dye Ferroptosis	Others
BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-147839

Topoisomerase II inhibitor 10	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC₅₀ value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells .

HY-N4251

Periplocoside M (-)-Periplocoside M	Others	Cancer
Periplocoside M (compound 8) is a natural product isolated from the root bark of Periploca sepium. Periplocoside M shows antitumor activity against human A-549 and HepG2 cell lines, with the IC₅₀ of 4.84 and 7.06 μM .

HY-137605

WSF1-IN-1	Others	Cancer
WSF1-IN-1 (compound 136), an orally active WSF1 inhibitor, can be used in the study for WSF1 (Wolfram syndrome) related tumors, with IC₅₀ values of 0.33 μM and >27 μM in HepG2 parental and HepG2 WFS1 KO cell lines, respectively .

HY-133667

Bromoiodoacetamide	Apoptosis	Cancer
Bromoiodoacetamide is a kind of iodinated haloacetamides (I-HAcAms), with cytotoxicity. Bromoiodoacetamide induces cytotoxicity by via reactive oxygen species (ROS) accumulation and apoptosis in HepG-2 cells .

HY-163077

Anticancer agent 175	Reactive Oxygen Species Apoptosis	Cancer
Anticancer agent 175 (complex 1) ia a near-infrared (NIR) luminescent theranostic complex. Anticancer agent 175 induces ROS accumulation, mitochondrial damage, disruption of Bax/Bcl-2 equilibrium, and tumor cell apoptosis in HepG2 cell line .

HY-156593

ROCK-IN-9	ROCK	Cancer
ROCK-IN-9 (Compound T345) is a ROCK inhibitor. ROCK-IN-9 shows cytotoxicity in HepG2 cell, with an IC₅₀ of 40.8 μM. ROCK-IN-9 has good pharmacokinetic properties in mice, and shows high in vivo exposure and oral bioavailability at lower doses .

HY-N1324

Sanggenon N	Others	Others
Sanggenon N is an isoprenylated flavonoid that can be isolated from the root bark of Morus alba.Sanggenon N has hepatoprotective activities on t-BHP-induced cell cytotoxicity in HepG2 cells with an EC₅₀ of 23.45 μM .

HY-151573

EGFR/CDK2-IN-1	EGFR CDK	Cancer
EGFR/CDK2-IN-1 (Compound 3b) is an *EGFR/CDK2* inhibitor. EGFR/CDK2-IN-1 shows good cytotoxicity against MCF7 and HepG2 cells. EGFR/CDK2-IN-1 can be used in cancer research .

HY-153547

HSP90-IN-21	Parasite	Infection Inflammation/Immunology
HSP90-IN-21 (5e) is an antiplasmodial agent, with IC₅₀ values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2 strains), cytotoxicity of human liver hepatocellular carcinoma cell line (HepG2), respectively .

HY-N7340

Withaperuvin C	Others	Cancer
Withaperuvin C is a withanolide that can be isolated from Physalis Minima. Withaperuvin C has moderate cytotoxicity against cancer cells such as HepG2, SK-LU-1, and MCF7 cells (IC₅₀: 19.5, 14.65, 11.74 μg/mL) .

HY-13623A

Entecavir monohydrate 10+ Cited Publications BMS200475 monohydrate; SQ34676 monohydrate	HBV	Infection Cancer
Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC₅₀ of 3.75 nM in HepG2 cell.

HY-13623

Entecavir 10+ Cited Publications BMS200475; SQ34676	HBV	Infection Cancer
Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC₅₀ of 3.75 nM in HepG2 cell.

HY-N12299

Parthenosin Quercetin 3-O-β-D-glucuronide butyl ester	Others	Cancer
Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester) is a flavonoid, that can be isolated from the aerial parts of Calligoum polygonoides. Parthenosin shows cytotoxic activity against HepG2 and MCF-7 cell lines with IC₅₀ values of 60.46 and 61.4 μg/mL, respectively .

HY-N4043

Hirsutanonol 5-O-β-D-glucopyranoside Hirsutanonol 5-O-glucoside	Others	Cancer
Hirsutanonol 5-O-glucoside is a diarylheptanoid derivatives that can be isolated from Alnus hirsuta. Hirsutanonol 5-O-glucoside exhibits significant hepatoprotective effects against t-BHP-induced toxicity in HepG2 cells with 42.8% protection .

HY-163287

QPy-TPA	Fluorescent Dye	Others
QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm .

HY-162239

Anticancer agent 187	Others	Cancer
Anticancer agent 187 (Compound 4) is an anticancer agent that can target sarcoma cells in tumor-bearing mouse models. Anticancer agent 187 exhibits cytotoxic activity against HepG2, Caco2, and MCF-7 cells .

HY-N0125

Diosmetin

5 Publications Verification

Cytochrome P450 Cancer

Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.
HY-N1323

Sanggenol P

HBV Infection

Sanggenol P, a flavonoid, shows anti-HBV activity on HepG2.2.15 cell line in vitro .

Cat. No.	Product Name	Type

HY-D1255

Sel-green	Fluorescent Dyes/Probes
Sel-green, a selective selenol fluorescent probe, is applied to quantify the Sec content in the selenoenzyme thioredoxin reductase and image endogenous Sec in live HepG2 cells .

HY-D1533

RhoNox-1 1 Publications Verification	Fluorescent Dyes/Probes
RhoNox-1 is a fluorescent probe for the specific detection of divalent iron ions, and when RhoNox-1 reacts with Fe ²⁺. RhoNox-1 can generate an irreversible orange (red) fluorescent product (Ex/Em：540/575 nm) . FeRhoNox-1 can enter the cell well, suitable for the detection of Fe ²⁺ in living cells, and tends to be localized in the Golgi apparatus .

HY-162129

Antitumor agent-131	Fluorescent Dyes/Probes
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC₅₀ value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .

HY-163286

BODIQPy-TPA	Dyes
BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-163287

QPy-TPA	Dyes
QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm .

HY-D1259

NEP VDP-green (NEP)	Fluorescent Dyes/Probes
NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λ_ex/λ_em=430/535 nm). NEP has the potential for parkinsonism .

HY-D1258

AC-green VDP-green	Fluorescent Dyes/Probes
AC-green (VDP-green) is a β-allyl carbamate fluorescent probe for specifically imaging vicinal dithiol proteins (VDPs) in living systems (λ_ex/λ_em=400/475 nm). AC-green can detect the reduced bovine serum albumin (rBSA) with high sensitivity. AC-green displays low toxicity and features high sensitivity, and is suitable for sensing VDPs in living cells and zebrafishes .

Cat. No.	Product Name	Target	Research Area

HY-P2276

Pep2-8

Ser/Thr Protease Cancer

Pep2-8 is a PCSK9 inhibitor with a binding K_D of 0.7 μM and an IC₅₀ of 1.4 μM .

HY-P3455

Ac-SVVVRT-NH2	PGC-1α	Metabolic Disease Cancer
Ac-SVVVRT-NH2 is a PGC-1α modulator that modulates the activity of the human PGC-1α promoter (114%). Ac-SVVVRT-NH2 increases PGC-1α mRNA (125%) and accumulation of intracellular lipids (128%) in subcutaneous human adipocytes. Ac-SVVVRT-NH2 can be used in the research of diseases which is modulated by PGC-1α .

HY-P1935

Cyclo(Ala-Pro)

Biochemical Assay Reagents Cancer

Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HY-P4284

Z-GGF-CMK	ClpP Proteasome	Others
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM .

HY-113064

Selenocystine	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-144292

HDAC-IN-30	HDAC	Cancer
HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC₅₀=13.4 nM),HDAC2 (IC₅₀=28.0 nM), HDAC3 (IC₅₀=9.18 nM), HDAC6 (IC₅₀=42.7 nM), HDAC8 (IC₅₀=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy .

HY-N6693

Valinomycin 3 Publications Verification NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research ^[2].

HY-P2282

APTSTAT3-9R 1 Publications Verification	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0876

Arenobufagin 3 Publications Verification	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Others
Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.

HY-P1935

Cyclo(Ala-Pro)	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Biochemical Assay Reagents
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HY-N12158

Pipermethystine	Structural Classification Alkaloids Other Alkaloids Source classification Piper methysticum Forst Piperaceae Plants	Apoptosis
Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces apoptosis .

HY-N10089

Psiguadial D	Structural Classification Terpenoids Sesquiterpenes Source classification Psidium guajava Linn. Myrtaceae Plants	Others
Psiguadial D is a terpenoid that can be isolated from Psidium guajava, and it has a strong inhibitory effect on the growth of HepG2 cells, with an IC₅₀value of 128.3 nM .

HY-N11433

Celosin L	Triterpenes Structural Classification Terpenoids Celosia cristata L. Source classification Amaranthaceae Plants	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-N10207

Penicitide A	Infection Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism	Endogenous Metabolite
Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line .

HY-N12288

Wangzaozin A	Structural Classification Isodon excisoides (Sun ex C. H. Hu) H. Hara Terpenoids Labiatae Source classification Diterpenoids Plants	Others
Wangzaozin A is an ent-kaurene diterpenoid. Wangzaozin A has cytotoxic against HepG2 cells and Tb cells with IC₅₀ of 1.41 μM and 0.32 μM, respectively .

HY-N7321

Eucomol	Structural Classification Flavonoids Source classification Plants Other Flavonoids Asparagaceae Juss.	Others
Eucomol has potent cytotoxicity against KKU-M156 and HepG2 cells with the IC₅₀ values of 7.12 and 25.76? μg/mL, respectively. Eucomol can be isolated from an ethanolic extract of D. cochinchinensis .

HY-N10063

Penispidin A	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Others
Penispidin A inhibits hepatic lipid accumulation in HepG2 cells.

HY-N8361

Glycoborinine	Structural Classification Alkaloids Source classification Rutaceae Plants Indole Alkaloids Glycosmis arborea	HIV Apoptosis
Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells ^[2].

HY-N10846

Neotriptonoterpene	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.	Others
Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC₅₀ values of 65.80, 35.45 and 64.80 µM respectively .

HY-75564

Cyclo(Ala-Gly)	Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC₅₀ values range from 9.5 to 18.1 μM .

HY-N9966

Sanggenol O	Structural Classification Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	Others
Sanggenol O? is an active product that can be extracted from Morus alba. Sanggenol O? has hepatoprotective and neuroprotective activities with EC₅₀s more than 80 μM in HepG2 and HT22 cells .

HY-N4251

Periplocoside M (-)-Periplocoside M	Structural Classification Natural Products Source classification Asclepiadaceae Plants Periploca sepium Bunge	Others
Periplocoside M (compound 8) is a natural product isolated from the root bark of Periploca sepium. Periplocoside M shows antitumor activity against human A-549 and HepG2 cell lines, with the IC₅₀ of 4.84 and 7.06 μM .

HY-N1324

Sanggenon N	Structural Classification Flavanonols Flavonoids Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Others
Sanggenon N is an isoprenylated flavonoid that can be isolated from the root bark of Morus alba.Sanggenon N has hepatoprotective activities on t-BHP-induced cell cytotoxicity in HepG2 cells with an EC₅₀ of 23.45 μM .

HY-N7340

Withaperuvin C	Structural Classification Physalis minima Linn. Source classification Plants Solanaceae Steroids	Others
Withaperuvin C is a withanolide that can be isolated from Physalis Minima. Withaperuvin C has moderate cytotoxicity against cancer cells such as HepG2, SK-LU-1, and MCF7 cells (IC₅₀: 19.5, 14.65, 11.74 μg/mL) .

HY-N12299

Parthenosin Quercetin 3-O-β-D-glucuronide butyl ester	Structural Classification Flavonoids Flavones Polygonaceae Source classification Phenols Polyphenols Plants Calligonum aphyllum (Pall.) Gurke	Others
Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester) is a flavonoid, that can be isolated from the aerial parts of Calligoum polygonoides. Parthenosin shows cytotoxic activity against HepG2 and MCF-7 cell lines with IC₅₀ values of 60.46 and 61.4 μg/mL, respectively .

HY-N4043

Hirsutanonol 5-O-β-D-glucopyranoside Hirsutanonol 5-O-glucoside	Structural Classification Source classification Phenols Polyphenols Alnus hirsuta Turczaninow ex Ruprecht Plants Betulaceae	Others
Hirsutanonol 5-O-glucoside is a diarylheptanoid derivatives that can be isolated from Alnus hirsuta. Hirsutanonol 5-O-glucoside exhibits significant hepatoprotective effects against t-BHP-induced toxicity in HepG2 cells with 42.8% protection .

HY-N0125

Diosmetin 5 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Flavones Citrus limon (L.) Burm. F. Source classification Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer	Cytochrome P450
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N1323

Sanggenol P	Structural Classification Flavonoids Flavonones Source classification Plants Moraceae Morus alba Linn.	HBV
Sanggenol P, a flavonoid, shows anti-HBV activity on HepG2.2.15 cell line in vitro .

HY-N12128

Ophiopogonin R	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Polysaccharides Liliaceae Source classification Plants Saccharides	Others
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-120607

Chevalone C	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields	Parasite
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC₅₀ value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines ^[2].

HY-N10952

Epicornuin F	Structural Classification Flavonoids Source classification Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Isoflavones	Others
Epicornuin F is a prenylated flavonoid. Epicornuin F can be isolated from the leaves of Epimedium brevicornu. Epicornuin F has the cytotoxic activity against HepG2 cells with an IC₅₀ value of 33.4 μM. Epicornuin F can be used for the research of cancer .

HY-N11792

Pedunculosumoside F	Structural Classification Flavonoids Source classification Ophioglossaceae Plants Other Flavonoids Ophioglossum reticulatum L.	Others
Pedunculosumoside F is a homoflavonoid glucoside. Pedunculosumoside F can be isolated from Ophioglossum pedunculosum. Pedunculosumoside F has cytotoxicity against HepG2 22.15 cells with CC₅₀ value of 56.7 μM without anti-HBV activity. While its analogs block HBsAg secretion in HBV-infected HepG2 2.2.15 cells .

HY-N0316

Mollugin 1 Publications Verification	Monophenols Classification of Application Fields Terpenoids Sesquiterpenes Source classification Rubiaceae Phenols Plants Disease Research Fields Cancer Rubia cordifolia L.	NF-κB Reactive Oxygen Species Apoptosis VEGFR c-Myc
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway ^[2] .

HY-N7980

Rubipodanone A	Quinones Classification of Application Fields Rubia podantha Source classification Rubiaceae Plants Naphthalene Quinones Disease Research Fields Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-N6683

15-Acetyl-deoxynivalenol	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Drug Metabolite
15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

HY-N8882

Oleoside 11-methyl ester	Iridoids Classification of Application Fields Oleaceae Ligustrum lucidum Ait. Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Oleoside 11-methyl ester is a secoiridoid glucoside and possesses a strong cytotoxic activity against Hep-G2 cells .

HY-N0882

Desacetylcinobufotalin Deacetylcinobufotalin	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis
Desacetylcinobufotalin is a natural compound; apoptosis inducer and shows the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml.

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Plants Solanaceae Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity ^[2].

HY-N12140

2'-epi-2'-O-Acetylthevetin B GHSC-74	Apocynaceae Structural Classification Polysaccharides Source classification Cerbera manghas Linn. Plants Saccharides	Apoptosis
2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be isolated from the seeds of Cerbera manghas L. 2'-epi-2'-O-Acetylthevetin B inhibits cell viability, induces apoptosis and loss of mitochondrial membrane potential in HepG2 cells .

HY-N1514

Ganoderenic acid B	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Endogenous metabolite Disease Research Fields Cancer	P-glycoprotein
Ganoderenic acid B is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid B exhibits potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to Doxorubicin .

HY-N3542

Carpachromene	Structural Classification Flavonoids Flavones Source classification Plants Calophyllaceae Calophyllum symingtonianum M.R.Hend. & Wyatt-Sm.	Glucosidase
Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway .

HY-N8679

Physalin C	Structural Classification Cardiacglycosides Source classification Physalis angulata L. Plants Solanaceae Steroids	Endogenous Metabolite
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-N12426

Heilaohuguosu F	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-N8466

(-)-Lyoniresinol 9'-O-glucoside	Structural Classification Albizia julibrissin Durazz. Leguminosae Source classification Plants Saccharides Monosaccharides	Reactive Oxygen Species
(-)-Lyoniresinol 9'-O-glucoside is an inhibitor of ROS. (-)-Lyoniresinol 9'-O-glucoside reduces lipid accumulation and lipid metabolic disorders in FFAs-exposed HepG2 cells. (-)-Lyoniresinol 9'-O-glucoside inhibits high glucose-induced reactive oxygen species production .

HY-N8441

Neriifolin 17β-Neriifolin	Apocynaceae Structural Classification Classification of Application Fields Cardiacglycosides Cerbera manghas Linn. Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-N8934

6β-Hydroxytomentosin	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	Others
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines ^[2].

HY-N12440

Sarmenoside II	Structural Classification Source classification Crassulaceae Sedum sarmentosum Bunge Phenols Polyphenols Plants	Others
Sarmenoside II is a flavonol glycoside with activity that inhibits lipid accumulation. Sarmenoside II inhibits albumin-oleate-induced lipid accumulation in HepG2 cells by approximately 30% at 100 μM.

HY-N10447

Kurzipene D	Terpenoids Source classification Casearia kurzii C. B. Clarke Diterpenoids Plants Salicaceae	Apoptosis
Kurzipene D (compound 4) is a potent anticancer agent. Kurzipene D induces the apoptosis and arrested the HepG2 cell cycle at S stage. Kurzipene D shows anti-tumor effects using in vivo zebrafish model. Kurzipene D has the property of inhibiting tumor proliferation and migration .

HY-N9532

Isobyakangelicol Anhydrobyakangelicin	Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Disease Research Fields Cancer	Others
Isobyakangelicol is a coumarin that can be found in the roots of Angelica dahurica. Isobyakangelicol inhibits the growth of HeLa and HepG2 cells, with IC₅₀s of 70.04 μM and 17.97 μM .

HY-N7160

2-Hydroxy-3-methylanthraquinone	Quinones Structural Classification Anthraquinones Source classification Rubiaceae Plants Hedyotis diffusa Willd.	Src Apoptosis
2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against protein tyrosine kinases v-src and pp60src, and induces growth arrest and apoptosis in the HepG2 cancer cells .

HY-N3121

Pachypodol	Flavonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Others
Pachypodol exerts antioxidant and cytoprotective effects in HepG2 cells .Pachypodol inhibits the growth of CaCo 2 colon cancer cell line in vitro(IC₅₀ = 185.6 mM) ^[2].

HY-N7464

Jolkinolide E	Structural Classification Terpenoids Source classification Euphorbia rapulum Kar. et Kir. Diterpenoids Euphorbiaceae Plants	Others
Jolkinolide E is a casbane diterpenoid from the roots of Euphorbia rapulum. Jolkinolide E shows weak selective activity against HepG2, MCF-7, and C6 cell lines .

HY-N0907

Ginsenoside Rg6	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology Araliaceae	NF-κB Apoptosis
Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-N7605

11-epi-mogroside V	Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	Others
11-epi-mogroside V is a mogroside in the fruit of Siraitia grosvenori. 11-epi-mogroside V exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro .

HY-N9339

Norglaucine (+)-Norglaucine	Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Others
Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .

HY-N2936

Bi-linderone	Structural Classification Natural Products Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
Bi-linderone is isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. Bi-linderone has activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 μg/mL .

HY-N12337

Asperazine (+)-Asperazine	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Indole Alkaloids	Others
Asperazine (Compound 5) is an alkaloid derived from the fungus Penicillium oxalicum. Asperazine shows only moderate activity against HepG2 and CaSki cell lines (IC₅₀>50 μM) .

HY-N0125R

Diosmetin (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Citrus limon (L.) Burm. F. Source classification Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer	Cytochrome P450
Diosmetin (Standard) is the analytical standard of Diosmetin. This product is intended for research and analytical applications. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

Cat. No.	Product Name	Chemical Structure

HY-B0144AS1

Pitavastatin-d5 sodium
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-13623S

Entecavir-d2

Entecavir-d₂ is the deuterium labeled Entecavir. Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
HY-N0125S

Diosmetin-d3

Diosmetin-d₃ is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

HY-N6683S1

15-Acetyl-deoxynivalenol-13C17
15-Acetyl-deoxynivalenol- ¹³C₁₇ is the ¹³C labeled 15-Acetyl-deoxynivalenol (HY-N6683) . 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells ^[2].

HY-19937S1

Saroglitazar-d4
Saroglitazar-d₄ is the deuterium-labeled Saroglitazar (HY-19937). Saroglitazar-d₄ is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC₅₀ values of 0.65 pM and 3 nM in HepG2 cells, respectively.

HY-13623S1

Entecavir-13C2,15N
Entecavir- ¹³C₂, ¹⁵N (BMS200475- ¹³C₂, ¹⁵N; SQ34676- ¹³C₂, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Entecavir (HY-13623). Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC₅₀ of 3.75 nM in HepG2 cell.

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan[1]. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[2][3][4][5][6].

HY-B1826S2

Adefovir-d4
Adefovir-d₄ is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

HY-B0144S

Pitavastatin-d4 hemicalcium

Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-113066S1

Guanosine 5'-diphosphate-13C10 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀ (GDP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S3

Guanosine 5'-diphosphate-13C10,15N5 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀, ¹⁵N₅ (GDP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S

Guanosine 5'-diphosphate-15N5 dilithium

Guanosine 5'-diphosphate- ¹⁵N₅ (GDP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S2

Guanosine 5'-diphosphate-d13 dilithium

Guanosine 5'-diphosphate-d₁₃ (GDP-d₁₃) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks