Hexokinase

By Targets:	Hexokinase (10) Apoptosis (6) Autophagy (1) Endogenous Metabolite (1) HSV (4) Isotope-Labeled Compounds (3) Mitochondrial Metabolism (1) Parasite (1)
By Research Areas:	Cancer (7) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)

Targets Recommended: Hexokinase Glucokinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134929

Hexokinase 2 inhibitor 1

Hexokinase Infection

Hexokinase 2 inhibitor 1 (Compound 2a) is a hexokinase 2 (HK2) inhibitor with anti-tumor activity and can be used in cancer research .

Hexokinase 2 inhibitor 1	Hexokinase	Infection
Hexokinase 2 inhibitor 1 (Compound 2a) is a hexokinase 2 (HK2) inhibitor with anti-tumor activity and can be used in cancer research .

HY-P2776

Hexokinase, microorganism	Endogenous Metabolite	Metabolic Disease
Hexokinase (ScHEX1) (EC 2.7.1.1) is a glycolytic enzyme hexokinase that is inhibited by n-acetylglucosamine. Inhibition of Hexokinase (ScHEX1) by n-acetylglucosamine leads to its separation from the mitochondrial outer membrane, resulting in activation of NLRP3 inflammasome .

HY-19992

3-Bromopyruvic acid 15+ Cited Publications Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

HY-155008

PROTAC HK2 Degrader-1 1 Publications Verification	Hexokinase	Cancer
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .

HY-P10108

Hexokinase II VDAC binding domain peptide Hxk2VBD peptide	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

HY-13966S

2-Deoxy-D-glucose-d1 2-DG-d₁; 2-Deoxy-D-arabino-hexose-d₁; D-Arabino-2-deoxyhexose-d₁	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-13966S2

2-Deoxy-D-glucose-13C 2-DG-¹³C; 2-Deoxy-D-arabino-hexose-¹³C; D-Arabino-2-deoxyhexose-¹³C	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-13966S4

2-Deoxy-D-glucose-13C-1 2-DG-¹³C-1; 2-Deoxy-D-arabino-hexose-¹³C-1; D-Arabino-2-deoxyhexose-¹³C-1	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-139409A

2-Deoxy-D-glucose 6-phosphate disodium	Others	Metabolic Disease
2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-W000133

Metrizamide Amipaque	Hexokinase	Neurological Disease
Metrizamide (Amipaque) is used as the contrast medium for angiography in neuroradiological investigations . Metrizamide inhibits human brain hexokinase .

HY-13966

2-Deoxy-D-glucose Maximum Cited Publications 133 Publications Verification 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Hexokinase HSV Apoptosis	Cancer
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-B0486

Lonidamine 5+ Cited Publications AF-1890; Diclondazolic Acid; DICA	Hexokinase Mitochondrial Metabolism Apoptosis Parasite	Inflammation/Immunology Cancer
Lonidamine (AF-1890) is a *hexokinase* and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library	679 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 679 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

679 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 679 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L092

Glucose Metabolism Compound Library	993 compounds
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer. MCE offers a unique collection of 993 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

Glucose Metabolism Compound Library

993 compounds

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer.

MCE offers a unique collection of 993 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

HY-L009

Kinase Inhibitor Library	3103 compounds
Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. Kinase inhibitor library designed by MCE contains 3103 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Kinase Inhibitor Library

3103 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3103 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P10108

Hexokinase II VDAC binding domain peptide Hxk2VBD peptide	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13966

2-Deoxy-D-glucose 130+ Cited Publications 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Hexokinase HSV Apoptosis
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

Species:	Human (5)
Tag:	His (4) Tag Free (1) GST (1)
Source:	P. pastoris (2) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P700580

	*HK1/Hexokinase-1 Protein, Human (463a.a, His)* Hexokinase-1; HK1; Brain form Hexokinase; Hexokinase type I; HK I; Hexokinase-A	Human	E. coli
	The HK1/hexokinase-1 protein phosphorylates hexose sugars, including D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose, to form the corresponding hexose 6-phosphate. HK1/Hexokinase-1 Protein, Human (463a.a, His) is the recombinant human-derived HK1/Hexokinase-1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HK1/Hexokinase-1 Protein, Human (463a.a, His) is 463 a.a., with molecular weight of 55.9 kDa.

HY-P700581

	*HK1/Hexokinase-1 Protein, Human (463a.a, P. pastoris, His)* Hexokinase-1; HK1; Brain form Hexokinase; Hexokinase type I; HK I; Hexokinase-A	Human	P. pastoris
	The HK1/hexokinase-1 protein phosphorylates hexose sugars, including D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose, to form the corresponding hexose 6-phosphate. HK1/Hexokinase-1 Protein, Human (463a.a, P. pastoris, His) is the recombinant human-derived HK1/Hexokinase-1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of HK1/Hexokinase-1 Protein, Human (463a.a, P. pastoris, His) is 463 a.a., with molecular weight of 53.9 kDa.

HY-P74881

	*HK3/Hexokinase-3 Protein, Human (sf9, His-GST)* Hexokinase-3; HK III; Hexokinase-C; HK3	Human	Sf9 insect cells
	The HK3 (hexokinase-3) protein promotes the phosphorylation of hexoses (i.e., D-glucose and D-fructose) to form hexose-6-phosphate (specifically, D-glucose 6-phosphate and 6-phosphate), Plays a vital role in cell metabolism. D-fructose 6-phosphate. HK3/Hexokinase-3 Protein, Human (sf9, His-GST) is the recombinant human-derived HK3/Hexokinase-3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of HK3/Hexokinase-3 Protein, Human (sf9, His-GST) is 923 a.a., with molecular weight of ~115 kDa.

HY-P75790

	Glucokinase/GCK Protein, Human Hexokinase-4; HK4; Hexokinase-D; Glucokinase	Human	E. coli
	Glucokinase/GCK proteins catalyze hexose phosphorylation, converting D-glucose, D-fructose, and D-mannose into their respective hexose 6-phosphates. Glucokinase/GCK Protein, Human is the recombinant human-derived Glucokinase/GCK protein, expressed by E. coli , with tag free. The total length of Glucokinase/GCK Protein, Human is 464 a.a., with molecular weight of ~55 kDa.

HY-P71822

	GCKR Protein, Human (P.pastoris, His) FGQTL5; GCK ; GLRE; Glucokinase regulatory protein; Hexokinase 4 regulator; Hexokinase-D; HK IV; HK4	Human	P. pastoris
	The GCKR protein plays a critical regulatory role in glucokinase (GCK) by forming an inactive complex and recruiting GCK to the nucleus after meals. Its interaction with GCK is finely tuned by fructose metabolites; binding of GCKR to fructose-6-phosphate increases the affinity for GCK, whereas binding to fructose-1-phosphate decreases the affinity, thereby releasing inhibition. GCKR Protein, Human (P.pastoris, His) is the recombinant human-derived GCKR protein, expressed by P. pastoris , with N-His labeled tag. The total length of GCKR Protein, Human (P.pastoris, His) is 625 a.a., with molecular weight of ~70.7 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-13966S

2-Deoxy-D-glucose-d1
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-13966S2

2-Deoxy-D-glucose-13C
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-13966S4

2-Deoxy-D-glucose-13C-1
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80702

Hexokinase I Antibody (YA739) HK1; Hexokinase-1; Brain form Hexokinase; Hexokinase type I; HK I	WB	Human, Mouse, Rat
Hexokinase I Antibody (YA739) is a non-conjugated and Mouse origined monoclonal antibody about 102 kDa, targeting to Hexokinase I (6B8). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P82295

Glucokinase Antibody (YA2040)

GCK; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D
WB Human

HY-P80703

Hexokinase II Antibody HKII; HXK2	WB, IHC-P, IP	Human, Rat, Hamster
Hexokinase II Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 102 kDa, targeting to Hexokinase II. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Rat, Hamster.

HY-P83243

HKDC1 Antibody (YA2988)

Hexokinase domain-containing protein 1
WB, IP Human

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies