Hsp90

Isoforms Recommended:	HSP90

By Targets:	ADC Cytotoxin (4) Akt (2) Androgen Receptor (1) Antibiotic (7) Apoptosis (33) Autophagy (14) Bacterial (7) Beta-lactamase (1) CDK (1) DNA/RNA Synthesis (2) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (1) ERK (1) Estrogen Receptor/ERR (5) FAK (1) FKBP (1) Fungal (3) HDAC (4) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) HSP (117) HSV (1) Influenza Virus (2) JNK (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitophagy (1) Monoamine Oxidase (2) mTOR (1) Necroptosis (1) NF-κB (1) Orthopoxvirus (2) Parasite (3) PDHK (2) PKC (1) Potassium Channel (2) PROTACs (3) Reactive Oxygen Species (1) RIP kinase (1) Small Interfering RNA (siRNA) (5) Survivin (2) Topoisomerase (1) VEGFR (2)
By Research Areas:	Cancer (109) Cardiovascular Disease (1) Infection (18) Inflammation/Immunology (11) Metabolic Disease (4) Neurological Disease (7)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148215A

Hsp90-IN-17 hydrochloride	HSP	Cancer
Hsp90-IN-17 (Example 5) hydrochloride is an *HSP90* inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases .

HY-144724

HSP90-IN-10	HSP Apoptosis	Cancer
HSP90-IN-10 (Compound 16s) is a potent inhibitor of *HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC₅₀* value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis .

HY-146325

HSP90-IN-11	HSP	Cancer
HSP90-IN-11 (Compound 12c) is a potent inhibitor of *HSP90. HSP90-IN-11 displays potent HSP90α inhibition comparable to AUY-922 (Luminespib). HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP90*-IN-11 induces significant accumulation of a sub-G1 phase population .

HY-149891

HSP90-IN-23	HSP	Cancer
HSP90-IN-23 (Comp 12-1) is an inhibitor of heat shock protein 90(HSP90) with an IC₅₀ of 9 nM. HSP90-IN-23 induces apoptosis of tumor cells and arrests the tumor cell cycle in G0/G1 phase. HSP90-IN-23 can be used for cancer research .

HY-148215

Hsp90-IN-17

HSP Cancer

Hsp90-IN-17 (Example 5) is an HSP90 inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases .

Hsp90-IN-17	HSP	Cancer
Hsp90-IN-17 (Example 5) is an *HSP90* inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases .

HY-151137

HSP90/mTOR-IN-1	mTOR HSP Apoptosis Autophagy	Cancer
HSP90/mTOR-IN-1 is a potent and orally active *Hsp90* and mTOR inhibitor with IC₅₀ values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer .

HY-153588

HSP90-IN-22	HSP	Cancer
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC₅₀ values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.

HY-152027

HSP90-IN-18	HSP Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-18 is an effective *heat shock protein 90 (Hsp90)* inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-152028

HSP90-IN-19	HSP	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-19 is an effective *heat shock protein 90 (Hsp90)* inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-149531

HSP90-IN-25

HSP Cancer

HSP90-IN-25 (compound 4a) is an HSP90 inhibitor that specifically inhibits the ATPase activity of HSP90 .

HSP90-IN-25	HSP	Cancer
HSP90-IN-25 (compound 4a) is an HSP90 inhibitor that specifically inhibits the ATPase activity of HSP90 .

HY-150655

Hsp90-IN-15	HSP	Cancer
Hsp90-IN-15 is an *Hsp90* inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of *Hsp90* in Hela cell .

HY-147974

HSP90-IN-14	HSP Influenza Virus	Infection
HSP90-IN-14 (compound 4) is a potent *Hsp90* (heat shock protein 90) inhibitor, with a K_d of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC₅₀ values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively .

HY-113574

HSP90-IN-29	HSP	Cancer
HSP90-IN-29 (Compound 13), a benzoxazole derivative, is a potent and selective *HSP-90* inhibitor with an IC₅₀ value of 30 nM. HSP90-IN-29 has antitumor activity .

HY-148963

HSP90-IN-20

HSP Cancer

HSP90-IN-20 (compound 78p) is a potent HSP90 inhibitor with an IC₅₀ of ≤10 μM. HSP90-IN-20 has the potential for cancers research .
HY-156779

HSP90-IN-27

HSP Cancer

HSP90-IN-27 (compound 19) is an HSP90 inhibitor .

HSP90-IN-20	HSP	Cancer
HSP90-IN-20 (compound 78p) is a potent *HSP90* inhibitor with an IC₅₀ of ≤10 μM. HSP90-IN-20 has the potential for cancers research .

HSP90-IN-27	HSP	Cancer
HSP90-IN-27 (compound 19) is an *HSP90* inhibitor .

HY-145814

HSP90-IN-9	HSP Fungal	Infection
HSP90-IN-9 is a potent and selective *HSP90* inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2) .

HY-146228

HSP90-IN-13	HSP Apoptosis Topoisomerase EGFR VEGFR	Cancer
HSP90-IN-13 (compound 5k) is a highly potent *HSP90* pan inhibitor with an IC₅₀ value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway .

HY-144650

Hsp90-Cdc37-IN-3	Apoptosis HSP	Cancer
Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol−imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits *Hsp90−Cdc37* by covalent-binding, and induces apoptosis .

HY-111414

Hsp90-Cdc37-IN-1

HSP Cancer

Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC₅₀ of 140 nM.

Hsp90-Cdc37-IN-1	HSP	Cancer
Hsp90-Cdc37-IN-1 is an *Hsp90-Cdc37* interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC₅₀ of 140 nM.

HY-153547

HSP90-IN-21	Parasite	Infection Inflammation/Immunology
HSP90-IN-21 (5e) is an antiplasmodial agent, with IC₅₀ values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2 strains), cytotoxicity of human liver hepatocellular carcinoma cell line (HepG2), respectively .

HY-147747

HSP90-IN-12	HSP	Cancer
Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of *hsp90* related proteins in cells and inhibited *hsp90* mediated protein refolding of luciferase in vitro.

HY-RS06415

HSP90AA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90AA1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90AA1 Human Pre-designed siRNA Set A HSP90AA1 Human Pre-designed siRNA Set A

HY-RS06416

Hsp90aa1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90aa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsp90aa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90aa1 Mouse Pre-designed siRNA Set A Hsp90aa1 Mouse Pre-designed siRNA Set A

HY-RS06417

Hsp90aa1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90aa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsp90aa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90aa1 Rat Pre-designed siRNA Set A Hsp90aa1 Rat Pre-designed siRNA Set A

HY-RS06418

HSP90AB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90AB1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90AB1 Human Pre-designed siRNA Set A HSP90AB1 Human Pre-designed siRNA Set A

HY-RS06419

HSP90B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90B1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90B1 Human Pre-designed siRNA Set A HSP90B1 Human Pre-designed siRNA Set A

HY-115997

*PROTAC HSP90* degrader BP3**	PROTACs HSP	Cancer
PROTAC HSP90 degrader BP3 is a potent and selective degradation of *HSP90* in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain degradation effect on *HSP90* protein in MCF-7 cells (DC₅₀=0.99 μM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell . PROTAC HSP90 degrader BP3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151337

*Aha1/Hsp90-IN-1*	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology
Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC₅₀ of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation .

HY-146212

*HDAC/HSP90-IN-4*	HDAC HSP	Cancer
These compounds have strong hdac and *hsp90* inhibitory activities. Compound 20 (HDAC ic₅₀   =   194   nm; Hsp90 α < b> Ic₅₀ =   153   nm) and compound 26 ((HDAC ic₅₀=   360   nm; Hsp90 α < b> Ic₅₀   =   77   nm) shows the strongest HDAC and HSP90 α Inhibitory activity. Both compounds can induce *hsp90* expression and down regulate *hsp90* client proteins, which play an important role in regulating the survival and invasion of cancer cells.

HY-163288

*EZH2/HSP90-IN-29*	Histone Methyltransferase HSP Apoptosis	Cancer
EZH2/HSP90-IN-29 is a dual inhibitor for EZH2 and *HSP90, with IC₅₀s of 6.29 nM and 60.1 nM, for EZH2 and HSP90, respectively. EZH2/HSP90-IN-29 increases apoptosis/necrosis-related gene expression, induces cell cycle arrest at M phase and inhibits reactive oxygen species (ROS) catabolism pathway. EZH2/HSP90*-IN-29 is able to cross the blood-brain-barrier (BBB) .

HY-150774

*HDAC6/HSP90-IN-2*	HDAC HSP Apoptosis	Cancer
HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and *Hsp90, with IC₅₀s of 105.7 and 61 nM, respectively. HDAC6/HSP90*-IN-2 can be used for the research of cancer .

HY-158131

*FKBP51-Hsp90-IN-2*	FKBP HSP	Neurological Disease Cancer
FKBP51-Hsp90-IN-2 (Compound E08) is a selective *FKBP51-Hsp90* protein-protein interaction inhibitor with IC₅₀ values of 0.4 µM and 5 µM for FKBP51 and FKBP52, respectively. FKBP51-Hsp90-IN-2 also effectively stimulates cellular energy metabolism and neurite growth. FKBP51-Hsp90-IN-2 can be used in research on neurodegenerative diseases and cancer .

HY-146293

*HDAC6/HSP90-IN-1*	HDAC HSP	Cancer
HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and *HSP90, with IC₅₀* values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice .

HY-144694

*HDAC/HSP90-IN-3*	HSP HDAC Fungal	Infection
HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal *Hsp90* and HDAC dual inhibitor, with IC₅₀ values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1 .

HY-155577

*MAO A/HSP90-IN-1*	Monoamine Oxidase HSP	Cancer
MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC₅₀ value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research .

HY-155580

*MAO A/HSP90-IN-2*	Monoamine Oxidase HSP	Cancer
MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of *HSP90*and MAO A with the IC₅₀ values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases *HSP70* expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape ^[1].

HY-125759

3-Phenyltoxoflavin	HSP	Cancer
3-Phenyltoxoflavin, a derivative of Toxoflavin, is an *Hsp90* inhibitor, with a K_d of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity .

HY-106723

AMP-PCP	HSP	Cancer
AMP-PCP is an ATP analogue and can bind to *Hsp90* N-terminal domain with a K_d value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of *Hsp90* .

HY-106723A

AMP-PCP disodium	HSP	Cancer
AMP-PCP disodium is an ATP analogue and can bind to *Hsp90* N-terminal domain with a K_d value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of *Hsp90* .

HY-119906

Conglobatin FW-04-806	HSP Apoptosis	Cancer
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active *Hsp90* inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-107577

Gedunin	HSP	Infection Inflammation/Immunology Cancer
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent *Hsp90* inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research .

HY-139301

DDO-5936

HSP Cancer

DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer .

DDO-5936	HSP	Cancer
DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer .

HY-13757AS

Tamoxifen-d5 ICI 47699-d5; (Z)-Tamoxifen-d₅; trans-Tamoxifen-d₅	Estrogen Receptor/ERR HSP Autophagy Apoptosis	Cancer
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

HY-151335

KU-177	HSP	Cancer
KU-177 is a potent inhibitor of *Hsp90* ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts *Aha1/Hsp90* interactions (IC₅₀=4.08 μM) without inhibition of Hsp90’s ATPase activity. KU-177 can be used for tauopathies research .

HY-10210

Retaspimycin Hydrochloride

3 Publications Verification

IPI-504
HSP Cancer

Retaspimycin Hydrochloride is a potent inhibitor of Hsp90 with EC₅₀s of 119 nM for both Hsp90 and Grp9.
HY-10389

Alvespimycin

10+ Cited Publications

17-DMAG; NSC 707545
HSP Cancer

Alvespimycin (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC₅₀ of 62 ± 29 nM.
HY-15263

Retaspimycin

HSP Cancer

Retaspimycin is a potent inhibitor of Hsp90, with EC₅₀s of 119 nM for both Hsp90 and Grp9.

Retaspimycin Hydrochloride 3 Publications Verification IPI-504	HSP	Cancer
Retaspimycin Hydrochloride is a potent inhibitor of *Hsp90* with EC₅₀s of 119 nM for both Hsp90 and Grp9.

Alvespimycin 10+ Cited Publications 17-DMAG; NSC 707545	HSP	Cancer
Alvespimycin (17-DMAG) is a potent inhibitor of *Hsp90, binding to Hsp90* with an EC₅₀ of 62 ± 29 nM.

HY-10214

SNX-2112 2 Publications Verification PF-04928473	HSP Autophagy	Cancer
SNX-2112 (PF 04928473) is an orally active *Hsp90* inhibitor, with a K_d of 16 nM for *Hsp90* and IC₅₀s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC₅₀s of 10 nM, 4.275 μM and 0.862 μM, respectively . SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with K_ds of 4 nM, 6 nM and 484 nM, respectively .

HY-149780

Flavokawain 1i

DiNap
HSP Cancer

Flavokawain 1i (DiNap) is an Hsp90 inhibitor. Flavokawain 1i (DiNap) has anti-cell proliferation activity and can be used in cancer research .

HY-12024

Alvespimycin hydrochloride 10+ Cited Publications 17-DMAG hydrochloride; KOS-1022; BMS 826476	HSP Apoptosis	Cancer
Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of *Hsp90, binding to Hsp90* with EC₅₀ of 62±29 nM.

Cat. No.	Product Name	Type

HY-133705

Geldanamycin-FITC	Fluorescent Dyes/Probes
Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90 .

HY-122878

HS-131	Fluorescent Dyes/Probes
HS-131, a near infrared dye tethered *Hsp90* inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers .

Cat. No.	Product Name	Target	Research Area

HY-P1750A

Shepherdin (79-87) (TFA)	HSP Survivin	Cancer
Shepherdin (79-87) TFA is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity .

HY-P1750

Shepherdin (79-87)	HSP Survivin	Cancer
Shepherdin (79-87) is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity .

Cat. No.	Product Name	Target	Research Area

HY-P9962

Efungumab	Fungal	Infection
Efungumab is a monoclonal antibody with antifungal activity. Efungumab binds to HSP 90, preventing a conformational change needed for fungal viability. Efungumab can be used for research on invasive candidiasis (IC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107577

Gedunin	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	HSP
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent *Hsp90* inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research .

HY-N3417

Kongensin A	Classification of Application Fields Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Croton kongensis Gagnep.	HSP RIP kinase Apoptosis Necroptosis
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent *HSP90* inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications .

HY-N0754

Eupalinolide A	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Inflammation/Immunology	HSP
Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90 .

HY-119906

Conglobatin FW-04-806	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HSP Apoptosis
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active *Hsp90* inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-N10393

Vibsanin A	Structural Classification Natural Products Classification of Application Fields Viburnaceae Source classification Viburnum awabuki K. Koch Plants Disease Research Fields Cancer	PKC HSP
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a *HSP90* inhibitor .

HY-15230

Geldanamycin Maximum Cited Publications 21 Publications Verification	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Inflammation/Immunology Disease Research Fields	HSP Bacterial Influenza Virus Antibiotic
Geldanamycin is a *Hsp90* inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	HSP Endogenous Metabolite
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90) .

HY-B0425A

Novobiocin sodium 5 Publications Verification Albamycin sodium; Cathomycin sodium	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Cancer	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-108486

Herbimycin A	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-N10502

Colletofragarone A2	Other Terpenoids Structural Classification Microorganisms Terpenoids	MDM-2/p53 HSP
Colletofragarone A2 can be be isolated from the fungus Colletotrichum sp. (13S020). Colletofragarone A2 inhibits mutant p53 and *HSP90* with anti-cancer activity. Colletofragarone A2 promotes degradation and aggregation of mutant p53 and suppressing tumor growth in vivo .

HY-13425

Deguelin 5 Publications Verification (-)-Deguelin; (-)-cis-Deguelin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Isoflavanones Source classification Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Akt Autophagy Apoptosis
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N6769

Radicicol 3 Publications Verification Monorden	Structural Classification Antifungal Classification of Application Fields Source classification Marine natural products Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Disease Research Fields Marine microorganism	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of *Hsp90* with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

HY-B1434

7-Aminocephalosporanic acid 1 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a *HSP90β* inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

Species:	Human (3) Mouse (2)
Tag:	SUMO (1) His (3) Tag Free (1) GST (3)
Source:	Sf9 insect cells (4) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75364

	CDC37 Protein, Human (sf9, GST) Hsp90 co-chaperone Cdc37; CDC37; CDC37A	Human	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds multiple kinases and promotes their interaction with the Hsp90 complex, resulting in stability and enhanced activity. CDC37 Protein, Human (sf9, GST) is the recombinant human-derived CDC37 protein, expressed by Sf9 insect cells , with C-GST labeled tag. The total length of CDC37 Protein, Human (sf9, GST) is 378 a.a., with molecular weight of ~70.7 kDa.

HY-P72238

	HSP90AA1 Protein, Human (His-SUMO) Heat shock 86 kDa; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein Hsp 90 alpha ; Heat shock protein Hsp 90 beta; Heat shock protein Hsp 90-alpha; HS90A_HUMAN; Hsp 84; Hsp 86; Hsp 90; Hsp86; Hsp90A; Hsp90AA1; Hsp90AB1; Hsp90B; HspC1; HspC2; HspCAL1 ; HspCAL4; Renal carcinoma antigen NY-REN-38	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HSP90AA1 Protein, Human (His-SUMO) is 224 a.a., with molecular weight of ~43 kDa.

HY-P75363

	CDC37 Protein, Mouse (sf9) Hsp90 co-chaperone Cdc37; CDC37; CDC37A	Mouse	Sf9 insect cells
	CDC37 protein, a co-chaperone, binds to kinases and promotes their interaction with the Hsp90 complex, stabilizing and activating them. It inhibits HSP90AA1's ATPase activity. CDC37 likely forms a complex with HSP90, HSP70, STIP1/HOP, PPP5C, PTGES3/p23, TSC1, and TSC2. This complex may include CDK4, AKT, RAF1, and NR3C1 but lacks STIP1/HOP and PTGES3/p23. CDC37 also forms a separate complex with Hsp90/HSP90AB1 and CDK6. It interacts with HSP90AA1, AR, CDK4, CDK6, EIF2AK1, RB1, KSR1, FLCN, FNIP1, and FNIP2. CDC37 Protein, Mouse (sf9) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of CDC37 Protein, Mouse (sf9) is 379 a.a., with molecular weight of ~46 kDa.

HY-P75362

	CDC37 Protein, Mouse (sf9, His-GST) Hsp90 co-chaperone Cdc37; CDC37; CDC37A	Mouse	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CDC37 Protein, Mouse (sf9, His-GST) is 379 a.a., with molecular weight of ~66 kDa.

HY-P72051

	HSP90AA1 Protein, Sus scrofa (Baculovirus, His) Hsp90AA1; Hsp90A; HspCAHeat shock protein Hsp 90-alpha	Others	Sf9 insect cells
	HSP90AA1 is a molecular chaperone that regulates target proteins involved in cell cycle control and signal transduction. It interacts with co-chaperones to regulate substrate recognition and chaperone function. HSP90AA1 Protein, Sus scrofa (Baculovirus, His) is the recombinant HSP90AA1 protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of HSP90AA1 Protein, Sus scrofa (Baculovirus, His) is 146 a.a., with molecular weight of ~19.7 kDa.

HY-P71537

	TRAP1 Protein, Human (GST) Heat shock protein 75kDa; Heat shock protein 75kDa, mitochondrial; Hsp 75; Hsp75; Hsp90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein	Human	E. coli
	As a chaperone with ATPase activity, TRAP1 protein plays a crucial role in protecting mitochondrial function and polarization, especially downstream of PINK1 and mitochondrial complex I. TRAP1 acts as a negative regulator of mitochondrial respiration, affecting the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1 Protein, Human (GST) is the recombinant human-derived TRAP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRAP1 Protein, Human (GST) is 249 a.a., with molecular weight of ~54.5 kDa.

Cat. No.	Product Name	Chemical Structure

HY-13757AS

Tamoxifen-d5
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[1][2].

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

Cat. No.	Product Name	Application	Reactivity

HY-P80186

Hsp90 alpha Antibody	WB, ICC/IF, IHC-P	Human, Mouse, Monkey
Hsp90 alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Hsp90 alpha. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse, Monkey.

HY-P80187

Hsp90 beta Antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
Hsp90 beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to Hsp90 beta. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80714

Hsp90 alpha/beta Antibody Hsp90AA1; Hsp90A; HspC1; HspCA; Heat shock protein Hsp 90-alpha; Heat shock 86 kDa; Hsp 86; Hsp86; Renal carcinoma antigen NY-REN-38; Hsp90AB1; Hsp90B; HspC2; HspCB; Heat shock protein Hsp 90-beta; Hsp 90; Heat shock 84 kDa; Hsp 84; Hsp84	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
Hsp90 alpha/beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Hsp90 alpha/beta. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83386

p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat

HY-P82880

Hsp75 Antibody (YA2625)

Hsp75; Hsp90L; Trap1
WB, IHC-P, ICC/IF Human
HY-P82774

GRP94 Antibody (YA2519)

Endoplasmin; GRP-94; gp96 homolog; Hsp90B1; GRP 94; TRA1
WB, IHC-P, ICC/IF Human, Mouse

Cat. No.	Product Name		Classification

HY-117395

PU-H54		Alkynes
PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy . PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


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