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Results for "

Human+IL-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CRAC Channel (2) Interleukin Related (5) mRNA (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Inflammation/Immunology (5) Metabolic Disease (1)
Oligonucleotides:	mRNA (2) Interleukin & Receptors (2)

Inhibitors & Agonists

MCE Kits

Inhibitory Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99728

Melredableukin alfa RG7835; RO7049665	Interleukin Related	Metabolic Disease Inflammation/Immunology
Melredableukin alfa (RG7835) is a bivalent conjugate composed of a human IL-2 mutant (T3A, N88D, C125A) and human IgG1. Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models. Melredableukin alfa can be used in research related to ulcerative colitis and autoimmune hepatitis ^[2].

HY-113618B

RO2959 monohydrochloride	CRAC Channel Interleukin Related	Cardiovascular Disease
RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of *human IL-2* production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways ^[2].

HY-113618A

RO2959 hydrochloride 5 Publications Verification	CRAC Channel Interleukin Related	Cardiovascular Disease
RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 hydrochloride is also a potent inhibitor of *human IL-2* production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways ^[2].

HY-P991678

Efpixileukin alfa XENP-27564; XMAB-27564	Interleukin Related	Inflammation/Immunology
Efpixileukin alfa is a fusion protein that combines human IL-2 variant fused at the C-terminus to human immunoglobulin G1 (IgG1) Fc fragment. Efpixileukin alfa is an immunomodulator .

HY-P991696

Lecomkafusp alfa	Interleukin Related	Inflammation/Immunology Cancer
Lecomkafusp alfa is a fusion protein that combines human IL-2 fused via a protease cleavable peptide linker to a humanized single-domain VHH fragment anti-ALB (149-263). Lecomkafusp alfa is an immunomodulator and has antineoplastic activity .

HY-174611

Human IL2RA mRNA	mRNA	Inflammation/Immunology
Human IL2RA mRNA encodes the human interleukin 2 receptor subunit alpha (IL2RA) protein, a receptor for interleukin-2. IL2RA is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

HY-174625

Human IL2 mRNA	mRNA	Inflammation/Immunology
Human IL2 mRNA encodes the human interleukin 2 (IL2) protein, a member of the interleukin 2 (IL2) cytokine subfamily. IL2 is produced by activated CD4+ and CD8+ T lymphocytes. It is important for the proliferation of T and B lymphocytes.

Cat. No.	Product Name

HY-K2101

*HOLO Human* Interleukin-2 (IL-2) Detection Kit**
MCE HOLO Human Interleukin-2 (IL-2) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-2 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

HY-K2115

*HOLO Human* Interleukin-2 Receptor (IL-2R) Detection Kit**
MCE HOLO Human Interleukin-2 Receptor (IL-2R) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-2R concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Cat. No.	Product Name	Target	Research Area	Image

HY-P99728

Melredableukin alfa RG7835; RO7049665	Interleukin Related	Metabolic Disease Inflammation/Immunology
Melredableukin alfa (RG7835) is a bivalent conjugate composed of a human IL-2 mutant (T3A, N88D, C125A) and human IgG1. Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models. Melredableukin alfa can be used in research related to ulcerative colitis and autoimmune hepatitis ^[2].

HY-P991678

Efpixileukin alfa XENP-27564; XMAB-27564	Interleukin Related	Inflammation/Immunology
Efpixileukin alfa is a fusion protein that combines human IL-2 variant fused at the C-terminus to human immunoglobulin G1 (IgG1) Fc fragment. Efpixileukin alfa is an immunomodulator .

HY-P991696

Lecomkafusp alfa	Interleukin Related	Inflammation/Immunology Cancer
Lecomkafusp alfa is a fusion protein that combines human IL-2 fused via a protease cleavable peptide linker to a humanized single-domain VHH fragment anti-ALB (149-263). Lecomkafusp alfa is an immunomodulator and has antineoplastic activity .

Cat. No.	Product Name		Classification

HY-174611

Human IL2RA mRNA		mRNA Interleukin & Receptors
Human IL2RA mRNA encodes the human interleukin 2 receptor subunit alpha (IL2RA) protein, a receptor for interleukin-2. IL2RA is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

HY-174625

Human IL2 mRNA		mRNA Interleukin & Receptors
Human IL2 mRNA encodes the human interleukin 2 (IL2) protein, a member of the interleukin 2 (IL2) cytokine subfamily. IL2 is produced by activated CD4+ and CD8+ T lymphocytes. It is important for the proliferation of T and B lymphocytes.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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