Search Result

Results for "

Hypothalamic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) CRFR (3) Dopamine Receptor (1) Endogenous Metabolite (3) ERK (1) Free Fatty Acid Receptor (1) G protein-coupled Bile Acid Receptor 1 (3) GCGR (1) GHSR (2) GnRH Receptor (1) HIV (1) Melanocortin Receptor (1) MMP (1) Neurokinin Receptor (1) Neuropeptide Y Receptor (1) NF-κB (1) Orexin Receptor (OX Receptor) (1) Oxytocin Receptor (2) Prostaglandin Receptor (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (4) Endocrinology (15) Infection (1) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (15)

By Targets:

5-HT Receptor (2)

CRFR (3)

Dopamine Receptor (1)

Endogenous Metabolite (3)

ERK (1)

Free Fatty Acid Receptor (1)

G protein-coupled Bile Acid Receptor 1 (3)

GCGR (1)

GHSR (2)

GnRH Receptor (1)

HIV (1)

Melanocortin Receptor (1)

MMP (1)

Neurokinin Receptor (1)

Neuropeptide Y Receptor (1)

NF-κB (1)

Orexin Receptor (OX Receptor) (1)

Oxytocin Receptor (2)

Prostaglandin Receptor (1)

Reactive Oxygen Species (1)

By Research Areas:

Cancer (4)

Endocrinology (15)

Infection (1)

Inflammation/Immunology (1)

Metabolic Disease (3)

Neurological Disease (15)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130223

11β-Prostaglandin E2 11β-Dinoprostone; 11β-PGE2	Prostaglandin Receptor	Endocrinology
11β-Prostaglandin E2 (11β-Dinoprostone), a Prostanoid derivative, inhibits [ ^3H]PGE₂ binding to hypothalamic membranes in the rat with a K_i of 53.3 nM .

HY-P0089A

Human growth hormone-releasing factor TFA Growth Hormone Releasing Factor human TFA; Somatorelin (1-44) amide (human) (TFA)	GHSR	Endocrinology
Human growth hormone-releasing factor TFA (Growth Hormone Releasing Factor human TFA) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary .

HY-P3685

[Met(O)21] Corticotropin Releasing Factor, ovine	CRFR	Endocrinology
[Met(O)21] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor isolated from ovine hypothalamic extracts. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH) .

HY-P0089

Human growth hormone-releasing factor Growth Hormone Releasing Factor human; Somatorelin (1-44) amide (human)	GHSR	Endocrinology
Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary .

HY-117787

TUG-905	Free Fatty Acid Receptor	Neurological Disease Metabolic Disease
TUG-905 is a potent GPR40 agonist with an pEC₅₀ value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression .

HY-P1303

CART(62-76)(human,rat)	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain .

HY-P1303A

CART(62-76)(human,rat) TFA	5-HT Receptor	Neurological Disease
CART(62-76)(human,rat) TFA is a neuropeptide (62-76 residues of the CART peptide) with neurotransmitter-like effects. CART(62-76)(human,rat) TFA can modulate the activity of striatal noradrenergic and corticostriatal and hypothalamic serotoninergic (5-HT) system in the rat brain .

HY-17571

Oxytocin Maximum Cited Publications 11 Publications Verification α-Hypophamine; Oxytocic hormone	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-17571A

Oxytocin acetate Maximum Cited Publications 11 Publications Verification α-Hypophamine acetate; Oxytocic hormone acetate	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-P3683

a-Helical Corticotropin Releasing Factor (12-41)	CRFR	Endocrinology
a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect .

HY-P3684

[DPro5] Corticotropin Releasing Factor, human, rat	CRFR	Endocrinology
[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .

HY-118064

(R)-Thionisoxetine LY-368975	Others	Neurological Disease
(R)-Thionisoxetine is a potent and selective inhibitor of central and peripheral norepinephrine (NE) uptake. (R)-thionisoxetine prevented hypothalamic NE depletion by 6-hydroxydopamine with an ED₅₀ of 0.21 mg/kg. (R)-Thionisoxetine can be used for the research of a variety of diseases including depression and urinary incontinence .

HY-P2277

PEN (rat)	G protein-coupled Bile Acid Receptor 1	Neurological Disease
PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83 .

HY-P2278

PEN (human) 1 Publications Verification	G protein-coupled Bile Acid Receptor 1	Neurological Disease
PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83 .

HY-P4675

LHRH free acid	GnRH Receptor	Endocrinology
LHRH (free acid), the luteinizing hormone-releasing hormone, is a neuropeptide hypothalamic. LHRH regulates reproduction. LHRH can be used for the research of cancer .

HY-P2277A

PEN (rat) (TFA)	G protein-coupled Bile Acid Receptor 1	Neurological Disease
PEN (rat) TFA, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83 .

HY-119332

3-Keto petromyzonol	Others	Endocrinology
3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey .

HY-P4815

Prokineticin 2 Isoform 2 (human)	Endogenous Metabolite	Neurological Disease Metabolic Disease
Prokineticin 2 Isoform 2 (human) is a hypothalamic neuropeptide. Prokineticin 2 Isoform 2 (human) decreases food intake and involves in thermoregulation and energy metabolism in rodents. Prokineticin 2 has the potential for the research of hyperglycemia, metabolic syndrome (MetS) and obesity .

HY-18678

Bremelanotide PT-141	Melanocortin Receptor	Endocrinology
Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

HY-B1811

Vasopressin 4 Publications Verification
Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .

HY-P1250

RFRP-3(human) Neuropeptide VF(124-131)(human)	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca ²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM .

HY-106224B

Orexin A (human, rat, mouse) (acetate) 3 Publications Verification Hypocretin-1 (human, rat, mouse) (acetate)	Orexin Receptor (OX Receptor)	Neurological Disease
Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate is also an OX1R agonist that induces the expression of BDNF and TH proteins in SH-SY5Y cells in a time- and dose-dependent manner. Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging .

HY-P3539

Exendin-4 (3-39)	GCGR	Neurological Disease Endocrinology
Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis .

HY-A0068

Aurothioglucose 1 Publications Verification Gold thioglucose	NF-κB HIV Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .

HY-B1904A

Fluphenazine decanoate dihydrochloride	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate dihydrochloride is a dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .

Cat. No.	Product Name	Target	Research Area