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Results for "

I��B��

" in MCE Product Catalog:

By Targets:	Adenosine Receptor (5) Apoptosis (1) Autophagy (1) Bacterial (1) CDK (2) Cholinesterase (ChE) (2) DNA/RNA Synthesis (4) ERK (1) Eukaryotic Initiation Factor (eIF) (1) Farnesyl Transferase (1) GSK-3 (1) Nucleoside Antimetabolite/Analog (5) Parasite (1) Potassium Channel (1) ROCK (1) Sodium Channel (3) Topoisomerase (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (6) Infection (3) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-N0557

Isoescin IB
Others Cancer

Isoescin IB is an isomer of Escin IB. Isoescin IB and Escin IB are the chief active ingredients in escin.

Isoescin IB	Others	Cancer
Isoescin IB is an isomer of Escin IB. Isoescin IB and Escin IB are the chief active ingredients in escin.

HY-145441

GEM–IB	Others	Cancer
GEM–IB is the conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB). GEM–IB as a single agent or in combination with Docetaxel (DTX) demonstrates reduced tumor burden, preservation of the bone architecture, and improved the survival in a murine model of osteosarcoma (OS).

HY-N0555

Escin IB	Others	Metabolic Disease
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.

HY-N2211

Picfeltarraenin IB	Cholinesterase (ChE)	Cancer Infection Inflammation/Immunology
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.

HY-N8755

Chikusetsusaponin Ib
Cholinesterase (ChE) Neurological Disease

Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.

Chikusetsusaponin Ib	Cholinesterase (ChE)	Neurological Disease
Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.

HY-W008848S1

DMT-dG(ib) Phosphoramidite-15N5	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
DMT-dG(ib) Phosphoramidite-¹⁵N₅ is the ¹⁵N labeled DMT-dG(ib) Phosphoramidite[1]. DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA[2].

HY-W008848

DMT-dG(ib) Phosphoramidite
DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others

DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA.

DMT-dG(ib) Phosphoramidite	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Others
DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA.

HY-W008848S

DMT-dG(ib) Phosphoramidite-13C10,15N5	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
DMT-dG(ib) Phosphoramidite-¹³C₁₀,¹⁵N₅ is the ¹³C and ¹⁵N labeled DMT-dG(ib) Phosphoramidite[1]. DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA[2].

HY-112654

GCN2iB	Eukaryotic Initiation Factor (eIF) Autophagy	Cancer
GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC₅₀ of 2.4 nM.

HY-P1602

Apidaecin IB	Bacterial	Infection
Apidaecin IB is a insect antimicrobial peptide, with minimum inhibitory concentration (MIC) values of 8 μM for E. coli (ML35, O18K1H7 and ATCC 25922).

HY-130517

Cdc7-IN-5	CDK	Cancer
Cdc7-IN-5 (compound I-B) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I-B. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle.

HY-125027

Isobutyl-deoxynyboquinone IB-DNQ	Others	Cancer
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer.

HY-104014

DMT-2'O-MOE-rG(ib) Phosphoramidite	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Others
DMT-2'O-MOE-rG(ib) Phosphoramidite (1g), belonging to the amide family of trivalent phosphate H3PO3, is a derivative of nucleotides and guanosine and can be used in the stereochemical synthesis of phosphorothioate oligonucleotides.

HY-13591

Piclidenoson IB-MECA; CF-101	Adenosine Receptor Apoptosis	Cancer Inflammation/Immunology
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19.

HY-153011

ROCK-IN-5	ROCK ERK GSK-3	Neurological Disease Cardiovascular Disease
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK, ERK, GSK, and AGC protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research.

HY-45492

DMT-2'Fluoro-DG(IB) Amidite 2'-F-ibu-dG Phosphoramidite	Nucleoside Antimetabolite/Analog	Others
DMT-2'Fluoro-DG(IB) Amidite (2'-F-ibu-dG Phosphoramidite) is a nucleoside that can be used in the preparation of 4'-modified 2'-deoxy-2'-fluorouridine.

HY-130515

Cdc7-IN-3	CDK	Cancer
Cdc7-IN-3 (compound I-A) is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1, compound I-B. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle.

HY-A0236A

Aprindine hydrochloride	Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na⁺/Ca²⁺ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias treatment research.

HY-A0093

Mexiletine hydrochloride KOE-1173 hydrochloride	Sodium Channel	Cardiovascular Disease
Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker.

HY-A0093S

Mexiletine-d6 hydrochloride KOE-1173-d₆ (hydrochloride)	Sodium Channel	Cardiovascular Disease
Mexiletine-d₆ (hydrochloride) is a deuterium labeled Mexiletine hydrochloride (KOE-1173 hydrochloride). Mexiletine hydrochloride, a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1].

HY-A0093S1

Mexiletine-d3 hydrochloride KOE-1173-d₃ (hydrochloride)	Sodium Channel	Cardiovascular Disease
Mexiletine-d₃ (hydrochloride) is deuterium labeled Mexiletine (hydrochloride). Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1][2].

HY-12365

Namodenoson CF-102; 2-Cl-IB-MECA	Adenosine Receptor	Cancer
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.

HY-N6054

Niranthin	Parasite Topoisomerase	Infection Inflammation/Immunology
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis treatment.

HY-103174

MRS1334	Adenosine Receptor	Cardiovascular Disease
MRS1334 is a potent and selective human adenosine A₃ receptor antagonist with K_is of 2.69 nM, >100 nM, >100 nM for hA₃, rA₁, rA_2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment.

HY-128044

Ftase inhibitor I B581	Farnesyl Transferase	Cancer
Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras).

HY-151899

A3AR modulator 1	Adenosine Receptor	Inflammation/Immunology
A3AR modulator 1 (MRS8054) is an orally active A3 adenosine receptor (A3AR) (Adenosine Receptor) positive allosteric modulator (PAM). A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [³⁵S]GTPγS binding E_max.

HY-134422

Isobutyryl coenzyme A lithium salt Isobutyryl-CoA sodium salt		Others
Isobutyryl coenzyme A lithium salt (Quin 2,tetrapotassium salt) is a kind of Coenzyme A. Coenzyme A acts as an acyl carrier, namely acetyl-CoA. Isobutyryl-CoA (IB-CoA) is a short-chain branched acyl-CoA that provides the starting unit for myxalamid B biosynthesis. Isobutyryl-CoA was used as a substrate to study the specificity and kinetics of isobutyryl-CoA (CoA) mutase (EC 5.4.99.13).

HY-103178

MRE3008F20	Adenosine Receptor	Inflammation/Immunology
MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A₃ receptor (AA₃R) antagonist (K_i=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC₅₀ value of 5 nM. MRE3008F20 can be used in the study of AA3R.

Cat. No.	Product Name	Type

HY-W008848

DMT-dG(ib) Phosphoramidite
Gene Sequencing and Synthesis

DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA.

DMT-dG(ib) Phosphoramidite	Gene Sequencing and Synthesis
DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA.

HY-134422

Isobutyryl coenzyme A lithium salt Isobutyryl-CoA sodium salt	Biochemical Assay Reagents
Isobutyryl coenzyme A lithium salt (Quin 2,tetrapotassium salt) is a kind of Coenzyme A. Coenzyme A acts as an acyl carrier, namely acetyl-CoA. Isobutyryl-CoA (IB-CoA) is a short-chain branched acyl-CoA that provides the starting unit for myxalamid B biosynthesis. Isobutyryl-CoA was used as a substrate to study the specificity and kinetics of isobutyryl-CoA (CoA) mutase (EC 5.4.99.13).

Cat. No.	Product Name	Target	Category

HY-N0557

Isoescin IB	Others	Terpenoids Other Terpenoids Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Isoescin IB is an isomer of Escin IB. Isoescin IB and Escin IB are the chief active ingredients in escin.

HY-N0555

Escin IB	Others	Triterpenes Terpenoids Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants Hippocastanaceae Aesculus hippocastanum
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.

HY-N2211

Picfeltarraenin IB	Cholinesterase (ChE)	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Infection Inflammation/Immunology Source classification Plants Scrophulariaceae Scrophularia ningpoensis Hemsl.
Picfeltarraenin IB, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.

HY-N8755

Chikusetsusaponin Ib	Cholinesterase (ChE)	Terpenoids Triterpenes Source classification Plants other families
Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.

HY-N6054

Niranthin	Parasite Topoisomerase	Phenylpropanoids Lignans Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields Source classification Plants Euphorbiaceae Phyllanthus amarus chumacher & Thonning
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis treatment.

Species:	Human (14) Rhesus Macaque (2) Rat (2) Mouse (4) E.coli (1) Cynomolgus (1)
Tag:	His (10) SUMO (1) Avi (1) Fc (5)
Source:	HEK293 (21) E. coli (3)

Cat. No.	Product Name	Species	Source

HY-P77323

CD42c Protein, Rat (HEK293, Fc)
Platelet glycoprotein Ib beta chain; GP-Ib beta; GP1BB
Rat HEK293
HY-P76485

MAN1A2 Protein, Human (HEK293, His)
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Alpha-1,2-mannosidase IB; MAN1B
Human HEK293
HY-P71212

PLA2G1B Protein, Mouse (131a.a, HEK293, His)
Phospholipase A2; Group IB phospholipase A2; PLA2-Ib; Phosphatidylcholine 2-acylhydrolase 1B; Pla2g1b; Pla2
Mouse HEK293

HY-P76718

Activin RIB/ALK-4 Protein, Rat (HEK293, Fc) Activin Receptor IB; ALK-4; Activin RIB; ACVR1B	Rat	HEK293
Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Rat (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 126 amino acids (M1-E126).

HY-P7485

Activin RIB/ALK-4 Protein, Human (HEK293, His) rHuActivin Receptor IB, His; ALK-4; Activin RIB; ACVR1B	Human	HEK293
Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 103 amino acids (S24-E126).

HY-P75571

Activin RIB/ALK-4 Protein, Human (HEK293, Fc) Activin Receptor IB, His; ALK-4; Activin RIB; ACVR1B	Human	HEK293
Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 126 amino acids (M1-E126).

HY-P77294

Activin RIB/ALK-4 Protein, Rhesus Macaque (HEK293, Fc) Activin Receptor IB; ALK-4; Activin RIB; ACVR1B	Rhesus Macaque	HEK293
Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Rhesus Macaque (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 126 amino acids (M1-E126).

HY-P7486

Activin RIB/ALK-4 Protein, Mouse (HEK293, Fc) rMuActivin Receptor IB, C-Fc; ALK-4; Activin RIB; ACVR1B	Mouse	HEK293
Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 95 amino acids (L32-E126).

HY-P75572

Activin RIB/ALK-4 Protein, Human (HEK293, His-Fc) Activin Receptor IB, His; ALK-4; Activin RIB; ACVR1B	Human	HEK293
Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Human (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 126 amino acids (M1-E126).

HY-P76804

CD42b/GP1BA Protein, Human (519a.a, HEK293, His)
Platelet glycoprotein Ib alpha; GP1BA
Human HEK293
HY-P76805

CD42c/GP1BB Protein, Human (HEK293, His)
Platelet glycoprotein Ib beta chain; GPIb-beta; CD42b-beta
Human HEK293
HY-P71511

Gamma-GCS Protein, E.coli (His-SUMO)
gshA; gsh-I; b2688; JW2663Glutamate--cysteine ligase; EC 6.3.2.2; Gamma-ECS; GCS; Gamma-glutamylcysteine synthetase
E.coli E. coli
HY-P71071

PLA2G1B Protein, Human (HEK293, His)
PLA2G1B; Phospholipase A2; Group IB phospholipase A2; PLA2; PLA2A; PPLA2
Human HEK293
HY-P77686

CD42c/GP1BB Protein, Mouse (HEK293, Fc)
GP-Ib beta; GPIb-beta; GPIbB; Gp1bb; BDPLT1; BS; CD42c; GP1BB; GPIbb; GPIbbeta
Mouse HEK293
HY-P75976

PLA2G1B Protein, Mouse (146a.a, HEK293, His)
PLA2G1B; Phospholipase A2; Group IB phospholipase A2; PLA2; PLA2A; PPLA2
Mouse HEK293
HY-P77688

HLA-G Complex Protein, Human (HEK293, His-Avi)
HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
Human HEK293
HY-P78455

HLA-G Protein, Human (C66S, His-Avi)
HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
Human E. coli

HY-P77687

HLA-G Complex Tetramer Protein, Cynomolgus (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Cynomolgus	HEK293

HY-P77689

HLA-G Complex Protein, Human (Biotinylated, HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293

HY-P77690

HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi)
HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
Human HEK293

HY-P77691

HLA-G Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293

HY-P77692

HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Rhesus Macaque	HEK293

HY-P71185

PAFAHB Protein, Human (His) Platelet-Activating Factor Acetylhydrolase IB Subunit Beta; PAF Acetylhydrolase 30 kDa Subunit; PAF-AH 30 kDa Subunit; PAF-AH Subunit Beta; PAFAH Subunit Beta; PAFAH1B2; PAFAHB	Human	E. coli

HY-P77951

CD42b/GP1BA Protein, Human (515a.a, HEK293, His)
GP-Ib alpha; GPIb-alpha; GPIbA; GP1BA; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; VWDP; BP1BA; MGC34595
Human HEK293

Cat. No.	Product Name

HY-W008848S1

DMT-dG(ib) Phosphoramidite-15N5

DMT-dG(ib) Phosphoramidite-¹⁵N₅ is the ¹⁵N labeled DMT-dG(ib) Phosphoramidite[1]. DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA[2].

HY-W008848S

DMT-dG(ib) Phosphoramidite-13C10,15N5
DMT-dG(ib) Phosphoramidite-¹³C₁₀,¹⁵N₅ is the ¹³C and ¹⁵N labeled DMT-dG(ib) Phosphoramidite[1]. DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA[2].

HY-A0093S

Mexiletine-d6 hydrochloride
Mexiletine-d₆ (hydrochloride) is a deuterium labeled Mexiletine hydrochloride (KOE-1173 hydrochloride). Mexiletine hydrochloride, a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1].

HY-A0093S1

Mexiletine-d3 hydrochloride
Mexiletine-d₃ (hydrochloride) is deuterium labeled Mexiletine (hydrochloride). Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1][2].

I��B��

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
Products