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Results for "

IDH1-IN-1

" in MCE Product Catalog:

By Targets:	Apoptosis (1) Bacterial (1) Fungal (1) Isocitrate Dehydrogenase (IDH) (2) Reactive Oxygen Species (1) Virus Protease (1)
By Research Areas:	Cancer (3)

3

Inhibitors & Agonists

1

Natural
Products

Targets Recommended: AIM2

Cat. No.	Product Name	Target	Research Areas

Mutant IDH1-IN-1	Isocitrate Dehydrogenase (IDH)	Cancer
Mutant IDH1-IN-1 is a mutant-selective *IDH1* inhibitor with with IC₅₀s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

alpha-Mangostin α-MangostIN	Reactive Oxygen Species Apoptosis Bacterial Fungal Virus Protease	Cancer
alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a K_i of 2.85 μM.

*IDH1 Inhibitor 1*	Isocitrate Dehydrogenase (IDH)	Cancer
IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant *IDH1* inhibitor with IC₅₀s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1 R132H, IDH1 R132C, and IDH1 WT, respectively. Anticancer activity.

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