Search Result

Results for "

IKK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IKK (68) Akt (4) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (4) Apoptosis (17) Autophagy (9) Bacterial (4) Caspase (2) COX (4) Fungal (4) IAP (1) Integrin (2) Isotope-Labeled Compounds (3) Keap1-Nrf2 (4) Lipoxygenase (1) LRRK2 (2) MAPKAPK2 (MK2) (2) Mitophagy (4) Na+/H+ Exchanger (NHE) (1) NF-κB (11) NO Synthase (2) p38 MAPK (1) PDK-1 (1) Phosphodiesterase (PDE) (3) PROTACs (2) Sirtuin (4) Sodium Channel (2) SphK (2) STAT (2) TNF Receptor (1) ULK (3)
By Research Areas:	Cancer (45) Cardiovascular Disease (3) Infection (4) Inflammation/Immunology (56) Metabolic Disease (2) Neurological Disease (3)

By Targets:

IKK (68)

Akt (4)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (4)

Apoptosis (17)

Autophagy (9)

Bacterial (4)

Caspase (2)

COX (4)

Fungal (4)

IAP (1)

Integrin (2)

Isotope-Labeled Compounds (3)

Keap1-Nrf2 (4)

Lipoxygenase (1)

LRRK2 (2)

MAPKAPK2 (MK2) (2)

Mitophagy (4)

Na+/H+ Exchanger (NHE) (1)

NF-κB (11)

NO Synthase (2)

p38 MAPK (1)

PDK-1 (1)

Phosphodiesterase (PDE) (3)

PROTACs (2)

Sirtuin (4)

Sodium Channel (2)

SphK (2)

STAT (2)

TNF Receptor (1)

ULK (3)

By Research Areas:

Cancer (45)

Cardiovascular Disease (3)

Infection (4)

Inflammation/Immunology (56)

Metabolic Disease (2)

Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: IKK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13687

IKK 16 15+ Cited Publications	IKK LRRK2	Inflammation/Immunology
IKK 16 is a selective IκB kinase (IKK) inhibitor for *IKK2, IKK* complex and *IKK1* with IC₅₀s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC₅₀ of 50 nM.

HY-13687A

IKK 16 hydrochloride 15+ Cited Publications	IKK LRRK2	Inflammation/Immunology
IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for *IKK2, IKK* complex and *IKK1* with IC₅₀s of 40 nM, 70 nM and 200 nM, respectively . IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC₅₀ of 50 nM .

HY-136392

IKK-IN-3	IKK	Inflammation/Immunology
IKK-IN-3 is a potent and selective IkappaB kinase 2 (IKK2 or IKKβ) inhibitor, with IC₅₀s of 19 and 400 nM for IKK2 and IKK1 (or IKKα), respectively .

HY-112456

IKK2-IN-4

IKK Inflammation/Immunology

IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC₅₀ of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs .
HY-136393

IKK-IN-4

IKK Inflammation/Immunology

IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC₅₀s of 45 and 650 nM for IKKβ and IKKα, respectively .
HY-111135

IKK2-IN-3

IKK Inflammation/Immunology Cancer

IKK2-IN-3 (Compound 8) is an IKK2 inhibitor with an IC₅₀ of 0.075 μM .
HY-13873

IKK-IN-1

1 Publications Verification

IKK Inflammation/Immunology

IKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13.

IKK2-IN-4	IKK	Inflammation/Immunology
IKK2-IN-4 (compound 4) is a potent *IKK-2* inhibitor, with an IC₅₀ of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs .

IKK-IN-4	IKK	Inflammation/Immunology
IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC₅₀s of 45 and 650 nM for IKKβ and IKKα, respectively .

IKK2-IN-3	IKK	Inflammation/Immunology Cancer
IKK2-IN-3 (Compound 8) is an *IKK2* inhibitor with an IC₅₀ of 0.075 μM .

IKK-IN-1 1 Publications Verification	IKK	Inflammation/Immunology
IKK-IN-1 is an inhibitor of *IKK* extracted from patent WO2002024679A1, compound example 18-13.

HY-13060

ACHP Hydrochloride 5+ Cited Publications IKK-2 Inhibitor VIII	IKK	Inflammation/Immunology
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective *IKK-β* inhibitor with an IC₅₀ of 8.5 nM.

HY-10172

IMD-0354 10+ Cited Publications IKK2 Inhibitor V	IKK	Cancer
IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC₅₀ of 1.2 uM .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-163412

IKKβ-IN-3	IKK	Inflammation/Immunology
IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC₅₀ value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis .

HY-146723

IKKβ-IN-1	IKK	Inflammation/Immunology
IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC₅₀ of 0.20 μM. IKKβ-IN-1 can reduce PGE₂ and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality .

HY-138537

NF-κB-IN-1 2 Publications Verification	IKK	Cancer
NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits *IKK* to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	p38 MAPK	Neurological Disease Inflammation/Immunology
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-10518

BMS-345541 hydrochloride 15+ Cited Publications	IKK	Cancer
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of *IKK* (IKK-2 IC₅₀=0.3 μM, *IKK-1* IC₅₀=4 μM). BMS-345541 binds at an allosteric site of IKK.

HY-10519

BMS-345541 15+ Cited Publications	IKK	Cancer
BMS-345541 is a selective inhibitor of the catalytic subunits of *IKK* (IKK-2 IC₅₀=0.3 μM, *IKK-1* IC₅₀=4 μM). BMS-345541 binds at an allosteric site of IKK.

HY-12453

TBK1/IKKε-IN-2

2 Publications Verification

IKK Inflammation/Immunology

TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
HY-138931

TBK1/IKKε-IN-6

IKK Cancer

TBK1/IKKε-IN-6 (example 110) is a TBK1 and IKKε inhibitor, with IC₅₀ values of <100 nM for both TBK1 and IKKε .

TBK1/IKKε-IN-2 2 Publications Verification	IKK	Inflammation/Immunology
TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.

TBK1/IKKε-IN-6	IKK	Cancer
TBK1/IKKε-IN-6 (example 110) is a TBK1 and IKKε inhibitor, with IC₅₀ values of <100 nM for both TBK1 and IKKε .

HY-128679

TBK1/IKKε-IN-5	IKK	Cancer
TBK1/IKKε-IN-5 (compound 1) is an orally active TBK1 and IKKε dual inhibitor, with IC₅₀ values of 1 and 5.6 nM, respectively. TBK1/IKKε-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKε-IN-5 can be used in cancer research, especially in tumour immunity .

HY-13802

SC-514 5 Publications Verification GK 01140	IKK	Cancer
SC-514 is a selective *IKK-2* inhibitor (IC₅₀=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

HY-124652

TBK1/IKKε-IN-4	IKK	Cancer
TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC₅₀ values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR .

HY-U00457

TBK1/IKKε-IN-1

IKK Cancer

TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC₅₀s of <100 nM.

TBK1/IKKε-IN-1	IKK	Cancer
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC₅₀s of <100 nM.

HY-122706

TBK1/IKKε-IN-3	IKK	Metabolic Disease
TBK1/IKKε-IN-3 is a potent IP6K inhibitor with IC₅₀ values of 3, 8.65 and 3.72 μM for IP6K1, IP6K2 and IP6K3, respectively. TBK1/IKKε-IN-3 can be used in the study of obesity diseases. .

HY-135366

HPN-01	IKK	Inflammation/Immunology
HPN-01 is a potent and selective *IKK* inhibitor, with pIC₅₀ values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2 .

HY-14682

GSK319347A 1 Publications Verification	IKK	Inflammation/Immunology
GSK319347A is a dual inhibitor of TBK1 and IKKε with IC₅₀s of 93 nM and 469 nM, respectively. GSK319347A also inhibits *IKK2* with an IC₅₀ of 790 nM.

HY-10074

TPCA-1 20+ Cited Publications	IKK STAT Apoptosis	Inflammation/Immunology Cancer
TPCA-1 is a potent and selective inhibitor of *IKK-2* with IC₅₀ of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.

HY-107591

(Rac)-PF-184	IKK	Inflammation/Immunology
(Rac)-PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC₅₀ of 37 nM. (Rac)-PF-184 has anti-inflammatory effects .

HY-107591A

(Rac)-PF-184 hydrate	IKK	Inflammation/Immunology
(Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC₅₀ of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects .

HY-B0713

Amlexanox 15+ Cited Publications AA673; Amoxanox; CHX3673	IKK	Metabolic Disease
Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC₅₀ of approximately 1-2 μM.

HY-114454

INH14 1 Publications Verification	IKK	Inflammation/Immunology Cancer
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC₅₀s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity .

HY-19362

AZD3264

2 Publications Verification

IKK Inflammation/Immunology

AZD3264 is a selective IkB-kinase IKK2 inhibitor.
HY-50948

Bay 65-1942 hydrochloride

3 Publications Verification

IKK Inflammation/Immunology

Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor.

AZD3264 2 Publications Verification	IKK	Inflammation/Immunology
AZD3264 is a selective IkB-kinase *IKK2* inhibitor.

Bay 65-1942 hydrochloride 3 Publications Verification	IKK	Inflammation/Immunology
Bay 65-1942 hydrochloride is an ATP-competitive and selective IKKβ inhibitor.

HY-133117

BAY-985	IKK	Cancer
BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC₅₀s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy .

HY-18008

PS-1145

2 Publications Verification

IKK Apoptosis Cancer

PS-1145 is an IκB kinase (IKK) inhibitor with an IC₅₀ of 88 nM.

PS-1145 2 Publications Verification	IKK Apoptosis	Cancer
PS-1145 is an IκB kinase (IKK) inhibitor with an IC₅₀ of 88 nM.

HY-19383

Ertiprotafib PTP 112
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC₅₀ of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC₅₀ of ~1 μM for PPARα/PPARβ.

HY-14180

PHA 408	IKK	Inflammation/Immunology
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation .

HY-50949

Bay 65-1942 free base

IKK Inflammation/Immunology

Bay 65-1942 free base is an ATP-competitive and selective IKKβ inhibitor.

Bay 65-1942 free base	IKK	Inflammation/Immunology
Bay 65-1942 free base is an ATP-competitive and selective IKKβ inhibitor.

HY-107591B

PF-184	IKK	Inflammation/Immunology
PF-184 is a potent and selective *IKK-2* inhibitor (IC₅₀: 37 nM) over rhIKK-1, IKKi, and more than 30 tyrosine and serine/threonine kinases. PF-184 can be used in the research of inflammation, such as asthma and chronic obstructive pulmonary disease .

HY-B0788A

LY2409881 trihydrochloride

2 Publications Verification

IKK Apoptosis Cancer

LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.
HY-B0788

LY2409881

IKK Cancer

LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

LY2409881 trihydrochloride 2 Publications Verification	IKK Apoptosis	Cancer
LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

LY2409881	IKK	Cancer
LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

HY-N10768

1-Dehydro-[10]-gingerdione	IKK NF-κB	Inflammation/Immunology
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-N10112

Glabrescone C

IKK Inflammation/Immunology

Glabrescone C possesses potent anti-inflammatory activity by directly bnding to IKKα/β.
HY-13019

BI605906

5+ Cited Publications

IKK Others

BI605906 is a novel IKKβ inhibitor with an IC₅₀ value of 380 nM when assayed at 0.1 mM ATP.
HY-18710

BMS-066

BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC₅₀s of 9 nM and 72 nM, respectively.

Glabrescone C	IKK	Inflammation/Immunology
Glabrescone C possesses potent anti-inflammatory activity by directly bnding to IKKα/β.

BI605906 5+ Cited Publications	IKK	Others
BI605906 is a novel IKKβ inhibitor with an IC₅₀ value of 380 nM when assayed at 0.1 mM ATP.

BMS-066
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC₅₀s of 9 nM and 72 nM, respectively.

HY-N5063

Plantainoside D	Angiotensin-converting Enzyme (ACE) IKK	Cardiovascular Disease
Plantainoside D shows ACE inhibitory activity with IC₅₀ 2.17 mM . And plantainoside D is a promising *IKK-β* inhibitor .

HY-148206

DMX-129

IKK Cancer

DMX-129 is an ΙΚΚε and TBK-1 inhibitor with IC₅₀ values of <30 nM for both TBK1 and IKKε .

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct *IKK* inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N10111

Siegesbeckialide I

IKK Inflammation/Immunology

Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.
HY-50949A

Bay 65-1942 (R form)

IKK Inflammation/Immunology

Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is an ATP-competitive and selective IKKβ inhibitor.

Cat. No.	Product Name	Target	Research Area

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

HY-P1098B

Ac2-26 ammonium 3 Publications Verification	IKK	Inflammation/Immunology
Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .

HY-P1740

RGD peptide (GRGDNP) 3 Publications Verification	Integrin Apoptosis	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation .

HY-P1740A

RGD peptide (GRGDNP) (TFA) 3 Publications Verification	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation .

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5063

Plantainoside D	Cardiovascular Disease Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Scrophulariaceae Phenylpropanoids Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields	Angiotensin-converting Enzyme (ACE) IKK
Plantainoside D shows ACE inhibitory activity with IC₅₀ 2.17 mM . And plantainoside D is a promising *IKK-β* inhibitor .

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Cardiovascular Disease Classification of Application Fields Neurological Disease Anti-aging Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Apocynaceae Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct *IKK* inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	Structural Classification Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants	p38 MAPK
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-N10768

1-Dehydro-[10]-gingerdione	Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-N10112

Glabrescone C	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Pterocarpus macrocarpus Kurz Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	IKK
Glabrescone C possesses potent anti-inflammatory activity by directly bnding to IKKα/β.

HY-N10111

Siegesbeckialide I	Classification of Application Fields Terpenoids Pterocarpus macrocarpus Kurz Sesquiterpenes Source classification Plants Compositae Disease Research Fields Inflammation/Immunology	IKK
Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.

HY-N1949

Homoplantaginin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Phenols Polyphenols Plants Stevia rebaudiana (Bertoni) Bertoni Inflammation/Immunology Disease Research Fields	TNF Receptor NF-κB
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

HY-N11085

Isophysalin A	Structural Classification Natural Products Source classification Plants Solanaceae Alkekengi officinarum Moench	NO Synthase IKK
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity .

HY-13425

Deguelin 5 Publications Verification (-)-Deguelin; (-)-cis-Deguelin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Isoflavanones Source classification Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Akt Autophagy Apoptosis
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Flavonoids Leguminosae Source classification Plants Other Flavonoids Erythrina variegata Linn.	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase
1,3,5-Trihydroxy-4-prenylxanthone is a Na ⁺/H ⁺ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-N0551

Wedelolactone 10+ Cited Publications	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-16561

Resveratrol Maximum Cited Publications 77 Publications Verification trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Microorganisms Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-N2435

[8]-Shogaol	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer Zingiberaceae	COX Apoptosis
[8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC₅₀=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC₅₀=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC₅₀=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA).

HY-16561R

Resveratrol (Standard) Maximum Cited Publications 77 Publications Verification trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Source classification Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Species:	Human (5)
Tag:	His (2) Tag Free (1) Strep (1) GST (2)
Source:	Sf9 insect cells (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P701788

	IKKε Protein, Human (Sf9, GST) IKKε; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	Human	Sf9 insect cells
	IKKε protein is a serine/threonine kinase that coordinates the inflammatory response to viral infection by activating type I IFN, NF-kappa-B, and STAT signaling pathways. Upon activation of the viral RNA sensor, IKKε binds to DDX3X and phosphorylates IRF3, IRF7, and DDX3X, resulting in IRF3 nuclear translocation. IKKε Protein, Human (Sf9, GST) is the recombinant human-derived IKKε protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of IKKε Protein, Human (Sf9, GST) is 715 a.a., .

HY-P701786

	IKKβ Protein, Human (Sf9, GST) IKBKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB	Human	Sf9 insect cells
	IKKβ protein is a serine kinase that is critical in the NF-kappa-B signaling pathway and can respond to various stimuli such as cytokines or cellular stress. As part of the classical IKK complex, IKKβ activates NF-kappa-B through phosphorylation inhibitors, leading to its degradation and release of NF-kappa-B for gene transcription. IKKβ Protein, Human (Sf9, GST) is the recombinant human-derived IKKβ protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P701489

	UB2V1 Protein, Human (Sf9) UBE2V1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A	Human	Sf9 insect cells
	The UBE2V1 protein does not have intrinsic ubiquitin ligase activity and can cooperate with UBE2N to synthesize non-canonical polyubiquitin chains linked through Lys-63. This type of polyubiquitination activates IKK and mediates NF-kappa-B activation, thereby affecting transcriptional activation, cell cycle progression, and DNA repair. UB2V1 Protein, Human (Sf9) is the recombinant human-derived UB2V1 protein, expressed by Sf9 insect cells , with tag free. The total length of UB2V1 Protein, Human (Sf9) is 146 a.a., .

HY-P701501

	UB2V1 Protein, Human (Sf9, His, Strep) UBE2V1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A	Human	Sf9 insect cells
	The UBE2V1 protein does not have intrinsic ubiquitin ligase activity and can cooperate with UBE2N to synthesize non-canonical polyubiquitin chains linked through Lys-63. This type of polyubiquitination activates IKK and mediates NF-kappa-B activation, thereby affecting transcriptional activation, cell cycle progression, and DNA repair. UB2V1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UB2V1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UB2V1 Protein, Human (Sf9, His, Strep) is 146 a.a., .

HY-P71410

	UBE2V1 Protein, Human (His) Ubiquitin-Conjugating Enzyme E2 Variant 1; UEV-1; CROC-1; TRAF6-Regulated IKK Activator 1 Beta Uev1A; UBE2V1; CROC1; UBE2V; UEV1; P/OKcl.19	Human	E. coli
	The UBE2V1 protein does not have intrinsic ubiquitin ligase activity and can cooperate with UBE2N to synthesize non-canonical polyubiquitin chains linked through Lys-63. This type of polyubiquitination activates IKK and mediates NF-kappa-B activation, thereby affecting transcriptional activation, cell cycle progression, and DNA repair. UBE2V1 Protein, Human (His) is the recombinant human-derived UBE2V1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of UBE2V1 Protein, Human (His) is 146 a.a., with molecular weight of ~17.0 kDa.

Cat. No.	Product Name	Chemical Structure

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

Cat. No.	Product Name	Application	Reactivity

HY-P80414

IKK alpha + IKK beta Antibody	WB, ICC/IF, IP	Human, Mouse
IKK alpha + IKK beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to IKK alpha + IKK beta. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse.

HY-P80413

IKK alpha Antibody	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
IKK alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to IKK alpha. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse.

HY-P80415

IKK gamma Antibody	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
IKK gamma Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to IKK gamma. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80719

IKK beta Antibody IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ICC/IF	Human, Mouse, Rat
IKK beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to IKK beta. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P81866

IKK epsilon Antibody (YA1611) IKBKE; IKKE; IKKI; KIAA0151; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	WB, IHC-P, ICC/IF, FC	Human

HY-P82126

IKK alpha/beta Antibody (YA1871) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, ICC/IF, IP	Human, Mouse, Rat

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