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IL

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1387

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

221

Inhibitory Antibodies

220

Natural
Products

837

Recombinant Proteins

Isotope-Labeled Compounds

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254

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150051

IL-2-IN-1 1 Publications Verification	Interleukin Related	Inflammation/Immunology
IL-2-IN-1 is a potent *IL-2* inhibitor with an IC₅₀ value of 1978 nM. IL-2-IN-1 shows antiproliferative activities .

HY-102049

IL-15-IN-1	Interleukin Related	Inflammation/Immunology
IL-15-IN-1 (compound 76) is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC₅₀ of 0.8 μM .

HY-139092

IL-4-inhibitor-1 1 Publications Verification	Interleukin Related	Infection Cancer
IL-4-inhibitor-1 (compound 52) is an *IL-4* inhibitor, with an EC₅₀ of 1.81 µM .

HY-160052

IL-6 aptamer sodium	Interleukin Related	Cancer
IL-6 aptamer sodium is a nucleic acid aptamer that specifically targets *IL-6* and can be used for the specific detection of IL-6 .

HY-168084

IL-17-IN-1	Interleukin Related	Inflammation/Immunology
IL-17-IN-1 (26) is an orally active *IL-17* inhibitor, with IC₅₀ values of 0.013 μM and 0.004 μM for IL-17A and IL-6 release, respectively. IL-17-IN-1 (26) effectively reduces knee swelling in a rat arthritis model .

HY-163140

IL-33 probe-1	Interleukin Related	Inflammation/Immunology
IL-33 probe-1 is a fluorescent analogue of the interleukin IL-33_[1].

HY-148272

IL-17A modulator-3	Interleukin Related	Inflammation/Immunology Cancer
IL-17A modulator-3 (compound 253) is a *IL-17A* modulator. IL-17A modulator-3 inhibits IL-17A/A with an IC₅₀ value ＜10 μM. IL-17A modulator-3 can be used for the research of inflammation, cancer and autoimmune disease .

HY-170611

IL-17-IN-3	Interleukin Related	Inflammation/Immunology
IL-17-IN-3 (compound 11) is an IL-17A inhibitor with an IC₅₀ value of 35 nM. IL-17-IN-3 exhibits no adverse effects in a rat tolerability study after a four-day administration of up to 300 mg/kg/day .

HY-168582

IL-17-IN-2	Interleukin Related	Inflammation/Immunology
IL-17-IN-2 (Example 51) is a potent inhibitor of *IL-17, with the IC₅₀* of < 0.4 μM in HTRF and NHK assay .

HY-160026

IL-17 modulator 8	Interleukin Related	Inflammation/Immunology
IL-17 modulator 8 (compound 286) is an orally active modulator of *IL-17*. IL-17 modulator 8 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 8 can used in study arthritis .

HY-160028

IL-17 modulator 9	Interleukin Related	Inflammation/Immunology
IL-17 modulator 9 (compound 453) is an orally active modulator of *IL-17*. IL-17 modulator 9 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 9 can used in study inflammation .

HY-134371

IL-17 modulator 2	Interleukin Related	Inflammation/Immunology
IL-17 modulator 2 (compound 159) is an orally active modulator of *IL-17*. IL-17 modulator 2 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 2 can used in study arthritis .

HY-169420

IL-6-IN-1	Interleukin Related	Inflammation/Immunology
IL-6-IN-1 (Compound 22) inhibits the release of *IL-6* with an IC₅₀ of 1.065 μM. IL-6-IN-1 exhibits anti-inflammatory efficacy in LPS (HY-D1056)-induced acute lung injury in mouse model .

HY-145429

IL-17A modulator-2 2 Publications Verification	Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
IL-17A modulator-2 is a *IL-17A* modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC₅₀ of 8.3. IL-17A modulator-2 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders .

HY-145430

IL-17A modulator-1	Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
IL-17A modulator-1 is a *IL-17A* modulator, extracted from patent WO2021239743+A1, example 9. IL-17A modulator-1 inhibits the biological action of IL-17A with a pIC₅₀ of 8.2. IL-17A modulator-1 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders .

HY-141692

IL-17 modulator 4	Interleukin Related	Inflammation/Immunology Cancer
IL-17 modulator 4 is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome .

HY-149282

IL-1β-IN-2	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-1β-IN-2, cannabigerol derivative, is a potent *IL-1β* inhibitor. IL-1β-IN-2 has anti-inflammatory and pain-resolving properties .

HY-149281

IL-1β-IN-1	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-1β-IN-1, cannabidiol derivative, is a potent *IL-1β* inhibitor. IL-1β-IN-1 has anti-inflammatory and pain-resolving properties .

HY-144373

IL-17 modulator 6	Interleukin Related	Inflammation/Immunology
IL-17 modulator 6 (compound 61) is a potent *Interleukin 17 (IL-17)* modulator (pIC₅₀=9.1). IL-17 modulator 6 has the ability to inhibit IL-17 and can be used for the research of inflammatory and autoimmune diseases .**

HY-139203

IL-17 modulator 3	Interleukin Related	Inflammation/Immunology Cancer
IL-17 modulator 3 is an IL-17 modulator (US20200247785A1). IL-17 modulator 3 can be used for the research of inflammation, cancer and autoimmune diseases .

HY-145434

IL-17 modulator 5	Interleukin Related	Inflammation/Immunology
IL-17 modulator 5 (compound 26) is a *IL-17* inhibitor, with an IC₅₀ of 1 nM .

HY-141692A

IL-17 modulator 4 sulfate	Interleukin Related	Inflammation/Immunology
IL-17 modulator 4 sulfate is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 sulfate is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome .

HY-101915

IL-17A antagonist 3	Interleukin Related	Inflammation/Immunology
IL-17A antagonist 3 is an *IL-17A* antagonist, compound 3 .

HY-141535

IL-17 modulator 1	Interleukin Related	Infection Inflammation/Immunology
IL-17 modulator 1 is an orally active, highly efficacious small molecule IL-17 modulators extracted from patent WO 2020127685. IL-17 modulator 1 can be used for the research of preventing, researching or ameliorating a variety of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis .

HY-139686

IL-17A inhibitor 2	Interleukin Related	Inflammation/Immunology
IL-17A inhibitor 2 is an *IL-17A* inhibitor for researching psoriasis, rheumatoid arthritis, and multiple sclerosis.

HY-169306

IL-17A inhibitor 4	Interleukin Related	Inflammation/Immunology
IL-17A inhibitor 4 (Example 449) is a potent *IL-17A* inhibitor. IL-17A inhibitor 4 inhibits HTRF and NHK cells viability with IC₅₀s of 0.028 and 0.0047 μM, respectively .

HY-141535A

IL-17 modulator 1 disodium	Interleukin Related	Infection Inflammation/Immunology
IL-17 modulator 1 (disodium) is an orally active, highly efficacious IL-17 modulator extracted from patent WO 2020127685. IL-17 modulator 1 (disodium) can be used for the research of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis .

HY-158159

IL17A-IN-1	Interleukin Related	Inflammation/Immunology Cancer
IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer .

HY-101913

IL-17A antagonist 1 1 Publications Verification	Interleukin Related	Inflammation/Immunology
IL-17A antagonist 1 (compound 1) is an *IL-17A* antagonist, with a K_d of 0.66 μM and an IC₅₀ of 1.14 μM .

HY-139206

LY3509754 3 Publications Verification IL-17A inhibitor 1	Interleukin Related	Inflammation/Immunology
LY3509754 (IL-17A inhibitor 1) is a *IL-17A* inhibitor, with IC₅₀ values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells .

HY-P10723

IL-23R inhibitor peptide-1	Interleukin Related	Inflammation/Immunology
IL-23R inhibitor peptide-1 (comp 475) is an interleukin-23 receptor inhibitor, with an IC₅₀ of 0.0069 μM .

HY-P99759

Nogapendekin alfa (his tag) IL-15N72D	Interleukin Related	Inflammation/Immunology Cancer
Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL)-15 variant, is a superagonist of *IL-15*. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8 ⁺ T cells .

HY-108822

Rilonacept Arcalyst; IL 1 Trap; Interleukin 1 Trap	Interleukin Related	Inflammation/Immunology
Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes .

HY-RS06779

IL7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL7 Human Pre-designed siRNA Set A contains three designed siRNAs for IL7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL7 Human Pre-designed siRNA Set A IL7 Human Pre-designed siRNA Set A

HY-RS06776

Il6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il6 Rat Pre-designed siRNA Set A Il6 Rat Pre-designed siRNA Set A

HY-RS24213

Il31 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il31 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il31 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il31 Rat Pre-designed siRNA Set A Il31 Rat Pre-designed siRNA Set A

HY-RS06685

IL13 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL13 Human Pre-designed siRNA Set A contains three designed siRNAs for IL13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL13 Human Pre-designed siRNA Set A IL13 Human Pre-designed siRNA Set A

HY-RS06772

Il5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5 Rat Pre-designed siRNA Set A Il5 Rat Pre-designed siRNA Set A

HY-RS18136

Il20 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il20 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il20 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il20 Mouse Pre-designed siRNA Set A Il20 Mouse Pre-designed siRNA Set A

HY-RS06771

Il5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5 Mouse Pre-designed siRNA Set A Il5 Mouse Pre-designed siRNA Set A

HY-RS06728

IL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL2 Human Pre-designed siRNA Set A contains three designed siRNAs for IL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL2 Human Pre-designed siRNA Set A IL2 Human Pre-designed siRNA Set A

HY-RS23120

Il18 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il18 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il18 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il18 Rat Pre-designed siRNA Set A Il18 Rat Pre-designed siRNA Set A

HY-RS06692

Il15 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il15 Rat Pre-designed siRNA Set A Il15 Rat Pre-designed siRNA Set A

HY-RS17267

Il19 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il19 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il19 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il19 Mouse Pre-designed siRNA Set A Il19 Mouse Pre-designed siRNA Set A

HY-RS06694

IL16 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL16 Human Pre-designed siRNA Set A contains three designed siRNAs for IL16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL16 Human Pre-designed siRNA Set A IL16 Human Pre-designed siRNA Set A

HY-RS06675

IL11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL11 Human Pre-designed siRNA Set A contains three designed siRNAs for IL11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL11 Human Pre-designed siRNA Set A IL11 Human Pre-designed siRNA Set A

HY-RS16646

Il11 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il11 Mouse Pre-designed siRNA Set A Il11 Mouse Pre-designed siRNA Set A

HY-RS06767

Il4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il4 Rat Pre-designed siRNA Set A Il4 Rat Pre-designed siRNA Set A

HY-RS06765

IL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL4 Human Pre-designed siRNA Set A contains three designed siRNAs for IL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL4 Human Pre-designed siRNA Set A IL4 Human Pre-designed siRNA Set A

HY-RS06712

IL19 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL19 Human Pre-designed siRNA Set A contains three designed siRNAs for IL19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL19 Human Pre-designed siRNA Set A IL19 Human Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L156

Autoimmune Disease Compound Library

675 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 675 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

HY-L161

Cytokine Inhibitors Library

1,043 compounds

Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases.

MCE designs a unique collection of 1,043 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.

Cat. No.	Product Name	Type

HY-B1046

Clofazimine

5+ Cited Publications

Chromogenic Assays

Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .

HY-163140

IL-33 probe-1	Fluorescent Dyes/Probes
IL-33 probe-1 is a fluorescent analogue of the interleukin IL-33_[1].

HY-B1046R

Clofazimine (Standard)

Chromogenic Assays

Clofazimine (Standard) is the analytical standard of Clofazimine. This product is intended for research and analytical applications. Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .

Cat. No.	Product Name	Type

HY-114360A

Taurohyodeoxycholic acid sodium 1 Publications Verification	Biochemical Assay Reagents
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-137131

DC-Chol hydrochloride

DC-Cholesterol hydrochloride

Drug Delivery

DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-139414

Lysophosphatidylcholines 1 Publications Verification	Cell Assay Reagents
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of *IL-1β* and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis .

HY-W251428

Phosphatidylglycerols (egg) sodium salt Egg PG