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Results for "

IL-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (29) Itk (3) 5-HT Receptor (3) Adenosine Receptor (2) Antibiotic (4) Apoptosis (5) Aryl Hydrocarbon Receptor (1) Autophagy (3) Bacterial (6) Bcl-2 Family (1) Biochemical Assay Reagents (1) Btk (2) Caspase (1) CDK (1) COX (1) CRAC Channel (2) Cytochrome P450 (3) DNA/RNA Synthesis (1) Dopamine Receptor (3) E1/E2/E3 Enzyme (1) FKBP (3) Fungal (3) HIV (4) IFNAR (2) IKK (1) Influenza Virus (1) Integrin (1) Isotope-Labeled Compounds (1) JAK (4) LAG-3 (2) Leukotriene Receptor (1) Ligands for E3 Ligase (4) MALT1 (2) MAP4K (5) Mitochondrial Metabolism (1) Molecular Glues (4) NF-κB (3) NO Synthase (1) Nucleoside Antimetabolite/Analog (2) p38 MAPK (1) PD-1/PD-L1 (8) Phosphatase (3) Phosphodiesterase (PDE) (2) PKC (5) Potassium Channel (2) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (6) Src (3) STAT (3) TNF Receptor (3) VEGFR (1)
By Research Areas:	Cancer (49) Cardiovascular Disease (2) Infection (14) Inflammation/Immunology (48) Metabolic Disease (1) Neurological Disease (4)

By Targets:

Interleukin Related (29)

Itk (3)

5-HT Receptor (3)

Adenosine Receptor (2)

Antibiotic (4)

Apoptosis (5)

Aryl Hydrocarbon Receptor (1)

Autophagy (3)

Bacterial (6)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Btk (2)

Caspase (1)

CDK (1)

COX (1)

CRAC Channel (2)

Cytochrome P450 (3)

DNA/RNA Synthesis (1)

Dopamine Receptor (3)

E1/E2/E3 Enzyme (1)

FKBP (3)

Fungal (3)

HIV (4)

IFNAR (2)

IKK (1)

Influenza Virus (1)

Integrin (1)

Isotope-Labeled Compounds (1)

JAK (4)

LAG-3 (2)

Leukotriene Receptor (1)

Ligands for E3 Ligase (4)

MALT1 (2)

MAP4K (5)

Mitochondrial Metabolism (1)

Molecular Glues (4)

NF-κB (3)

NO Synthase (1)

Nucleoside Antimetabolite/Analog (2)

p38 MAPK (1)

PD-1/PD-L1 (8)

Phosphatase (3)

Phosphodiesterase (PDE) (2)

PKC (5)

Potassium Channel (2)

Prostaglandin Receptor (1)

Small Interfering RNA (siRNA) (6)

Src (3)

STAT (3)

TNF Receptor (3)

VEGFR (1)

By Research Areas:

Cancer (49)

Cardiovascular Disease (2)

Infection (14)

Inflammation/Immunology (48)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

IL-2-IN-1	Interleukin Related	Inflammation/Immunology
IL-2-IN-1 is a potent *IL-2* inhibitor with an IC₅₀ value of 1978 nM. IL-2-IN-1 shows antiproliferative activities .

IL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL2 Human Pre-designed siRNA Set A contains three designed siRNAs for IL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL2RA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL2RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL2RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL2RB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL2RB Human Pre-designed siRNA Set A contains three designed siRNAs for IL2RB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL2RG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL2RG Human Pre-designed siRNA Set A contains three designed siRNAs for IL2RG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tucotuzumab Anti-EPCAM Recombinant Antibody; huKS-IL2	Interleukin Related	Inflammation/Immunology Cancer
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule .

Cergutuzumab amunaleukin CEA-IL2v; RG 7813; RO 6895882	Interleukin Related	Inflammation/Immunology Cancer
Cergutuzumab amunaleukin (CEA-IL2v) is a monomeric carcinoembryonic antigen (CEA)-targeted IL-2 variant-based immunocytokine. Cergutuzumab amunaleukin has immunostimulating and antineoplastic activities .

N-Myristoyl-Lys-Arg-Thr-Leu-Arg	PKC	Inflammation/Immunology
N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor with an IC₅₀ value of 75 μM. N-Myristoyl-Lys-Arg-Thr-Leu-Arg inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat .

Simlukafusp alfa FAP-IL2v	Interleukin Related	Cancer
Simlukafusp alfa (FAP-IL2v) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAPα) and an IL-2 variant that only binds IL-2Rβγ. Isotype: human IgG1 .

SP4206	Interleukin Related	Inflammation/Immunology
SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (K_d=70 nM) to *IL-2* and blocks binding to its natural receptor IL-2Rα (K_d=10 nM) .

HPK1-IN-35	MAP4K	Cancer
HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC₅₀ value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion .

Nemvaleukin alfa ALKS 4230; RDB-1450	Interleukin Related	Inflammation/Immunology Cancer
Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer ^[2] .

CC-90005	PKC	Inflammation/Immunology
CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC₅₀ of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC₅₀=4440 nM). CC-90005 can inhibit T cell activation by inhibiting IL-2 expression .

Cbl-b-IN-16	E1/E2/E3 Enzyme	Cancer
Cbl-b-IN-16 (compound 31) is an orally active Cbl-b inhibtor with IC₅₀ of 30 nM and induces IL-2 production in Hu-T-cells with EC₅₀ of 230 nM. Cbl-b-IN-16 exhibits antitumor activity .

Nosantine racemate NPT 15392 racemate	Interleukin Related	Inflammation/Immunology
Nosantine racemate is the racemate of Nosantine. Nosantine is an inducer of *IL-2* or enhancer of *IL-2* induction by phytohemagglutinin (PHA).

HMC-B17	MAP4K	Cancer
HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC₅₀ = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC₅₀ = 11.56 nM). HMC-B17 can be used for the research of cancer .

BIRT 377	Integrin Interleukin Related	Inflammation/Immunology
BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), with a K_i of 25.8 nM. BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders .

Keliximab SB-210396; IDEC CE9.1	Interleukin Related	Cancer
Keliximab (SB-210396) is a chimeric human/macaque IgG1 anti-CD4 monoclonal antibody with a K_i value of 1.0 nM for soluble CD4. Keliximab blocks T cell proliferation and inhibits IL-2 production. Keliximab can be used for cancer research ^[2].

HPK1-IN-3	MAP4K	Inflammation/Immunology
HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC₅₀ of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC₅₀ of 108 nM in human peripheral blood mononuclear cells (PBMCs) .

HPK1-IN-33	MAP4K	Cancer
HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a K_i value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC₅₀s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively .

AP-1/NF-κB activation inhibitor 1 1 Publications Verification	NF-κB	Inflammation/Immunology
AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC₅₀=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells .

BMSpep-57	PD-1/PD-L1	Cancer
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs .

BMSpep-57 hydrochloride	PD-1/PD-L1	Cancer
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs .

SP-100030	NF-κB	Inflammation/Immunology
SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC₅₀s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA) ^[2].

SU5201
SU5201 is an inhibitor of interleukin-2 (IL-2) production .

(R)-MLT-985	MALT1	Cancer
(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC₅₀ of 3 nM. (R)-MLT-985 has an IC₅₀ of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells .

PD1-PDL1-IN 2	PD-1/PD-L1	Cancer
PD1-PDL1-IN 2 (ZE132) is a potent and selective PD-1/PD-L1 inhibitor, which has robust anti-tumour activity in vivo. PD1-PDL1-IN 2 promotes cytotoxic T-cell tumour infiltration and induces IL-2 expression. In addition, PD1-PDL1-IN 2 elicits strong inhibitory effects on the mRNA expression of TGF-β .

RO2959 hydrochloride	CRAC Channel Interleukin Related	Cardiovascular Disease
RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways ^[2].

NFAT Transcription Factor Regulator-1	Interleukin Related	Inflammation/Immunology
NFAT Transcription Factor Regulator-1 is an IL-2 synthesis inhibitor with an IC₅₀ of 182 nM.

Ppc-1	Mitochondrial Metabolism Interleukin Related Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate **interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis**. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities ^[2] .

RO2959 monohydrochloride	CRAC Channel Interleukin Related	Cardiovascular Disease
RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways ^[2].

4-Maleimidosalicylic acid	Others	Others
4-Maleimidosalicylic acid is a polar maleimide, and does not suppress IL-2 production in JURKAT T cells .

KTX-Sp2	Potassium Channel	Inflammation/Immunology
KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca ²⁺ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells .

cis-Burchellin
cis-Burchellin is a bioactive neolignan with anti-allergic activity. cis-Burchellin inhibits IL-2 production in Jurkat T-cells .

Lck Inhibitor III	Src Interleukin Related	Cancer
Lck Inhibitor III (compound 12h) is a potent Lck inhibitor, with an IC₅₀ of 867 nM. Lck Inhibitor III inhibits *IL-2* synthesis in Jurkat cells, with an IC₅₀ of 1.270 μM .

Daclizumab Zenapax; Ro 24-7375	Interleukin Related	Inflammation/Immunology
Daclizumab (Zenapax) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab (Zenapax) reversibly binds to CD25and prevents the interaction of IL-2 with the IL-2R-HA. Daclizumab (Zenapax) can be used for multiple sclerosis research .

Tucaresol BWA589C	HIV	Infection Cancer
Tucaresol is an orally bioavailable immunopotentiatory drug that show to enhance T-helper-cell activity, with the induction of increased IL-2 and IFN-γ levels in mice and humans. Tucaresol has anti-HIV effect .

Tacrolimus monohydrate Maximum Cited Publications 65 Publications Verification FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate	Phosphatase FKBP Autophagy Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

Tacrolimus Maximum Cited Publications 65 Publications Verification FK506; Fujimycin; FR900506	Phosphatase FKBP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

PKC-theta inhibitor 1	PKC	Inflammation/Immunology
PKC-theta inhibitor 1 is the PKCθ inhibitor with an K_i value of 6 nM, inhibits IL-2 production in vivo with an IC₅₀ of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis .

NX-2127	Btk	Cancer
NX-2127 is an orally and potent BTK inhibitor, inducing degradation of the mutated BTK ^C481S in cells. NX-2127 inhibits proliferation of BTK ^C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells ^[2].

Ginsenoside F3	Interleukin Related IFNAR	Inflammation/Immunology
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

Immuno modulator-1	TNF Receptor Interleukin Related Potassium Channel	Inflammation/Immunology Cancer
Immuno modulator-1 (compound 22) inhibits TNFα and *IL-2* secretion in human peripheral blood mononuclear cells (hPBMC), with IC₅₀ values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM .

Tacrolimus-13C,d2 FK506-¹³C,d₂; Fujimycin-¹³C,d₂; FR900506-¹³C,d₂	Phosphatase FKBP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Tacrolimus- ¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

Cat. No.	Product Name	Type

HY-B1046

Clofazimine

5+ Cited Publications

Chromogenic Assays

Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P3143A

BMSpep-57 hydrochloride	PD-1/PD-L1	Cancer
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs .

HY-P3083

N-Myristoyl-Lys-Arg-Thr-Leu-Arg	PKC	Inflammation/Immunology
N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor with an IC₅₀ value of 75 μM. N-Myristoyl-Lys-Arg-Thr-Leu-Arg inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat .

HY-P3143

BMSpep-57	PD-1/PD-L1	Cancer
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC₅₀ of 7.68 nM. BMSpep-57 binds to PD-L1 with K_ds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs .

HY-P5870

KTX-Sp2	Potassium Channel	Inflammation/Immunology
KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca ²⁺ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells .

HY-P3736

Myelopeptide-2 MP-2	Interleukin Related	Cancer
Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures, can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. Myelopeptide-2 also recover depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression. Myelopeptide-2 involves in immunity homeostasis, is perspective to be applied in antitumor and antivirus research ^[2].

HY-P1997

Ferrichrome Iron-free Desferrichrome; DFC; N-Desferriferrichrome	Biochemical Assay Reagents	Others
Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be used as a heterosiderophore by bacteria, including Pseudomonas aeruginosa and Vibrio parahaemolyticus. Ferrichrome (0.8 μM) inhibits concanavalin A-induced proliferation of mouse spleen monocytes and reduces the number of concanavalin A-stimulated CD4+ T cells expressing IL-2 receptor. It also inhibits the heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.

HY-P1453

CMD178

STAT Cancer

CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T_reg cell development .

HY-P1453A

CMD178 TFA	STAT	Cancer
CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T_reg cell development .

HY-P2520

Influenza HA (110-119)	Influenza Virus	Inflammation/Immunology
Influenza HA (110-119) is the 110-119 fragment of influenza virus hemagglutinin that can stimulate Treg cells proliferation ^[2].

Cat. No.	Product Name	Target	Research Area

HY-P99328

Tucotuzumab Anti-EPCAM Recombinant Antibody; huKS-IL2	Interleukin Related	Inflammation/Immunology Cancer
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule .

HY-P99498

Cergutuzumab amunaleukin CEA-IL2v; RG 7813; RO 6895882	Interleukin Related	Inflammation/Immunology Cancer
Cergutuzumab amunaleukin (CEA-IL2v) is a monomeric carcinoembryonic antigen (CEA)-targeted IL-2 variant-based immunocytokine. Cergutuzumab amunaleukin has immunostimulating and antineoplastic activities .

HY-P99902

Simlukafusp alfa FAP-IL2v	Interleukin Related	Cancer
Simlukafusp alfa (FAP-IL2v) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAPα) and an IL-2 variant that only binds IL-2Rβγ. Isotype: human IgG1 .

HY-P990219

Anti-Mouse IL-2 Antibody (JES6-1A12)

Inhibitory Antibodies Others

Anti-Mouse IL-2 Antibody (JES6-1A12) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse IL-2.

HY-P99479

Bifikafusp alfa L19-IL2	Inhibitory Antibodies	Cancer
Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity .

HY-P990076

Lorukafusp alfa 14.18 mAb; hu14.18-IL2; EMD 273063	Inhibitory Antibodies	Cancer
Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity .

HY-P99752

Nemvaleukin alfa ALKS 4230; RDB-1450	Interleukin Related	Inflammation/Immunology Cancer
Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer ^[2] .

HY-P99680

Keliximab SB-210396; IDEC CE9.1	Interleukin Related	Cancer
Keliximab (SB-210396) is a chimeric human/macaque IgG1 anti-CD4 monoclonal antibody with a K_i value of 1.0 nM for soluble CD4. Keliximab blocks T cell proliferation and inhibits IL-2 production. Keliximab can be used for cancer research ^[2].

HY-108738

Daclizumab Zenapax; Ro 24-7375	Interleukin Related	Inflammation/Immunology
Daclizumab (Zenapax) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab (Zenapax) reversibly binds to CD25and prevents the interaction of IL-2 with the IL-2R-HA. Daclizumab (Zenapax) can be used for multiple sclerosis research .

HY-P99877

Efavaleukin alfa AMG592	Inhibitory Antibodies	Others
Efavaleukin alfa (AMG592) is a human monoclonal antibody. Efavaleukin alfa is composed of the IGHG1 Fc fragment fused to IL-2. The expression system of Efavaleukin alfa is usually CHO (Chinese Hamster Ovary) cells .

HY-P99817

Pegaldesleukin	Interleukin Related HIV	Infection
Pegaldesleukin is a conjugate of polyethylene glycol and interleukin-2 (PEG-IL2). Pegaldeslukin has antiviral activity and has potential applications in HIV, possibly delaying the progression of HIV infection by retaining the immune repertoire ^[2] .

HY-P9933

Dinutuximab Unituxin; APN-311	Inhibitory Antibodies	Cancer
Dinutuximab (Unituxin; APN-311) is a chimeric, human-murine, anti-GD2 monoclonal antibody. Dinutuximab potently enlongs event-free survival and overall survival, in high-risk neuroblastoma treatment, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), aldesleukin (interleukin-2 [IL-2]), and isotretinoin (13-cis-retinoic acid [RA]) .

HY-P990293

*Anti-Mouse CD122/IL-2Rβ Antibody (5H4)*	Inhibitory Antibodies	Others
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse CD122/IL-2Rβ.

HY-P99728

Melredableukin alfa RG7835; RO7049665	Interleukin Related	Inflammation/Immunology
Melredableukin alfa (RO-7049665) is a fusion protein that consists of a human IgG1-κ fused to a mutated human interleukin 2 (IL2 mutein) via a peptide linker. Melredableukin alfa can be used for the research of autoimmune hepatitis and ulcerative colitis .

HY-P990281

*Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3)*	Inhibitory Antibodies	Others
Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) is a rat-derived IgG1, λ type antibody inhibitor, targeting to mouse CD25/IL-2Rα.

HY-P99499

Cetrelimab JNJ 63723283; JNJ 3283	PD-1/PD-L1 Interleukin Related TNF Receptor	Cancer
Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (K_d=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and *PD-L2* (IC₅₀s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, *IL-2, TNF-α* level and inhibits tumor growth in vivo .

HY-P990086

Vopikitug	Interleukin Related	Cancer
Vopikitug is an IgG1-kappa, anti-IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25) homo sapiens monoclonal antibody. Vopikitug shows antineoplastic activity .

HY-P99664

Inolimomab	Interleukin Related	Inflammation/Immunology
Inolimomab is an anti-interleukin-2 receptor (IL-2R) α chain monoclonal antibody. Inolimomab improves the survival rate in the early research of treating acute graft-versus-host disease (aGVHD) ^[2].

HY-P99410

Ordesekimab AMG 714; PRV-015	Interleukin Related	Inflammation/Immunology
Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .

HY-P99736

Miptenalimab BI-754111	LAG-3	Cancer
Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (K_D: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II .

HY-P99156

Relatlimab BMS-986016	LAG-3	Cancer
Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC₅₀ value of 0.67 nM and LAG-3/FGL1 interaction with an IC₅₀ value of 0.019 nM. Relatlimab can be used in research of cancer .

HY-P990029

Eciskafusp alfa	PD-1/PD-L1	Infection Cancer
Eciskafusp alfa is a programmed cell death 1 (PDCD1, best known as PD-1) cis-targeted IL2v immunocytokine. Eciskafusp alfa preferentially targets antigen-specific stem-like PD-1+ TCF-1+ CD8+ T cells and differentiates them towards a novel population of better effectors. Eciskafusp alfa can be used for the research of cancer and chronic infections .

Recombinant Proteins Recommended:

IL-2

Species:	Human (28) Rhesus Macaque (3) Mouse (12) Rat (7) Cynomolgus (5) Pig (1) Canine (3)
Tag:	His (37) Tag Free (10) Avi (11) GST (3) Fc (11)
Source:	HEK293 (41) CHO (1) P. pastoris (1) Sf9 insect cells (4) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P70646AF

	*Animal-Free IL-2* Protein, Mouse (His)** rMuIL-2; IL2; T-cell Growth Factor; TCGF; Aldesleukin	Mouse	E. coli
	IL-2 Protein is usually produces by antigen-activated CD4+ T cells, CD8+ T cells, NK cells and NKT cells. IL-2 Protein is involved in signaling pathways including JAK/STAT, inosine phosphate 3-kinase /PI3K, and mitogen-activated protein kinase /MAPK. Animal-Free IL-2 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-2 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-2 Protein, Mouse (His) is 149 a.a., with molecular weight of ~18.2 kDa.

HY-P700247AF

Animal-Free IL-2 Protein, Pig (His)

IL2; IL-2; TCGF; lymphokine; Interleukin-2; Interleukin2; IL2R; IL-2 R; Interleukin 2; T-cell growth factor
Pig E. coli

HY-P7037AF

	*Animal-Free IL-2* Protein, Human (His)** Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	E. coli
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. Animal-Free IL-2 Protein, Human (His) is the recombinant human-derived animal-FreeIL-2 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-2 Protein, Human (His) is 133 a.a., with molecular weight of ~16.4 kDa.

HY-P78551

	*GMP IL-2* Protein, Human (solution)** Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	E. coli
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. GMP IL-2 Protein, Human is the recombinant human-derived IL-2 protein, expressed by E. coli , with tag free. The total length of GMP IL-2 Protein, Human is 133 a.a., with molecular weight of ~15.5 kDa.

HY-P70758G

	*GMP IL-2* Protein, Human (HEK293, His)** Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	HEK293
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. GMP IL-2 Protein, Human (HEK293, His) is the recombinant human-derived IL-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP IL-2 Protein, Human (HEK293, His) is 133 a.a., with molecular weight of 14-18 kDa.

HY-P7037G

	*GMP IL-2* Protein, Human (Tag Free)** Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	E. coli
	IL-2 Protein, Human is an adjunctive immunotherapeutic agent to treat tuberculosis (TB).

HY-P7037B

	IL-2 Protein, Human (His) 2 Publications Verification Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	E. coli
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. IL-2 Protein, Human (His) is the recombinant human-derived IL-2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-2 Protein, Human (His) is 133 a.a., with molecular weight of ~16 kDa.

HY-P70718

	IL-2 Protein, Rat (HEK293, His) Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin; IL2	Rat	HEK293
	IL-2 Protein, produced by activated T-cells, NK cells, and helper T-cells, is crucial for immune response and tolerance. It binds to receptor complexes, activating downstream signaling pathways. IL-2 Protein acts as a growth factor, enhances NK-cell activity, promotes B-cell proliferation, and regulates regulatory T-cells. It also participates in differentiating effector T-cell subsets and memory CD8-positive T-cells. IL-2 Protein, Rat (HEK293, His) is the recombinant rat-derived IL-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-2 Protein, Rat (HEK293, His) is 135 a.a., with molecular weight of 14-16 kDa.

HY-P70758

	IL-2 Protein, Human (HEK293, His) 1 Publications Verification Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	HEK293
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. IL-2 Protein, Human (HEK293, His) is the recombinant human-derived IL-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-2 Protein, Human (HEK293, His) is 133 a.a., with molecular weight of 14-18 kDa.

HY-P70646

	IL-2 Protein, Mouse (149a.a) aldesleukin; interleukin 2; interleukin-2; IL-2; IL2; T-cell growth facter; T cell growth factor; TCGF	Mouse	E. coli
	IL-2 Protein is usually produces by antigen-activated CD4+ T cells, CD8+ T cells, NK cells and NKT cells. IL-2 Protein is involved in signaling pathways including JAK/STAT, inosine phosphate 3-kinase /PI3K, and mitogen-activated protein kinase /MAPK. IL-2 Protein, Mouse (149a.a) is the recombinant mouse-derived IL-2 protein, expressed by E. coli , with tag free. The total length of IL-2 Protein, Mouse (149a.a) is 149 a.a., with molecular weight of ~17.0 kDa.

HY-P70775

	IL-2 Protein, Human (C145S) Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin	Human	E. coli
	IL-2 protein, primarily produced by activated CD4-positive helper T-cells, plays vital roles in immune response and tolerance. Binding to IL-2R induces downstream signaling through phosphorylation of JAK1 and JAK3, leading to activation of various pathways, including STAT, PI3K, and MAPK. IL-2 serves as a T-cell growth factor, enhances NK-cell cytolytic activity, and promotes B-cell proliferation. It crucially regulates regulatory T-cells, maintaining immune tolerance, and participates in the differentiation and homeostasis of various T-cell subsets. IL-2 Protein, Human (C145S) is the recombinant human-derived IL-2 protein, expressed by E. coli , with tag free. and C145S mutation. The total length of IL-2 Protein, Human (C145S) is 132 a.a., with molecular weight of ~14.0 kDa.

HY-P72385

	IL-2 Protein, Human (Biotinylated, HEK293, His-Avi) Interleukin-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	HEK293
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. IL-2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-2 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of IL-2 Protein, Human (Biotinylated, HEK293, His-Avi) is 133 a.a., with molecular weight of 16-18 kDa.

HY-P73189

	IL-2 Protein, Rat Interleukin-2; T-cell growth factor; TCGF	Rat	E. coli
	IL-2 Protein, produced by activated T-cells, NK cells, and helper T-cells, is crucial for immune response and tolerance. It binds to receptor complexes, activating downstream signaling pathways. IL-2 Protein acts as a growth factor, enhances NK-cell activity, promotes B-cell proliferation, and regulates regulatory T-cells. It also participates in differentiating effector T-cell subsets and memory CD8-positive T-cells. IL-2 Protein, Rat is the recombinant rat-derived IL-2 protein, expressed by E. coli , with tag free. The total length of IL-2 Protein, Rat is 135 a.a., with molecular weight of ~15 kDa.

HY-P700649

	IL-2 Protein, Rat (145aa, HEK293, C-His) Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin; IL2	Rat	HEK293
	IL-2 Protein, produced by activated T-cells, NK cells, and helper T-cells, is crucial for immune response and tolerance. It binds to receptor complexes, activating downstream signaling pathways. IL-2 Protein acts as a growth factor, enhances NK-cell activity, promotes B-cell proliferation, and regulates regulatory T-cells. It also participates in differentiating effector T-cell subsets and memory CD8-positive T-cells. IL-2 Protein, Rat (145aa, HEK293, C-His) is the recombinant rat-derived IL-2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of IL-2 Protein, Rat (145aa, HEK293, C-His) is 145 a.a., with molecular weight of ~18 kDa.

HY-P72564

	IL-2 Protein, Human (L100F,R101D,L105V,I106V,I112F, HEK293, His) Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin	Human	HEK293
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. IL-2 Protein, Human (L100F,R101D,L105V,I106V,I112F, HEK293, His) is the recombinant human-derived IL-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-2 Protein, Human (L100F,R101D,L105V,I106V,I112F, HEK293, His) is 133 a.a., with molecular weight of 16 & 18 kDa, respectively.

HY-P73188

	IL-2 Protein, Canine (C147S) Interleukin-2; T-cell growth factor; TCGF	Canine	E. coli
	IL-2 Protein, produced by activated T-cells, NK cells, and helper T-cells, is crucial for immune response and tolerance. It binds to receptor complexes, activating signaling pathways. IL-2 Protein acts as a growth factor, enhances NK-cell activity, promotes B-cell proliferation, and regulates regulatory T-cells. It also participates in differentiating effector T-cell subsets and memory CD8-positive T-cells. IL-2 Protein, Canine (C147S) is the recombinant canine-derived IL-2 protein, expressed by E. coli , with tag free. and C147S mutation. The total length of IL-2 Protein, Canine (C147S) is 135 a.a., with molecular weight of ~15 kDa.

HY-P7037

	IL-2 Protein, Human 3 Publications Verification rHuIL-2; IL2; T-cell Growth Factor; TCGF; Aldesleukin	Human	E. coli
	IL-2 Protein, Human is an adjunctive immunotherapeutic agent to treat tuberculosis (TB).

HY-P7077

	IL-2 Protein, Mouse 5 Publications Verification rMuIL-2; IL2; T-cell Growth Factor; TCGF; Aldesleukin	Mouse	E. coli
	IL-2 Protein, Mouse is an immunomodulatory cytokine with widely varying functions including promotion of apoptosis, proliferation and survival of lymphocytes.

HY-P7037A

	IL-2 Protein, Human (CHO) rHuIL-2; IL2; T-cell Growth Factor; TCGF; Aldesleukin	Human	CHO
	IL-2 Protein, Human (CHO) is a CHO cell derived adjunctive immunotherapeutic agent to treat tuberculosis (TB).

HY-P78312

	IL-2 Protein, Mouse (HEK293, His-Avi) IL2; T-cell growth factor; TCGF; Aldesleukin	Mouse	HEK293
	IL-2 Protein is usually produces by antigen-activated CD4+ T cells, CD8+ T cells, NK cells and NKT cells. IL-2 Protein is involved in signaling pathways including JAK/STAT, inosine phosphate 3-kinase /PI3K, and mitogen-activated protein kinase /MAPK. IL-2 Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived IL-2 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-2 Protein, Mouse (HEK293, His-Avi) is 149 a.a., with molecular weight of 27-30 kDa.

HY-P78151

	IL-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) IL2; T-cell growth factor; TCGF; Aldesleukin	Mouse	HEK293
	IL-2 Protein is usually produces by antigen-activated CD4+ T cells, CD8+ T cells, NK cells and NKT cells. IL-2 Protein is involved in signaling pathways including JAK/STAT, inosine phosphate 3-kinase /PI3K, and mitogen-activated protein kinase /MAPK. IL-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived IL-2 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) is 149 a.a., with molecular weight of 27-30 kDa.

HY-P78858

	IL-2 Protein, Human (Biotinylated, HEK293, Fc-Avi) IL2; TCGF; lymphokine; Interleukin 2	Human	HEK293
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. IL-2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived IL-2 protein, expressed by HEK293 , with C-Avi, N-hFc labeled tag. The total length of IL-2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 133 a.a., with molecular weight of 45-50 kDa.

HY-P70631

	IL-2R beta/CD122 Protein, Human (HEK293, His) IL-2R beta; IL-2 R beta; IL-2RB; Interleukin-2 receptor subunit beta; IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; High affinity IL-2 receptor subunit beta; CD122	Human	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, His) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal 6*His tags, which is produced in HEK293 cells.

HY-P72386

	IL-2R beta/CD122 Protein, Human (Biotinylated, HEK293, His-Avi) IL-2R beta; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; igh affinity IL-2 receptor subunit beta; CD122	Human	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant human extracellular region of biotinylated IL-2R beta (A27-D239) with C-Terminal 6*His tags and an Avi tag, which is produced in HEK293 cells.

HY-P7784

	IL-2R beta/CD122 Protein, Human (HEK293, Fc) rHuCD122, C-Fc; Interleukin-2 receptor subunit beta; IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; High affinity IL-2 receptor subunit beta; CD122	Human	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, Fc) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal Fc tag, which is produced in HEK293 cells.

HY-P71746

	IL-2R beta/CD122 Protein, Mouse (P.pastoris, His) IL2rbInterleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; CD antigen CD122	Mouse	P. pastoris
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Mouse (P.pastoris, His) is a recombinant mouse IL-2R beta (27A-240E) with a N-Terminal His tag, which is produced in P.pastoris.

HY-P78412

	IL-2R alpha/CD25 Protein, Human (HEK293, His-Avi) CD25; IDDM10; IL-2 R alpha; IL2R; IL2RA; p55; TCGFR	Human	HEK293
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Human (HEK293, His-Avi) is a recombinant human IL-2R alpha protein with a His tag and an Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 192 amino acids (E22-C213).

HY-P78092

	IL-2R alpha/CD25 Protein, Human (Biotinylated, HEK293, His-Avi) CD25; IDDM10; IL-2 R alpha; IL2R; IL2RA; p55; TCGFR	Human	HEK293
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human IL-2R alpha protein with a His tag and an Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 192 amino acids (E22-C213).

HY-P76769

	IL-2R beta/CD122 Protein, Canine (HEK293, Fc) Interleukin-2 receptor subunit beta; IL2RB; High affinity IL-2 receptor subunit beta; CD122	Canine	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Canine (HEK293, Fc) is a recombinant canine IL-2R beta (M1-P244) with a C-Terminal hFc tag, which is produced in HEK293 cells.

HY-P76771

	IL-2R beta/CD122 Protein, Rat (HEK293, His) Interleukin-2 receptor subunit beta; IL2RB; High affinity IL-2 receptor subunit beta; CD122	Rat	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rat (HEK293, His) is a recombinant rat IL-2R beta (M1-E239) with a C-Terminal His tag, which is produced in HEK293 cells.

HY-P76785

	IL-2R alpha/CD25 Protein, Cynomolgus (HEK293) CD25; IDDM10; IL-2 R alpha; IL2-RA; Interleukin 2 receptor, alpha; TCGFR	Cynomolgus	HEK293
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Cynomolgus (HEK293) is a recombinant cynomolgus IL-2R alpha protein and is expressed in HEK293 cells. It consists of 213 amino acids (M1-R213).

HY-P7374

	IL-2R alpha/CD25 Protein, Human (HEK293, Fc) rHuIL-2R α/CD25, Fc Chimera; TAC antigen; IL-2-RA; IL-2 R alpha; IL-2Rα; IL2RA	Human	HEK293
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Human (HEK293, Fc) is a recombinant human IL-2R alpha protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 192 amino acids (E22-C213).

HY-P74809

	IL-2R alpha/CD25 Protein, Rat (sf9, His) CD25; IDDM10; IL-2 R alpha; IL2-RA; Interleukin 2 receptor, alpha; TCGFR	Rat	Sf9 insect cells
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Rat (sf9, His) is a recombinant rat IL-2R alpha protein with a His tag at the C-terminus and is expressed in Sf9 insect cells. It consists of 235 amino acids (M1-Q235).

HY-P74811

	IL-2R alpha/CD25 Protein, Mouse (HEK293, hFc) CD25; IDDM10; IL-2 R alpha; IL2-RA; Interleukin 2 receptor, alpha; TCGFR	Mouse	HEK293
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Mouse (HEK293, hFc) is a recombinant mouse IL-2R alpha protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 236 amino acids (M1-K236).

HY-P76772

	IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, Fc) Interleukin-2 receptor subunit beta; IL2RB; High affinity IL-2 receptor subunit beta; CD122	Rhesus Macaque	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, Fc) is a recombinant Rhesus Macaque IL-2R beta (M1-D239) with a C-Terminal hFc tag, which is produced in HEK293 cells.

HY-P76773

	IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, His) Interleukin-2 receptor subunit beta; IL2RB; High affinity IL-2 receptor subunit beta; CD122	Rhesus Macaque	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, His) is a recombinant Rhesus Macaque IL-2R beta (M1-D239) with a C-Terminal His tag, which is produced in HEK293 cells.

HY-P76786

	IL-2R alpha/CD25 Protein, Cynomolgus (HEK293, Fc) CD25; IDDM10; IL-2 R alpha; IL2-RA; Interleukin 2 receptor, alpha; TCGFR	Cynomolgus	HEK293
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus IL-2R alpha protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 213 amino acids (M1-R213).

HY-P76787

	IL-2R alpha/CD25 Protein, Cynomolgus (HEK293, His) CD25; IDDM10; IL-2 R alpha; IL2-RA; Interleukin 2 receptor, alpha; TCGFR	Cynomolgus	HEK293
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus IL-2R alpha protein with a His tag at the C-terminus and is expressed in HEK293 cells. It consists of 213 amino acids (M1-R213).

HY-P77591

	IL-2R gamma/CD132 Protein, Cynomolgus (HEK293, His) CD132; CIDX; IL-2 R gamma; IL2RG; IMD4; P64; SCIDX; SCIDX1; gammaC	Cynomolgus	HEK293
	IL-2R gamma/CD132 Protein, a common subunit for interleukin receptors, likely collaborates with IL15RA in stimulating neutrophil phagocytosis by IL15. It is shared among IL2, IL4, IL7, IL15, IL21, and possibly IL13 receptors. IL-2R gamma interacts with SHB upon interleukin stimulation and also interacts with IL9. IL-2R gamma/CD132 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-2R gamma/CD132 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-2R gamma/CD132 Protein, Cynomolgus (HEK293, His) is 232 a.a., with molecular weight of 50-68 kDa.

HY-P700858

	IL-2R gamma/CD132 Protein, Human (HEK293, hFc) CD132; CIDX; IL-2 R gamma; IL2RG; IMD4; P64; SCIDX; SCIDX1; gammaC	Human	HEK293
	IL-2R gamma/CD132 Protein, a common subunit for interleukin receptors, likely collaborates with IL15RA in stimulating neutrophil phagocytosis by IL15. It is shared among IL2, IL4, IL7, IL15, IL21, and possibly IL13 receptors. IL-2R gamma interacts with SHB upon interleukin stimulation and also interacts with IL9. IL-2R gamma/CD132 Protein, Human (HEK293, hFc) is the recombinant human-derived IL-2R gamma/CD132 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-2R gamma/CD132 Protein, Human (HEK293, hFc) is 232 a.a., with molecular weight of 70-100 kDa.

HY-P77715

	IL-2R beta & IL-2R gamma Heterodimer Protein, Human (HEK293, Fc) IL-2RB&IL-2RG; IL-2RG; IL-2R subunit gamma; IL-2R subunit beta; IL-2RB; IL15RB; IL-2 R beta&IL-2 R gamma	Human	HEK293
	IL-2R beta (CD122) and IL-2Rγ (CD132), type Ⅰ cytokine receptors expressed on T lymphocytes, are receptors for IL-2 (K_d: 1 nM for IL-2R beta approximately). IL-2R beta mediates T cell immune responses. IL-2Rγ mediates inflammatory response IL-2Rβ and IL-2Rγ heterodimer binds to IL-2 with intermediate affinity. IL-2R beta & IL-2R gamma Heterodimer Protein, Human (HEK293, Fc) is a recombinant human IL-2R beta (A27-D239) and IL-2R gamma (L23-A262) heterodimer complex, with a C-Terminal hFc tag, which is produced in HEK293 cells.

HY-P70628

	IL-2R alpha Protein, Human (HEK293, His) IL-2R alpha; IL-2RA; Interleukin-2 receptor subunit alpha; CD25; p55; TAC antigen; IL2-RA; IL-2R subunit alpha; IL-2-RA; IL-2 receptor subunit alpha	Human	HEK293
	IL-2R alpha protein is the receptor for interleukin 2 and plays a crucial role in immune tolerance by regulating the activity of regulatory T cells (TREG). These TREGs are responsible for inhibiting the activation and expansion of autoreactive T cells. IL-2R alpha Protein, Human (HEK293, His) is the recombinant human-derived IL-2R alpha protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-2R alpha Protein, Human (HEK293, His) is 192 a.a., with molecular weight of ~44.0 kDa.

HY-P78401

	IL-2R gamma/CD132 Protein, Human (HEK293, His-Avi) CD132; CIDX; IL-2 R gamma; IL2RG; IMD4; P64; SCIDX; SCIDX1; gammaC	Human	HEK293
	IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2. IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types. IL-2R gamma/CD132 Protein, Human (HEK293, His-Avi) is a recombinant human extracellular region of IL-2R gamma (L23-N254) with a C-Terminal Avi and a His tag, which is produced in HEK293 cells.

HY-P70693

	IL-2R gamma/CD132 Protein, Mouse (239a.a, HEK293, His) IL-2RG; IL-2 R gamma; IL-2Rγ; IL2R γ; Interleukin 2 receptor, gamma chain, isoform CRA_b; IL2rg	Mouse	HEK293
	IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2. IL-2R gamma takes part in inflammatory response and mediates activation of the cells . IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types. IL-2R gamma/CD132 Protein, Mouse (239a.a, HEK293, His) is a recombinant mice extracellular region of IL-2R gamma (S25-A263) with a C-Terminal 6*His tag, which is produced in HEK293 cells.

HY-P78083

	IL-2R gamma/CD132 Protein, Human (Biotinylated, HEK293, His-Avi) CD132; CIDX; IL-2 R gamma; IL2RG; IMD4; P64; SCIDX; SCIDX1; gammaC	Human	HEK293
	IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2. IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types. IL-2R gamma/CD132 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human extracellular region of IL-2R gamma (L23-N254) with a C-Terminal Avi and a His tag, which is produced in HEK293 cells.

HY-P75629

	IL-2R alpha/CD25 Protein, Rhesus Macaque (Biotinylated, HEK293, His-Avi) CD25; IDDM10; IL-2 R alpha; IL2-RA; Interleukin 2 receptor, alpha; TCGFR	Rhesus Macaque	HEK293
	IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions. IL-2R alpha/CD25 Protein, Rhesus Macaque (Biotinylated, HEK293, His-Avi) is a recombinant rhesus macaque IL-2R alpha protein with a His tag and an Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 213 amino acids (M1-R213) and is biotinylated.

HY-P70556

	IL-2R gamma/CD132 Protein, Human (HEK293, His) IL-2RG; IL-2 R gamma; IL-2Rγ; IL2R γ; Cytokine receptor common subunit gamma; Interleukin-2 receptor subunit gamma; gammaC; P64; CD132 and IL2RG	Human	HEK293
	IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2. IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types. IL-2R gamma/CD132 Protein, Human (HEK293, His) is a recombinant human extracellular region of IL-2R gamma (L23-A262) with a C-Terminal 6*His tag, which is produced in HEK293 cells.

HY-P77883

	IL-2R beta/CD122 Protein, Cynomolgus (HEK293, His) CD122; IL-15 R beta; IL-2 R beta; IL-2R subunit beta; IL2RB; P70-75; p75; RP5-1170K4.6	Cynomolgus	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus IL-2R beta (A27-D239) with a C-Terminal His tag, which is produced in HEK 293.

HY-P77594

	IL-2R beta/CD122 Protein, Human (HEK293, His-Avi) CD122; IL-15 R beta; IL-2 R beta; IL-2R subunit beta; IL2RB; P70-75; p75; RP5-1170K4.6	Human	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, His-Avi) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.

HY-P74805

	IL-2R gamma/CD132 Protein, Rat (HEK293, His) Cytokine receptor common subunit gamma; IL-2RG; p64; CD132	Rat	HEK293
	IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2. IL-2R gamma takes part in inflammatory response and mediates activation of the cells . IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types. IL-2R gamma/CD132 Protein, Rat (HEK293, His) is a recombinant rat extracellular region of IL-2R beta (M1-A262) with a C-Terminal His tag, which is produced in HEK293 cells.

Cat. No.	Product Name	Application	Reactivity

HY-P81709

IL-2 Antibody (YA1454)

IL2; Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin
FC, ELISA Human

HY-P82616

IL-2 Receptor alpha Antibody (YA2361) IL2RA; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; TAC antigen; p55; CD25	IHC-P, ICC/IF	Human

HY-P81712

IL-2RA Antibody (YA1457)

IL2RA; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; TAC antigen; p55; CD25
FC, ELISA Human

HY-P83601

ITK Antibody (YA3346) ITK; EMT; LYK; Tyrosine-protein kinase ITK/TSK; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk	WB, IHC-P, FC	Human

HY-P81408

ZEB1 Antibody (YA1153)

ZEB1; TCF8; AREB6; Zinc finger E-box-binding homeobox 1; NIL-2-A zinc finger protein; Negative regulator of IL2; Transcription factor 8 (TCF-8)
IHC-P Human

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