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Results for "

IL-6/GP130

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (3) Akt (1) Apoptosis (3) Estrogen Receptor/ERR (5) Isotope-Labeled Compounds (1) mTOR (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (1)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15614

SC144 3 Publications Verification	Interleukin Related Apoptosis	Cancer
SC144 is a first-in-class, orally active **gp130 (IL6-beta)** inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells .

HY-15614A

SC144 hydrochloride 3 Publications Verification	Interleukin Related Apoptosis	Cancer
SC144 hydrochloride is a first-in-class, orally active **gp130 (IL6-beta)** inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells .

HY-102084

LMT-28 5+ Cited Publications	Interleukin Related	Inflammation/Immunology
LMT-28 is an orally active and the first synthetic *IL-6* inhibitor that functions through direct binding to gp130. LMT-28 shows low toxicity and selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130 .

HY-A0036

Bazedoxifene acetate Maximum Cited Publications 10 Publications Verification TSE-424 acetate	Estrogen Receptor/ERR	Cancer
Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM), with IC₅₀s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene acetate can be used for the research of osteoporosis. Bazedoxifene acetate also acts as an inhibitor of *IL-6/GP130* protein-protein interactions and can be used for the research of pancreatic cancer .

HY-103438

BIBU1361	Apoptosis Akt mTOR	Cancer
BIBU1361 induces apoptosis and inhibits autophagy. BIBU1361 inhibits pro-survival pathways Akt/mTOR and *gp130/JAK/STAT3, and decreased levels of pro-inflammatory cytokine IL-6* .

HY-A0031

Bazedoxifene Maximum Cited Publications 10 Publications Verification TSE-424	Estrogen Receptor/ERR	Cancer
Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC₅₀s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of *IL-6/GP130* protein-protein interactions and can be used for the research of pancreatic cancer .

HY-A0031A

Bazedoxifene hydrochloride TSE-424 hydrochloride	Estrogen Receptor/ERR	Cancer
Bazedoxifene hydrochloride (TSE-424 hydrochloride) is an oral active, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC₅₀s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene hydrochloride can be used for the research of osteoporosis. Bazedoxifene hydrochloride acts as an inhibitor of *IL-6/GP130* protein-protein interactions. Bazedoxifene hydrochloride can be used for the research of pancreatic cancer .

HY-A0031S

Bazedoxifene-d4 TSE-424-d₄	Isotope-Labeled Compounds Estrogen Receptor/ERR	Cancer
Bazedoxifene-d₄ is deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

HY-A0031S2

Bazedoxifene-d4 acetate TSE-424-d₄ acetate	Estrogen Receptor/ERR	Cancer
Bazedoxifene-d₄ (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

Species:	Human (4) Rhesus Macaque (2) Mouse (3) Rat (2)
Tag:	His (7) Tag Free (1) Fc (5)
Source:	HEK293 (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P75792

	gp130/IL6ST Protein, Human (HEK293) Interleukin-6 receptor subunit beta; IL-6RB; CDw130; GP130; CD130; IL6ST	Human	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Human (HEK293) is a recombinant protein consisting of 596 amino acids (M23-I618) and is produced by HEK293 cells.

HY-P76371

	gp130/IL6ST Protein, Mouse (HEK293, His) Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; GP130; CD130	Mouse	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Mouse (617a.a, HEK293, His) is a recombinant protein with a His label and is produced by HEK293 cells.

HY-P76374

	gp130/IL6ST Protein, Rat (HEK293, His) Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; GP130; CD130	Rat	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Rat (HEK293, His) is a recombinant protein with a His label that consists of 614 amino acids (M4-E618) and is produced by HEK293 cells.

HY-P75794

	gp130/IL6ST Protein, Human (HEK293, Fc) Interleukin-6 receptor subunit beta; IL-6RB; CDw130; GP130; CD130; IL6ST	Human	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Human (HEK293, Fc) is a recombinant protein with a Fc label that consists of 618 amino acids (M1-I618) and is produced by HEK293 cells.

HY-P76375

	gp130/IL6ST Protein, Rat (HEK293, His-Fc) Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; GP130; CD130	Rat	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Rat (HEK293, His-Fc) is a recombinant protein with a His-Fc label that consists of 614 amino acids (M4-E618) and is produced by HEK293 cells.

HY-P701319

	gp130/IL6ST Protein, Human (HEK293, His) Interleukin-6 receptor subunit beta; IL-6RB; CDw130; GP130; CD130; IL6ST	Human	HEK293
	gp130/IL6ST is an important signal transduction molecule that can form high-affinity receptor complexes for cytokines such as IL6, LIF, and OSM. Upon IL6 binding, gp130/IL6ST homodimerizes and activates the JAK-MAPK and JAK-STAT3 pathways, leading to the phosphorylation of IL6ST tyrosine residues and subsequent activation of STAT3. gp130/IL6ST Protein, Human (HEK293, His) is the recombinant human-derived gp130/IL6ST protein, expressed by HEK293 , with C-His labeled tag. The total length of gp130/IL6ST Protein, Human (HEK293, His) is 597 a.a., with molecular weight of 80-110 kDa.

HY-P78781

	gp130/IL6ST Protein, Mouse (595a.a, HEK293, His) IL6ST; GP130; CD130; IL-6RB; IL-6R-beta; CDw130	Mouse	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Mouse (595a.a, HEK293, His) is a recombinant protein with a His label that consists of 595 amino acids (Q23-E617) and is produced by HEK293 cells.

HY-P75795

	gp130/IL6ST Protein, Human (HEK293, His-Fc) Interleukin-6 receptor subunit beta; IL-6RB; CDw130; GP130; CD130; IL6ST	Human	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Human (HEK293, His-Fc) is a recombinant protein with a His-Fc label that consists of 618 amino acids (M1-I618) and is produced by HEK293 cells.

HY-P77374

	gp130/IL6ST Protein, Rhesus Macaque (HEK293, Fc) Interleukin-6 receptor subunit beta; IL-6RB; CDw130; GP130; CD130; IL6ST	Rhesus Macaque	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Rhesus Macaque (HEK293, Fc) is a recombinant protein with a Fc label that consists of 618 amino acids (M1-I618) and is produced by HEK293 cells.

HY-P77375

	gp130/IL6ST Protein, Rhesus Macaque (HEK293, His) Interleukin-6 receptor subunit beta; IL-6RB; CDw130; GP130; CD130; IL6ST	Rhesus Macaque	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Rhesus Macaque (HEK293, His) is a recombinant protein with a His label that consists of 618 amino acids (M1-I618) and is produced by HEK293 cells.

HY-P76370

	gp130/IL6ST Protein, Mouse (617a.a, HEK293, Fc) Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; GP130; CD130	Mouse	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Mouse (617a.a, HEK293, Fc) is a recombinant protein with a Fc label that consists of 617 amino acids (M1-E617) and is produced by HEK293 cells.


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Bazedoxifene-d4
Bazedoxifene-d₄ is deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

Bazedoxifene-d4 acetate
Bazedoxifene-d₄ (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

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