Search Result

Results for "

Il-1β

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (58) IRAK (1) 5-HT Receptor (3) ADC Cytotoxin (1) Adrenergic Receptor (3) AIM2 (1) Akt (1) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (1) Antibiotic (2) AP-1 (3) Apoptosis (12) Autophagy (8) Bacterial (11) Biochemical Assay Reagents (1) Bradykinin Receptor (1) Btk (1) Calcium Channel (1) Cannabinoid Receptor (4) Caspase (13) COX (17) Cuproptosis (1) Cytochrome P450 (1) Deubiquitinase (2) Dipeptidyl Peptidase (1) Dopamine Receptor (5) Drug Metabolite (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (9) Epigenetic Reader Domain (2) ERK (2) FAAH (1) Ferroptosis (3) Formyl Peptide Receptor (FPR) (1) Fungal (2) FXR (1) GABA Receptor (1) Glucocorticoid Receptor (3) Histamine Receptor (6) Histone Acetyltransferase (1) Histone Methyltransferase (2) IKK (3) Imidazoline Receptor (2) Influenza Virus (1) Isotope-Labeled Compounds (3) JAK (2) JNK (3) Keap1-Nrf2 (3) Lactate Dehydrogenase (1) Leukotriene Receptor (1) Lipoxygenase (2) LPL Receptor (1) MAP3K (1) MDM-2/p53 (1) Mitophagy (2) MMP (4) Monoamine Oxidase (1) MyD88 (1) nAChR (1) Neurokinin Receptor (2) NF-κB (21) NO Synthase (9) NOD-like Receptor (NLR) (34) Nuclear Hormone Receptor 4A/NR4A (2) P2X Receptor (4) p38 MAPK (13) Parasite (4) PGE synthase (4) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (1) Potassium Channel (1) PPAR (2) PROTACs (1) Proteasome (1) Pyroptosis (4) Reactive Oxygen Species (3) ROS Kinase (1) SARS-CoV (1) STAT (2) STING (1) TNF Receptor (34) Toll-like Receptor (TLR) (8) TRP Channel (1) Tyrosinase (2) VEGFR (4) Wnt (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (7) Endocrinology (7) Infection (18) Inflammation/Immunology (192) Metabolic Disease (7) Neurological Disease (31)
Click Chemistry:	Alkynes (2)

223

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

CP-424174	NOD-like Receptor (NLR)	Inflammation/Immunology
CP-424174 is a reversible inhibitor against *IL-1β* processing with an IC₅₀ of 210 nM.CP-424174 indirectly inhibits NLRP3 ^[1].

IL-1β-IN-1	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-1β-IN-1, cannabidiol derivative, is a potent *IL-1β* inhibitor. IL-1β-IN-1 has anti-inflammatory and pain-resolving properties ^[1].

IL-1β-IN-2	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-1β-IN-2, cannabigerol derivative, is a potent *IL-1β* inhibitor. IL-1β-IN-2 has anti-inflammatory and pain-resolving properties ^[1].

Shegansu B (+)-Shegansu B; Parvifolol D	Interleukin Related	Inflammation/Immunology
Shegansu B is an inhibitor of *IL-1β. Shegansu B 6 inhibits IL-1β expression on LPS-induced THP*-1 cells with 64.74% inhibition. Shegansu B has anti-inflammatory activity ^[1].

Anti-inflammatory agent 76	NO Synthase Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 76 (Compd 8b), an anti-inflammatory agent, exhibits good NO, *IL-1β* and IL-6 inhibitory activities ^[1].

HP210	Glucocorticoid Receptor	Inflammation/Immunology
HP210 is a selective glucocorticoid receptor modulator (SGRM). HP210 can inhibit the mRNA expression of IL-1β and IL-6. HP210 has the potential to study inflammation-related diseases ^[1].

ZM640	NOD-like Receptor (NLR)	Inflammation/Immunology
ZM640 is a NLRP3 inhibitor. ZM640 enhances IL-1β release mediated by NLRP3 inflammasome activation in THP-1 cells. ZM640 shows low cytotoxicity ^[1].

NBC19	NOD-like Receptor (NLR)	Inflammation/Immunology
NBC19 is an NLRP3 inflammasome inhibitor with an IC₅₀ of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- and ATP-induced IL-1β release with IC₅₀s of 80 nM and 850 nM, respectively ^[1].

Ac-YVAD-cmk 5+ Cited Publications Caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases ^[1] .

Lupeol acetate 1 Publications Verification	COX Interleukin Related	Inflammation/Immunology
Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B ^[1].

Anti-inflammatory agent 58	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 58 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits *IL-1β* with an IC₅₀ of 1.08 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and NF-κB phosphorylation ^[1].

Anti-inflammatory agent 59	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 59 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits *IL-1β* with an IC₅₀ of 2.28 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and NF-κB phosphorylation ^[1].

p38 MAP Kinase Inhibitor III 1 Publications Verification	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an ₅₀ of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with ₅₀ values of 0.37 μM and 0.044 μM, respectively ^[1].

AZ 11645373	P2X Receptor	Inflammation/Immunology
AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors，AZ11645373 inhibits ATP-evoked *IL-1β* release from lipopolysaccharide-activated THP-1 cells , with an IC₅₀ value of 90 nM ^[1].

CU-CPT 4a 1 Publications Verification TLR3-IN-1	Toll-like Receptor (TLR)	Cancer
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β ^[1].

NLRP3-IN-12	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-12 is a specific NLRP3 inflammasome inhibitor. NLRP3-IN-12 reduces the release of IL-1β by targeting the NLRP3 protein, with an IC₅₀ of 0.45 μM. NLRP3-IN-12 can be used for the research of inflammatory bowel disease ^[1].

CU-115 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-115 is a potent TLR8 antagonist (IC₅₀=1.04 µM), and shows selective for TLR8 over TLR7 (IC₅₀=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells ^[1].

NLRP3-IN-9	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout ^[1].

NCI126224	Toll-like Receptor (TLR)	Inflammation/Immunology
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases ^[1].

NLRP3-IN-15	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-15 is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-15 inhibits IL-1β release with an IC₅₀ of 0.114 μM. NLRP3-IN-15 can be used for the research of inflammation ^[1].

NLRP3-IN-16	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-16 is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-16 inhibits IL-1β release with an IC₅₀ of 0.065 μM. NLRP3-IN-16 can be used for the research of inflammation ^[1].

PROTAC BTK Degrader-6	PROTACs Btk	Inflammation/Immunology
PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC₅₀: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6) ^[1].

Viscidulin II	Others	Inflammation/Immunology
Viscidulin II (FL6) is a flavone. Viscidulin II can be isolated from the root of Scutellaria baicalensis. Viscidulin II significantly suppresses P. acnes-induced IL-8 and IL-1β production in THP-1 cells ^[1].

Isoforskolin Coleonol B	TNF Receptor Interleukin Related	Inflammation/Immunology
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, *IL-1β, IL-6* and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis ^[1].

DCVC S-[(1E)-1,2-dichloroethenyl]--L-cysteine	TNF Receptor	Inflammation/Immunology
DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures ^[1] .

GDC-2394	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits *IL-1β* with IC₅₀s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation ^[1] .

NLRP3-IN-14	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-14 is a potent and selective NLRP3 inflammasome inhibitor (K_D: 5.87 μM). NLRP3-IN-14 inhibits IL-1β release with an IC₅₀ of 0.131 μM. NLRP3-IN-14 can be used for the research of inflammation ^[1].

Lutikizumab ABT-981	Interleukin Related	Inflammation/Immunology
Lutikizumab (ABT-981) is an anti-IL-1α and *IL-1β* dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis ^[1].

Muscone 3 Publications Verification	Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)	Cardiovascular Disease Inflammation/Immunology
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate ^[1].

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of COX-2, *IL-1β, IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects ^[1].

Canakinumab Ilaris; ACZ 885	Interleukin Related	Inflammation/Immunology
Canakinumab (ACZ885) is a recombinant human *anti-IL-1β* monoclonal antibody. Canakinumab shows IC₅₀ values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin ^[1] .

NLRP3-IN-17	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC₅₀ value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research ^[1].

Isogosferol (+)-Isogospherol; Isogospherol	Others	Inflammation/Immunology
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2 ^[1].

Orientin 2 Publications Verification	TNF Receptor Interleukin Related	Neurological Disease Cancer
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, *IL-1β* and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain ^[1] .

Gevokizumab	Interleukin Related	Inflammation/Immunology
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates *IL-1β* signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of *IL-1β* for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) ^[1] .

TPNA10168 KM05073	Keap1-Nrf2	Inflammation/Immunology
TPNA10168 is an Nrf-2 activator that activates the *Keap1-Nrf2-ARE* pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases ^[1].

Terminolic acid	Bacterial	Infection Inflammation/Immunology
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity ^[1] ^[1].

Pralnacasan VX-740; HMR 3480	Caspase	Inflammation/Immunology
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a K_i of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, *IL-1β* , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment ^[1] .

Armillarisin A	Interleukin Related	Inflammation/Immunology
Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β ^[1].

JT002	NOD-like Receptor (NLR)	Inflammation/Immunology
JT002 is an orally active inhibitor of the NLRP3 inflammasome. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice ^[1].

Taxamairin B	TNF Receptor PI3K Reactive Oxygen Species Interleukin Related	Inflammation/Immunology
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, *IL-1β* and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice ^[1] .

Ginsenoside Rh1 2 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	PPAR TNF Receptor Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and *IL-1β*.

Triptobenzene H Hypoglic acid	Others	Others
Triptobenzene H (Hypoglic acid) significantly increases TNF-α and IL-1β mRNA levels in macrophages, causing indirect liver damage ^[1].

CSC-6	NOD-like Receptor (NLR)	Inflammation/Immunology
CSC-6 is a NLRP3 inhibitor. CSC-6 can significantly inhibit IL-1β secreted by PMATHP-1 cells with an IC₅₀ value of 2.3 μM. CSC-6 specifically binds NLRP3 and inhibits NLRP3 activation by blocking ASC oligomerization during NLRP3 assembly. CSC-6 effectively reduces the symptoms of NLRP3 overactivation-mediated sepsis and gout in mouse models ^[1].

NLRP3-IN-13	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
NLRP3-IN-13 (Compound C77 in reference patent) is a selective and potent NLRP3 inhibitor (IC₅₀: 2.1 μM). NLRP3-IN-13 inhibits NLRP3 andNLRC4 inflammasomes, and inhibits NLRP3-mediated IL-1β production. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. NLRP3-IN-13 can be used in the research of neuroinflammatory disorders ^[1].

R-HP210	NF-κB	Inflammation/Immunology
R-HP210 acts on the NF-κB mediated tethered transrepression function (IC₅₀=3.80 μM). R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs) ^[1].

Cat. No.	Product Name

HY-L156

Autoimmune Disease Compound Library

454 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 454 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Cat. No.	Product Name	Type

HY-139414

Lysophosphatidylcholines 1 Publications Verification	Biochemical Assay Reagents
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of *IL-1β* and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis ^[1] .

HY-125864

Fibrinogen (Bovine)

Native Proteins

Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases ^[1] .

HY-W104821

Rosolic acid	Biochemical Assay Reagents
Rosolic Acid is an activator of Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α and *IL-1β) and apoptotic markers (CXCL10* and CCL2). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed ^[1].

HY-W145695

Chitoheptaose

Biochemical Assay Reagents

Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models ^[1].

Cat. No.	Product Name	Target	Research Area

HY-125083

Lys-D-Pro-Thr

Interleukin Related Metabolic Disease

Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta ^[1] .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation ^[1] .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation ^[1] .

HY-113893

β-Interleukin I (163-171), human	Peptides	Inflammation/Immunology
β-Interleukin I (163-171), human, an immunostimulatory fragment of human IL-1β peptide, is a T cell activator. β-Interleukin I (163-171), human is not an IL-1R-binding domain of IL-1β. β-Interleukin I (163-171), human is a potent adjuvant that enhances the immune response in a variety of exptl. situations ^[1] .

HY-103291

Sar-[D-Phe8]-des-Arg9-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P99721

Lutikizumab ABT-981	Interleukin Related	Inflammation/Immunology
Lutikizumab (ABT-981) is an anti-IL-1α and *IL-1β* dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis ^[1].

HY-108810

Canakinumab Ilaris; ACZ 885	Interleukin Related	Inflammation/Immunology
Canakinumab (ACZ885) is a recombinant human *anti-IL-1β* monoclonal antibody. Canakinumab shows IC₅₀ values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin ^[1] .

HY-P99171

Gevokizumab	Interleukin Related	Inflammation/Immunology
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates *IL-1β* signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of *IL-1β* for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) ^[1] .

HY-P99235

Nadunolimab	Interleukin Related	Cancer
Nadunolimab is a human monoclonal IgG1 antibody targeting *IL1RAP. Nadunolimab blocks IL-1α and IL-1*β signaling and triggering antibody-dependent cellular cytotoxicity. Nadunolimab can be used in research of cancer ^[1].

HY-112956

Drotrecogin alfa (activated)	Inhibitory Antibodies	Inflammation/Immunology
Drotrecogin alfa activated (DrotAA) is recombinant human activated protein C (APC). Drotrecogin alfa activated prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1β in rats. Drotrecogin alfa activated inhibits coagulation and inflammation and promotes fibrinolysis. Drotrecogin alfa activated can be used for severe sepsis reaearch ^[1] .

HY-P99111

Golimumab CNTO-148	TNF Receptor Apoptosis Interleukin Related Caspase	Inflammation/Immunology Cancer
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research ^[1] .

HY-P99379

Nidanilimab CAN04; Anti-Il-1RAP/Il-1R3 Reference Antibody (nidanIlimab)	Interleukin Related	Cancer
Nidanilimab (CAN04) is a fully humanized monoclonal *anti-IL1RAP* antibody with a K_d value of 1.10 pM. Nidanilimab blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) ^[1] .

HY-P9953

Certolizumab pegol Certolizumab; CDP870	TNF Receptor	Inflammation/Immunology
Certolizumab pegol (Certolizumab) is a recombinant, polyethylene glycolylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor-α (TNF-α). Certolizumab pegol can be used for rheumatoid arthritis and Crohn disease research ^[1] .

HY-P99751

Nebacumab

HA-1A; Septomonab
Bacterial Infection

Nebacumab (HA-1A) is a monoclonal antibody that binds to lipid A portion of endotoxin. Nebacumab can be used of research of sepsis ^[1] .

Species:	Human (13) Porcine (1) Rhesus Macaque (1) Rat (3) Mouse (5) Cat (1) Cynomolgus (3) Rabbit (1) Pig (1) Canine (1)
Tag:	His (16) Tag Free (14) Avi (2) GST (1)
Source:	HEK293 (1) CHO (2) P. pastoris (1) E. coli (27)

Cat. No.	Compare	Product Name	Species	Source

HY-P73900

	IL-1 beta Protein, Rat (268a.a, His) 2 Publications Verification Interleukin-1 beta; Il-1β; Il1F2; Il-1 beta; Il1B	Rat	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Rat (268a.a, His) is produced in E. coli with a N-Terminal His-tag. It consists of 268 amino acids (M1-S268).

HY-P73149

	IL-1 beta Protein, Human (E6K, His) 4 Publications Verification Interleukin-1 beta; Il-1β; Il1F2; Il-1 beta; Il1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (E6K, His) is produced in E. coli with a N-Terminal His-tag. It consists of 269 amino acids (M1-S269).

HY-P700243AF

	*Animal-Free IL-1* beta Protein, Pig (His)** Interleukin-1 beta; Il-1β; Il1F2; Il-1 beta; Il1B	Pig	E. coli
	IL-1 beta Protein, a potent pro-inflammatory cytokine, initiates various immune responses, including prostaglandin synthesis, neutrophil recruitment, T-cell cytokine production, B-cell activation, fibroblast proliferation, and collagen production. It promotes Th17 differentiation, synergizes with IL12 for IFNG synthesis by Th1 cells, and induces angiogenesis along with TNF and IL6. Involved in pyroptosis, its mature form is released through the GSDMD pore. Additionally, IL-1 beta Protein interacts with ASFV protein L83L during microbial infections. Animal-Free IL-1 beta Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-1 beta protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-1 beta Protein, Pig (His) is 153 a.a., with molecular weight of ~18.51 kDa.

HY-P73150

	IL-1 beta Protein, Rabbit Interleukin-1 beta; Il-1β; Il1F2; Il-1 beta; Il1B	Rabbit	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Rabbit consists of 152 amino acids (A117-S268) and is expressed in E. coli.

HY-P701104

	IL-1 beta Protein, Human (His, E6K) Interleukin-1 beta; Il-1β; Il1F2; Il-1 beta; Il1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (His) is produced in E. coli with a N-Terminal His-tag. It consists of 269 amino acids (M1-S269).

HY-P73148

	IL-1 beta Protein, Feline Interleukin-1 beta; Il-1β; Il1F2; Il-1 beta; Il1B	Cat	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Feline consists of 152 amino acids (A116-S267) and is expressed in E. coli.

HY-P73147

	IL-1 beta Protein, Cynomolgus Interleukin-1 beta; Il-1β; Il1F2; Il-1 beta; Il1B	Cynomolgus	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Cynomolgus consists of 153 amino acids (A117-S269) and is expressed in E. coli.

HY-P73146

	IL-1 beta Protein, Canine Interleukin-1 beta; Il-1β; Il1F2; Il-1 beta; Il1B	Canine	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Canine consists of 152 amino acids (A115-S266) and is expressed in E. coli.

HY-P78459A

	IL-1 beta Protein, Human (C-His) Interleukin-1 beta; Il-1 beta; Il1F2; Il1B; Il-1BETA; Il1F2; Il-1β; Il-1 beta; Il-1B ; Interleukin-1 β; Il-1 β; Il-1β; Il-1 β	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. IL-1 beta Protein, Human (C-His) is the recombinant human-derived IL-1 beta protein, expressed by E. coli , with C-6*His labeled tag. The total length of IL-1 beta Protein, Human (C-His) is 153 a.a., with molecular weight of ~19.0 kDa.

HY-P700888

	IL-1 beta Protein, Cynomolgus (C-His) Interleukin-1 beta; Il-1 beta; Il1F2; Il1B; Il-1BETA; Il1F2; Il-1β; Il-1 beta; Il-1B ; Interleukin-1 β; Il-1 β; Il-1β; Il-1 β	Cynomolgus	E. coli
	IL-1 beta Protein, a potent pro-inflammatory cytokine and endogenous pyrogen, induces diverse responses, including prostaglandin synthesis, neutrophil and T-cell activation, B-cell activation, and fibroblast proliferation. It promotes Th17 differentiation, synergizes with IL12 for Th1 IFNG synthesis, and contributes to angiogenesis by inducing VEGF production with TNF and IL6. Involved in pyroptosis, its mature form is released through the GSDMD pore. Existing as a monomer, IL-1 beta Protein interacts with MEFV. IL-1 beta Protein, Cynomolgus (C-His) is the recombinant cynomolgus-derived IL-1 beta protein, expressed by E. coli, with C-His labeled tag. The total length of IL-1 beta Protein, Cynomolgus (C-His) is 152 a.a., with molecular weight of 18.33 kDa.

HY-P700254

	IL-1beta Protein, Human (153aa, His) Interleukin-1 beta; Il-1 beta; Il1F2; Il1B; Il-1BETA; Il1F2; Il-1β; Il-1 beta; Il-1B ; Interleukin-1 β; Il-1 β; Il-1β; Il-1 β	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. IL-1beta Protein, Human (153aa, His) is the recombinant human-derived IL-1beta protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-1beta Protein, Human (153aa, His) is 153 a.a., with molecular weight of approximately 18 kDa.

HY-P700096AF

	*Animal-Free IL-1* beta Protein, Human (His)** Interleukin-1 beta; Il-1 beta; Il1F2; Il1B; Il-1BETA; Il1F2; Il-1β; Il-1 beta; Il-1B ; Interleukin-1 β; Il-1 β; Il-1β; Il-1 β	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. Animal-Free IL-1 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-1 beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-1 beta Protein, Human (His) is 153 a.a., with molecular weight of ~18.48 kDa.

HY-P78459

	IL-1 beta Protein, Human (His-Avi) Interleukin-1 beta; Il-1 beta; Il1F2; Il1B; Il-1BETA; Il1F2; Il-1β; Il-1 beta; Il-1B ; Interleukin-1 β; Il-1 β; Il-1β; Il-1 β	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (His-Avi) is produced in E. coli with a C-Terminal His-tag and a C-Terminal Avi-tag. It consists of 153 amino acids (A117-S269).

HY-P78143

	IL-1 beta Protein, Human (Biotinylated, His-Avi) Interleukin-1 beta; Il-1 beta; Il1F2; Il1B; Il-1BETA; Il1F2; Il-1β; Il-1 beta; Il-1B ; Interleukin-1 β; Il-1 β; Il-1β; Il-1 β	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (Biotinylated, His-Avi), a Biotinylated IL-1 beta protein, is produced in E. coli with a C-Terminal His-tag and a C-Terminal Avi-tag. It consists of 153 amino acids (A117-S269).

HY-P78585

	IL-1 beta Protein, Cynomolgus (His) Il1B; Il-1BETA; Il1F2; Il-1β	Cynomolgus	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Cynomolgus (His) is produced in E. coli with a N-Terminal His-tag. It consists of 152 amino acids (A117-S268).

HY-P7028

	IL-1 beta Protein, Human 5+ Cited Publications rHuIl-1β; Catabolin; Il1F2; Il-1 beta; Il1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta is produced as inactive pro-IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli. IL-1 beta Protein, Human consists of 153 amino acids (A117-S269) and is expressed in E. coli.

HY-P7073

	IL-1 beta Protein, Mouse Maximum Cited Publications 13 Publications Verification rMuIl-1β; Catabolin; Il1F2; Il-1 beta; Il1B	Mouse	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Mouse consists of 152 amino acids (V118-S269) and is expressed in E. coli.

HY-P7097

	IL-1 beta Protein, Rat 5+ Cited Publications rRtIl-1β; Catabolin; Il1F2; Il-1 beta; Il1B	Rat	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Rat consists of 152 amino acids (V117-S268) and is expressed in E. coli.

HY-P7097A

	IL-1 beta Protein, Rat (His) 2 Publications Verification rRtIl-1β; Catabolin; Il1F2; Il-1 beta; Il1B	Rat	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine and endogenous pyrogen that induces multiple inflammatory responses, including prostaglandin synthesis, neutrophil, T-cell and B-cell activation, and fibroblast proliferation. It promotes Th17 differentiation, synergizes with IL12 to promote IFNG synthesis, and induces VEGF production through TNF and IL6 to promote angiogenesis. IL-1 beta Protein, Rat (His) is the recombinant rat-derived IL-1 beta protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-1 beta Protein, Rat (His) is 152 a.a., with molecular weight of ~19 kDa.

HY-P7073A

	IL-1 beta Protein, Mouse (CHO) 3 Publications Verification rMuIl-1β; Catabolin; Il1F2; Il-1 beta; Il1B	Mouse	CHO
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Mouse (CHO) is produced in CHO cells, and consists of 152 amino acids (V118-S269).

HY-P70437

	IL-1beta Protein, Mouse Interleukin-1 Beta; Il-1 Beta; Il1b	Mouse	E. coli
	IL-1 beta protein is a potent pro-inflammatory cytokine and major endogenous pyrogen that induces immune cell effects such as prostaglandin synthesis, neutrophil activation, T- and B-cell activation, and fibroblast proliferation . It promotes Th17 differentiation and synergizes with IL12 to promote Th1 IFNG synthesis. IL-1beta Protein, Mouse is the recombinant mouse-derived IL-1beta protein, expressed by E. coli , with tag free. The total length of IL-1beta Protein, Mouse is 152 a.a., with molecular weight of ~16.0 kDa.

HY-P72571

	IL-1 beta Protein, Cavia porcellus (His) Interleukin-1 beta; Il-1 beta; Il1B	Others	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Cavia porcellus (His) is produced in E. coli with six C-Terminal His-tags. It consists of 152 amino acids (T115-S266).

HY-P700187AF

	*Animal-Free IL-1* beta Protein, Mouse (His)** rMuIl-1β; Catabolin; Il1F2; Il-1 beta; Il1B	Mouse	E. coli
	IL-1 beta Protein, a potent pro-inflammatory cytokine and major endogenous pyrogen, induces immune cell effects like prostaglandin synthesis, neutrophil activation, T-cell and B-cell activation, and fibroblast proliferation. It promotes Th17 differentiation and synergizes with IL12 for Th1 IFNG synthesis. Contributing to angiogenesis, it induces VEGF production with TNF and IL6. Involved in pyroptosis, its mature form is released through the GSDMD pore. Existing as a monomer, IL-1 beta Protein interacts with MEFV, integrins, TMED10, HSP90AB1, and HSP90B1, facilitating cargo translocation into the ERGIC. Animal-Free IL-1 beta Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-1 beta protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-1 beta Protein, Mouse (His) is 152 a.a., with molecular weight of ~18.3 kDa.

HY-P7206

	IL-1 beta Protein, Porcine rPoIl-1β; Il1B	Porcine	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Porcine consists of 153 amino acids (A115-P267) and is expressed in E. coli.

HY-P7207

	IL-1 beta Protein, Rhesus macaque rRhIl-1β; Il1B	Rhesus Macaque	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Rhesus macaque consists of 153 amino acids (A117-S269) and is expressed in E. coli.

HY-P7205

	IL-1 beta Protein, Human (CHO) rHuIl-1β; Catabolin; Il1F2; Il1B	Human	CHO
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (CHO) is produced in CHO cells, and consists of 153 amino acids (A117-S269).

HY-P70586

	IL-1 beta Protein, Human (solution) Interleukin-1 beta; Catabolin; Il1F2; Il1B.	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. IL-1 beta Protein, Human (solution) is the recombinant human-derived IL-1 beta protein, expressed by E. coli , with tag free. The total length of IL-1 beta Protein, Human (solution) is 153 a.a., with molecular weight of ~16.61 kDa.

HY-P70586G

	*GMP IL-1* beta Protein, Human** Interleukin-1 beta; Catabolin; Il1F2; Il1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. GMP IL-1 beta Protein, Human, is a recombinant GMP-grade protein, consists of 153 amino acids (A117-S269) and is expressed in E. coli.

HY-P71246

	PTX3 Protein, Mouse (HEK293, His) alpha-induced protein 5; pentaxin-related gene, rapidly induced by Il-1 beta, tumor necrosis factor; Pentaxin-related protein PTX3; Pentraxin 3; pentraxin 3, long; pentraxin-3; pentraxin-related gene, rapidly induced by Il-1 beta; pentraxin-related protein PTX3;	Mouse	HEK293
	PTX3 Protein, pivotal in innate pathogen resistance and inflammation regulation, may contribute to self-component clearance and female fertility. As a homooctamer with disulfide-linked structures, PTX3's multifaceted nature maintains immune homeostasis. Interaction with C1q underscores its significance in innate immune responses, positioning PTX3 as a key player in pathogen defense and inflammatory modulation. PTX3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PTX3 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PTX3 Protein, Mouse (HEK293, His) is 364 a.a., with molecular weight of ~54.0 kDa.

HY-P72117

	Caspase-1/CASP1 Protein, Human (GST) CASP-1; CASP1; CASP1_HUMAN; Caspase 1; ICE; Il-1 beta-converting enzyme; Il-1BC; Il1 beta converting enzyme; Il1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45	Human	E. coli
	Caspase-1/CASP1 is a thiol protease complex involved in inflammation by catalyzing the cleavage of IL1B, IL18, and Gasdermin-D (GSDMD). It activates a pro-inflammatory response, releases mature cytokines IL1B and IL18, and initiates pyroptosis through cleavage of GSDMD. Caspase-1/CASP1 Protein, Human (GST) is the recombinant human-derived Caspase-1/CASP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of Caspase-1/CASP1 Protein, Human (GST) is 150 a.a., with molecular weight of ~43.8 kDa.

HY-P700624

	RIPK2 Protein, Human (P. pastoris, His) receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing Il-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30	Human	P. pastoris
	RIPK2 is a multifunctional serine/threonine/tyrosine protein kinase that coordinates innate and adaptive immune responses. It is activated by bacterial peptidoglycan to form filaments in the NOD1 and NOD2 pathways, undergoing autophosphorylation and polyubiquitination. RIPK2 Protein, Human (P. pastoris, His) is the recombinant human-derived RIPK2 protein, expressed by P. pastoris , with C-6His, C-6His labeled tag. The total length of RIPK2 Protein, Human (P. pastoris, His) is 540 a.a., with molecular weight of 66 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P80503

IL-1 beta Antibody (YA345)	WB, ICC/IF, IHC-P, FC	Human
IL-1 beta Antibody (YA345) is a non-conjugated and Rabbit origined monoclonal antibody about 31 kDa, targeting to IL-1 beta. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human.

HY-P80720

IL-1 beta Antibody Il1B; Il1F2; Interleukin-1 beta; Il-1 beta; Catabolin	WB, IHC-P, ICC/IF	Human, Mouse, Rat
IL-1 beta Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 31 kDa, targeting to IL-1 beta. It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P81232

Caspase-1 p20 Antibody caspase-1 isoform alpha p20 subunit; CASP1; ICE; Il1BC; Caspase-1 subunit p20; CASP 1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; Il 1 beta converting enzyme; Il 1BC; Il1B convertase; Il1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; CASP-1; Interleukin-1 beta convertase; Il-1BC; Interleukin-1 beta-converting enzyme; ICE; Il-1 beta-converting enzyme; p45; CASP1_HUMAN; CASP1_MOUSE.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat,
Caspase-1 p20 Antibody is an unconjugated, approximately 20/46 kDa, rabbit-derived, anti-Caspase-1 p20 polyclonal antibody. Caspase-1 p20 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, background without labeling.

Cat. No.	Product Name		Classification

HY-130252

YQ128 1 Publications Verification		Alkynes
YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC₅₀ of 0.30 μM. YQ128 significantly and selectively suppresses the production of *IL-1β*, but not TNF-α, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity ^[1]. YQ128 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133870

Itaconate-alkyne 1 Publications Verification ITalk		Alkynes
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate ^[1]. Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Il-1β

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products