Import

By Targets:	Antibiotic (1) AP-1 (1) Apoptosis (2) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Dengue virus (1) Endogenous Metabolite (1) Flavivirus (1) HIV (1) HSP (1) HSV (1) Mitophagy (1) Monocarboxylate Transporter (1) Parasite (1) PKC (1) Ras (1) SARS-CoV (1) Sodium Channel (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015828

Ompenaclid 1 Publications Verification RGX-202; 3-Guanidinopropionic acid	Apoptosis Endogenous Metabolite	Cancer
Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy .

HY-N4250

Periplocoside N	Others	Infection
Periplocoside N, a pregnane glycoside isolated from root powder of Periploca sepium, possesses insecticidal activities against the red imported fire ant .

HY-156214

NICE-01 AP1867-PEG2-JQ1; AP-PEG2-JQ1	Others	Others
NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a “carrier” for co-import and nuclear trapping of cytosolic proteins .

HY-115467

MitoBloCK-10 1 Publications Verification	HSP	Metabolic Disease
MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70 .

HY-P3838

Protein Kinase C (gamma) Peptide	PKC	Others
Protein Kinase C γ Peptide is a peptide fragment of Protein Kinase Cγ. Protein Kinase Cγ is a protein causative for dominant ataxia, that can negatively regulate nuclear import of recessive-ataxia-related aprataxin .

HY-15310

Ivermectin Maximum Cited Publications 18 Publications Verification MK-933	Flavivirus Dengue virus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial	Infection Cancer
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-136830

ADP-Glucose disodium Adenosine-5'-diphosphoglucose disodium	Biochemical Assay Reagents	Others
ADP-Glucose disodiumIs an immediate precursor for the biosynthesis of storage polysaccharides in plants, green algae and cyanobacteria, and structural polysaccharides in some bacteria, by the addition of glucose. It is used to produce amylose, amylopectin, starch and other polysaccharides by amylose synthase or starch synthase in plastids. ADPGUsually produced in plastids, although it can be biosynthesized in the cytoplasm of some grasses and imported into plastids by membrane-bound transporters .

HY-110358

QAQ dichloride	Sodium Channel	Inflammation/Immunology
QAQ dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-139665

VB124	Monocarboxylate Transporter	Cardiovascular Disease
VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC₅₀s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism .

HY-110358A

QAQ	Sodium Channel	Inflammation/Immunology
QAQ dichloride dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-13991A

(S)-CCG-1423	Ras	Metabolic Disease Cancer
(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes .

HY-121607

INI-43	AP-1 Apoptosis	Cancer
INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G₂-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway .

Cat. No.	Product Name	Type

HY-136830

ADP-Glucose disodium Adenosine-5'-diphosphoglucose disodium	Biochemical Assay Reagents
ADP-Glucose disodiumIs an immediate precursor for the biosynthesis of storage polysaccharides in plants, green algae and cyanobacteria, and structural polysaccharides in some bacteria, by the addition of glucose. It is used to produce amylose, amylopectin, starch and other polysaccharides by amylose synthase or starch synthase in plastids. ADPGUsually produced in plastids, although it can be biosynthesized in the cytoplasm of some grasses and imported into plastids by membrane-bound transporters .

ADP-Glucose disodium

Adenosine-5'-diphosphoglucose disodium

Biochemical Assay Reagents

ADP-Glucose disodiumIs an immediate precursor for the biosynthesis of storage polysaccharides in plants, green algae and cyanobacteria, and structural polysaccharides in some bacteria, by the addition of glucose. It is used to produce amylose, amylopectin, starch and other polysaccharides by amylose synthase or starch synthase in plastids. ADPGUsually produced in plastids, although it can be biosynthesized in the cytoplasm of some grasses and imported into plastids by membrane-bound transporters .

Cat. No.	Product Name	Target	Research Area

HY-P0310

SV40 large T antigen NLS

Peptides Infection

SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.

SV40 large T antigen NLS	Peptides	Infection
SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.

HY-P3838

Protein Kinase C (gamma) Peptide	PKC	Others
Protein Kinase C γ Peptide is a peptide fragment of Protein Kinase Cγ. Protein Kinase Cγ is a protein causative for dominant ataxia, that can negatively regulate nuclear import of recessive-ataxia-related aprataxin .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015828

Ompenaclid 1 Publications Verification RGX-202; 3-Guanidinopropionic acid	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy .

HY-N4250

Periplocoside N	Infection other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids	Others
Periplocoside N, a pregnane glycoside isolated from root powder of Periploca sepium, possesses insecticidal activities against the red imported fire ant .

HY-15310

Ivermectin 15+ Cited Publications MK-933	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer	Flavivirus Dengue virus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

Species:	E.coli (1)
Tag:	SUMO (1) His (2) Tag Free (2)
Source:	E. coli Cell-free (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71460

	GltI/YbeJ Protein, E.coli (His-SUMO) gltI; ybeJ; yzzK; b0655; JW5092Glutamate/aspartate Import solute-binding protein	E.coli	E. coli
	The GltI/YbeJ protein is a key component of the ABC transporter complex GltIJKL and is essential for active transport of glutamate and aspartate. As the solute-binding protein in the complex, GltI binds glutamate and aspartate. GltI/YbeJ Protein, E.coli (His-SUMO) is the recombinant E. coli-derived GltI/YbeJ protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of GltI/YbeJ Protein, E.coli (His-SUMO) is 280 a.a., with molecular weight of ~47.2 kDa.

HY-P71366

	TIM-14 Protein, S.cerevisiae Mitochondrial Import inner membrane translocase subunit TIM14; Presequencetranslocated associated motor subunit PAM18; PAM18; TIM14	Others	E. coli
	The TIM-14 protein is an important component of the PAM complex and is required for the transport of transit peptide-containing proteins from the inner membrane to the mitochondrial matrix using ATP. TIM-14 Protein, S.cerevisiae is the recombinant TIM-14 protein, expressed by E. coli , with tag free. The total length of TIM-14 Protein, S.cerevisiae is 70 a.a., with molecular weight of ~9.0 kDa.

HY-P71367

	TIM-16 Protein, S. cerevisiae Mitochondrial Import inner membrane translocase subunit TIM16; Presequence translocated-associated motor subunit PAM16; PAM16; TIM16	Others	E. coli
	TIM-16 protein is an important component of the PAM complex, which uses ATP to promote the transfer of transit peptide-containing proteins from the inner membrane to the mitochondrial matrix. TIM-16 Protein, S. cerevisiae is the recombinant TIM-16 protein, expressed by E. coli , with tag free. The total length of TIM-16 Protein, S. cerevisiae is 66 a.a., with molecular weight of ~11.0 kDa.

HY-P702226

	BtuC Protein, Halobacterium salinarum (Cell-Free, strain ATCC 29341 / DSM 671 / R1) (Cell-Free, His) Cobalamin Import system permease protein BtuC	Others	E. coli Cell-free
	BtuC, a crucial component of the BtuCDF ABC transporter complex, is integral for corrinoid utilization, facilitating cobalamin (vitamin B12) import. It likely plays a vital role in substrate translocation across the membrane. The complete complex includes two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC), and a solute-binding protein (BtuF), collectively ensuring the efficient import of cobalamin into the cell. BtuC Protein, Halobacterium salinarum (Cell-Free, strain ATCC 29341 / DSM 671 / R1) (Cell-Free, His) is the recombinant BtuC protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of BtuC Protein, Halobacterium salinarum (Cell-Free, strain ATCC 29341 / DSM 671 / R1) (Cell-Free, His) is 369 a.a., with molecular weight of 40.3 kDa.


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HY-P81635

TOMM20 Antibody (YA1380) TOMM20; KIAA0016; Mitochondrial Import receptor subunit TOM20 homolog; Mitochondrial 20 kDa outer membrane protein; Outer mitochondrial membrane receptor Tom20	WB, IHC-F, IHC-P, ICC/IF	Human, Hamster

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