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Indomethacin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (4) Autophagy (3) Bacterial (4) Cannabinoid Receptor (1) COX (14) Influenza Virus (4) Isotope-Labeled Compounds (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (16)

Inhibitors & Agonists

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14397

*Indomethacin* Maximum Cited Publications 31 Publications Verification Indometacin	COX Antibiotic Influenza Virus Bacterial	Inflammation/Immunology Cancer
Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

HY-14397A

Indomethacin sodium hydrate Maximum Cited Publications 31 Publications Verification Indometacin sodium hydrate	COX Bacterial Influenza Virus Antibiotic	Inflammation/Immunology Cancer
Indomethacin (Indometacin) sodium hydrateis a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrateis has anticancer activity and anti-infective activity. Indomethacin sodium hydrateis can be used for cancer, inflammation and viral infection research .

HY-15034

Indomethacin sodium Indometacin sodium	COX Antibiotic Influenza Virus Bacterial	Inflammation/Immunology Cancer
Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research. .

HY-111274

Indomethacin farnesil Indometacin farnesil	COX Autophagy	Inflammation/Immunology
Indomethacin farnesil is an orally active proagent of Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC₅₀s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes .

HY-14397G

Indomethacin Indometacin	Antibiotic Influenza Virus Bacterial COX	Cancer
Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

HY-14397S1

Indomethacin-d4 Methyl Ester	COX Autophagy	Inflammation/Immunology Cancer
Indomethacin-d₄ Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-114795

Indomethacin heptyl ester

COX Inflammation/Immunology

Indomethacin heptyl ester is a selective COX-2 inhibitor with IC₅₀ of 0.04 μM, exhibits anti-inflammatory activity .

Indomethacin heptyl ester	COX	Inflammation/Immunology
Indomethacin heptyl ester is a selective COX-2 inhibitor with IC₅₀ of 0.04 μM, exhibits anti-inflammatory activity .

HY-14397S

Indomethacin-d4 Indometacin-d₄	Isotope-Labeled Compounds COX Autophagy	Inflammation/Immunology Cancer
Indomethacin-d₄ is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-15420

BML-190 Indomethacin morpholinylamide; IMMA	Cannabinoid Receptor	Cancer
BML-190(IMMA) is a potent and selective CB2 receptor ligand (Ki values are 435 nM and > 2 μM for CB2 and CB1 respectively).

HY-141790S

O-Desmethyl Indomethacin-d4

Isotope-Labeled Compounds Others

O-Desmethyl Indomethacin-d₄ is the deuterium labeled O-Desmethyl Indomethacin[1].

*O-Desmethyl Indomethacin-d4*	Isotope-Labeled Compounds	Others
O-Desmethyl Indomethacin-d₄ is the deuterium labeled O-Desmethyl Indomethacin[1].

HY-123639

LM-4108 N-(2-Phenylethyl)-Indomethacin amide	COX	Inflammation/Immunology Cancer
LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC₅₀ of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively .

HY-146295

COX-2/5-LOX-IN-2	COX	Inflammation/Immunology
COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 5.40, 0.01 and 1.78 μM, respectively .

HY-146294

COX-2/5-LOX-IN-1	COX	Inflammation/Immunology
COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 12.13, 0.4 and 4.96 μM, respectively .

HY-U00046

Apyramide	COX	Inflammation/Immunology
Apyramide is an anti-inflammatory agent (NSAID) and behaves as a proagent of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.

HY-120966

NCX 2121

Others Inflammation/Immunology

NCX 2121 (NO-indomethacin) is an anti-inflammatory agent. NCX 2121 inhibits PaCa-2 cells growth witn an IC₅₀ of 82 μM .

NCX 2121	Others	Inflammation/Immunology
NCX 2121 (NO-indomethacin) is an anti-inflammatory agent. NCX 2121 inhibits PaCa-2 cells growth witn an IC₅₀ of 82 μM .

HY-78131S

Ibuprofen-d3 (±)-Ibuprofen-d₃	COX	Inflammation/Immunology
Ibuprofen-d₃ is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].

HY-150551

COX-2-IN-27	COX	Inflammation/Immunology
COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC₅₀ values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity .

HY-114751

16,16-Dimethylprostaglandin E1 16,16-dimethyl-PGE1	Others	Cardiovascular Disease
16,16-Dimethylprostaglandin E1 (16,16-dimethyl-PGE1) is a PGE1 (HY-B0131) analog, induces bronchoconstrict and vascular smooth muscle contractions and suppresses the indomethacin induced cellular elongation .

HY-15033

ATB-343	Others	Infection Inflammation/Immunology
ATB-343 is a derivative of Indomethacin that releases H2S. H2S has cytoprotective and anti-inflammatory effects, inhibiting leukocyte adhesion to vascular endothelium and leukocyte migration to inflammatory sites. ATB-343 can be used to suppress respiratory infections .

HY-112533

11-Deoxy-11-methylene PGD2 11d-11m-PGD2; 11-Deoxy-11-Methylene prostaglandin D2	Others	Endocrinology
11-Deoxy-11-methylene PGD2 (11d-11m-PGD2) is a chemically stable, isosteric analogue of Prostaglandin 2 in which the 11-keto group is replaced by an exocyclic methylene. 11-Deoxy-11-methylene PGD2 is significantly stimulating the storage of fats suppressed in the presence of Indomethacin .

HY-N10603

Praeroside Baihuaqianhuoside	Others	Inflammation/Immunology
Praeroside (Baihuaqianhuoside), a coumarin glycoside. Praeroside can be extracted from the root of Peucedanum praeruptorum and Heracleum dissectum. Praeroside shows anti-inflammatory activity in vitro. Praeroside can be used for the research of inflammation .

Indomethacin (GMP) Indometacin (GMP)	Fluorescent Dye
Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

Indomethacin (GMP) Indometacin (GMP)	Biochemical Assay Reagents
Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10603

Praeroside Baihuaqianhuoside	Natural Products Plants Umbelliferae Cunila spicata Benth.	Others
Praeroside (Baihuaqianhuoside), a coumarin glycoside. Praeroside can be extracted from the root of Peucedanum praeruptorum and Heracleum dissectum. Praeroside shows anti-inflammatory activity in vitro. Praeroside can be used for the research of inflammation .

Cat. No.	Product Name	Chemical Structure

HY-14397S1

Indomethacin-d4 Methyl Ester
Indomethacin-d₄ Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-14397S

Indomethacin-d4
Indomethacin-d₄ is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-78131S

Ibuprofen-d3

Ibuprofen-d₃ is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].
HY-141790S

O-Desmethyl Indomethacin-d4

O-Desmethyl Indomethacin-d₄ is the deuterium labeled O-Desmethyl Indomethacin[1].

Ibuprofen-d3
Ibuprofen-d₃ is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].

*O-Desmethyl Indomethacin-d4*
O-Desmethyl Indomethacin-d₄ is the deuterium labeled O-Desmethyl Indomethacin[1].

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Indomethacin

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products