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Inobrodib

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111784
    Inobrodib
    4 Publications Verification

    CCS1477

    		 Epigenetic Reader Domain Cancer
    Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression .
    <em>Inobrodib</em>

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