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Results for "

Intestinal+disease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Amino Acid Derivatives (1) Biochemical Assay Reagents (1) Chloride Channel (1) Claudin (2) COX (1) Drug Metabolite (1) Endogenous Metabolite (4) Interleukin Related (1) mRNA (1) NF-κB (2) NOD-like Receptor (NLR) (1) OAT (1) PI3K (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2) RET (1) ROCK (1) SOD (1) TGF-beta/Smad (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (8) Metabolic Disease (7) Neurological Disease (1)
Oligonucleotides:	mRNA (1) Interleukin & Receptors (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W045271

Imidazole-5-propionic acid 1 Publications Verification Imidazolepropionic acid	Endogenous Metabolite Amino Acid Derivatives	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases .

HY-N7075

Inulin 4 Publications Verification	Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Cancer
Inulin is an orally active prebiotic targeting the intestinal microbiota, selectively promoting the proliferation and activity of beneficial bacteria such as bifidobacteria and lactic acid bacteria, and playing a role in regulating the intestinal microecology. The functions of Inulin include: Fermentation by probiotics in the colon to produce short-chain fatty acids (such as butyrate and propionate), lowering the intestinal pH and inhibiting the overgrowth of harmful bacteria; Enhancing the intestinal barrier function and reducing endotoxin translocation; Directly scavenging free radicals (such as superoxide free radicals, hydroxyl free radicals) and activating antioxidant enzymes (SOD, CAT) to reduce oxidative stress. Inulin can also be used in the study of intestinal diseases (constipation, IBD), metabolic syndrome (diabetes, obesity) and liver damage by regulating glucose and lipid metabolism (such as reducing triglycerides, improving insulin sensitivity) and immune response (enhancing NK cell activity, inhibiting inflammatory factors)[1][2][3][4].

HY-W012734

L-Pipecolic acid 1 Publications Verification H-HoPro-OH	Endogenous Metabolite	Metabolic Disease
L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases .

HY-N0847

Micheliolide Maximum Cited Publications 8 Publications Verification	NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT	Inflammation/Immunology
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of OATP2B1. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .

HY-P2758

Diamine oxidase DAO	Biochemical Assay Reagents	Metabolic Disease Inflammation/Immunology Cancer
Diamine oxidase (DAO) is an orally active enzyme. Diamine oxidase catalyzes oxidative deamination of various polyamines. Diamine oxidase degrades histamine and polyamines to maintain the metabolic balance of amines in the body. Diamine oxidase is a key regulatory enzyme in rapidly proliferating tissues such as bone marrow and intestinal mucosa. Diamine oxidase can be used in research related to intestinal diseases, small bowel transplant rejection, histamine intolerance, and other conditions .

HY-171152A

NSC 357754 dihydrochloride	Claudin	Metabolic Disease
NSC 357754 dihydrochloride is an inhibitor of Claudin. NSC 357754 dihydrochloride can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 dihydrochloride can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15 .

HY-W012734R

L-Pipecolic acid (Standard) H-HoPro-OH (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
L-Pipecolic acid (Standard) is an analytical standard of L-Pipecolic acid. This product is used for research and analytical applications. L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases .

HY-174620

Human IL22 mRNA	mRNA	Inflammation/Immunology
Human IL22 mRNA encodes the human interleukin 22 (IL22) protein, a member of the IL10 family of cytokines that mediate cellular inflammatory responses. IL22 functions in antimicrobial defense at mucosal surfaces and in tissue repair. It also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases.

HY-156550

ROCK-IN-8	ROCK	Inflammation/Immunology
ROCK-IN-8 (Example 4) is a ROCK inhibitor, with an IC₅₀ value less than 100 nM. ROCK-IN-8 has anti-inflammatory activity. ROCK-IN-8 can be used for research of respiratory and gastro-intestinal diseases .

HY-171152

NSC 357754	Claudin	Metabolic Disease
NSC 357754 is an inhibitor of Claudin. NSC 357754 can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15 .

HY-144029

RET-IN-13	RET	Cancer
RET-IN-13 (compound 1), a quinoline compound, is a potent RET inhibitor with IC₅₀s of 0.5 nM, 0.9 nM for RET (WT) and RET (V804M), respectively. RET-IN-13 has the potential for tumors or intestinal diseases related to abnormal activation of RET research .

HY-162033

PAT1inh-A0030	Chloride Channel	Others
PAT1inh-A0030 is a selective PAT1 (SLC26A6) inhibitor (IC₅₀= 1.0 μM). PAT1inh-A0030 inhibits fluid absorption in the ileum of wild-type and cystic fibrosis (CF) mice (CftrdelF508/delF508) in a closed-loop model of intestinal fluid absorption. PAT1inh-A0030 can be used in the study of intestinal diseases related to CF .

HY-N0847R

Micheliolide (Standard)	Reference Standards NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-182102

NLRP3-IN-88	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
NLRP3-IN-88 (Compound 1) is an NLRP3 inhibitor. NLRP3-IN-88 inhibits IL-1β. NLRP3-IN-88 can be used in research on intestinal diseases and inflammatory diseases.

Cat. No.	Product Name

HY-L114

Anti-inflammatory Traditional Chinese Medicine Active Compound Library	1,535 compounds
Inflammation promotes physiological and pathological processes by the activation of the immune system, local vascular system, and various cells within the damaged tissue. Accumulating epidemiological and clinical evidence shows that chronic inflammation is causally linked to various human diseases, including cerebrovascular, cardiovascular, joint, cutaneous, pulmonary, blood, liver, and intestinal diseases as well as diabetes. Various natural products from Traditional Chinese Medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. MCE designs a unique collection of 1,535 Traditional Chinese Medicine active compounds with anti-inflammatory activity, which are derived from Coptis chinensis, Radix isatidis, Flos Lonicerae, Forsythia suspensa, etc. MCE Anti-inflammatory Traditional Chinese Medicine Active Compound Library is a useful tool for discovery anti-inflammatory drugs from TCM.

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

1,535 compounds

Inflammation promotes physiological and pathological processes by the activation of the immune system, local vascular system, and various cells within the damaged tissue. Accumulating epidemiological and clinical evidence shows that chronic inflammation is causally linked to various human diseases, including cerebrovascular, cardiovascular, joint, cutaneous, pulmonary, blood, liver, and intestinal diseases as well as diabetes.

Various natural products from Traditional Chinese Medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. MCE designs a unique collection of 1,535 Traditional Chinese Medicine active compounds with anti-inflammatory activity, which are derived from Coptis chinensis, Radix isatidis, Flos Lonicerae, Forsythia suspensa, etc. MCE Anti-inflammatory Traditional Chinese Medicine Active Compound Library is a useful tool for discovery anti-inflammatory drugs from TCM.

Imidazole-5-propionic acid 1 Publications Verification Imidazolepropionic acid	Structural Classification Alkaloids Classification of Application Fields Metabolic Disease Imidazole Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Amino Acid Derivatives
Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases .

Inulin 4 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Polysaccharides Classification of Application Fields Metabolic Disease Plants Compositae Endogenous metabolite Disease Research Fields Saccharides Sophora tomentosa L. Source Classification	Endogenous Metabolite
Inulin is an orally active prebiotic targeting the intestinal microbiota, selectively promoting the proliferation and activity of beneficial bacteria such as bifidobacteria and lactic acid bacteria, and playing a role in regulating the intestinal microecology. The functions of Inulin include: Fermentation by probiotics in the colon to produce short-chain fatty acids (such as butyrate and propionate), lowering the intestinal pH and inhibiting the overgrowth of harmful bacteria; Enhancing the intestinal barrier function and reducing endotoxin translocation; Directly scavenging free radicals (such as superoxide free radicals, hydroxyl free radicals) and activating antioxidant enzymes (SOD, CAT) to reduce oxidative stress. Inulin can also be used in the study of intestinal diseases (constipation, IBD), metabolic syndrome (diabetes, obesity) and liver damage by regulating glucose and lipid metabolism (such as reducing triglycerides, improving insulin sensitivity) and immune response (enhancing NK cell activity, inhibiting inflammatory factors)[1][2][3][4].

L-Pipecolic acid 1 Publications Verification H-HoPro-OH	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases .

Micheliolide Maximum Cited Publications 8 Publications Verification	Other Monoterpenes other families Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Source Classification	NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of OATP2B1. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .

L-Pipecolic acid (Standard) H-HoPro-OH (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
L-Pipecolic acid (Standard) is an analytical standard of L-Pipecolic acid. This product is used for research and analytical applications. L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases .

Micheliolide (Standard)	Structural Classification Other Monoterpenes other families Terpenoids Plants Source Classification	Reference Standards NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

Cat. No.	Product Name		Classification

HY-174620

Human IL22 mRNA		mRNA Interleukin & Receptors
Human IL22 mRNA encodes the human interleukin 22 (IL22) protein, a member of the IL10 family of cytokines that mediate cellular inflammatory responses. IL22 functions in antimicrobial defense at mucosal surfaces and in tissue repair. It also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases.

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