Search Result
Results for "
Ionizing
" in MedChemExpress (MCE) Product Catalog:
49
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-148648
-
|
Liposome
|
Others
|
Lipid 29 is an ionizable amino lipid. Lipid 29 can be used to form lipid nanoparticles .
|
-
-
- HY-160439
-
|
Liposome
|
Others
|
Ionizable lipid-2 (compound 1) is an ionizable lipid used for nucleic acid delivery and construct lipid nanoparticles (LNPs) .
|
-
-
- HY-W440753
-
|
Liposome
|
Others
|
BP Lipid 114 is an ethanolamine ionizable lipid (CN113387825A) .
|
-
-
- HY-142995
-
|
Liposome
|
Others
|
DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .
|
-
-
- HY-160553
-
|
Liposome
|
Others
|
9322-O16B, an ionizable cationic lipid, is used for LNP generation .
|
-
-
- HY-W590548
-
|
Liposome
|
Others
|
ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .
|
-
-
- HY-W598178
-
|
Liposome
|
Others
|
93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .
|
-
-
- HY-W440779
-
|
Liposome
|
Metabolic Disease
|
BP Lipid 135 is a cationieally ionizable lipid. BP Lipid 135 can be used to prepare lipid nanoparticles (LNP) (WO2022218503A1) .
|
-
-
- HY-112418
-
|
CDK
|
Cancer
|
CDK4/6-IN-18 (Example 2BrIC) is a selective CDK4/6 inhibitor. CDK4/6-IN-18 inhibits ionizing radiation (IR)-induced DNA damage in cells .
|
-
-
- HY-151507
-
|
Liposome
|
Others
|
306Oi10 is a branched-chain ionizable lipidoid that can be used for constructing lipid nanoparticles (LNPs) for the delivery of messenger RNA .
|
-
-
- HY-W590681
-
|
Liposome
|
Others
|
113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B can be used in that generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
-
- HY-W590679
-
|
Liposome
|
Others
|
113-O16B is a disulfide bond-containing ionizable cationic lipidoid. 113-O16B has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA .
|
-
-
- HY-107641
-
α-Cyano-4-hydroxycinnamate
|
Monocarboxylate Transporter
|
Metabolic Disease
|
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications .
|
-
-
- HY-D0202
-
|
Fluorescent Dye
|
Others
|
Arsenazo III is a dye useful for detection of micromolar concentrations of ionized Ca 2+. Arsenazo III can be used for determination of thorium, zirconium, uranium and rare earth elements .
|
-
-
- HY-130751
-
|
Liposome
|
Inflammation/Immunology
|
DODAP is a cationic lipid. The ionizable lipid DODAP is the lipid component of liposomes (pKa = 5.59 in TNS binding tests). DODAP can be used for siRNA encapsulation and in vitro and in vivo delivery of immunostimulated chemotherapeutic active molecules .
|
-
-
- HY-145405
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C12-200
5 Publications Verification
|
Liposome
|
Others
|
C12-200 is an ionizable cationic lipid and auxiliary lipid. C12-200 is commonly used for mRNA delivery. Administration of human erythropoietin (EPO) mRNA or factor VII siRNA increased and decreased serum factor VII levels, respectively, in LNPs mice containing C12-200 .
|
-
-
- HY-160552
-
|
Liposome
|
Others
|
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
|
-
-
- HY-N0232
-
|
COX
Lipoxygenase
Notch
Reactive Oxygen Species
Bacterial
|
Cancer
|
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation .
|
-
-
- HY-154974
-
|
Liposome
|
Cancer
|
LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model .
|
-
-
- HY-129460
-
|
Reactive Oxygen Species
|
Neurological Disease
|
XJB-5-131 is a mitochondria-targeted ROS and electron scavenger . XJB-5-131 is a bi-functional antioxidant that comprises a radical scavenger. XJB-5-131 is a synthetic antioxidant that targets mitochondria . XJB-5-131 is an effective ionizing irradiation protector and mitigator of cord blood mononuclear cells (CB MNCs) .
|
-
-
- HY-156630
-
|
Liposome
|
Others
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
|
-
-
- HY-156630A
-
|
Liposome
|
Others
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
|
-
-
- HY-145739
-
-
-
- HY-145796
-
|
Liposome
|
Others
|
503O13 is a degradable ionizable lipid for siRNA delivery.
|
-
-
- HY-147332
-
|
Liposome
|
Neurological Disease
|
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .
|
-
-
- HY-150116
-
|
Liposome
|
Others
|
Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
-
- HY-150115
-
|
Liposome
|
Others
|
Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
-
- HY-153378
-
|
Liposome
|
Others
|
Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
-
- HY-150117
-
|
Liposome
|
Others
|
Lipid 6 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
-
- HY-150118
-
|
Liposome
|
Others
|
Lipid 8 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
-
- HY-134782
-
|
Liposome
|
Others
|
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
-
- HY-153377
-
-
-
- HY-153373
-
|
Liposome
|
Others
|
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).
|
-
-
- HY-107273
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Sinpeinine A
|
Others
|
Inflammation/Immunology
|
Delavinone (Sinpeinine A) is an alkaloid . Delavinone is suitable for electrospray ionization (ESI) positive electrode detection .
|
-
-
- HY-145797
-
|
Liposome
|
Others
|
L343 is an ionizable cationic lipidoid and can be used to synthetic liposomes for systemic delivery of RNAi therapeutics.
|
-
-
- HY-156857
-
-
-
- HY-160705
-
|
Liposome
|
|
PNI 132, an ionizable lipid derived from the patent WO2020252589A, is useful in the formulation of lipid nanoparticles.
|
-
-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
45 Publications Verification
|
Liposome
|
Cancer
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
-
- HY-145795
-
|
Liposome
|
Others
|
OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.
|
-
-
- HY-148049
-
|
Liposome
|
Others
|
TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
|
-
-
- HY-W590532
-
|
Liposome
|
Others
|
306-O12B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs).
|
-
-
- HY-153372
-
|
Liposome
|
Others
|
93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
|
-
-
- HY-153186
-
|
Liposome
|
Others
|
LNP Lipid-3 is an ionizable lipid extracted from patent WO2021113777A, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
-
- HY-113485
-
Melanin
1 Publications Verification
|
Endogenous Metabolite
|
Others
|
Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation.
|
-
-
- HY-112757
-
DLinDMA
1 Publications Verification
|
Liposome
|
Others
|
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
|
-
-
- HY-112772A
-
|
Liposome
|
Others
|
98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.
|
-
-
- HY-139298
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Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate
|
Liposome
|
Inflammation/Immunology
|
L319 is an ionizable cationic lipidoid and can be used for synthetic liposomes, from the patent WO-2011153493-A2, compound 1 .
|
-
-
- HY-148842
-
|
Liposome
|
Others
|
C14-4 is an ionizable lipid for lipid nanoparticles (LNPs) formulation. C14-4 was identified for its potent transfection and low cytotoxicity.
|
-
-
- HY-W590531
-
-
-
- HY-156985
-
|
Isotope-Labeled Compounds
Liposome
|
Others
|
Lipid AX4 is an ionizable cationic lipid with the pKa of 6.89, and can be used the study for the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo .
|
-
- HY-151511
-
|
Liposome
|
Cancer
|
A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
|
-
- HY-46759
-
|
Liposome
|
Infection
|
Genevant CL1 is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery [1][2].
|
-
- HY-149156
-
|
Liposome
|
Cancer
|
Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids .
|
-
- HY-153375
-
|
Liposome
|
Others
|
LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles (LNP) .
|
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- HY-153376
-
|
Liposome
|
Others
|
LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP) .
|
-
- HY-46759A
-
|
Liposome
|
Infection
|
Genevant CL1 monohydrochloride is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery .
|
-
- HY-15620
-
|
DNA/RNA Synthesis
|
Others
|
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks .
|
-
- HY-149167
-
|
Liposome
Biochemical Assay Reagents
|
Others
|
mRNA-Encapsulating Lipid Excipient 1 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. mRNA-Encapsulating Lipid Excipient 1 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .
|
-
- HY-142654
-
|
Liposome
|
Others
|
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
|
-
- HY-160580
-
|
Liposome
|
Others
|
G1-OC2-K3-E10 is an ionizable lipid, and can be used for delivery of mRNA in lipid nanoparticles (LNPs) .
|
-
- HY-W590678
-
|
Liposome
|
Others
|
SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for drug delivery.
|
-
- HY-156936
-
|
Liposome
|
Others
|
RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .
|
-
- HY-153737
-
|
Liposome
|
Others
|
113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
|
-
- HY-15044
-
|
PARP
|
Neurological Disease
Cancer
|
NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer agents. NU1025 has anti-cancer and neuroprotective activity .
|
-
- HY-148855
-
|
Liposome
|
Others
|
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
|
-
- HY-134781
-
CKK-E12
1 Publications Verification
|
Liposome
|
Others
|
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
|
-
- HY-W590683
-
|
Liposome
CRISPR/Cas9
|
Others
|
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for CRISPR-Cas9 gene editing in mice .
|
-
- HY-16336
-
PCI 0120; Gadolinium texaphyrin; Gd-Tex
|
Others
|
Cancer
|
Motexafin gadolinium (PCI 0120) is a potent antitumor agent. Motexafin gadolinium is a specific texaphyrin in complex with gadolinium(III). Motexafin gadolinium increases intracellular ROS production. Motexafin gadolinium enhances sensitivity of tumor cells to ionizing radiation .
|
-
- HY-P1733
-
BMF-Y
|
Apoptosis
|
Cancer
|
BMf-BH3 (BMF-Y) belongs to the Bcl-2 apoptosis mediator family. BH3-only protein, Bmf is a key molecule for histone deacetylase (HDAC) inhibitors mediated enhancing effect on ionizing radiation-induced cell death .
|
-
- HY-151512
-
-
- HY-112251S
-
|
Isotope-Labeled Compounds
|
Others
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].
|
-
- HY-13767
-
SR259075; SR4233; Win59075; SML 0552; SR 259075; Tirazone
|
DNA/RNA Synthesis
|
Cancer
|
Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells .
|
-
- HY-W010800A
-
Cholesterol hydrogen succinate Tris salt; CHS-Tris
|
Topoisomerase
DNA/RNA Synthesis
Apoptosis
Necroptosis
|
Cancer
|
Cholesterol hemisuccinate Tris salt (CHS-Tris) is an ionizable anionic detergent that stabilizes large unilamellar vesicles. CHS-Tris and Lauryl Maltose Neopentyl Glycol (LMNG) or n-Dodecyl-β-D-Maltoside (DDM) are used together for the solubilization of membrane proteins while maintaining structural integrity and activity. Cholesteryl succinate also reportedly exhibits antiproliferative activity.
|
-
- HY-145798
-
|
Liposome
|
Others
|
N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
|
-
- HY-157252
-
|
Liposome
|
Cancer
|
CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .
|
-
- HY-P1698
-
AB-103
|
Bacterial
CD28
|
Infection
Inflammation/Immunology
|
Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs) .
|
-
- HY-P1698B
-
AB-103 TFA
|
Bacterial
CD28
|
Infection
Inflammation/Immunology
|
Reltecimod (AB-103) TFA is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod TFA has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod TFA can be used to research necrotizing soft-tissue infections (NSTIs) .
|
-
- HY-N8639
-
|
Others
|
Others
|
Chrysin 8-C-β-D-glucoside is a natural compound isolated from the herbs of Psidium guajava .
|
-
-
-
HY-L178
-
|
1788 Compounds compounds
|
Radiation sickness is a general term for various types and degrees of damage (or disease) occurring in the human body after exposure to ionizing radiation. Although small amounts of ionizing radiation can also cause the body to produce free radicals and ROS, causing oxidative stress, resulting in DNA damage and chromosomal aberration. Radioprotector are compounds with radiation protection that can be used to prevent/protect non-tumor cells from the harmful effects of radiation. Radioprotective compounds can prevent the damage of radioactive substances to the human body and reduce the clinical symptoms of various radioactive diseases. In addition, radioprotectors can protect normal cells from damage during radiation therapy. The ideal anti-radiation drug should not affect the sensitivity of tumor cells to radiation therapy while protecting normal cells.
MCE designs a unique collection of 1788 radioprotectors. Radioprotector Library is an effective tool for acute Radiation Syndrome, drug combination research with radiation drugs.
|
Cat. No. |
Product Name |
Type |
-
- HY-D0202
-
|
Dyes
|
Arsenazo III is a dye useful for detection of micromolar concentrations of ionized Ca 2+. Arsenazo III can be used for determination of thorium, zirconium, uranium and rare earth elements .
|
Cat. No. |
Product Name |
Type |
-
- HY-148648
-
|
Drug Delivery
|
Lipid 29 is an ionizable amino lipid. Lipid 29 can be used to form lipid nanoparticles .
|
-
- HY-151507
-
|
Drug Delivery
|
306Oi10 is a branched-chain ionizable lipidoid that can be used for constructing lipid nanoparticles (LNPs) for the delivery of messenger RNA .
|
-
- HY-W440753
-
|
Drug Delivery
|
BP Lipid 114 is an ethanolamine ionizable lipid (CN113387825A) .
|
-
- HY-142995
-
|
Drug Delivery
|
DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery .
|
-
- HY-W440779
-
|
Drug Delivery
|
BP Lipid 135 is a cationieally ionizable lipid. BP Lipid 135 can be used to prepare lipid nanoparticles (LNP) (WO2022218503A1) .
|
-
- HY-130751
-
|
Drug Delivery
|
DODAP is a cationic lipid. The ionizable lipid DODAP is the lipid component of liposomes (pKa = 5.59 in TNS binding tests). DODAP can be used for siRNA encapsulation and in vitro and in vivo delivery of immunostimulated chemotherapeutic active molecules .
|
-
- HY-145405
-
C12-200
5 Publications Verification
|
Drug Delivery
|
C12-200 is an ionizable cationic lipid and auxiliary lipid. C12-200 is commonly used for mRNA delivery. Administration of human erythropoietin (EPO) mRNA or factor VII siRNA increased and decreased serum factor VII levels, respectively, in LNPs mice containing C12-200 .
|
-
- HY-156630
-
|
Drug Delivery
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
|
-
- HY-156630A
-
|
Drug Delivery
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure .
|
-
- HY-145739
-
-
- HY-145796
-
|
Drug Delivery
|
503O13 is a degradable ionizable lipid for siRNA delivery.
|
-
- HY-147332
-
|
Drug Delivery
|
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .
|
-
- HY-150116
-
|
Drug Delivery
|
Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150115
-
|
Drug Delivery
|
Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153378
-
|
Drug Delivery
|
Lipid 15 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150117
-
|
Drug Delivery
|
Lipid 6 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-150118
-
|
Drug Delivery
|
Lipid 8 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-134782
-
|
Drug Delivery
|
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-153377
-
|
Drug Delivery
|
Lipid 14 is a potent ionizable lipid and can be used to synthesize lipid nanoparticles (LNPs) .
|
-
- HY-153373
-
|
Drug Delivery
|
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).
|
-
- HY-145797
-
|
Drug Delivery
|
L343 is an ionizable cationic lipidoid and can be used to synthetic liposomes for systemic delivery of RNAi therapeutics.
|
-
- HY-156857
-
|
Drug Delivery
|
PPZ-A10 is a ionizable lipid that delivered mRNA preferentially to liver and spleen immune cells.
|
-
- HY-112251
-
D-Lin-MC3-DMA
Maximum Cited Publications
45 Publications Verification
|
Drug Delivery
|
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
|
-
- HY-145795
-
|
Drug Delivery
|
OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.
|
-
- HY-148049
-
|
Drug Delivery
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TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
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- HY-W590532
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Drug Delivery
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306-O12B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs).
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- HY-153372
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Drug Delivery
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93-O17S is a chalcogen-containing ionizable cationic lipid used for making lipid nanoparticles (LNPs).
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- HY-153186
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Drug Delivery
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LNP Lipid-3 is an ionizable lipid extracted from patent WO2021113777A, and can be used for the generation of Lipid nanoparticles (LNPs).
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- HY-112757
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DLinDMA
1 Publications Verification
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Drug Delivery
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DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery .
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- HY-112772A
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Drug Delivery
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98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.
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- HY-139298
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Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate
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Drug Delivery
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L319 is an ionizable cationic lipidoid and can be used for synthetic liposomes, from the patent WO-2011153493-A2, compound 1 .
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- HY-148842
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Drug Delivery
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C14-4 is an ionizable lipid for lipid nanoparticles (LNPs) formulation. C14-4 was identified for its potent transfection and low cytotoxicity.
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- HY-151511
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Drug Delivery
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A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
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- HY-46759
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Drug Delivery
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Genevant CL1 is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery [1][2].
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- HY-149156
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Drug Delivery
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Lipid C24 is a cationic ionizable lipid, and can be used in the formation of lipid nanoparticles (LNPs). Lipid C24 can be used for research of delivery of nucleic acids .
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- HY-153375
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Drug Delivery
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LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles (LNP) .
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- HY-153376
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Drug Delivery
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LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP) .
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- HY-46759A
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Drug Delivery
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Genevant CL1 monohydrochloride is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery .
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- HY-15620
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Biochemical Assay Reagents
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Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks .
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- HY-149167
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Drug Delivery
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mRNA-Encapsulating Lipid Excipient 1 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. mRNA-Encapsulating Lipid Excipient 1 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .
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- HY-142654
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Drug Delivery
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ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .
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- HY-Y0030A
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3-HPA
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Biochemical Assay Reagents
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3-Hydroxypicolinic acid, matrix substance for MALDI-MS is a matrix material used in matrix-assisted laser desorption/ionization (MALDI) based mass spectroscopy (MS) for the analysis of large biomolecules and quantification of oligonucleotides. .
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- HY-W590678
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Drug Delivery
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SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for drug delivery.
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- HY-153737
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Drug Delivery
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113-N16B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs). 113-N16B delivers mRNA preferentially to pulmonary endothelial cells.
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- HY-148855
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Drug Delivery
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OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA .
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- HY-134781
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CKK-E12
1 Publications Verification
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Drug Delivery
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CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
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- HY-151512
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Drug Delivery
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A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .
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- HY-145798
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Drug Delivery
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N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA and CRISPR/Cas9 delivery .
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- HY-157252
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Drug Delivery
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CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-W141932
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Stearoylglycine; N-Octadecanoylglycine
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Peptides
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Others
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N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films .
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- HY-P1698B
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AB-103 TFA
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Bacterial
CD28
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Infection
Inflammation/Immunology
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Reltecimod (AB-103) TFA is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod TFA has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod TFA can be used to research necrotizing soft-tissue infections (NSTIs) .
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- HY-P1733
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BMF-Y
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Apoptosis
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Cancer
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BMf-BH3 (BMF-Y) belongs to the Bcl-2 apoptosis mediator family. BH3-only protein, Bmf is a key molecule for histone deacetylase (HDAC) inhibitors mediated enhancing effect on ionizing radiation-induced cell death .
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- HY-P1698
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AB-103
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Bacterial
CD28
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Infection
Inflammation/Immunology
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Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs) .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-112251S
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D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].
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