Search Result
Results for "
Isotope-Labeled Compounds
" in MCE Product Catalog:
6494
Inhibitors & Agonists
4
Biochemical Assay Reagents
6507
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
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- HY-Y1298S
-
|
Methyl acetylacetate-13C4
Acetoacetate methyl ester-13C4; Methyl 3-oxobutanoate-13C4; Methyl acetoacetate-13C4
|
Endogenous Metabolite
|
Others
|
|
Methyl acetylacetate- 13C4 is an isotopically labeled compound. Methyl acetylacetate- 13C4 can be used for various biochemical studies[1].
|
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- HY-146874S
-
-
- HY-146873S
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-
- HY-Y0261AS1
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-
- HY-B0863S2
-
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Glyphosate-d2-1
|
Apoptosis
Autophagy
|
Cancer
|
|
Glyphosate-d2-1 is the deuterium labeled Glyphosate[1]. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[2].
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- HY-W014787S
-
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Decanedioic acid-d4
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Decanedioic acid-d4 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].
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- HY-W010243S
-
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Methylisothiazolinone-d3 hydrochloride
|
Bacterial
|
Infection
|
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Methylisothiazolinone-d3 (hydrochloride) is the deuterium labeled Methylisothiazolinone (hydrochloride). Methylisothiazolinone hydrochloride is the constituent of the biocide Kathon CG. Methylisothiazolinone hydrochloride is an isothiazolone derivative widely used as a preservative. Methylisothiazolinone hydrochloride is also a moderate sensitizer and reacts with GSH.
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- HY-14299S
-
-
- HY-143800S
-
-
- HY-13284S
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-
- HY-10261S
-
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Afatinib D6
BIBW 2992 d6
|
EGFR
Autophagy
|
Cancer
|
|
Afatinib-d6 is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor[1].
|
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- HY-146485S
-
-
- HY-113215S
-
|
Allotetrahydrocortisol-d5
|
Endogenous Metabolite
|
Others
|
|
Allotetrahydrocortisol-d5 is the deuterium labeled Allotetrahydrocortisol. Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes[1][2].
|
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- HY-Y1352S
-
-
- HY-B0457S2
-
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Clomipramine-13C,d3 hydrochloride
Chlorimipramine-13C,d3 (hydrochloride); G-34586-13C,d3 (hydrochloride); NSC-169865-13C,d3 (hydrochloride)
|
Serotonin Transporter
|
Neurological Disease
|
|
Clomipramine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
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- HY-146777S
-
-
- HY-A0020S
-
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Eldecalcitol-d6
|
VD/VDR
|
Metabolic Disease
|
|
Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis.
|
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- HY-N0111S2
-
-
- HY-15142AS1
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-
- HY-B0389S16
-
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D-Glucose-13C-4
Glucose-13C-4; D-(+)-Glucose-13C-4; Dextrose-13C-4
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
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- HY-I1124
-
|
L-Valine-d8
L-VALINE-2,3,4,4,4,5,5,5-d8
|
Isotope-Labeled Compounds
|
Others
|
|
L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].
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- HY-B0928S
-
|
Homosalate-d4
Homomenthyl salicylate-d4
|
Isotope-Labeled Compounds
|
Others
|
|
Homosalate-d4 is the deuterium labeled Homosalate. Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage.
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- HY-10984S2
-
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Pomalidomide-d4
CC-4047-d4
|
Molecular Glues
Ligands for E3 Ligase
Apoptosis
|
Cancer
|
|
Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors<
|
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- HY-B0389S13
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D-Glucose-13C-3
|
Endogenous Metabolite
|
Metabolic Disease
|
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D-Glucose- 13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
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- HY-131897S
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-
- HY-76547S
-
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p-Toluic acid-d4
4-Methylbenzoic acid-d4
|
Endogenous Metabolite
|
Others
|
|
p-Toluic acid-d4 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted?benzoic acid?and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
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- HY-W213592S
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- HY-B0391S1
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Naftopidil-d5
KT-611-d5; BM-15275-d5
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
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Naftopidil-d5 is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia[1][2].
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- HY-144432S
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-
- HY-W115763S
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- HY-17436S1
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Clevidipine-d7
|
Calcium Channel
|
Cardiovascular Disease
|
|
Clevidipine-d7 is the deuterium labeled Clevidipine. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension[1][2].
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- HY-143699S
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- HY-N7139S1
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- HY-13683S1
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- HY-B0389S4
-
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D-Glucose-d1-2
|
Endogenous Metabolite
|
Metabolic Disease
|
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D-Glucose-d-22 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-N0537S5
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- HY-143959S
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- HY-B0141S
-
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Estradiol-d3
β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
|
Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
|
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- HY-113121S1
-
|
Vanillylmandelic acid-d1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Vanillylmandelic acid-d is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].
|
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- HY-N0486S11
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- HY-142842S
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-
- HY-Y0226S
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- HY-W010708S
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- HY-B0667S1
-
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- HY-N1429S2
-
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Taurochenodeoxycholic acid-d4-1 sodium
12-Deoxycholyltaurine-d4-1 (sodium)
|
Apoptosis
Endogenous Metabolite
|
|
|
Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
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- HY-W013812S2
-
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Ethyl linoleate-d2
Linoleic Acid ethyl ester-d2; Mandenol-d2
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Ethyl linoleate-d2 (Linoleic Acid ethyl ester-d2; Mandenol-d2) is the deuterium labeled Ethyl linoleate (HY-W013812). Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators.
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- HY-N0215S11
-
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L-Phenylalanine-13C9,15N
(S)-2-Amino-3-phenylpropionic acid-13C9,15N
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C9, 15N is the 13C- and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
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- HY-B0084S2
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- HY-B1392S
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- HY-W012791S
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- HY-135391S
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Ezetimibe phenoxy glucuronide-d4
Ezetimibe glucuronide-d4; Ezetimibe β-D-glucuronide-d4
|
Drug Metabolite
|
Metabolic Disease
|
|
Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
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- HY-128554S
-
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N-Desethyl amodiaquine-d5
|
Parasite
|
Infection
|
|
N-Desethyl amodiaquine-d5 is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].
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- HY-150642S
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- HY-14153AS
-
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Tegaserod-13C,d3 maleate
SDZ-HTF-919-13C,d3; HTF-919-13C,d3
|
5-HT Receptor
|
Metabolic Disease
Neurological Disease
|
|
Tegaserod- 13C,d3 (maleate) is the 13C- and deuterium labeled Tegaserod (maleate). Tegaserod maleate is a selective 5-HT4 receptor partial agonist and a 5-HT2B receptor antagonist. Tegaserod maleate exhibits a promotile effect throughout the gastrointestinal (GI) tract[1][2][5].
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- HY-142768S
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- HY-18260S
-
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Bisphenol A-d16
|
Endogenous Metabolite
|
Endocrinology
|
|
Bisphenol A-d16 is the deuterium labeled Bisphenol A[1]. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[2][3].
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- HY-B0942S1
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- HY-23149S
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- HY-Y0001S
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- HY-146917S
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- HY-146621S
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Gibberellic acid-d2
Gibberellin A3-d2
|
Isotope-Labeled Compounds
|
Others
|
|
Gibberellic acid-d22 is the deuterium labeled Gibberellic acid. Gibberellic acid is named after a fungus Gibberella fujikuroi. Gibberellic Acid regulates processes of plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time[1][2].
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- HY-40136S
-
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cis-4-Hydroxy-L-proline-d3
|
Endogenous Metabolite
|
|
|
cis-4-Hydroxy-L-proline-d3 is the deuterium labeled cis-4-Hydroxy-L-proline. cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].
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- HY-139959S
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- HY-W018004S
-
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L-Homocitrulline-d3
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Homocitrulline-d3 is the deuterium labeled L-Homocitrulline. L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).
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- HY-128790S
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- HY-N6810S
-
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Thymol-d13
|
Bacterial
|
|
|
Thymol-d13 is the deuterium labeled Thymol[1]. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects[2].
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- HY-17016S
-
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Oseltamivir-d5 phosphate
GS 4104-d5
|
Influenza Virus
|
Infection
|
|
Oseltamivir-d5 (phosphate) is the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B[1][2].
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- HY-B1674S
-
-
- HY-79491S
-
-
- HY-17363S1
-
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Dimethyl fumarate-d2
|
Autophagy
HIV
Keap1-Nrf2
Endogenous Metabolite
Reactive Oxygen Species
|
|
|
Dimethyl fumarate-d2 is the deuterium labeled Dimethyl fumarate[1]. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[2][3].
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- HY-B0330S2
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- HY-150771S
-
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- HY-N6719S
-
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Fumonisin B1-13C34
|
Isotope-Labeled Compounds
|
Infection
|
|
Fumonisin B1- 13C34 is the 13C labeled Fumonisin B1 (HY-N6719). Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin.
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- HY-15321S
-
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Etoricoxib-d4
MK-0663-d4; L-791456-d4
|
COX
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Others
|
|
Etoricoxib-d4 is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
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- HY-B1510S
-
-
- HY-Y0479S
-
-
- HY-W008630S
-
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- HY-B0256S1
-
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Azathioprine-13C4
BW 57-322-13C4
|
Isotope-Labeled Compounds
|
Others
|
|
Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis.
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- HY-15463S1
-
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Imatinib D4
STI571 d4; CGP-57148B d4
|
Bcr-Abl
PDGFR
c-Kit
SARS-CoV
Autophagy
|
Cancer
|
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Imatinib-d4 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].
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- HY-B0780S
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-
- HY-N0717S9
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-
- HY-B0031S
-
-
- HY-15256S1
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- HY-B0341S
-
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Nicorandil-d4
|
Potassium Channel
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Cardiovascular Disease
|
|
Nicorandil-d4 (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].
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- HY-Y1004S4
-
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- HY-W014340S
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-
- HY-P3146S
-
-
- HY-W001472S
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- HY-113252S1
-
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- HY-B0154S1
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- HY-W011819S
-
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Tetradecanedioic acid-d24
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Tetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid[1]. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions[2].
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- HY-20390S
-
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- HY-151893S
-
-
- HY-W031727S1
-
-
- HY-90009BS
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- HY-13571AS1
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- HY-121467S
-
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Acotiamide-d6
Z-338-d6 (free base); YM443-d6 (free base)
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Cholinesterase (ChE)
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Metabolic Disease
|
|
Acotiamide-d6 is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia[1][2].
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- HY-144149S
-
-
- HY-W017758S2
-
-
- HY-150659S
-
-
- HY-141905S
-
-
- HY-144154S
-
-
- HY-B0389S7
-
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D-Glucose-d1-3
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-W004681S
-
-
- HY-W011940S
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- HY-B0216S2
-
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- HY-142275S
-
-
- HY-114524S
-
-
- HY-137255S
-
-
- HY-W440986S
-
-
- HY-150661S
-
-
- HY-10195BS
-
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Ruboxistaurin-d6 hydrochloride
|
PKC
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Metabolic Disease
|
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Ruboxistaurin-d6 (hydrochloride) is the deuterium labeled Ruboxistaurin hydrochloride. Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC50 of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC50 of 5.9 nM[1][2].
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- HY-Z0792S
-
-
- HY-113041S
-
-
- HY-B0612AS
-
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Lercanidipine-13C,d3 hydrochloride
|
Calcium Channel
|
Cardiovascular Disease
|
|
Lercanidipine- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Lercanidipine hydrochloride[1]. Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[2][3][4].
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- HY-W041171S
-
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3-Chloro-L-tyrosine-13C6
|
Endogenous Metabolite
|
Others
|
|
3-Chloro-L-tyrosine- 13C6 is the 13C labeled 3-Chloro-L-tyrosine[1]. 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima[2].
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- HY-B1159S
-
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Nitroxoline-D4
8-Hydroxy-5-nitroquinoline-d4; 5-Nitro-8-quinolinol-d4
|
Bacterial
Autophagy
Antibiotic
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Infection
Cancer
|
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Nitroxoline-d4 is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix[1][2].
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- HY-146965S
-
-
- HY-143991S
-
-
- HY-N7057S3
-
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Nonanoic acid-d2
Pelargonic acid-d2; Pelargonic acid-d2 (n-Nonanoic acid, C9 )
|
Bacterial
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Infection
|
|
Nonanoic acid-d2 is the deuterium labeled Nonanoic acid[1]. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[2].
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- HY-W009444S4
-
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- HY-113359AS
-
-
- HY-W015301S
-
-
- HY-132490S
-
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- HY-B1617AS1
-
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Zuclomiphene-d5 citrate
|
Estrogen Receptor/ERR
|
|
|
Zuclomiphene-d5 (citrate) is the deuterium labeled Zuclomiphene citrate[1]. Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[2][3][4][5].
|
-
- HY-W004283S2
-
-
- HY-N7032S
-
-
- HY-I0983S
-
-
- HY-W012982S
-
|
3-Amino-2-oxazolidinone-d4
AOZ-d4
|
Drug Metabolite
|
Others
|
|
3-Amino-2-oxazolidinone-d4 is a deuterium labeled 3-Amino-2-oxazolidinone. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as an indicator of furazolidone residues[1][2].
|
-
- HY-B0833S1
-
-
- HY-14763S
-
|
Cariprazine-d6
RGH-188-d6
|
Dopamine Receptor
5-HT Receptor
|
Neurological Disease
|
|
Cariprazine-d6 is a deuterium labeled Cariprazine. Cariprazine Cariprazine is an antipsychotic agent that exhibits high affinity for the D3 (Ki of 0.085 nM) and D2 (Ki of 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki of 2.6 nM)[1].
|
-
- HY-W015198S
-
-
- HY-12389S
-
-
- HY-146882S
-
-
- HY-121809S
-
-
- HY-144239S
-
-
- HY-151097S
-
-
- HY-151124S
-
-
- HY-106950CS
-
-
- HY-W440239
-
-
- HY-B0806S1
-
|
Proguanil-d4
|
Antifolate
Parasite
|
Infection
|
|
Proguanil-d4 is the deuterium labeled Proguanil[1]. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor[2][3].
|
-
- HY-12760S
-
-
- HY-W010382S
-
-
- HY-105124S
-
-
- HY-W009240S
-
-
- HY-132421S
-
-
- HY-N0658S5
-
|
L-Threonine-d2
|
Endogenous Metabolite
|
Others
|
|
L-Threonine-d2 is the deuterium labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed[1].
|
-
- HY-20797S
-
-
- HY-141942S
-
-
- HY-W015854S
-
-
- HY-Y0332BS
-
|
Phosphate monobasic-d2 potassium
|
Isotope-Labeled Compounds
|
Others
|
|
Phosphate monobasic-d2 (potassium) is the deuterium labeled Potassium phosphate monobasic[1]. Potassium phosphate monobasic (DiA) is a commonly used in biological assay buffers. Potassium phosphate monobasic is moderate to highly concentrated aqueous solutions of potassium phosphate monobasic for the production of phosphate buffers and other laboratory applications.
|
-
- HY-142196S
-
-
- HY-N0216S1
-
|
Benzoic acid-13C6
|
Bacterial
Fungal
Endogenous Metabolite
|
Infection
|
|
Benzoic acid- 13C6 is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
|
-
- HY-110159S
-
-
- HY-B0660S
-
-
- HY-19581S
-
|
Baquiloprim-d6
|
Antibiotic
Bacterial
|
Infection
|
|
Baquiloprim-d6 is deuterium labeled Baquiloprim. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria[1][2].
|
-
- HY-129951S
-
-
- HY-17393S
-
|
Carboplatin-d4
NSC 241240-d4
|
DNA Alkylator/Crosslinker
Autophagy
DNA/RNA Synthesis
|
Cancer
|
|
Carboplatin-d4 is the deuterium labeled Carboplatin. Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
|
-
- HY-B1781S
-
|
Sulfachloropyridazine-13C6
Sulfachlorpyridazine-13C6
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfachloropyridazine- 13C6 is the 13C6 labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria.
|
-
- HY-B0330S1
-
|
(S)-Ofloxacin-d3
|
Bacterial
Antibiotic
|
Infection
|
|
(S)-Ofloxacin-d3 is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
|
-
- HY-W010562S
-
-
- HY-150918S
-
-
- HY-100964S
-
-
- HY-13442AS
-
-
- HY-47762S
-
-
- HY-N6729S2
-
-
- HY-120829S
-
-
- HY-17507CS
-
-
- HY-B0527AS
-
|
Amitriptyline-d6 hydrochloride
|
Serotonin Transporter
5-HT Receptor
Histamine Receptor
mAChR
Adrenergic Receptor
Sodium Channel
Trk Receptor
|
Neurological Disease
|
|
Amitriptyline-d6 (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].
|
-
- HY-116084S
-
-
- HY-W027751S
-
|
2-Methylanisole-d3
|
Isotope-Labeled Compounds
|
Others
|
|
2-Methylanisole-d3 is the deuterium labeled 2-Methylanisole[1]. 2-Methylanisole is a monomethoxybenzene and acts as an intermediate for the preparation of compounds with methylhydroquinone core[2].
|
-
- HY-124489S
-
-
- HY-50898S3
-
|
Lapatinib-d4-1
GW572016-d4-1; GW2016-d4-1
|
EGFR
Autophagy
Ferroptosis
|
Cancer
|
|
Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
|
-
- HY-150664S
-
-
- HY-109077S
-
-
- HY-146879S
-
-
- HY-I1111S
-
-
- HY-N0728S
-
|
α-Linolenic acid-d5
|
PI3K
Akt
|
Cancer
Cardiovascular Disease
|
|
α-Linolenic acid-d5 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
|
-
- HY-131104S
-
-
- HY-W011235S
-
-
- HY-B0260S1
-
-
- HY-150674S
-
-
- HY-W111879S
-
-
- HY-B2219S2
-
-
- HY-A0281S3
-
|
4-Phenylbutyric acid-d2
4-PBA-d2; Benzenebutyric acid-d2
|
HDAC
Virus Protease
|
|
|
4-Phenylbutyric acid-d2 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
|
-
- HY-B1986S
-
|
p,p'-DDE-d8
4,4'-DDE-d8; p,p'-Dichlorodiphenyldichloroethylene-d8
|
Androgen Receptor
Drug Metabolite
|
Endocrinology
|
|
p,p'-DDE-d8 is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].
|
-
- HY-N0098S2
-
|
Vanillin-13C6
p-Vanillin-13C6; m-Methoxy-p-hydroxybenzaldehyde-13C6; p-Hydroxy-m-methoxybenzaldehyde-13C6
|
Endogenous Metabolite
|
Others
|
|
Vanillin- 13C6 is the 13C labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
|
-
- HY-B1203S
-
-
- HY-Y1311S
-
|
Malic acid-d3
Hydroxybutanedioic acid-d3; E 296-d3
|
Endogenous Metabolite
|
Others
|
|
Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods[1][2].
|
-
- HY-B1260S3
-
|
Cetrimonium-d9(bromide)
CTAB-d9; Cetyltrimethylammonium-d9 bromide; Hexadecyltrimethylammonium-d9 bromide
|
Isotope-Labeled Compounds
|
Others
|
|
Cetrimonium-d9 (bromide) is the deuterium labeled Cetrimonium bromide[1]. Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.
|
-
- HY-B0400S2
-
|
D-Sorbitol-13C-1
Sorbitol-13C-1; D-Glucitol-13C-1
|
Endogenous Metabolite
|
Others
|
|
D-Sorbitol- 13C-1 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-75087S
-
-
- HY-143807S
-
-
- HY-W008917S1
-
-
- HY-136450S1
-
|
Triclabendazole sulfoxide-13C,d3
TCBZ-SO-13C,d3
|
Parasite
BCRP
|
Infection
|
|
Triclabendazole sulfoxide- 13C,d3 is the 13C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
|
-
- HY-B0032S
-
-
- HY-142887S
-
-
- HY-B0817S
-
|
Pyridaben-d13
|
Parasite
|
Infection
|
|
Pyridaben-d13 is the deuterium labeled Pyridaben[1]. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[2][3].
|
-
- HY-W012499S
-
|
N-Acetyl-L-methionine-d3
N-Acetylmethionine-d3
|
Endogenous Metabolite
|
|
|
N-Acetyl-L-methionine-d3 is the deuterium labeled N-Acetyl-L-methionine. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development[1].
|
-
- HY-D0838S1
-
|
Dodecyltrimethylammonium-d34(bromide)
|
Isotope-Labeled Compounds
|
Others
|
|
Dodecyltrimethylammonium-d34 (bromide) is the deuterium labeled Dodecyltrimethylammonium (bromide)[1]. Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction[2].
|
-
- HY-143984S
-
-
- HY-N0538S2
-
-
- HY-N0623S5
-
-
- HY-B1322AS
-
-
- HY-Y0079S
-
|
D-Phenylalanine-d5
|
Endogenous Metabolite
|
Others
|
|
D-Phenylalanine-d5 is the deuterium labeled D-Phenylalanine. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014[1].
|
-
- HY-B1014S1
-
-
- HY-144230S
-
-
- HY-I0202S
-
-
- HY-146972S
-
-
- HY-W018772S
-
|
D-Ribose-18O
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
D-Ribose- 18O is the 18O labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
|
-
- HY-110189S1
-
|
Pregnenolone monosulfate-d4 sodium
3β-Hydroxy-5-pregnen-20-one monosulfate-d4 (sodium)
|
Cannabinoid Receptor
TRP Channel
Endogenous Metabolite
Autophagy
|
|
|
Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication[1][2]. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
|
-
- HY-B0827S
-
|
Dinotefuran-d3
MTI-446-d3
|
nAChR
Parasite
|
Infection
|
|
Dinotefuran-d3 is the deuterium labeled Dinotefuran[1]. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors[2].
|
-
- HY-76299S
-
-
- HY-14649S2
-
|
11-cis-Retinoic Acid-d5
|
RAR/RXR
PPAR
Endogenous Metabolite
Autophagy
|
Cancer
|
|
11-cis-Retinoic Acid-d5 is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].
|
-
- HY-N0113S
-
-
- HY-N0379S19
-
|
D-Mannose-d-4
|
Endogenous Metabolite
|
Others
|
|
D-Mannose-d-4 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
|
-
- HY-W010452S
-
|
3-Hydroxybutyric acid-d2 sodium
β-Hydroxybutyric acid-d2 sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid-d2 (sodium) is the deuterium labeled 3-Hydroxybutyric acid sodium[1]. 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids[2].
|
-
- HY-D0186S3
-
|
2'-Deoxyuridine-5′-13C
|
Endogenous Metabolite
|
Infection
|
|
2'-Deoxyuridine-5′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
|
-
- HY-A0007S
-
-
- HY-14187S
-
-
- HY-112530S
-
-
- HY-N0684S1
-
-
- HY-128417S1
-
-
- HY-B0256S
-
|
Azathioprine-d3
BW 57-322-d3
|
Isotope-Labeled Compounds
|
Others
|
|
Azathioprine-d3 (BW 57-322-d3) is the deuterium labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis.
|
-
- HY-B2246S
-
|
L-Carnitine-d9 chloride
(R)-Carnitine-d9 (chloride); Levocarnitine-d9 (chloride)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Carnitine-d9 (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].
|
-
- HY-W007928S1
-
-
- HY-50896S
-
|
Erlotinib-d6
CP-358774-d6; NSC 718781-d6; OSI-774-d6
|
EGFR
|
Cancer
|
|
Erlotinib-d6 (CP-358774 D6) is a deuterium labeled Erlotinib (CP-358774). Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR[1].
|
-
- HY-B1659AS
-
-
- HY-W008091S
-
|
5-Methylcytosine-d4
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Others
|
|
5-Methylcytosine-d4 is the deuterium labeled 5-Methylcytosine[1]. 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine in mRNA is a new epitranscriptome marker inArabidopsis, and that regulation of this modification is an integral part of gene regulatory networks underlying plant development[2].
|
-
- HY-N0469S
-
-
- HY-W062703S1
-
-
- HY-B0878S
-
-
- HY-B0114S
-
|
Oxcarbazepine-D4
GP 47680-d4
|
Sodium Channel
Apoptosis
|
Cancer
Neurological Disease
|
|
Oxcarbazepine-d4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
|
-
- HY-N6608S
-
|
Physostigmine-d3
Eserine-d3
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Physostigmine-d3 is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].
|
-
- HY-17507S
-
|
Pantoprazole-d6
BY1023-d6; SKF96022-d6
|
Proton Pump
Autophagy
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Pantoprazole-d6 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
|
-
- HY-W011926S
-
-
- HY-B1282S
-
|
Sulfaquinoxaline-d4
|
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Sulfaquinoxaline-d4 is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].
|
-
- HY-B0804S
-
-
- HY-17042AS
-
|
Cetirizine D4 dihydrochloride
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Cetirizine-d4 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
|
-
- HY-B0421S2
-
|
Mycophenolic acid-13C17
Mycophenolate-13C17
|
Isotope-Labeled Compounds
|
Cancer
|
|
Mycophenolic acid- 13C17 (Mycophenolate- 13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
|
-
- HY-B1340S
-
-
- HY-N0229S7
-
-
- HY-141945S
-
-
- HY-B1955S
-
-
- HY-77956S1
-
-
- HY-W017209S
-
-
- HY-B0161BS1
-
-
- HY-150709S
-
-
- HY-144180S
-
-
- HY-135336BS
-
-
- HY-Y0252S4
-
-
- HY-79648S
-
|
Fmoc-Methylalanine-d3
|
Isotope-Labeled Compounds
|
Others
|
|
Fmoc-Methylalanine-d3 is the deuterium labeled Trifloxystrobin. Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h[1].
|
-
- HY-128850S1
-
|
N-Acetyl-D-mannosamine-13C
N-Acetylmannosamine-13C; ManNAc-13C
|
Bacterial
|
Neurological Disease
|
|
N-Acetyl-D-mannosamine- 13C is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1][2]
|
-
- HY-79369S
-
|
Succinic anhydride-d4
|
Isotope-Labeled Compounds
ADC Linker
|
Cancer
|
|
Succinic anhydride-d4 is the deuterium labeled Succinic anhydride. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide[1].
|
-
- HY-W008758S1
-
-
- HY-144242S
-
-
- HY-141934S
-
-
- HY-B0739AS
-
|
Citicoline-d9 sodium
Cytidine diphosphate-choline-d9 (sodium); CDP-Choline-d9(sodium); Cytidine 5'-diphosphocholine-d9 (sodium)
|
Endogenous Metabolite
Apoptosis
|
Neurological Disease
|
|
Citicoline-d9 (sodium) is the deuterium labeled Citicoline sodium. Citicoline sodium salt is an intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes and also exerts neuroprotective effects.
|
-
- HY-W008816S
-
-
- HY-N0215S7
-
|
L-Phenylalanine-3-13C
(S)-2-Amino-3-phenylpropionic acid-3-13C
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-3- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
|
-
- HY-132382S
-
-
- HY-B0361S1
-
|
Aspartame-d5
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Aspartame-d5 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
|
-
- HY-125783S1
-
-
- HY-Y0366S5
-
|
Lauric acid-d5
|
Endogenous Metabolite
Bacterial
|
|
|
Lauric acid-d5 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
|
-
- HY-66006S
-
-
- HY-B0219S
-
-
- HY-Y0688S
-
-
- HY-113296S
-
-
- HY-W007872S
-
-
- HY-143935S
-
-
- HY-N0683S
-
-
- HY-B0334AS
-
|
Sulbactam-d5 sodium
|
Bacterial
Antibiotic
|
Infection
|
|
Sulbactam-d5 (sodium) is the deuterium labeled Sulbactam sodium. Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2].
|
-
- HY-125407S
-
|
Palmitoyl serinol-d5
N-Palmitoyl serinol-d5
|
Cannabinoid Receptor
|
Inflammation/Immunology
|
|
Palmitoyl serinol-d5 is the deuterium labeled Palmitoyl serinol[1]. Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin[2][3].
|
-
- HY-W012689S
-
-
- HY-17591S
-
|
Penicillin G-d5 potassium
Benzylpenicillin-d5 (potassium)
|
Bacterial
Antibiotic
|
Infection
|
|
Penicillin G-d5 (potassium) is the deuterium labeled Penicillin G potassium. Penicillin G potassium is a fast-acting antibiotic; used to treat bacterial infections that affect the blood, heart, lungs, joints, and genital areas[1][2].
|
-
- HY-123230S1
-
-
- HY-D0185S4
-
-
- HY-139474S
-
-
- HY-18260S5
-
|
Bisphenol A-d4-1
|
Endogenous Metabolite
|
Endocrinology
|
|
Bisphenol A-d4-1 is the deuterium labeled Bisphenol A[1]. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[2][3].
|
-
- HY-B0322S
-
-
- HY-107447S
-
-
- HY-19489S1
-
-
- HY-B0901S1
-
-
- HY-108496S
-
|
Sphingosine-1-phosphate-d7
S1P-d7
|
Endogenous Metabolite
LPL Receptor
|
Endocrinology
|
|
Sphingosine-1-phosphate-d7 is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].
|
-
- HY-B0592S
-
-
- HY-D0017S
-
-
- HY-Y0836S1
-
|
Diethyl succinate-d4
Diethyl Butanedioate-d4
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Diethyl succinate-d4 is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
- HY-W017456S
-
-
- HY-B0978S1
-
|
Diethyltoluamide-d7
DEET-d7; N,N-Diethyl-m-toluamide-d7
|
Parasite
|
Infection
|
|
Diethyltoluamide-d7 is the deuterium labeled Diethyltoluamide[1]. Diethyltoluamide is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects[2].
|
-
- HY-W011591S1
-
-
- HY-12542S
-
|
Dantrolene-13C3
F 368-13C3
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
Neurological Disease
|
|
Dantrolene- 13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
|
-
- HY-Y0491S
-
-
- HY-N0283S
-
|
Diacerein-d6
Diacerhein-d6; Diacetylrhein-d6
|
Interleukin Related
|
Inflammation/Immunology
|
|
Diacerein-d6 is the deuterium labeled Diacerein[1]. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases[2].
|
-
- HY-146951S
-
-
- HY-100560S
-
-
- HY-W009204S1
-
-
- HY-N0210S6
-
-
- HY-B1190BS
-
-
- HY-13570BS1
-
-
- HY-14543S
-
-
- HY-107372S
-
-
- HY-B0228S9
-
|
Adenosine-13C10,15N5
|
Apoptosis
Nucleoside Antimetabolite/Analog
Autophagy
Endogenous Metabolite
|
|
|
Adenosine- 13C10, 15N5 is the 13C and 15N labeled Adenosine[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[2][3].
|
-
- HY-N7933S
-
-
- HY-D0186S2
-
|
2'-Deoxyuridine-3′-13C
|
Endogenous Metabolite
|
Infection
|
|
2'-Deoxyuridine-3′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
|
-
- HY-N6696S
-
|
Aflatoxin B2-13C17
|
Isotope-Labeled Compounds
|
Cancer
|
|
Aflatoxin B2- 13C17 is 13C- and 15N-labeled Aflatoxin B2 (HY-N6696). Aflatoxin B2 is a major naturally produced aflatoxin. Aflatoxin B2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2.
|
-
- HY-10353S
-
-
- HY-W004051S
-
-
- HY-101064S3
-
|
Fmoc-leucine-d10
|
PPAR
|
|
|
Fmoc-leucine-d10 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
|
-
- HY-N0470S3
-
-
- HY-Y1027S2
-
-
- HY-16397AS
-
-
- HY-B1121S
-
-
- HY-129297S
-
-
- HY-B0852S
-
|
Tebuconazole-d9
|
Cytochrome P450
Fungal
|
Infection
|
|
Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
|
-
- HY-W011471S
-
-
- HY-Y0531S
-
-
- HY-Y0366S3
-
|
Lauric acid-d3
|
Endogenous Metabolite
Bacterial
|
Infection
|
|
Lauric acid-d33 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
|
-
- HY-151874S
-
-
- HY-133694S
-
-
- HY-B1465S2
-
-
- HY-113114S
-
|
Tetrahydrocortisone-d5
|
Endogenous Metabolite
|
Others
|
|
Tetrahydrocortisone-d5 is the deuterium labeled Tetrahydrocortisone. Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase[1].
|
-
- HY-150660S
-
-
- HY-N1150S4
-
-
- HY-12053AS
-
|
Vinorelbine-d3 ditartrate
KW-2307-d3 (ditartrate); Nor-5'-anhydrovinblastine-d3 (ditartrate)
|
Microtubule/Tubulin
Autophagy
|
Cancer
|
|
Vinorelbine-d3 (ditartrate) is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
|
-
- HY-146935S
-
-
- HY-B0454AS
-
-
- HY-B0647S1
-
|
Butylphthalide-d3
3-n-Butylphthalide-d3; 3-Butylphthalide-d3
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Butylphthalide-d3 is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.
|
-
- HY-150962S
-
-
- HY-143675S
-
-
- HY-N0394S3
-
-
- HY-W011873S
-
-
- HY-B1623S
-
-
- HY-W011883S
-
-
- HY-W040240S2
-
|
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one-13C-2
|
Endogenous Metabolite
|
Others
|
|
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- 13C-2 is the 13C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite[1].
|
-
- HY-B0031S2
-
|
Quetiapine-d8 fumarate
|
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Quetiapine-d8 (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1][2].
|
-
- HY-116865S
-
-
- HY-B1115S
-
-
- HY-Y0258S1
-
-
- HY-17373S
-
|
Posaconazole-d5
SCH 56592-d5
|
Fungal
|
Infection
|
|
Posaconazole-d5 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].
|
-
- HY-W014674S
-
-
- HY-133091S
-
-
- HY-D0314S
-
-
- HY-N1369S
-
|
Menthol-d4
|
Calcium Channel
|
Neurological Disease
|
|
Menthol-d4 is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes[1].
|
-
- HY-17464S
-
-
- HY-I0678S
-
|
Regorafénib N-oxyde-d3 (M2)
|
PDGFR
Drug Metabolite
|
Cancer
|
|
Regorafénib N-oxyde-d3(M2) is the deuterium labeled Regorafénib N-oxyde M2[1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[2].
|
-
- HY-W011591S2
-
-
- HY-W020044S
-
|
DL-alpha-Tocopherol-13C3
|
Ferroptosis
|
Others
|
|
DL-alpha-Tocopherol- 13C3 is the 13C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB[1].
|
-
- HY-B0563S1
-
|
Ropivacaine-d7
|
Sodium Channel
Potassium Channel
|
Neurological Disease
Cardiovascular Disease
|
|
Ropivacaine-d7 is deuterium labeled Ropivacaine. Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of neuropathic pain management[1].
|
-
- HY-W015883S2
-
|
Fumaric acid-13c2,2h2
|
Endogenous Metabolite
|
|
|
Fumaric acid- 13C2,d2 is the deuterium and 13C labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
|
-
- HY-B0508S
-
-
- HY-N0322S8
-
|
Cholesterol-18O
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
|
|
|
Cholesterol- 18O is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
|
-
- HY-132709S
-
-
- HY-101064S4
-
|
Fmoc-leucine-15N
|
SARS-CoV
Enterovirus
HCV
Topoisomerase
|
Infection
|
|
Fmoc-leucine- 15N is a 15N-labeled and 13C-labled EIDD-1931. EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine ence
|
-
- HY-118472S
-
-
- HY-A0093S1
-
-
- HY-W012713S
-
-
- HY-144198S
-
-
- HY-143985S
-
-
- HY-143794S
-
-
- HY-W013378S3
-
-
- HY-17492S2
-
-
- HY-B0431AS1
-
|
Phenoxybenzamine (benzyl-2,3,4,5,6-d5) (hydrochloride)
|
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Phenoxybenzamine (benzyl-2,3,4,5,6-d5) (hydrochloride) is the deuterium labeled Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity[1][2][3].
|
-
- HY-16562S1
-
-
- HY-N2073S
-
|
Ethyl linolenate-d5
|
MCHR1 (GPR24)
|
Cardiovascular Disease
|
|
Ethyl linolenate-d5 is the deuterium labeled Ethyl linolenate. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects[1].
|
-
- HY-Y0936S
-
-
- HY-N0666S9
-
-
- HY-Y0740S
-
|
4-Methoxybenzaldehyde-d1
|
Endogenous Metabolite
|
Others
|
|
4-Methoxybenzaldehyde-d1 is the deuterium labeled 4-Methoxybenzaldehyde[1]. 4-Methoxybenzaldehyde is a naturally occurring fragrant phenolic compound. 4-Methoxybenzaldehyde has been found in many plant species including horseradish, anise, star anise. 4-Methoxybenzaldehyde is a possible neurotoxicant and it has shown effects that include mortality, attractancy, and interference with host seeking[2].
|
-
- HY-Y0252S3
-
-
- HY-B0267AS
-
-
- HY-B0866S
-
|
Ametryn-13C,d3
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Ametryn- 13C,d3 is the 13C- and deuterium labeled Ametryn. Ametryn, a member of the Triazine chemical family, is a herbicide which inhibits photosynthesis and other enzymatic processes. Ametryn is effective against annual broadleaf weeds and grasses[1].
|
-
- HY-121883S4
-
|
Lignoceric acid-d4-2
Tetracosanoic acid-d4-2
|
Endogenous Metabolite
|
|
|
Lignoceric acid-d4-2 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].
|
-
- HY-144427S
-
-
- HY-133972S
-
-
- HY-139235S
-
-
- HY-113342S
-
-
- HY-W134259S
-
-
- HY-W018772S15
-
|
D-Ribose(mixture of isomers)-13c5
|
Endogenous Metabolite
|
|
|
D-Ribose(mixture of isomers)- 13C5 isomers)- 13C5 is the 13C labeled D-Ribose(mixture of isomers)[1]. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1].
|
-
- HY-W009296S1
-
-
- HY-141919S
-
-
- HY-N1914S1
-
|
Ergothioneine-d9
L-(+)-Ergothioneine-d9
|
Endogenous Metabolite
|
Others
|
|
Ergothioneine-d9 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
|
-
- HY-B1207S
-
|
Urethane-d5
Ethyl carbamate-d5; Carbamic acid ethyl ester-d5; Ethylurethane-d5
|
Bacterial
Parasite
|
Cancer
Infection
Neurological Disease
|
|
Urethane-d5 is the deuterium labeled Urethane. Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro[1].
|
-
- HY-146949S
-
-
- HY-139532S
-
-
- HY-B0312S
-
-
- HY-66005S2
-
-
- HY-41417S
-
|
Octanoic acid-d15
Caprylic acid-d15
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Octanoic acid-d15 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-121883S1
-
|
Lignoceric acid-d3
Tetracosanoic acid-d3
|
Endogenous Metabolite
|
Neurological Disease
|
|
Lignoceric acid-d3 is the deuterium labeled Lignoceric acid[1]. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[2][3].
|
-
- HY-133668S
-
|
Monoethyl phthalate-d4
|
Isotope-Labeled Compounds
|
Cancer
|
|
Monoethyl phthalate-d4 is the deuterium labeled Monoethyl phthalate[1]. Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule[2][3].
|
-
- HY-N7123S
-
|
Sulfacetamide-d4
Sulphacetamide-d4
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfacetamide-d4 is the deuterium labeled Sulfacetamide. Sulfacetamide (Sulphacetamide), a bacteriostatic sulphonamide, is a popular antibiotic prescribed for treating ocular infections[1][2].
|
-
- HY-111112S
-
-
- HY-139427S
-
-
- HY-N0322S7
-
|
Cholesterol-d1
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
|
|
|
Cholesterol-d is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
|
-
- HY-113366S
-
-
- HY-142106
-
-
- HY-W010542S
-
-
- HY-Y0418S3
-
|
Dulcite-13C-3
Dulcitol-13C-3; Melampyrit-13C-3; NSC 1944-13C-3
|
Endogenous Metabolite
|
Others
|
|
Dulcite- 13C-3 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
|
-
- HY-17355S
-
|
Pramipexole-d7 dihydrochloride
|
Dopamine Receptor
|
Neurological Disease
|
|
Pramipexole-d7 (dihydrochloride) is the deuterium labeled Pramipexole dihydrochloride. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].
|
-
- HY-119447S
-
|
Mavacoxib-d4
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Mavacoxib-d4 is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs[1].
|
-
- HY-Y0669S
-
|
Pipecolic acid-d9
|
Endogenous Metabolite
Bacterial
|
|
|
Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid, a metabolite of Lysine, is an important precursor of many useful microbial secondary metabolites. Pipecolic acid can be used as a diagnostic marker of Pyridoxine-dependent epilepsy[1][2].
|
-
- HY-W011103S
-
-
- HY-W018772S9
-
|
D-Ribose-d-3
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
D-Ribose-d-3 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein g
|
-
- HY-B0495S4
-
|
Lamotrigine-13C3
LTG-13C3; BW430C-13C3
|
Sodium Channel
Autophagy
|
Neurological Disease
|
|
Lamotrigine- 13C3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
|
-
- HY-N0168AS
-
-
- HY-143909S
-
-
- HY-146855S
-
-
- HY-118431S3
-
-
- HY-W088017S
-
-
- HY-D0227ES
-
-
- HY-144221S
-
-
- HY-W268542S
-
-
- HY-B1198S
-
|
Piperonyl butoxide-d9
ENT-14250-d9
|
Parasite
|
Infection
|
|
Piperonyl butoxide-d9 is the deuterium labeled Piperonyl butoxide. Piperonyl butoxide is a semisynthetic derivative of safrole，used as a component of pesticide formulations. It is a synergist, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as Carbamates, Pyrethrins, Pyrethroids, and Rotenone.
|
-
- HY-B1342S1
-
-
- HY-W128916S
-
-
- HY-Y0553S2
-
-
- HY-B1421S1
-
-
- HY-N8723S
-
-
- HY-113365S3
-
|
Cholestenone-d7
4-Cholesten-3-one-d7
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Cholestenone-d7 is deuterium labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop
|
-
- HY-146946S
-
-
- HY-100805S
-
-
- HY-121046S
-
|
Flunixin-d3
|
COX
|
Inflammation/Immunology
|
|
Flunixin-d3 is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity[1][2].
|
-
- HY-B0370S
-
|
Tolnaftate (D7)
|
Fungal
|
Infection
|
|
Tolnaftate-d7 is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].
|
-
- HY-B0261S1
-
-
- HY-N0402S
-
|
Artemether-d3
Dihydroqinghaosu methyl ether-d3; Dihydroartemisinin methyl ether-d3; SM224-d3
|
Parasite
|
Infection
Cancer
|
|
Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
|
-
- HY-14648S3
-
|
Dexamethasone-4,6α,21,21-d4
|
Glucocorticoid Receptor
SARS-CoV
Autophagy
Complement System
Mitophagy
Bacterial
Antibiotic
|
|
|
Dexamethasone-4,6α,21,21-d4 is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
- HY-N1366S
-
-
- HY-132313S
-
-
- HY-W099580S1
-
-
- HY-B1355AS1
-
-
- HY-24385S1
-
-
- HY-150707S
-
-
- HY-W094748S
-
-
- HY-W015309S1
-
|
Decanoic acid-d19
|
iGluR
|
Neurological Disease
|
|
Decanoic acid-d199 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects[1][2][3].
|
-
- HY-113322S
-
-
- HY-D0859S
-
|
MOPS-d15
|
Isotope-Labeled Compounds
|
Others
|
|
MOPS-d15 is the deuterium labeled MOPS[1]. MOPS is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media[2][3].
|
-
- HY-N7926S
-
-
- HY-B1306S
-
|
4-Aminohippuric acid-d4
p-Aminohippuric acid-d4
|
Endogenous Metabolite
|
Others
|
|
4-Aminohippuric acid-d4 is the deuterium labeled 4-Aminohippuric acid. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.
|
-
- HY-W067358S
-
-
- HY-W214059S
-
-
- HY-W424788S
-
-
- HY-13904S
-
|
Flumatinib-d3
HHGV678-d3
|
Bcr-Abl
c-Kit
PDGFR
|
Cancer
|
|
Flumatinib-d3 is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].
|
-
- HY-118527S
-
-
- HY-13204S2
-
-
- HY-W015933S2
-
-
- HY-113468AS
-
-
- HY-N0067S1
-
|
γ-Aminobutyric acid-d2
4-Aminobutyric acid-d2
|
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
γ-Aminobutyric acid-d2 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
|
-
- HY-100806S
-
-
- HY-107327S1
-
-
- HY-Y0966S9
-
|
Glycine-15N,d2
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine- 15N,d2 is the deuterium and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-W015777S
-
-
- HY-Y0012S
-
-
- HY-144248S
-
-
- HY-15121S
-
|
L-Theanine-d5
L-Glutamic Acid γ-ethyl amide-d5; Nγ-Ethyl-L-glutamine-d5
|
Apoptosis
Endogenous Metabolite
|
Neurological Disease
|
|
L-Theanine-d5 is the deuterium labeled L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake[1][2][3].
|
-
- HY-10585S4
-
|
Valproic acid-d4-1
VPA-d4-1; 2-Propylpentanoic Acid-d4-1
|
HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
|
Cancer
|
|
Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
|
-
- HY-14545S
-
-
- HY-132334S
-
-
- HY-145989S
-
-
- HY-B0405S
-
-
- HY-B0991S
-
-
- HY-N7092S9
-
|
D-Fructose-d4
D(-)-Fructose-d4
|
Endogenous Metabolite
|
Others
|
|
D-Fructose-d4 is the deuterium labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
|
-
- HY-W012382S
-
|
N-Acetyl-L-tyrosine-d3
|
Endogenous Metabolite
|
|
|
N-Acetyl-L-tyrosine-d3 is the deuterium labeled N-Acetyl-L-tyrosine. N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.
|
-
- HY-Y0306S
-
-
- HY-N0650S12
-
-
- HY-W011215S
-
-
- HY-W015339S2
-
-
- HY-107349S
-
|
Fenoverine-d8
Spasmopriv-d8
|
Calcium Channel
|
Neurological Disease
|
|
Fenoverine-d8 is the deuterium labeled Fenoverine[1]. Fenoverine (Spasmopriv) is an antispasmodic agent and inhibits calcium channel currents[2]. Fenoverine induces rhabdomyolysis[3].
|
-
- HY-B1790S
-
|
Terconazole-d4
R42470-d4
|
Fungal
|
Infection
|
|
Terconazole-d4 is the deuterium labeled Terconazole. Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
|
-
- HY-143988S
-
-
- HY-Y0400S
-
-
- HY-W008507S3
-
-
- HY-Y0921S1
-
|
(±)-1,2-Propanediol-d2
1,2-(RS)-Propanediol-d2; 1,2-Propylene glycol-d2; Propylene glycol-d2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
(±)-1,2-Propanediol-d2 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
|
-
- HY-115704S
-
-
- HY-B0400S15
-
|
D-Sorbitol-18O-1
Sorbitol-18O-1; D-Glucitol-18O-1
|
Endogenous Metabolite
|
Others
|
|
D-Sorbitol- 18O-1 is the 18O labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-90003S
-
-
- HY-B2130S
-
|
Uric acid-13C,15N3
|
Reactive Oxygen Species
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Uric acid- 13C, 15N3 is the 13C-labeled and 15N-labeled Uric acid. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].
|
-
- HY-B0402S
-
|
Amantadine-d15
1-Adamantanamine-d15; 1-Aminoadamantane-d15
|
Influenza Virus
Orthopoxvirus
SARS-CoV
Apoptosis
|
Cancer
Infection
Neurological Disease
|
|
Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].
|
-
- HY-W134007S1
-
-
- HY-142547S
-
-
- HY-144148S
-
-
- HY-113404S
-
-
- HY-B0916S
-
-
- HY-143839S
-
-
- HY-N0593S1
-
-
- HY-10981S1
-
|
Lenvatinib-d5
E7080-d5
|
VEGFR
FGFR
PDGFR
c-Kit
RET
|
Cancer
|
|
Lenvatinib-d5 is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].
|
-
- HY-123533S
-
|
Resorufin-d6
NSC 12097-d6
|
Reactive Oxygen Species
|
Others
|
|
Resorufin-d6 is the deuterium labeled Resorufin. Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte[1].
|
-
- HY-B1323S
-
-
- HY-131113S
-
-
- HY-14519CS
-
-
- HY-114988S
-
-
- HY-150854S
-
-
- HY-17461S2
-
-
- HY-146944S
-
-
- HY-Y1362S
-
-
- HY-W141978S
-
-
- HY-B0005S
-
|
Toremifene-d6 citrate
|
Estrogen Receptor/ERR
Apoptosis
|
Cancer
Infection
|
|
Toremifene-d6 (citrate) is the deuterium labeled Toremifene citrate. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].
|
-
- HY-B0104S
-
-
- HY-N6787S
-
|
5,6-Dihydro-5-methyluracil-d6
Dihydrothymine-d6
|
Endogenous Metabolite
|
Metabolic Disease
|
|
5,6-Dihydro-5-methyluracil-d6 is the deuterium labeled 5,6-Dihydro-5-methyluracil. 5,6-Dihydro-5-methyluracil (Dihydrothymine), an intermediate breakdown product of thymine, comes from animal or plants. 5,6-Dihydro-5-methyluracil (Dihydrothymine) can be toxic when present at abnormally high levels[1].
|
-
- HY-Y0747S
-
-
- HY-N0623S4
-
-
- HY-B0680S
-
-
- HY-N0390S1
-
|
L-Glutamine-13C5
L-Glutamic acid 5-amide-13C5
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
|
L-Glutamine- 13C5 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-125784S
-
-
- HY-W013049S4
-
-
- HY-N3686S1
-
-
- HY-W002004S1
-
-
- HY-113119S1
-
-
- HY-B0135S
-
|
Furosemide-d5
|
NKCC
GABA Receptor
|
Metabolic Disease
Cancer
|
|
Furosemide-d5 is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].
|
-
- HY-15455S1
-
|
Roflumilast-d4 N-Oxide
|
Phosphodiesterase (PDE)
RSV
|
Inflammation/Immunology
|
|
Roflumilast-d4 N-Oxide is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells[1][2].
|
-
- HY-W015410S
-
|
Disodium succinate-13C2
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Disodium succinate- 13C2 is the 13C labeled Disodium succinate[1]. Disodium succinate is the?disodium?salt of?Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism[2].
|
-
- HY-W011591S
-
-
- HY-100641S
-
|
4-Hydroxytolbutamide-d9
Hydroxytolbutamide-d9
|
Potassium Channel
Autophagy
|
Cancer
Metabolic Disease
|
|
4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
|
-
- HY-W011311S
-
|
Eicosapentaenoic acid methyl ester-d5
|
Apoptosis
|
Others
|
|
Eicosapentaenoic acid methyl ester-d5 is the deuterium labeled Eicosapentaenoic acid methyl ester. Eicosapentaenoic acid methyl ester is a degradant of a monogalactosyl diacylglycerol (an anticancer compound by inducing apoptosis)[1].
|
-
- HY-146929S
-
-
- HY-115364S
-
-
- HY-139610S1
-
-
- HY-W012926S1
-
-
- HY-N0537S12
-
-
- HY-139926S
-
-
- HY-W272058S1
-
-
- HY-N0437S
-
-
- HY-100573S
-
|
Necrosulfonamide-d4
|
Mixed Lineage Kinase
|
Cancer
|
|
Necrosulfonamide-d4 is the deuterium labeled Necrosulfonamide. Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis.
|
-
- HY-Y0337S5
-
|
L-Cysteine-d3
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Cysteine-d3 is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].
|
-
- HY-B0892S4
-
-
- HY-66011AS
-
|
Moxifloxacin-d4
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Moxifloxacin-d4 is the deuterium labeled Moxifloxacin. Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia[1][2].
|
-
- HY-B0239S1
-
-
- HY-148233S
-
|
JNJ-6204
|
Casein Kinase
|
Others
|
|
JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2].
|
-
- HY-146821S
-
-
- HY-139928S
-
-
- HY-133712S
-
-
- HY-Y0921S
-
|
(±)-1,2-Propanediol-d8
1,2-(RS)-Propanediol-d8; 1,2-Propylene glycol-d8; Propylene glycol-d8
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
(±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
|
-
- HY-N0830S11
-
-
- HY-12857S
-
-
- HY-W013378S2
-
|
Carbamazepine 10,11-epoxide-13C,d2
|
Endogenous Metabolite
|
Others
|
|
Carbamazepine 10,11-epoxide- 13C,d2 is the deuterium labeled Carbamazepine 10,11-epoxide-C13. Carbamazepine 10,11-epoxide-C13 is a 13C-labled Carbamazepine 10,11-epoxide. Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine (HY-B0246). Carbamazepine has anticonvulsant effect. Carbamazepine can be used for the research of seizures[1][2].
|
-
- HY-W010583S
-
-
- HY-143937S
-
-
- HY-12703S
-
-
- HY-W009204S3
-
-
- HY-W018386S
-
-
- HY-146909S
-
-
- HY-W040273S
-
-
- HY-B1851S
-
|
Hexythiazox-d11
|
Parasite
|
Infection
|
|
Hexythiazox-d11 is deuterium labeled Hexythiazox. Hexythiazox is a selective acaricide with ovicidal, larvicidal and nymphicidal activities. Hexythiazox is widely used for chemical control of mites on cotton, fruits and vegetables. Hexythiazox is harmless to mammals and has no effect on beneficial insects and predators of mites[1][2].
|
-
- HY-78131CS
-
-
- HY-B0375S
-
-
- HY-Y1220S
-
-
- HY-P5190S1
-
-
- HY-N0650S8
-
|
L-Serine-d3
(-)-Serine-d3; (S)-Serine-d3
|
Endogenous Metabolite
|
Cancer
|
|
L-Serine-d3 is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-W017443S
-
-
- HY-W357141S1
-
-
- HY-132392S
-
-
- HY-B0261S
-
-
- HY-146992S
-
-
- HY-50667S
-
|
Apixaban-13C,d3
BMS-562247-01-13C,d3
|
Factor Xa
|
Cardiovascular Disease
|
|
Apixaban- 13C,d3 is a deuterium and 13C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].
|
-
- HY-116790BS
-
-
- HY-Y1250S3
-
-
- HY-133695S
-
|
ent-Florfenicol Amine-d3
|
Antibiotic
|
Infection
|
|
ent-Florfenicol Amine-d3 is the deuterium labeled Florfenicol amine. Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases[1].
|
-
- HY-13317S
-
|
Oseltamivir-d3
|
Influenza Virus
|
Infection
|
|
Oseltamivir-d3 is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[1].
|
-
- HY-N0168S
-
|
Hesperetin-d3
|
p38 MAPK
Apoptosis
Autophagy
|
|
|
Hesperetin-d3 is the deuterium labeled Hesperetin[1]. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis[2][3].
|
-
- HY-W168915S
-
-
- HY-151911S
-
-
- HY-B0351S1
-
|
Taurine-13C2
2-Aminoethanesulfonic acid-13C2
|
Autophagy
Endogenous Metabolite
|
Metabolic Disease
|
|
Taurine- 13C2 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3].
|
-
- HY-N0455AS4
-
|
L-Arginine-13C6,15N4,d7 hydrochloride
(S)-(+)-Arginine-13C6,15N4,d7 (hydrochloride)
|
NO Synthase
Endogenous Metabolite
|
Others
|
|
L-Arginine- 13C6, 15N4,d7 (hydrochloride) is the deuterium, 13C-, and 15-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-146942S
-
-
- HY-146828S
-
-
- HY-Y1250S1
-
-
- HY-144249S
-
-
- HY-B0400S7
-
|
D-Sorbitol-d1-2
Sorbitol-d1-2; D-Glucitol-d1-2
|
Endogenous Metabolite
|
Others
|
|
D-Sorbitol-d-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
|
-
- HY-W018710S
-
-
- HY-17464S1
-
-
- HY-143938S
-
-
- HY-N0667S1
-
-
- HY-114464S1
-
|
11-Beta-hydroxyandrostenedione-d7
4-Androsten-11β-ol-3,17-dione-d7
|
Endogenous Metabolite
11β-HSD
|
Others
|
|
11-Beta-hydroxyandrostenedione-d7 is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor[1][2]
|
-
- HY-N0473S5
-
-
- HY-17358S
-
|
Loteprednol Etabonate-d5
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
Loteprednol Etabonate-d5 is a deuterium labeled Loteprednol etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology[1][2][3].
|
-
- HY-132493S
-
-
- HY-B0934S
-
-
- HY-W282887S
-
-
- HY-123320S
-
-
- HY-W001239S
-
-
- HY-N9929S
-
|
Docosane-d46
|
Isotope-Labeled Compounds
|
Others
|
|
Docosane-d46 is the deuterium labeled Docosane[1]. Docosane, a straight chain alkane, can be used to synthesize structural composites with thermal energy storage/release capability[2][3].
|
-
- HY-G0016S1
-
-
- HY-Z3421S1
-
-
- HY-B0141AS1
-
-
- HY-113420S
-
-
- HY-50767S
-
|
Palbociclib-d8
PD 0332991-d8
|
CDK
|
Cancer
|
|
Palbociclib-d8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].
|
-
- HY-109590S2
-
-
- HY-B0461S
-
|
Trospium-d8 chloride
|
mAChR
|
Neurological Disease
|
|
Trospium-d8 (chloride) is the deuterium labeled Trospium chloride. Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors[1][2].
|
-
- HY-132950S
-
-
- HY-17514S
-
|
Itraconazole-d5
R51211-d5
|
Fungal
Hedgehog
Cytochrome P450
Autophagy
Antibiotic
|
Infection
Cancer
|
|
Itraconazole-d5 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].
|
-
- HY-B1659S6
-
|
Glycerol-d5
1,1,2,3,3-Pentadeuteriopropane-1,2,3-triol
|
Endogenous Metabolite
|
|
|
Glycerol-d5 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].
|
-
- HY-B0304S
-
|
Dapoxetine-d6
|
Serotonin Transporter
|
Neurological Disease
|
|
Dapoxetine-d6 is the deuterium labeled Dapoxetine[1]. Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[2].
|
-
- HY-B0456S1
-
-
- HY-W011297S
-
-
- HY-I0392S
-
-
- HY-Y0262S
-
-
- HY-W272058S
-
-
- HY-N0091S2
-
-
- HY-B1773AS5
-
-
- HY-142193S
-
-
- HY-113254S1
-
-
- HY-W032015S3
-
-
- HY-76204S
-
-
- HY-13609S1
-
-
- HY-90006S2
-
|
5-Fluorouracil-15N2
|
Nucleoside Antimetabolite/Analog
HIV
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
5-Fluorouracil- 15N2 is the 15N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].
|
-
- HY-143810S
-
-
- HY-A0181S1
-
-
- HY-W275290S
-
-
- HY-W142578S
-
-
- HY-13011S1
-
|
Alectinib-d6
CH5424802-d6; RO5424802-d6; AF802-d6
|
Anaplastic lymphoma kinase (ALK)
|
Cancer
|
|
Alectinib-d6 is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
|
-
- HY-W004515S
-
-
- HY-144173S
-
-
- HY-N0593S
-
-
- HY-N0453S1
-
-
- HY-15025AS
-
-
- HY-B1459AS
-
|
Dicloxacillin-13C4
|
Bacterial
Antibiotic
|
Infection
|
|
Dicloxacillin- 13C4 is the 13C labeled Dicloxacillin[1]. Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[2].
|
-
- HY-B1689AS
-
-
- HY-10933S
-
|
CX516-d10
BDP 12-d10
|
Isotope-Labeled Compounds
iGluR
|
Neurological Disease
|
|
CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI)[1].
|
-
- HY-113046S
-
|
5-Methyltetrahydrofolic acid-13C5
5-Methyl THF-13C5
|
Endogenous Metabolite
|
Metabolic Disease
|
|
5-Methyltetrahydrofolic acid- 13C5 is the 13C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].
|
-
- HY-W339978S
-
|
2,3,5,6-Tetrachloro-1,1'-biphenyl-d5
|
Isotope-Labeled Compounds
|
Others
|
|
2,3,5,6-Tetrachloro-1,1'-biphenyl-d5 is the deuterium labeled 2,3,5,6-Tetrachloro-1,1'-biphenyl[1].
|
-
- HY-B1804S1
-
|
Tricaprilin-d50
Trioctanoin-d50; Glyceryl trioctanoate-d50
|
Endogenous Metabolite
|
|
|
Tricaprilin-d50 is the deuterium labeled Tricaprilin. Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite[1][2].
|
-
- HY-B0636S
-
-
- HY-118774S
-
-
- HY-18260S1
-
|
Bisphenol A-d6
|
Endogenous Metabolite
|
Endocrinology
|
|
Bisphenol A-d6 is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[1][2][3].
|
-
- HY-146938S
-
-
- HY-W016825S1
-
-
- HY-W031727S
-
-
- HY-17586AS
-
|
Dalbavancin-d6
MDL-63397-d6; BI-397-d6
|
Bacterial
Antibiotic
|
Infection
|
|
Dalbavancin-d6 is the deuterium labeled Dalbavancin[1]. Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[2][3].
|
-
- HY-10219S
-
|
Rapamycin-d3
Sirolimus-d3; AY-22989-d3
|
mTOR
FKBP
Autophagy
|
Cancer
|
|
Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].
|
-
- HY-W015427S
-
-
- HY-B0410S1
-
|
Pramipexole-d5
|
Dopamine Receptor
|
Neurological Disease
|
|
Pramipexole-d5 is the deuterium labeled Pramipexole[1]. Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[2][3][4].
|
-
- HY-Y1809S
-
-
- HY-W145652S1
-
-
- HY-17355BS
-
-
- HY-10572BS1
-
-
- HY-B0637S1
-
|
Bezafibrate-d4
BM15075-d4
|
PPAR
|
Metabolic Disease
Cardiovascular Disease
|
|
Bezafibrate-d4 is deuterium labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
|
-
- HY-W014633S
-
-
- HY-B1490AS1
-
|
Imipramine-d4
|
Serotonin Transporter
Apoptosis
Autophagy
|
Others
|
|
Imipramine-d4 is deuterium labeled Imipramine. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].
|
-
- HY-113410S
-
|
3-Methylglutaric acid-d4
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
|
-
- HY-150985S
-
-
- HY-14740S
-
|
Elvitegravir-d8
GS-9137-d8; JTK-303-d8; D06677-d8
|
HIV Integrase
HIV
|
Infection
|
|
Elvitegravir-d8 is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
|
-
- HY-Y1213S
-
-
- HY-B0241S
-
|
Ipratropium-d3 bromide
Sch 1000-d3
|
mAChR
|
Inflammation/Immunology
Neurological Disease
|
|
Ipratropium-d3 (bromide) is the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].
|
-
- HY-15321S1
-
|
Etoricoxib-13C,d3
MK-0663-13C,d3; L-791456-13C,d3
|
COX
|
Inflammation/Immunology
Cancer
|
|
Etoricoxib- 13C,d3 is the 13C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
|
-
- HY-N0390S
-
|
L-Glutamine-15N
L-Glutamic acid 5-amide-15N
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
|
L-Glutamine- 15N is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-B1881S
-
|
Pirimiphos-methyl-d6
|
Parasite
Cholinesterase (ChE)
|
Infection
|
|
Pirimiphos-methyl-d6 is the deuterium labeled Pirimiphos-methyl. Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains[1][2][3].
|
-
- HY-N0610S1
-
|
trans-Cinnamic acid-d7
trans-3-Phenylacrylic acid-d7
|
Bacterial
Endogenous Metabolite
|
|
|
trans-Cinnamic acid-d7 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].
|
-
- HY-N0830S4
-
-
- HY-22274S
-
-
- HY-B0503S
-
|
2-Thiouracil-13C,15N2
Thiouracil-13C,15N2
|
NO Synthase
|
Endocrinology
Cancer
|
|
2-Thiouracil- 13C, 15N2 is the 13C, 15N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.
|
-
- HY-W011026S1
-
-
- HY-W011240S1
-
-
- HY-B1912S
-
-
- HY-N0379S17
-
|
D-Mannose-d-3
|
Endogenous Metabolite
|
Others
|
|
D-Mannose-d-3 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
|
-
- HY-B0568S
-
-
- HY-B1776S
-
|
Spermidine-d6
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Spermidine-d6 is the deuterium labeled Spermidine[1]. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents[2].
|
-
- HY-12767S
-
-
- HY-Y0304S
-
-
- HY-W004113S
-
-
- HY-A0033S1
-
|
Darifenacin-d4
UK-88525-d4
|
mAChR
|
|
|
Darifenacin-d4 is the deuterium labeled Darifenacin[1]. Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. IC50 value: 8.9 (pKi)[2].
|
-
- HY-W220946S
-
-
- HY-B0580S
-
|
Ketorolac-d5
|
COX
|
Inflammation/Immunology
|
|
Ketorolac-d5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1].
|
-
- HY-W012478S
-
-
- HY-11063S1
-
|
Fingolimod-d4 hydrochloride
FTY720-d4
|
LPL Receptor
PAK
|
Cancer
Inflammation/Immunology
|
|
Fingolimod-d4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].
|
-
- HY-100642S
-
|
3-O-Methyltolcapone-d7
Ro 40-7591 d7
|
COMT
|
Neurological Disease
|
|
3-O-Methyltolcapone-d7 is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
|
-
- HY-141740S
-
-
- HY-Y0194S
-
-
- HY-N0469S1
-
-
- HY-W010482S
-
|
3-Ethylaniline-d5
|
Isotope-Labeled Compounds
|
Cancer
|
|
3-Ethylaniline-d5 is the deuterium labeled 3-Ethylaniline (HY-W010482). 3-Ethylaniline is metabolized in vivo to electrophilic intermediates that covalently bind to DNA and that adducts are formed in the DNA of bladder. 3-Ethylaniline can be used for the research of bladder cancer[1][2].
|
-
- HY-113313S2
-
|
Aldosterone-d4
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Aldosterone-d4 is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by t
|
-
- HY-146795S
-
-
- HY-126182S4
-
-
- HY-143922S
-
-
- HY-17598S
-
-
- HY-W002094S
-
-
- HY-151930S1
-
-
- HY-13575S1
-
-
- HY-50935S
-
-
- HY-W017443S3
-
-
- HY-B1449S1
-
-
- HY-101392S1
-
|
Harmane-d2
|
Imidazoline Receptor
Monoamine Oxidase
Adrenergic Receptor
|
Cancer
Neurological Disease
|
|
Harmane-d2 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].
|
-
- HY-W008507S1
-
-
- HY-17356S1
-
|
Fenofibrate-d4
|
PPAR
Autophagy
Cytochrome P450
|
|
|
Fenofibrate-d4 is the deuterium labeled Fenofibrate[1]. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively[2][3].
|
-
- HY-17497S1
-
-
- HY-70013S
-
|
Abiraterone-D4
CB-7598-d4
|
Cytochrome P450
|
Cancer
|
|
Abiraterone-d4 is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.
|
-
- HY-Y0417S
-
-
- HY-21323S
-
-
- HY-A0161S
-
|
Chlophedianol-13C6
Clofedanol-13C6; Calmotusin-13C6; NSC 113595-13C6
|
Isotope-Labeled Compounds
|
Infection
|
|
Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
|
-
- HY-B0006S
-
|
Carvedilol-d3
|
Adrenergic Receptor
Autophagy
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
|
Carvedilol-d3 is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome[3].
|
-
- HY-A0009S
-
|
Galanthamine-d3 hydrobromide
Galantamine-d3 (hydrobromide)
|
Cholinesterase (ChE)
nAChR
|
Neurological Disease
|
|
Galanthamine-d3 (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD)[1][2][3].
|
-
- HY-A0251AS
-
-
- HY-142107S
-
-
- HY-N0473S12
-
-
- HY-B0228S8
-
-
- HY-136820S1
-
-
- HY-78726S
-
-
- HY-Y0966S2
-
|
Glycine-2-13C
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-2- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-50898S
-
|
Lapatinib-d4
GW572016-d4; GW2016-d4
|
EGFR
Autophagy
Ferroptosis
|
Cancer
|
|
Lapatinib-d4 is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1][2].
|
-
- HY-D0145S
-
|
7-Ethoxyresorufin-d5
Resorufin ethyl ether-d5
|
Cytochrome P450
NO Synthase
|
Others
|
|
7-Ethoxyresorufin-d5 is deuterium labeled 7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase[1][2].
|
-
- HY-B0114S1
-
|
Oxcarbazepine-d4-1
GP 47680-d4-1
|
Sodium Channel
Apoptosis
|
Cancer
Neurological Disease
|
|
Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
|
-
- HY-128383S1
-
-
- HY-B1278S1
-
-
- HY-13238S2
-
|
Dolutegravir-d5
S/GSK1349572-d5
|
HIV Integrase
HIV
|
Infection
|
|
Dolutegravir-d5 is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].
|
-
- HY-150670S
-
-
- HY-N0486S6
-
-
- HY-B0515AS
-
-
- HY-113456S
-
|
Leukotriene D4-d5
|
Drug Metabolite
Endogenous Metabolite
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.
|
-
- HY-150871S
-
-
- HY-D0184S2
-
|
2'-Deoxycytidine-15N3
Deoxycytidine-15N3; Cytosine deoxyriboside-15N3; Deoxyribose cytidine-15N3
|
Endogenous Metabolite
|
Others
|
|
2'-Deoxycytidine- 15N3 is the 15N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].
|
-
- HY-B0151S1
-
|
Pregnenolone-13C2,d2
3β-Hydroxy-5-pregnen-20-one-13C2,d2
|
Isotope-Labeled Compounds
TRP Channel
Endogenous Metabolite
Cannabinoid Receptor
Autophagy
|
Neurological Disease
|
|
Pregnenolone- 13C2,d2 is the deuterium and 13C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[1][2][3][4].
|
-
- HY-Y0978S
-
-
- HY-14546S1
-
|
Aripiprazole (1,1,2,2,3,3,4,4-d8)
|
5-HT Receptor
|
Neurological Disease
|
|
Aripiprazole (1,1,2,2,3,3,4,4-d8) is the deuterium labeled Aripiprazole. Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM[1][2].
|
-
- HY-Y0860S
-
-
- HY-132447S
-
-
- HY-143961S
-
-
- HY-W131353S
-
-
- HY-151877S
-
-
- HY-79096S2
-
-
- HY-Y0677S
-
-
- HY-113217S
-
|
Cholesteryl oleate-d7
|
Endogenous Metabolite
|
Others
|
|
Cholesteryl oleate-d7 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an esterified form of Cholesterol. Cholesteryl oleate can be used in the generation of solid lipid nanoparticle (SLN, a nanoparticle-based method for gene therapy)[1
|
-
- HY-B0005AS
-
|
Toremifene-d6
Z-Toremifene-d6; NK 622-d6 (free base); FC-1157a-d6 (free base)
|
Estrogen Receptor/ERR
|
Cancer
Infection
|
|
Toremifene-d6 is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].
|
-
- HY-14598S1
-
-
- HY-145004S
-
-
- HY-143977S
-
-
- HY-B1465S4
-
-
- HY-W008719S
-
|
MPP+-d3(iodide)
|
Mitochondrial Metabolism
|
Neurological Disease
|
|
MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
|
-
- HY-130466S
-
|
Stearoyl-L-carnitine-d3 chloride
|
Endogenous Metabolite
GlyT
|
Metabolic Disease
|
|
Stearoyl-L-carnitine-d3 (chloride) is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2].
|
-
- HY-121267S
-
-
- HY-A0132S9
-
-
- HY-A0095S
-
|
Flibanserin-d4
BIMT-17-d4; BIMT-17BS-d4
|
5-HT Receptor
|
Neurological Disease
|
|
Flibanserin-d4 is a deuterium labeled Flibanserin (BIMT-17). Flibanserin is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM)[1].
|
-
- HY-B2219S5
-
-
- HY-B0125AS
-
-
- HY-B1272AS
-
-
- HY-N8440S
-
-
- HY-124265S2
-
-
- HY-N0666S4
-
-
- HY-17422S1
-
|
Acyclovir-d4
Aciclovir-d4; Acycloguanosine-d4
|
HSV
Bacterial
Apoptosis
Antibiotic
|
Cancer
Infection
|
|
Acyclovir-d4 is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].
|
-
- HY-13738S
-
|
Raloxifene-d4
|
Estrogen Receptor/ERR
|
Cancer
|
|
Raloxifene-d4 is the deuterium labeled Raloxifene. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].
|
-
- HY-116214S1
-
|
Cyprodinil-13C6
|
Isotope-Labeled Compounds
Fungal
Androgen Receptor
|
Infection
Endocrinology
|
|
Cyprodinil- 13C6 is the 13C6 labeled Cyprodinil. Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil acts as an androgen receptor (AR) agonist (EC50=1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC50=15.1 µM).
|
-
- HY-132384S
-
-
- HY-14274S
-
-
- HY-W013375S
-
-
- HY-W080986S
-
-
- HY-B0389S24
-
|
D-Glucose-d4
Glucose-d4; D-(+)-Glucose-d4; Dextrose-d4
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Glucose-d4 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
|
-
- HY-13315S1
-
|
Montelukast-d6 sodium
MK0476-d6
|
Leukotriene Receptor
|
Inflammation/Immunology
|
|
Montelukast-d6 (sodium) is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].
|
-
- HY-10163AS1
-
-
- HY-B1858S
-
|
Isoprothiolane-d4
|
Fungal
|
Infection
|
|
Isoprothiolane-d4 is the deuterium labeled Isoprothiolane. Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav[1][2].
|
-
- HY-124920S
-
-
- HY-136540S
-
-
- HY-109506S6
-
|
DPPC-d66
129Y83-d66
|
Endogenous Metabolite
|
Others
|
|
DPPC-d66 is deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in
|
-
- HY-20778S
-
-
- HY-B0131S2
-
-
- HY-N0379S5
-
|
D-Mannose-13C
|
Endogenous Metabolite
|
Others
|
|
D-Mannose- 13C is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
|
-
- HY-143670S
-
-
- HY-B0497BS
-
|
Niclosamide-13C6 monohydrate
BAY2353-13C6 monohydrate
|
STAT
Parasite
Antibiotic
|
|
|
Niclosamide- 13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate[1]. Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[2]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[5]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[3][4][6].
|
-
- HY-W001132S2
-
-
- HY-B0192AS1
-
-
- HY-126356S
-
-
- HY-N9914S
-
-
- HY-Y1138S
-
-
- HY-16060S2
-
|
Apalutamide-13C,d3
ARN-509-13C,d3
|
Androgen Receptor
|
Cancer
|
|
Apalutamide- 13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].
|
-
- HY-W414878S
-
-
- HY-B0125S1
-
|
Ofloxacin-d8
|
Bacterial
Antibiotic
|
Infection
|
|
Ofloxacin-d8 (Hoe-280-d8) is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.
|
-
- HY-W004264S
-
-
- HY-124489S1
-
|
2-Hydroxyestradiol-d5
|
Endogenous Metabolite
|
Infection
|
|
2-Hydroxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].
|
-
- HY-W133986S1
-
-
- HY-B0184S
-
|
Felbamate-d4
|
iGluR
|
Neurological Disease
|
|
Felbamate-d4 (W-554-d4) is the deuterium labeled Felbamate. Felbamate (W-554) is a potent anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).
|
-
- HY-B0002BS1
-
|
Ondansetron-d3
GR 38032-d3; SN 307-d3
|
5-HT Receptor
|
|
|
Ondansetron-d3 is the deuterium labeled Ondansetron[1]. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2].
|
-
- HY-144165S
-
-
- HY-132641S
-
-
- HY-W007941S
-
-
- HY-143858S
-
-
- HY-B0234S4
-
|
Estrone-d2-1
E1-d2-1; Oestrone-d2-1
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
|
|
Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-W012241S1
-
|
Dodecanedioic acid-d4
|
Endogenous Metabolite
|
Others
|
|
Dodecanedioic acid-d4 is the deuterium labeled Dodecanedioic acid[1]. Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates[2].
|
-
- HY-N0229S13
-
-
- HY-B1260S1
-
|
Cetrimonium-d33 bromide
CTAB-d33; Cetyltrimethylammonium-d33 bromide; Hexadecyltrimethylammonium-d33 bromide
|
Isotope-Labeled Compounds
|
Others
|
|
Cetrimonium-d33 (bromide) is the deuterium labeled Cetrimonium bromide[1]. Cetrimonium bromide (CTAB) is an amine based cationic quaternary surfactant, is one of the components of the topical antiseptic Cetrimide.
|
-
- HY-143840S
-
-
- HY-W004328S2
-
-
- HY-W114255S
-
-
- HY-12778S
-
-
- HY-B1374S1
-
|
Florfenicol-d3
(-)-Florfenicol-d3; SCH-25298-d3
|
Bacterial
Antibiotic
|
Infection
|
|
Florfenicol-d3 is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.
|
-
- HY-B0330S
-
|
Levofloxacin-d8
(-)-Ofloxacin-d8
|
Bacterial
Antibiotic
|
Infection
|
|
Levofloxacin-d8 is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
|
-
- HY-W040185S
-
-
- HY-21953S
-
-
- HY-B0947S1
-
|
Sulfanitran-13C6
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Sulfanitran- 13C6 is the 13C labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG).
|
-
- HY-120734S
-
-
- HY-N0210S1
-
-
- HY-W014423S8
-
-
- HY-146631S
-
|
4-Hydroxy-17β-estradiol-1,2,16,16,17-d5
|
Isotope-Labeled Compounds
|
|
|
4-Hydroxy-17β-estradiol-1,2,16,16,17-d5 is the deuterium labeled 4-Hydroxy-17β-estradiol-1,2,16,16,17[1].
|
-
- HY-146837S
-
-
- HY-W016773S
-
-
- HY-77956S2
-
-
- HY-13683S
-
-
- HY-B1059S
-
-
- HY-B0143S3
-
-
- HY-13571S
-
-
- HY-B0129S
-
|
Aztreonam-d6
SQ-26,776-d6
|
Bacterial
Antibiotic
|
Infection
|
|
Aztreonam-d6 is deuterium labeled Aztreonam. Aztreonam (SQ-26,776) is a synthetic monocyclic beta-lactam antibiotic, which has a very high affinity for penicillin-binding protein 3 (PBP-3).
|
-
- HY-W011026S
-
-
- HY-151214S
-
-
- HY-G0003S1
-
-
- HY-N0090S3
-
-
- HY-79504S
-
-
- HY-10065S
-
|
Axitinib 13CD3
AG-013736-13C，d3
|
VEGFR
PDGFR
|
Cancer
|
|
Axitinib- 13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.
|
-
- HY-B0031S1
-
-
- HY-32351AS1
-
-
- HY-Y1129S
-
|
3-Hydroxypyridine-d4
|
Isotope-Labeled Compounds
|
Others
|
|
3-Hydroxypyridine-d4 is the deuterium labeled 3-Hydroxypyridine[1]. 3-Hydroxypyridine is isolated from Bamboo grass. 3-Hydroxypyridine derivatives are structural analogues of vitamin B6 and have a wide range of pharmacological properties, such as antioxidant properties[2][3].
|
-
- HY-W013780S2
-
-
- HY-143021S
-
-
- HY-132423S
-
-
- HY-N7092S2
-
-
- HY-50898S2
-
|
Lapatinib-d5
GW572016-d5; GW2016-d5
|
EGFR
Autophagy
Ferroptosis
|
Cancer
|
|
Lapatinib-d5 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
|
-
- HY-111975S5
-
-
- HY-B0949AS
-
-
- HY-W087988S
-
|
3-Pentanol-d5
|
Bacterial
|
Infection
|
|
3-Pentanol-d5 is the deuterium labeled 3-Pentanol[1]. 3-Pentanol is an active organic compound produced by plants and is a component of emitted insect sex pheromones. 3-pentanol elicits plant immunity against microbial pathogens and an insect pest in crop plants[2].
|
-
- HY-10163S
-
|
Dabigatran-d4
BIBR 953-d4; BIBR 953ZW-d4
|
Thrombin
|
Cardiovascular Disease
|
|
Dabigatran-d4 is deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].
|
-
- HY-W151136S
-
-
- HY-N0229S11
-
-
- HY-139939S
-
-
- HY-B0479S
-
|
Thiamphenicol-d3
Thiophenicol-d3; Dextrosulphenidol-d3
|
Bacterial
Antibiotic
|
Infection
|
|
Thiamphenicol-d3 is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].
|
-
- HY-W051189S
-
-
- HY-N0470S4
-
-
- HY-B1176S
-
|
Equilin-d4
7-Dehydroestrone-d4
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
Equilin-d4 is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].
|
-
- HY-W007357S1
-
-
- HY-B1145S
-
-
- HY-12956S
-
|
Dinoprost-d4
Prostaglandin F2a-d4; PGF2α-d4
|
Prostaglandin Receptor
Endogenous Metabolite
Autophagy
Apoptosis
|
Endocrinology
|
|
Dinoprost-d4 is the deuterium labeled Dinoprost. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].
|
-
- HY-131119S
-
-
- HY-132676S
-
-
- HY-Y0252S5
-
-
- HY-13832S3
-
|
cis-Atovaquone-d4
cis-Atavaquone-d4
|
Parasite
Cytochrome P450
Antibiotic
|
Infection
|
|
cis-Atovaquone-d4 is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].
|
-
- HY-W115788S1
-
-
- HY-W013378S
-
-
- HY-B0808S1
-
|
Oxaprozin-d5
Oxaprozinum-d5; Wy21743-d5
|
COX
NF-κB
|
Inflammation/Immunology
Cancer
|
|
Oxaprozin-d5 is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.
|
-
- HY-N0733S3
-
-
- HY-151117S
-
-
- HY-111431AS
-
-
- HY-W087983S2
-
-
- HY-B1779S5
-
|
Sucrose-13C6
D-(+)-Saccharose-13C6
|
Endogenous Metabolite
|
|
|
Sucrose- 13C6 is the 13C labeled Sucrose[1]. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al[2].
|
-
- HY-N1150S5
-
-
- HY-B0794S
-
|
AZ7550-d5
|
EGFR
IGF-1R
Drug Metabolite
|
Others
|
|
AZ7550-d5 is the deuterium labeled AZ7550 (HY-B0794). AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of IGF1R with an IC50 of 1.6 μM[1][2].
|
-
- HY-17492S
-
-
- HY-146638S
-
|
5α-Pregnan-11β,17α,21-triol-3,20-dione-1,2,4,5-d4
|
Isotope-Labeled Compounds
|
Cancer
|
|
5α-Pregnan-11β,17α,21-triol-3,20-dione-1,2,4,5-d4 is the deuterium labeled 5α-Pregnan-11β,17α,21-triol-3,20-dione-1,2,4,5[1].
|
-
- HY-B0594S
-
|
Iohexol-d5
|
Autophagy
Mitophagy
|
Cancer
|
|
Iohexol-d5 is deuterium labeled Iohexol. Iohexol is a radiographic contrast agent and can be applied for myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging in vivo[1].
|
-
- HY-B1092AS
-
-
- HY-W009204S
-
-
- HY-N7092S5
-
-
- HY-B1090S
-
-
- HY-Y0252S
-
-
- HY-N0382S
-
|
Galangin-13C3
|
Cytochrome P450
Autophagy
|
Cancer
|
|
Galangin- 13C3 is the 13C-labeled Galangin. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.
|
-
- HY-B0126S
-
|
Marbofloxacin-d8
|
Bacterial
Antibiotic
|
Infection
|
|
Marbofloxacin-d8 is the deuterium labeled Marbofloxacin. Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma[1][2][3].
|
-
- HY-Y1042S
-
-
- HY-B0111S1
-
-
- HY-W099613S
-
-
- HY-90005S
-
-
- HY-W010042S
-
-
- HY-110232
-
-
- HY-150964S
-
-
- HY-Y1019S
-
-
- HY-12009S
-
|
Pazopanib-13C,d3 hydrochloride
GW786034-13C,d3 hydrochloride
|
VEGFR
PDGFR
Autophagy
c-Fms
FGFR
c-Kit
|
Cancer
|
|
Pazopanib- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
|
-
- HY-143852S
-
-
- HY-W010256S
-
-
- HY-B0330BS
-
-
- HY-W284558S
-
-
- HY-W015548S1
-
-
- HY-Y0721S
-
-
- HY-14774S1
-
|
(Rac)-Monepantel sulfone-d5
|
nAChR
|
Cancer
|
|
(Rac)-Monepantel sulfone-d5 is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
|
-
- HY-122422S
-
-
- HY-119686S
-
-
- HY-13704S1
-
|
SN-38-d5
NK012-d5
|
Topoisomerase
ADC Cytotoxin
Autophagy
|
Cancer
|
|
SN-38-d5 is deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].
|
-
- HY-W015466S
-
-
- HY-W116478S
-
-
- HY-14545S1
-
-
- HY-N3686S
-
-
- HY-B1659S1
-
-
- HY-132963S
-
-
- HY-W008848S1
-
-
- HY-W094846S
-
-
- HY-142515S
-
-
- HY-10019AS
-
-
- HY-150663S
-
|
1α,25-Dihydroxyvitamin D3-(23,24,25,26,27-13C5) solution
|
Isotope-Labeled Compounds
|
Others
|
|
1α,25-Dihydroxyvitamin D3-(23,24,25,26,27- 13C5) solution is the 13C labeled 1α,25-Dihydroxyvitamin D3[1].
|
-
- HY-W015304S
-
-
- HY-A0294AS
-
-
- HY-B1617AS
-
-
- HY-W017006S
-
-
- HY-W128333S
-
-
- HY-W002300S
-
-
- HY-111614S
-
|
Melengestrol acetate-d6
|
Progesterone Receptor
|
Cancer
Metabolic Disease
|
|
Melengestrol acetate-d6 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].
|
-
- HY-N1150S2
-
-
- HY-78139S
-
|
L-Xylose-1-13C
L-(-)-Xylose-1-13C
|
Isotope-Labeled Compounds
|
Others
|
|
L-Xylose-1- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
|
-
- HY-W104010S
-
-
- HY-B0960S
-
-
- HY-143975S
-
-
- HY-W013061S4
-
-
- HY-139505
-
-
- HY-100354S4
-
-
- HY-N6801S
-
|
Nivalenol-13C15
|
Isotope-Labeled Compounds
|
Infection
|
|
Nivalenol- 13C15 is the 13C labeled Nivalenol (HY-N6801). Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect.
|
-
- HY-N0680S1
-
-
- HY-146763S
-
-
- HY-W339957S
-
|
2,6-Dichlorobiphenyl-2′,3′,4′,5′,6′-d5
|
Isotope-Labeled Compounds
|
Others
|
|
2,6-Dichlorobiphenyl-2′,3′,4′,5′,6′-d5 is the deuterium labeled 2,6-Dichloro-1,1'-biphenyl[1].
|
-
- HY-17504AS
-
-
- HY-B0282AS1
-
-
- HY-107434S
-
|
Molindone-d8
(±)-Molindone-d8; SPN-810M-d8
|
Dopamine Receptor
|
Neurological Disease
|
|
Molindone-d8 is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses[1][2].
|
-
- HY-W011012S1
-
-
- HY-N0390S10
-
|
L-Glutamine-1,2-13C2
L-Glutamic acid 5-amide-1,2-13C2
|
mGluR
Endogenous Metabolite
Ferroptosis
|
Metabolic Disease
|
|
L-Glutamine-1,2- 13C2 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].
|
-
- HY-W015301S2
-
-
- HY-B1971S
-
-
- HY-W034097S
-
-
- HY-B0215S1
-
|
Acetylcysteine-15N
N-Acetylcysteine-15N; N-Acetyl-L-cysteine-15N; NAC-15N
|
Reactive Oxygen Species
Endogenous Metabolite
Apoptosis
Ferroptosis
Influenza Virus
|
Infection
Neurological Disease
|
|
Acetylcysteine- 15N (N-Acetylcysteine- 15N) is the 15N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].
|
-
- HY-14874S
-
|
Topiroxostat-d4
FYX-051-d4
|
Xanthine Oxidase
Cytochrome P450
|
Metabolic Disease
|
|
Topiroxostat-d4 is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment[1][2].
|
-
- HY-13272S3
-
|
Dacomitinib-d10
PF-00299804-d10; PF-299804-d10
|
EGFR
Apoptosis
|
Cancer
|
|
Dacomitinib-d10 is deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively[1].
|
-
- HY-Y0252S2
-
-
- HY-108506S1
-
-
- HY-N7057S2
-
|
Nonanoic acid-d4
Pelargonic acid-d4
|
Bacterial
|
|
|
Nonanoic acid-d4 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
|
-
- HY-B2157S
-
|
Robenidine-d8 hydrochloride
|
Bacterial
Parasite
|
Infection
|
|
Robenidine-d8 (hydrochloride) is the deuterium labeled Robenidine hydrochloride. Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.
|
-
- HY-W283596S
-
-
- HY-N0473S2
-
-
- HY-W038500S
-
-
- HY-N0470S2
-
-
- HY-B0075S
-
-
- HY-A0024AS1
-
-
- HY-W018811S
-
-
- HY-146905S
-
-
- HY-Y0366S2
-
|
Lauric acid-d2
|
Endogenous Metabolite
Bacterial
|
|
|
Lauric acid-d2 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
|
-
- HY-B1622S
-
-
- HY-N7092S18
-
|
D-Fructose-d2-1
D(-)-Fructose-d2-1
|
Endogenous Metabolite
|
Others
|
|
D-Fructose-d2-1 is the deuterium labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants[1].
|
-
- HY-W009512S
-
-
- HY-N2041S
-
|
Myristic acid-d27
|
Endogenous Metabolite
|
Others
|
|
Myristic acid-d277 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
|
-
- HY-10241S
-
|
Simeprevir-13C,d3
TMC435-13C,d3; TMC435350-13C,d3
|
HCV
HCV Protease
SARS-CoV
DNA/RNA Synthesis
|
Infection
|
|
Simeprevir- 13C,d3 is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].
|
-
- HY-B0389S31
-
|
D-Glucose-18O-2
Glucose-18O-2; D-(+)-Glucose-18O-2; Dextrose-18O-2
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Glucose- 18O-2 is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecule
|
-
- HY-100646AS
-
-
- HY-B0925AS
-
|
Oxacillin-d5
|
Bacterial
Antibiotic
|
Infection
|
|
Oxacillin-d5 is the deuterium labeled Oxacillin[1]. Oxacillin is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens[2].
|
-
- HY-13317S3
-
|
Oseltamivir-d5
|
Influenza Virus
|
Infection
|
|
Oseltamivir-d5 is the deuterium labeled Oseltamivir[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[2].
|
-
- HY-B0006BS
-
|
(S)-Carvedilol-d4
(S)-BM 14190-d4
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
(S)-Carvedilol-d4 is deuterium labeled (S)-Carvedilol. (S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1].
|
-
- HY-W156511S
-
-
- HY-N0325S3
-
|
DL-Methionine-d3
|
Parasite
|
|
|
DL-Methionine-d3 is the deuterium labeled DL-Methionine. DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants[1][2][3][4].
|
-
- HY-B0892S2
-
-
- HY-Y0139S
-
-
- HY-78004S
-
-
- HY-16322S
-
|
Minodronic acid-d4
YM-529-d4
|
P2X Receptor
Apoptosis
|
Cancer
|
|
Minodronic acid-d4 is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].
|
-
- HY-143917S
-
-
- HY-132649S
-
-
- HY-B1470S
-
|
Azaperone-d4
R-1929-d4
|
Isotope-Labeled Compounds
Dopamine Receptor
|
Neurological Disease
|
|
Azaperone-d4 is the deuterium labeled Azaperone. Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
|
-
- HY-B0337S
-
|
Sulfadimethoxine-d4
Sulphadimethoxine-d4
|
Bacterial
|
Infection
|
|
Sulfadimethoxine-d4 is a deuterium labeled Sulfadimethoxine (Sulphadimethoxine). Sulfadimethoxine is a sulfonamide antibiotic used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections[1].
|
-
- HY-B0257S
-
-
- HY-143964S
-
-
- HY-N0180S
-
-
- HY-16508S
-
|
Ulipristal acetate-d6
CDB-2914-d6
|
Progesterone Receptor
Autophagy
|
Endocrinology
Cancer
|
|
Ulipristal acetate-d6 is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma[1][2].
|
-
- HY-B0925S
-
-
- HY-Z1917S
-
-
- HY-N0108S
-
|
Physcion-d3
Parietin-d3; Rheochrysidin-d3
|
Isotope-Labeled Compounds
Bacterial
|
Cancer
Infection
Inflammation/Immunology
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Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects.
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- HY-N1380S4
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- HY-111614S2
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Melengestrol acetate-d3
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Progesterone Receptor
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Cancer
Metabolic Disease
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Melengestrol acetate-d3 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].
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- HY-113416AS
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- HY-Y1359S
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- HY-Y0544S
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- HY-Y0337S7
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L-Cysteine-d3,15N
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Endogenous Metabolite
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Metabolic Disease
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L-Cysteine-d3, 15N is the deuterium and 15N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].
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- HY-15321S2
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Etoricoxib-d3
MK-0663-d3; L-791456-d3
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COX
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Etoricoxib-d3 is the deuterium labeled Etoricoxib[1]. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood[2][3][4].
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- HY-110228
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- HY-145008S
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- HY-N0131S1
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- HY-135119
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Salmeterol-D3
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Adrenergic Receptor
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Endocrinology
Inflammation/Immunology
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Salmeterol-d3 is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].
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- HY-113943S
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- HY-W006057AS13
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- HY-13749AS
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- HY-W130478S
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- HY-113904S1
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- HY-W001138S
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- HY-76570S
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(Rac)-5-Hydroxymethyl Tolterodine-d14
(Rac)-Desfesoterodine-d14; (Rac)-PNU-200577-d14
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mAChR
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Neurological Disease
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(Rac)-5-Hydroxymethyl Tolterodine-d14 is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].
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- HY-10585AS
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Valproic acid-d7 sodium
Sodium Valproate-d7(sodium)
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HDAC
Autophagy
Mitophagy
HIV
Notch
Endogenous Metabolite
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Cancer
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Valproic acid-d7 (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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- HY-B1227S1
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- HY-Y0219S1
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- HY-B0339S
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Primidone-d5
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Sodium Channel
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Neurological Disease
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Primidone-d5 is the deuterium labeled Primidone. Primidone is a potent anticonvulsant agent of the barbiturate class. Primidone is a neuronal voltage-gated sodium channel (VGSC) blocker and can be used for the study of epilepsy, essential tremor, and Psychiatric disorders[1].
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- HY-10064S
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- HY-12715S1
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- HY-W019726S
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- HY-B0166S6
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- HY-N0830S7
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- HY-B0004S1
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- HY-W011814S
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- HY-B1075AS
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(Rac)-Fosfomycin (benzylamine)-13C3
MK-0955 (benzylamine)-13C3
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Bacterial
Antibiotic
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Infection
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(Rac)-Fosfomycin (benzylamine)- 13C3 is the 13C labeled Fosfomycin[1]. Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[2][3].
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- HY-143859S
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- HY-N1150S1
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Thymidine-d4
DThyd-d4; NSC 21548-d4
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DNA/RNA Synthesis
Endogenous Metabolite
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Others
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Thymidine-d4 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].
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- HY-12222S1
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Obeticholic Acid-d4
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FXR
Autophagy
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Others
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Obeticholic Acid-d4 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].
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- HY-100355S
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- HY-B0394S
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Atropine-d5
Tropine tropate-d5; DL-Hyoscyamine-d5
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mAChR
Autophagy
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Neurological Disease
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Atropine-d5 is the deuterium labeled Atropine (sulfate monohydrate). Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect[1].
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- HY-137155S
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- HY-10451S2
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Canagliflozin-d6
JNJ 28431754-d6
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SGLT
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Canagliflozin-d6 is the deuterium labeled Canagliflozin[1]. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[2].
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- HY-17436S3
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(R)-Clevidipine-13C,d3
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Calcium Channel
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(R)-Clevidipine- 13C,d3 is the deuterium and 13C labeled Clevidipine[1]. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension[2].
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- HY-B1205S
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- HY-W088426S
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- HY-144409S
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- HY-17423S1
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- HY-17512S3
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Losartan-d2
DuP-753-d2
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Angiotensin Receptor
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Losartan-d2 is the deuterium labeled Losartan[1]. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM[2].
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- HY-13955S1
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- HY-W007798S1
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- HY-109506S8
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DPPC-d75
129Y83-d75
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Endogenous Metabolite
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Others
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DPPC-d75 is deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in
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- HY-B0389S14
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D-Glucose-13C2
Glucose-13C2; D-(+)-Glucose-13C2; Dextrose-13C2
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Endogenous Metabolite
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Metabolic Disease
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D-Glucose- 13C2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-14608S8
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- HY-119311S
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- HY-17427S
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- HY-16060S
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Apalutamide-d4
ARN-509-d4
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Androgen Receptor
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Cancer
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Apalutamide-d4 is a deuterium labeled Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].
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- HY-W101642S
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- HY-143976S
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- HY-144927S
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- HY-W015300S
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Suberic acid-d4
Octanedioic acid-d4
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Endogenous Metabolite
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Metabolic Disease
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Suberic acid-d4 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].
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- HY-B0896S1
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Triacetin-d5
Glyceryl triacetate-d5; 1,2,3-Triacetoxypropane-d5
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Fungal
Endogenous Metabolite
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Triacetin-d5 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
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- HY-12749AS
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- HY-A0019S
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Paliperidone-d4
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Dopamine Receptor
5-HT Receptor
Adrenergic Receptor
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Neurological Disease
|
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Paliperidone-d4 is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].
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- HY-17416S
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- HY-113031S
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- HY-14300AS
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- HY-B0352S
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Mirtazapine D3
Org3770 d3; 6-Azamianserin d3
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5-HT Receptor
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Neurological Disease
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Mirtazapine-d3 is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].
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- HY-N1428S3
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Citric acid-13C3
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Apoptosis
Endogenous Metabolite
Antibiotic
|
|
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Citric acid- 13C3 is the 13C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].
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- HY-132422S
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- HY-W019773S
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- HY-10820S
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Pemetrexed-d5
LY231514-d5
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Antifolate
Autophagy
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Cancer
|
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Pemetrexed-d5 is the deuterium labeled Pemetrexed[1]. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[2].
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- HY-W011297S1
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- HY-G0021S
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N-Desmethylclozapine-d8
Norclozapine-d8; Desmethylclozapine-d8; Normethylclozapine-d8
|
mAChR
Opioid Receptor
Drug Metabolite
Virus Protease
|
Infection
|
|
N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].
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- HY-Y1075S1
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- HY-B0282S
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Acetylcholine-d4 chloride
ACh-d4 (chloride)
|
nAChR
Calcium Channel
Endogenous Metabolite
|
Neurological Disease
Cancer
|
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Acetylcholine-d4 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].
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- HY-Y0339S
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- HY-A0287S
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Clomifene-d5 hydrochloride
Clomiphene-d5 (hydrochloride)
|
Isotope-Labeled Compounds
|
Others
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Clomifene-d5 (hydrochloride) is a deuterium labeled Clomifene. Clomifene is an orally active compound used for infertility. Clomifene is a simple, relatively safe, easily administered and well-tolerated efficacious compound to induce ovulation[1].
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- HY-B0373S
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- HY-D0186S8
-
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2'-Deoxyuridine-d2-1
|
Endogenous Metabolite
|
Infection
|
|
2'-Deoxyuridine-d2-1 is the deuterium labeled 2'-Deoxyuridine[1]. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine[2].
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- HY-113367S1
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-
