Kidney

By Targets:	11β-HSD (1) 5-HT Receptor (1) Adenosine Receptor (2) Adrenergic Receptor (7) Amino Acid Derivatives (2) AMPK (1) Angiotensin Receptor (9) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (10) Apoptosis (14) ATP Synthase (1) Autophagy (9) Bacterial (11) Bcl-2 Family (1) Biochemical Assay Reagents (1) c-Met/HGFR (1) Calcium Channel (4) Cannabinoid Receptor (2) Caspase (3) CD28 (1) CDK (7) CFTR (1) COX (2) Cytochrome P450 (1) Drug Metabolite (1) Dynamin (1) EGFR (1) Endogenous Metabolite (26) Epigenetic Reader Domain (3) Ferroptosis (4) Fluorescent Dye (4) Free Fatty Acid Receptor (1) Fungal (6) FXR (2) GABA Receptor (2) Glucosylceramide Synthase (GCS) (3) GLUT (2) Glutaminase (3) GPR84 (1) GSK-3 (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (7) Histamine Receptor (1) Histone Methyltransferase (2) HIV Integrase (1) HSV (1) iGluR (1) Imidazoline Receptor (4) Influenza Virus (1) Interleukin Related (3) Isotope-Labeled Compounds (3) Keap1-Nrf2 (2) Ketohexokinase (1) Kisspeptin Receptor (2) Lipoxygenase (1) MAP3K (1) MDM-2/p53 (2) MicroRNA (1) Microtubule/Tubulin (1) Mineralocorticoid Receptor (4) Mitophagy (1) MMP (1) Monoamine Oxidase (2) mTOR (2) Na+/K+ ATPase (2) NADPH Oxidase (2) Necroptosis (1) Neurotensin Receptor (1) NF-κB (9) NKCC (2) NO Synthase (2) NOD-like Receptor (NLR) (4) Opioid Receptor (3) Parasite (6) PDGFR (1) Phosphatase (7) Phosphodiesterase (PDE) (1) Phospholipase (1) PINK1/Parkin (1) Potassium Channel (6) PPAR (1) Prostaglandin Receptor (2) Proton Pump (1) Pyroptosis (2) Ras (1) Reactive Oxygen Species (3) RET (1) RIP kinase (2) SARS-CoV (1) SGLT (2) SHP2 (2) Sirtuin (5) Small Interfering RNA (siRNA) (4) Sodium Channel (3) Src (1) STAT (4) TGF-beta/Smad (1) Tie (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (2) TRP Channel (6) URAT1 (2) Vasopressin Receptor (2) VEGFR (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (45) Endocrinology (21) Infection (21) Inflammation/Immunology (52) Metabolic Disease (76) Neurological Disease (26)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5314

OK2	EGFR STAT	Others
OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research .

HY-17623C

(R)-Tegoprazan (R)-CJ-12420; (R)-RQ-00000004	Proton Pump	Metabolic Disease
(R)-Tegoprazan (example 3), a benzimidazole derivative, is a potent kidney H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 98 nM of canine kidney Na ⁺/K ⁺-ATPase. (R)-Tegoprazan has the potential for gastrointestinal diseases research .

HY-139725

CDK5-IN-1

CDK Metabolic Disease

CDK5-IN-1, a potent CDK5 inhibitor, is against CDK5 activity less than 10 nM. CDK5-IN-1 is used for kidney diseases research .

CDK5-IN-1	CDK	Metabolic Disease
CDK5-IN-1, a potent CDK5 inhibitor, is against CDK5 activity less than 10 nM. CDK5-IN-1 is used for kidney diseases research .

HY-153092

Avenciguat BI-685509	Others	Cardiovascular Disease Metabolic Disease
Avenciguat (BI-685509) is a potent and orally active sGC activator. Avenciguat restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. Avenciguat can be used in research of chronic kidney disease (CKD) and diabetic kidney disease (DKD) .

HY-132827

Ocedurenone KBP-5074	Mineralocorticoid Receptor	Endocrinology
Ocedurenone is a corticosteroid receptor antagonist. Ocedurenone can be used for the research of kidney disease (WO2018054357, compound I) .

HY-135772

12-Ketodeoxycholic acid 12-Ketolithocholic acid	Endogenous Metabolite	Metabolic Disease
12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury

HY-14179

PPQ-102 3 Publications Verification CFTR Inhibitor	CFTR	Others
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC₅₀ ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease .

HY-156368

RIPK3-IN-4	RIP kinase	Inflammation/Immunology
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. RIPK3-IN-4 inhibits HK-2 cell damage, necroptosis and inflammatory responses. RIPK3-IN-4 reduces Cisplatin (HY-17394)- and I/R-induced kidney damage, inflammatory response and necroptosis in acute kidney injury .

HY-13995A

Sevelamer hydrochloride 1 Publications Verification	FXR Autophagy	Others
Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin .

HY-132820

Inaxaplin VX-147	Others	Others
Inaxaplin (VX-147) is an orally active apolipoprotein L1 (APOL1) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease .

HY-109153

Nerindocianine	Biochemical Assay Reagents	Others
Nerindocianine is a fluorescent diagnostic contrast agent. Nerindocianine is highly hydrophilic and is primarily metabolized by the kidneys, allowing for a non-invasive intraoperative ureteral imaging .

HY-136201

Sodium Glucoheptonate	Others	Cancer
Sodium Glucoheptonate is used as a kit for radio-labeling with Tc-99m. Tc-99m glucoheptonate is kidney- and brain-imaging agent, and can be used in brain-tumor detection .

HY-120441

CAY10590 GK115	Phospholipase Prostaglandin Receptor	Inflammation/Immunology
CAY10590 (GK115) is an inhibitor of secreted phospholipase A₂ (sPLA₂) and can be used for the research of chronic inflammatory kidney diseases .

HY-W416250

p-Cresol glucuronide	Others	Cardiovascular Disease
p-Cresol glucuronide, a metabolite of p-cresol, is a prototype protein-bound uremic toxin. p-Cresol glucuronide is associated with chronic kidney disease (CKD) .

HY-149594

CL-Pa	Others	Metabolic Disease
CL-Pa is a chemiluminescent probe suitable for detection of urinary Vanin-1. CL-Pa can be used to detect drug-induced acute kidney injury (AKI) through urinalysis .

HY-N11108

Gochnatiolide A	Others	Cancer
Gochnatiolide A is a dimeric sesquiterpene that can be found in Ainsliaea henryi. Gochnatiolide A exhibits antiproliferative activity against the kidney, melanoma, ovarian-resistant and glioma cell lines .

HY-148304

VU6036720	Potassium Channel	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
VU6036720 is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 can inhibit Kir4.1/5.1 channels with an IC₅₀ value of 0.24 μM. VU6036720 can be used for the research of brain and kidney .

HY-148304A

VU6036720 hydrochloride	Potassium Channel	Metabolic Disease Inflammation/Immunology Cancer
VU6036720 hydrochloride is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 hydrochloride can inhibit Kir4.1/5.1 channels with an IC₅₀ value of 0.24 μM. VU6036720 hydrochloride can be used for the research of brain and kidney .

HY-14909

Bardoxolone 10+ Cited Publications CDDO; RTA 401	Keap1-Nrf2 Necroptosis	Metabolic Disease
Bardoxolone (CDDO) is a novel nuclear regulatory factor (Nrf-2) activator for the study of chronic kidney disease. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis .

HY-141411A

Zevaquenabant (S)-MRI-1867	Cannabinoid Receptor NO Synthase	Metabolic Disease
Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible NOS antagonist. Zevaquenabant ameliorates obesity-induced chronic kidney disease (CKD) .

HY-144429

TRPC5-IN-4	TRP Channel	Metabolic Disease
TRPC5-IN-4 is potent and safe TRPC inhibitor with IC₅₀ value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD) .

HY-101277

Vadadustat 4 Publications Verification PG-1016548; AKB-6548	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .

HY-P99717

Lulizumab pegol BMS-931699	CD28	Inflammation/Immunology
Lulizumab pegol (BMS-931699) is an anti-CD28 antibody antagonist. Lulizumab pegol effectively inhibits T-cell proliferation and it can be used for the reseach of kidney transplantation and autoimmunity disease .

HY-156519

ALPK1-IN-3	NF-κB	Inflammation/Immunology
ALPK1-IN-3 is an inhibitor of ALPK1 extracted from patent WO2022063153A1 compound T007. ALPK1-IN-3 inhibits kidney proinflammatory gene expression and improves the survival rate of the animals in sepsis induced acute kidney injury animal model . ALPK1-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P3434

Ac-FEID-CMK	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-111547

M1001	HIF/HIF Prolyl-Hydroxylase	Cancer
M1001 is a weak hypoxia-inducible factor-2α (HIF-2α) agonist. M1001 can bind to the HIF-2α PAS-B domain, with a K_d of 667 nM. M1001 can be used in chronic kidney disease research .

HY-124838

EG1	Others	Cancer
EG1, a specific Pax2 inhibitor, directly binds the paired domain of Pax2 (K_d=1.35-1.5 μM) and inhibits Pax2-DNA interactions. EG1 can inhibit embryonic kidney development, a process directly dependent on Pax2 activity .

HY-N9941

2,8-Dihydroxyadenine	Endogenous Metabolite	Metabolic Disease
2,8-Dihydroxyadenine, an endogenous metabolite, can cause the formation of urinary crystals and kidney stones. 2,8-Dihydroxyadenine can be used to diagnose adenine phosphoribosyltransferase (APRT) deficiency .

HY-P3434A

Ac-FEID-CMK TFA	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-N12007

OAT1/3-IN-1	Others	Metabolic Disease
OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage .

HY-N12008

OAT1/3-IN-2	Others	Metabolic Disease
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage .

HY-128442

Phenyl sulfate Phenyl hydrogen sulfate	Endogenous Metabolite	Metabolic Disease
Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker and future therapeutic target in diabetic kidney disease .

HY-146272

Vasopressin V2 receptor antagonist 1	Vasopressin Receptor	Metabolic Disease
Vasopressin V2 receptor antagonist 1 (Compound 4g) is a vasopressin V₂ receptor (V₂R) antagonist with a K_i of 3.8 nM. Vasopressin V2 receptor antagonist 1 can be used for autosomal dominant polycystic kidney disease (ADPKD) research .

HY-N1428C

Ferric citrate 1 Publications Verification Iron(III) citrate; Zerenex	Reactive Oxygen Species Antibiotic	Metabolic Disease
Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research .

HY-149426

SIRT5 inhibitor 7	Sirtuin	Inflammation/Immunology
SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury .

HY-17609

Difelikefalin CR-845; FE-202845	Opioid Receptor	Neurological Disease
Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-145694

CDK5-IN-3	CDK	Metabolic Disease
CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC₅₀s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD) .

HY-149770

CYP4A11/CYP4F2-IN-2	Cytochrome P450	Metabolic Disease
CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC₅₀s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease .

HY-132613

Lumasiran sodium	Small Interfering RNA (siRNA)	Metabolic Disease
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-161026

JM-9	Toll-like Receptor (TLR)	Inflammation/Immunology
JM-9 is a inhibitor of MD2. JM-9 suppresses high glucose and palmitic acid -induced inflammation in MPMs. JM-9 improves diabetic kidney disease by inhibiting MD2-mediated inflammation .

HY-148207

S-Benzylglutathione	Amino Acid Derivatives	Metabolic Disease
S-Benzylglutathione is a competitive glutathionase inhibitor. S-Benzylglutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-Benzylglutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system .

HY-A0090A

Nitrofurantoin sodium	Antibiotic Bacterial	Infection
Nitrofurantoin sodium is a potent and orally active antibacterial agent. Nitrofurantoin sodium acts as an antibiotic. Nitrofurantoin sodium can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .

HY-122052

UK‑396082	Others	Metabolic Disease
UK‑396082 is a potent thrombin activated fibrinolytic inhibitor (TAFI) inhibitor. UK‑396082 increases plasmin activity and induces a parallel decrease in ECM levels. UK‑396082 can be used in research of chronic kidney disease (CKD) .

HY-156430

MMP-7-IN-3	MMP	Cancer
MMP-7-IN-3 is a potent and selective inhibitor of MMP-7. MMP-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction .

HY-120274

Balcinrenone AZD9977	Mineralocorticoid Receptor	Cardiovascular Disease Metabolic Disease
Balcinrenone (AZD9977) is a potent, selective, and orally active mineralocorticoid receptor (MR) modulator. Balcinrenone is used for heart failure, and chronic kidney disease research .

HY-155657

BT424	Src	Inflammation/Immunology
BT424 is a specific HCK inhibitor. BT424 can regulate macrophage activation and autophagy in vitro. BT424 ameliorates inflammation and kidney fibrosis in UUO model .

HY-A0090

Nitrofurantoin 5+ Cited Publications	Bacterial Antibiotic	Infection
Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .

HY-B0516A

Articaine Hoe-045 free base	NF-κB NOD-like Receptor (NLR) Sodium Channel	Inflammation/Immunology
Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway .

HY-B0516

Articaine hydrochloride Hoe-045	Sodium Channel NF-κB NOD-like Receptor (NLR)	Neurological Disease
Articaine hydrochloride (Hoe-045) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine hydrochloride ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway .

HY-148208

S-(p-Nitrobenzyl)glutathione	Amino Acid Derivatives	Metabolic Disease
S-(p-Nitrobenzyl)glutathione is a competitive glutathionase inhibitor. S-(p-Nitrobenzyl)glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-(p-Nitrobenzyl)glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system .

Cat. No.	Product Name

HY-L018

TGF-beta/Smad Compound Library

220 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 220 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L040

Anti-diabetic Compound Library

733 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 733 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Type

HY-153229

Firefly luciferase mRNA-LNP

Drug Delivery

Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing Firefly luciferase mRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. Luciferase is commonly used as a bioluminescent reporter gene for gene regulation and function studies. Firefly Luciferase mRNA will express firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Common luciferase are firefly luciferase and sea kidney luciferase .

HY-153230

Firefly luciferase circRNA-LNP

Drug Delivery

Firefly luciferase circRNA-LNP is a lipid nanoparticle (LNP) containing Firefly luciferase circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. Luciferase is commonly used as a bioluminescent reporter gene for gene regulation and function studies. Firefly Luciferase circRNA will express firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Common luciferase are firefly luciferase and sea kidney luciferase .

Cat. No.	Product Name	Target	Research Area

HY-P5314

OK2	EGFR STAT	Others
OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research .

HY-P3434A

Ac-FEID-CMK TFA	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-17609

Difelikefalin CR-845; FE-202845	Opioid Receptor	Neurological Disease
Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-P3434

Ac-FEID-CMK	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-P10016

Pegmolesatide HS-20039; EPO-018B	Peptides	Endocrinology
Pegmolesatide(HS-20039; EPO-018B) a synthetic peptide-based erythropoiesis-stimulating agent, can be used for ??the study of anemia in chronic kidney disease .

HY-156430

MMP-7-IN-3	MMP	Cancer
MMP-7-IN-3 is a potent and selective inhibitor of MMP-7. MMP-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction .

HY-P5495

Uroguanylin-15 (Rat)	Peptides	Others
Uroguanylin-15 (Rat) is a biological active peptide. (Uroguanylin is a natriuretic peptide, a hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. Uroguanylin and guanylin are related peptides that activate common guanylate cyclase signaling molecules in the intestine and kidney. Uroguanylin was isolated from urine and duodenum but was not detected in extracts from the colon of rats.)

HY-P3108

Alamandine	Angiotensin Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions .

HY-P2636

Cholecystokinin Precursor (24-32) (rat) Prepro CCK Fragment V-9-M	Peptides	Metabolic Disease
Cholecystokinin Precursor (24-32) (rat) is a cholecystokinin precursor that can be expressed in the heart, lungs, and kidneys as well as in the gastrointestinal tract and brain. Cholecystokinin is a brain-gut peptide that stimulates gallbladder contraction and pancreatic exocrine secretion and also acts as a neurotransmitter .

HY-P4053

Dalargin	Opioid Receptor	Neurological Disease
Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity .

HY-113089

Epsilon-(gamma-glutamyl)-lysine H-Glu(H-Lys-OH)-OH; γ-Glu-ε-Lys	Endogenous Metabolite	Metabolic Disease
Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration .

HY-P1237

C-Type Natriuretic Peptide (CNP) (1-22), human 1 Publications Verification	Peptides	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P1237A

C-Type Natriuretic Peptide (CNP) (1-22), human TFA 1 Publications Verification	Peptides	Cardiovascular Disease Neurological Disease Metabolic Disease
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor .

HY-P5978

Atriopeptin III (rat) ANP 127-150 (rat)	Peptides	Cardiovascular Disease
Atriopeptin III (ANP 127-150) (rat), a 24-amino acid atrial peptide, is a potent vasodilator and natriuretic/diuretic agent. Atriopeptin III (rat) improves renal functions and decreases blood pressure in a ureter-obstructed rat kidney model. Atriopeptin III (rat) can be used for research of chronic renal failure .

HY-113089A

Epsilon-(gamma-glutamyl)-lysine TFA H-Glu(H-Lys-OH)-OH TFA; γ-Glu-ε-Lys TFA	Endogenous Metabolite	Metabolic Disease
Epsilon-(gamma-glutamyl)-lysine (H-Glu(H-Lys-OH)-OH) TFA is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration .

HY-P5984

Thioether-cyclized helix B peptide, CHBP	mTOR	Others
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-P5984A

Thioether-cyclized helix B peptide, CHBP TFA	mTOR	Others
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P0254

Kisspeptin-10, human	Kisspeptin Receptor	Cardiovascular Disease Cancer
Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression .

HY-P0254A

Kisspeptin-10, human TFA	Kisspeptin Receptor	Cardiovascular Disease Cancer
Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression .

HY-P4079

hCT(18-32)

Peptides Metabolic Disease

hCT(18-32) is a hCT (human calcitonin)-derived peptide .

Cat. No.	Product Name

HY-K6116

*Human Kidney* Tubular Organoid Kit**
MCE Human Kidney Tubular Organoid Kit contains Human Kidney Tubular Organoid Basal Medium A, Human Kidney Tubular Organoid Supplement B (50x), Human Kidney Tubular Organoid Supplement C (250x). This product can be used to efficiently construct human kidney tubular organoid.

Cat. No.	Product Name	Target	Research Area

HY-P99198

Fletikumab NNC 0109-0012	Interleukin Related	Inflammation/Immunology
Fletikumab (NNC0109-0012) is a monoclonal antibody targeting to IL-20. Fletikumab can be used for inflammation research, such as rheumatoid arthritis .

HY-P99717

Lulizumab pegol BMS-931699	CD28	Inflammation/Immunology
Lulizumab pegol (BMS-931699) is an anti-CD28 antibody antagonist. Lulizumab pegol effectively inhibits T-cell proliferation and it can be used for the reseach of kidney transplantation and autoimmunity disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-135772

12-Ketodeoxycholic acid 12-Ketolithocholic acid	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury

HY-N9941

2,8-Dihydroxyadenine	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,8-Dihydroxyadenine, an endogenous metabolite, can cause the formation of urinary crystals and kidney stones. 2,8-Dihydroxyadenine can be used to diagnose adenine phosphoribosyltransferase (APRT) deficiency .

HY-N11108

Gochnatiolide A	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Gochnatia polymorpha (Less) Cabr.	Others
Gochnatiolide A is a dimeric sesquiterpene that can be found in Ainsliaea henryi. Gochnatiolide A exhibits antiproliferative activity against the kidney, melanoma, ovarian-resistant and glioma cell lines .

HY-N12007

OAT1/3-IN-1	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	Others
OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage .

HY-N12008

OAT1/3-IN-2	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	Others
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage .

HY-128442

Phenyl sulfate Phenyl hydrogen sulfate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker and future therapeutic target in diabetic kidney disease .

HY-B0130

Perindopril 4 Publications Verification S-9490	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Angiotensin-converting Enzyme (ACE) NF-κB STAT Sirtuin
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .

HY-101410

SDMA Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other disease Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.

HY-N0164

Matrine Maximum Cited Publications 12 Publications Verification Matridin-15-one; Vegard; α-Matrine	Structural Classification Classification of Application Fields Source classification Sophora flavescens Aiton Plants Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Leguminosae Inflammation/Immunology Disease Research Fields Cancer	PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-111431

p-Cresyl sulfate 1 Publications Verification p-Tolyl sulfate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
p-Cresyl Sulfate, a major uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver, existed in the blood of patients with chronic kidney disease (CKD).

HY-108844

Rasburicase	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Rasburicase is a recombinant urate oxidase and a hyperuricemia inhibitor. Rasburicase converts uric acid into allantoin, making it easier to be cleared by the kidneys and improving the elevated level of uric acid in the blood .

HY-N2070

Acevaltrate 1 Publications Verification	Structural Classification Iridoids Terpenoids Source classification Valeriana officinalis Linn. Plants Valerianaceae	Na+/K+ ATPase
Acevaltrate inhibits the Na ⁺/K ⁺-ATPase activity in the rat kidney and brain hemispheres with IC₅₀s of 22.8 μM and 42.3 μM, respectively .

HY-N2608

7-O-Ethylmorroniside	Structural Classification Iridoids Classification of Application Fields Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	Others
7-O-Ethylmorroniside is a iridoid glucoside from the fruit of Cornus officinalis which is a traditional medicine in China and used for the reserch of kidney diseases, including diabetic nephropathy .

HY-N10229

Harzianum A	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal Antibiotic
Harzianum A is a trichothecene that isolated from the soil-borne fungus Trichoderma harzianum. Harzianum A shows no cytotoxicity against baby hamster kidney cells, no activity against Gram-negative and Gram-positive bacteria, but modest antifungal activity at 100 μg/mL .

HY-N0506

Rosarin	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Source classification Crassulaceae Phenylpropanoids Plants	Interleukin Related
Rosarin is a cinnamyl alcohol glycoside isolated from Rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .

HY-111054A

N-methyl-N-dithiocarboxyglucamine sodium MDCG sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound ¹⁰⁹Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity .

HY-N7665

Prosaikogenin G	Triterpenes Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Umbelliferae Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Prosaikogenin G, isolated from the roots of Bupleurum chinensis DC., exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney . Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract .

HY-113089

Epsilon-(gamma-glutamyl)-lysine H-Glu(H-Lys-OH)-OH; γ-Glu-ε-Lys	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration .

HY-W013215

Adrenic Acid cis-7,10,13,16-Docosatetraenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) is a naturally polyunsaturated fatty acid in the adrenal gland, brain, kidney, and vasculature. Adrenic Acid can regulate the vascular tone in arteries of the adrenal cortex. Adrenic Acid also is an inflammation enhancer in non-alcoholic fatty liver disease .

HY-N4130

25S-Inokosterone	Natural Products Classification of Application Fields Source classification Amaranthaceae Plants Cyathula capitata Moq. Disease Research Fields Inflammation/Immunology	Others
25S-Inokosterone is a phytoecdysone in the roots of two same species of A. bidentata Blume and A. japonica Nakai, and two different species of C. capitata Moq and C. officinalis Kuan. 25S-Inokosterone has the potential for the LPS-induced acute kidney injury research .

HY-B0303A

Diphenhydramine hydrochloride 3 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Histamine Receptor Endogenous Metabolite Bacterial Apoptosis
Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .

HY-18260

Bisphenol A 5+ Cited Publications	Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite
Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-N125722

Venturicidin A Aabomycin A1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	ATP Synthase Antibiotic
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-113089A

Epsilon-(gamma-glutamyl)-lysine TFA H-Glu(H-Lys-OH)-OH TFA; γ-Glu-ε-Lys TFA	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Epsilon-(gamma-glutamyl)-lysine (H-Glu(H-Lys-OH)-OH) TFA is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration .

HY-125923

Djenkolic acid	other families Source classification Metabolic Disease Amino acids Plants Disease Research Fields Archidendron jiringa	Others
Djenkolic acid is a sulfur-containing non-protein amino acid naturally found in the djenkol beans of the Southeast Asian plant Archidendron jiringa. Djenkolic Acid often causes renal injury, including hypersensitivity to or a direct toxic effect of a djenkol bean metabolite, resulting in acute kidney injury and/or urinary tract obstruction by djenkolic acid crystals, sludge, and/or possible ureteral spasms .

HY-N7741

Isozaluzanin C Dehydrozaluzanin C-derivative	Saussurea costus (Falc.) Lipsch. Structural Classification Natural Products Source classification Plants Compositae	Others
Isozaluzanin C (Dehydrozaluzanin c-derivative) is an anti-inflammatory agent that can be isolated from Saussurea lappa and has immunomodulatory effects. Isozaluzanin C improves tissue damage (lung, kidney, and liver) and excessive inflammation in mice induced by LPS (HY-D1056) or CRKP infection. Isozaluzanin C can be used in the study of bacterial infections and sepsi .

HY-W003445

4-Bromo-3-hydroxybenzoic acid	Structural Classification Monophenols Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC₅₀s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC₅₀s of 1 mM for both enzymes .

HY-18260R

Bisphenol A (Standard)	Structural Classification Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite
Bisphenol A (Standard) is the analytical standard of Bisphenol A. This product is intended for research and analytical applications. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-18646

23,25-Dihydroxy-24-oxovitamin D3 24-Oxo-23,25-dihydroxyvitamin D3	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
23,25-Dihydroxy-24-oxovitamin D3 is a major metabolite of 24(R),25-Dihydroxyvitamin D3. 23,25-Dihydroxy-24-oxovitamin D3 can be used for the research of metabolic diseases .

HY-N9019

1,4-Epidioxybisabola-2,10-dien-9-one	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Zingiberaceae	Influenza Virus
1,4-Epidioxybisabola-2,10-dien-9-one is a 1,4-epidioxy-bisabola-2,12-diene derivate, which can be isolated from Curcuma longa L. 1,4-Epidioxybisabola-2,10-dien-9-one exhibits antiviral activity against influenza virus A/PR/8/34 (H1N1) in the MDCK cell line with an IC₅₀ of 16.79 ± 4.03 μg/mL .

HY-N0142

Phloretin Maximum Cited Publications 12 Publications Verification NSC 407292; RJC 02792	Structural Classification Classification of Application Fields Source classification Rosaceae Plants Dihydrochalcones Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Malus pumila Mill. Phenols Polyphenols Disease Research Fields Cancer	SGLT Endogenous Metabolite GLUT
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .

HY-N0930B

Galegine hydrochloride	Alkaloids Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Disease Research Fields Galega officinalis Linn.	AMPK Bacterial
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .

HY-N0142R

Phloretin (Standard) NSC 407292 (Standard); RJC 02792 (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Source classification Malus pumila Mill. Rosaceae Phenols Plants Endogenous metabolite Disease Research Fields Cancer	SGLT Endogenous Metabolite GLUT
Phloretin (Standard) is the analytical standard of Phloretin. This product is intended for research and analytical applications. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA)?and allergic airway inflammation .

HY-B1357

Digitoxin 3 Publications Verification	Cardiovascular Disease Digitalis purpurea Linn. Structural Classification Microorganisms Classification of Application Fields Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Bcl-2 Family Caspase Apoptosis HSV Na+/K+ ATPase Calcium Channel
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

HY-W674241A

4-Ethylphenyl sulfate sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Ethylphenyl sulfate sodium is a gut microbial metabolite. 4-Ethylphenyl sulfate sodium is also a protein-bound uremic toxin, a xenobiotic substrate, and causes endothelial dysfunction .

HY-Y0966

Glycine 4 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite iGluR VEGFR Small Interfering RNA (siRNA)
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .

Species:	Human (14) Mouse (6) Rat (1) Cynomolgus (1)
Tag:	His (21) SUMO (3) Strep (1) Myc (1) MBP (2) Flag (3) Fc (1)
Source:	HEK293 (13) E. coli Cell-free (2) Sf9 insect cells (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P71081

	Renin Protein, Mouse (HEK293, His) Renin-1; Angiotensinogenase; Kidney renin; Ren1; Ren; Ren-1	Mouse	HEK293
	Renin Protein, a highly specific endopeptidase, generates angiotensin I from angiotensinogen, initiating a cascade that elevates blood pressure and enhances kidney sodium retention. Renin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Renin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Renin Protein, Mouse (HEK293, His) is 381 a.a., with molecular weight of 48-60 kDa.

HY-P77037

	Cadherin-6/KCAD Protein, Mouse (HEK293, His) Cadherin-6; Kidney cadherin; K-cadherin; CDH6	Mouse	HEK293
	Cadherin-6/KCAD Proteins, as calcium-dependent cell adhesion proteins, mediate cell-cell interactions. They preferentially interact with other cadherin molecules of the same type in a homophilic manner, promoting adhesion between cells. This selective interaction contributes to the sorting and organization of heterogeneous cell types in tissues and organs. Additionally, Cadherin-6/KCAD maintains tissue integrity and regulates developmental, differentiation, and morphogenetic processes. Cadherin-6/KCAD Protein, Mouse (HEK293, His) is the recombinant mouse-derived Cadherin-6/KCAD protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-6/KCAD Protein, Mouse (HEK293, His) is 597 a.a., with molecular weight of ~98 kDa.

HY-P77038

	Cadherin-6/KCAD Protein, Rat (HEK293, His) Cadherin-6; Kidney cadherin; K-cadherin; CDH6	Rat	HEK293
	Cadherin-6/KCAD Protein, a member of the calcium-dependent cell adhesion protein family, assumes a crucial role in mediating cellular adhesion. It exhibits a preference for interacting with other cadherin molecules of the same type in a homophilic manner, facilitating the adhesion between connecting cells. As a calcium-dependent adhesion protein, Cadherin-6/KCAD participates in maintaining the structural integrity of tissues and regulating cellular processes such as development, differentiation, and morphogenesis. Cadherin-6/KCAD Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-6/KCAD protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-6/KCAD Protein, Rat (HEK293, His) is 597 a.a., with molecular weight of ~67.9 KDa.

HY-P702006

	SLC15A2 Protein, Human (HEK293, His, MBP, FLAG) SLC15A2; Solute carrier family 15 member 2; Kidney H(+)/peptide cotransporter; Oligopeptide transporter; Kidney isoform; Peptide transporter 2	Human	HEK293
	The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC15A2 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived SLC15A2 protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC15A2 Protein, Human (HEK293, His, MBP, FLAG) is 728 a.a., .

HY-P702018

	SLC15A2 Protein, Human (Sf9, His, MBP, FLAG) SLC15A2; Solute carrier family 15 member 2; Kidney H(+)/peptide cotransporter; Oligopeptide transporter; Kidney isoform; Peptide transporter 2	Human	Sf9 insect cells
	The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC15A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC15A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC15A2 Protein, Human (Sf9, His, MBP, FLAG) is 728 a.a., .

HY-P702025

	SLC15A2 Protein, Human (Sf9, His, Strep, FLAG) SLC15A2; Solute carrier family 15 member 2; Kidney H(+)/peptide cotransporter; Oligopeptide transporter; Kidney isoform; Peptide transporter 2	Human	Sf9 insect cells
	The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC15A2 Protein, Human (Sf9, His, Strep, FLAG) is the recombinant human-derived SLC15A2 protein, expressed by Sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag. The total length of SLC15A2 Protein, Human (Sf9, His, Strep, FLAG) is 728 a.a., .

HY-P77429

K-Cadherin/CDH6 Protein, Cynomolgus (HEK293, His)

Cadherin-6; Kidney cadherin; K-cadherin; CDH6
Cynomolgus HEK293

HY-P7702

	Cadherin-6/KCAD Protein, Human (HEK293, Fc) rHuCadherin-6, C-Fc; Cadherin-6; Kidney Cadherin; CDH6	Human	HEK293
	Cadherin-6/KCAD Protein, Human (HEK293, Fc), a recombinant human Cadherin-6 produced in HEK293 cells, has an Fc fragment at the C-terminus. Cadherin-6 (CDH6) is a type 2 cadherin, which drives epithelial cells toward a mesenchymal condition (EMT) during embryonic development and it is aberrantly re-activated in cancer.

HY-P7703

	Cadherin-6/KCAD Protein, Human (594a.a, HEK293, His) rHuCadherin-6, His; Cadherin-6; Kidney Cadherin; CDH6	Human	HEK293
	Cadherin-6 Protein, Human (594a.a, HEK293, His), a recombinant human Cadherin-6 produced in HEK293 cells, has a His tag at the N-terminus. Cadherin-6 (CDH6) is a type 2 cadherin, which drives epithelial cells toward a mesenchymal condition (EMT) during embryonic development and it is aberrantly re-activated in cancer.

HY-P702474

TMEM72 Protein, Human (Cell-Free, His, Myc)

Transmembrane protein 72; Kidney-specific secretory protein of 37 kDa
Human E. coli Cell-free

HY-P73262

	Kallikrein-1 Protein, Human (240a.a, HEK293, His) Kallikrein 1; Kidney/pancreas/salivary gland kallikrein; KLK1; Klk6; KLKR	Human	HEK293
	Kallikrein-1 protein cleaves bonds in kininogen to release Lys-bradykinin. It also cleaves Neisseria meningitidis NHBA in saliva during microbial infection. Kallikrein-1 Protein, Human (240a.a, HEK293, His) is the recombinant human-derived Kallikrein-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kallikrein-1 Protein, Human (240a.a, HEK293, His) is 240 a.a., with molecular weight of ~50 kDa.

HY-P70144

	Kallikrein-1 Protein, Human (244a.a, HEK293, His) rHuKallikrein-1/KLK1, His; Kallikrein-1; Kidney/Pancreas/Salivary Gland Kallikrein; Tissue Kallikrein; KLK1	Human	HEK293
	Kallikrein-1 protein cleaves bonds in kininogen to release Lys-bradykinin. It also cleaves Neisseria meningitidis NHBA in saliva during microbial infection. Kallikrein-1 Protein, Human (244a.a, HEK293, His) is the recombinant human-derived Kallikrein-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Kallikrein-1 Protein, Human (244a.a, HEK293, His) is 244 a.a., with molecular weight of 38-55 kDa.

HY-P72090

	Arginase-2/ARG2 Protein, Mouse (His-SUMO) Arg2Arginase-2; mitochondrial; EC 3.5.3.1; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase	Mouse	E. coli
	Arginase-2 (ARG2) is a multifunctional regulator central to the regulation of arginine metabolism and nitric oxide synthesis outside the urea cycle. In addition to its hepatic effects, ARG2 affects innate and adaptive immune responses, negatively affecting the survival of activated CD4(+) and CD8(+) T cells. Arginase-2/ARG2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Arginase-2/ARG2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Arginase-2/ARG2 Protein, Mouse (His-SUMO) is 332 a.a., with molecular weight of ~52.4 kDa.

HY-P70082

	L-xylulose reductase/DCXR Protein, Human (His) rHuL-xylulose reductase/DCXR, His; L-Xylulose Reductase; XR; Carbonyl Reductase II; Dicarbonyl/L-Xylulose Reductase; Kidney Dicarbonyl Reductase; kiDCR; Sperm Surface Protein P34H; DCXR	Human	E. coli
	L-xylulose reductase, encoded by the DCXR gene, plays a vital role in cellular metabolism by catalyzing the NADPH-dependent reduction of various pentoses, tetoses, trisaccharides, α-dicarbonyl compounds, and L-xylulose role. This enzyme is actively involved in the uronic acid cycle of glucose metabolism. L-xylulose reductase/DCXR Protein, Human (His) is the recombinant human-derived L-xylulose reductase/DCXR protein, expressed by E. coli , with N-6*His labeled tag. The total length of L-xylulose reductase/DCXR Protein, Human (His) is 244 a.a., with molecular weight of ~28.0 kDa.

HY-P71365

	TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) Hepatitis A virus cellular receptor 1 homolog; HAVcr-1; Kidney injury molecule 1; KIM-1; T cell membrane protein 1; TIM-1	Mouse	HEK293
	The TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that is critical for B cell homeostasis, affecting generation, expansion, and inhibitory functions. As a P-selectin/SELPLG ligand, it facilitates trafficking of activated T cells during inflammation and controls T cell accumulation in the inflamed central nervous system. TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) is 191 a.a., with molecular weight of 35-50 kDa.

HY-P71887A

	CXCL14/BRAK Protein, Mouse (His) Cxcl14; Bmac; Kec; Ks1; Mip2g; Scyb14C-X-C motif chemokine 14; B-cell and monocyte-activating chemokine; Chemokine BRAK; Kidney-expressed chemokine CXC; MIP-2G; Small-inducible cytokine B14	Mouse	E. coli
	CXCL14/BRAK protein selectively attracts CESS B cells and THP-1 monocytes without affecting T cells. Its specific chemical attraction emphasizes its role in mediating B cell and monocyte migration, contributing to immune responses within the microenvironment. CXCL14/BRAK Protein, Mouse (His) is the recombinant mouse-derived CXCL14/BRAK protein, expressed by E. coli , with N-6*His labeled tag. The total length of CXCL14/BRAK Protein, Mouse (His) is 77 a.a., with molecular weight of ~13 kDa.

HY-P70067

	Collectin-11/CL-K1 Protein, Mouse (HEK293, His) rMuCollectin-11, His ; Collectin-11; Collectin Kidney Protein 1; CL-K1; Colec11	Mouse	HEK293
	Collectin-11/CL-K1 Protein is a secreted protein that activates tyrosine kinase receptors (EGFR, HER3) and ERK, JNK, and AKT signaling pathways to promote cell proliferation. Collectin-11/CL-K1 Protein plays an important role in innate immunity and apoptosis. Collectin-11/CL-K1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Collectin-11/CL-K1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Collectin-11/CL-K1 Protein, Mouse (HEK293, His) is 246 a.a., with molecular weight of 30-35 kDa.

HY-P70100

	Collectin-11/CL-K1 Protein, Human (HEK293, His) rHuCollectin-11/CL-K1, His; Collectin-11; Collectin Kidney Protein 1; CL-K1; COLEC11	Human	HEK293
	Collectin-11/CL-K1 is an important lectin in innate immunity, apoptosis, and embryogenesis that recognizes sugars presenting high mannose oligosaccharides with at least one terminal α-1,2-linked mannose epitope protein. It also recognizes fucosylated glycans and lipopolysaccharides. Collectin-11/CL-K1 Protein, Human (HEK293, His) is the recombinant human-derived Collectin-11/CL-K1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Collectin-11/CL-K1 Protein, Human (HEK293, His) is 246 a.a., with molecular weight of 30-35 kDa.

HY-P7880

	Alkaline Phosphatase/ALPL Protein, Human (HEK293, His) rHuAlkaline phosphatase, tissue-nonspecific isozyme/ALPL, His; Alkaline Phosphatase; Tissue-Nonspecific Isozyme; AP-TNAP; TNSALP; Alkaline Phosphatase Liver/Bone/Kidney Isozyme; ALPL	Human	HEK293
	Alkaline Phosphatase/ALPL Protein, Human (HEK 293, His) is a cell-surface homodimeric phosphohydrolase that is richly expressed in the skeleton, liver, kidney and developing teeth.

HY-P700138AF

	Animal-Free MDK Protein, Human (His) Amphiregulin associated protein; Amphiregulin-associated protein; ARAP; FLJ27379; Mdk; Midgestation and Kidney protein; Midkine; MK 1; MK; MK_HUMAN; MK1; NEGF 2; NEGF2; Neurite growth promoting factor 2; Neurite outgrowth promoting protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein; Retinoic acid inducible factor	Human	E. coli
	Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. Animal-Free MDK Protein, Human (His) is the recombinant human-derived animal-FreeMDK protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free MDK Protein, Human (His) is 123 a.a., with molecular weight of ~14.36 kDa.

HY-P72085

	AQP1 Protein, Human (His-SUMO) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; Water channel protein CHIP 29; Water channel protein CHIP29; Water channel protein for red blood cells and Kidney proximal tubule	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (His-SUMO) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of AQP1 Protein, Human (His-SUMO) is 50 a.a., with molecular weight of ~21.6 kDa.

HY-P700377

	Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; Water channel protein CHIP 29; Water channel protein CHIP29; Water channel protein for red blood cells and Kidney proximal tubule	Human	E. coli Cell-free
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) is the recombinant human-derived Aquaporin-1/AQP1 protein, expressed by E. coli Cell-free , with N-SUMO, N-6*His labeled tag. The total length of Aquaporin-1/AQP1 Protein, Human (Cell-Free, His-SUMO) is 268 a.a., with molecular weight of 41.3 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B1306S

4-Aminohippuric acid-d4
4-Aminohippuric acid-d₄ is the deuterium labeled 4-Aminohippuric acid. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.

HY-A0090S

Nitrofurantoin-13C3
Nitrofurantoin- ¹³C₃is the ¹³C labeledNitrofurantoin(HY-A0090) . Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .

HY-18260S1

Bisphenol A-d6

Bisphenol A-d₆ is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[1][2][3].

HY-18260S

Bisphenol A-d16

Bisphenol A-d₁₆ is the deuterium labeled Bisphenol A[1]. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[2][3].

HY-18260S4

Bisphenol A-d4

Bisphenol A-d₄ is the deuterium labeled Bisphenol A[1]. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[2][3].

HY-18260S6

Bisphenol A-d14

Bisphenol A-d₁₄ is a deuterium labeled Bisphenol A (HY-18260). Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-18260S3

Bisphenol A-d8

Bisphenol A-d₈ is the deuterium labeled Bisphenol A[1]. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[2][3][4].

HY-18260S5

Bisphenol A-d4-1

Bisphenol A-d₄-1 is the deuterium labeled Bisphenol A[1]. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders[2][3].

HY-B0202S2

Irbesartan-d6-1
Irbesartan-d₆-1 is the deuterium labeled Irbesartan[1]. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[2].

HY-111372S

Finerenone-d3

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P80762

NADPH Oxidase 4 Antibody NADPH oxidase 4; Kidney oxidase-1; KOX-1; KOX1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; NOX4; RENOX	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
NADPH Oxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 67 kDa, targeting to NADPH Oxidase 4. It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81731

Cadherin 16 Antibody (YA1476)

CDH16; Cadherin-16; Kidney-specific cadherin; Ksp-cadherin
WB, IHC-P, IP Human, Mouse

HY-P81186

HAVCR1 Antibody HAVCR; HAVCR 1; HA; Vcr-1; hepatitis A virus cellular receptor 1; HKIM-1; Kidney Injury Molecule1; KIM1; KIM 1; KIM-1; TIM-1; TIMD 1; TIMD1; KM-1; TIMD1_HUMAN; T cell immunoglobin domain and mucin domain protein 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell membrane protein 1. 肾脏损伤分子1	WB; ELISA; Flow-Cyt;	Human, Mouse(predicted: Rat, Dog, Pig, Cow)
HAVCR1 Antibody is an unconjugated, approximately 39 kDa, rabbit-derived, anti-HAVCR1 polyclonal antibody. HAVCR1 Antibody can be used for: WB, ELISA, Flow-Cyt, expriments in human, mouse, and predicted: rat, dog, pig, cow background without labeling.

HY-P80690

Glutaminase Antibody Glutaminase Kidney isoform; GLS; GLS1; KGA; K-glutaminase; GAM; GAC; Glutaminase C; L-glutamine amidohydrolase	WB, ICC/IF, IP	Human, Mouse, Rat
Glutaminase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 73 kDa, targeting to Glutaminase. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83324

IFT88 Antibody (YA3069)

Recessive polycystic Kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10
WB Human, Mouse, Rat
HY-P81404

Aquaporin 1 Antibody (YA1149)

AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and Kidney proximal tubule
IHC-P Human

Cat. No.	Product Name		Classification

HY-156519

ALPK1-IN-3		Alkynes
ALPK1-IN-3 is an inhibitor of ALPK1 extracted from patent WO2022063153A1 compound T007. ALPK1-IN-3 inhibits kidney proinflammatory gene expression and improves the survival rate of the animals in sepsis induced acute kidney injury animal model . ALPK1-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


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