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Isoforms Recommended:	LIMK1

Results for "

LIMK1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcr-Abl (1) CDK (1) Cyclin G-associated Kinase (GAK) (1) Ferroptosis (1) FGFR (1) LIM Kinase (LIMK) (14) MAP3K (1) MAP4K (1) MAPKAPK2 (MK2) (1) PROTACs (1) Reverse Transcriptase (1) Ribosomal S6 Kinase (RSK) (1) ROCK (2) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (3) Src (1) ULK (1)
By Research Areas:	Cancer (10) Infection (1) Neurological Disease (2)

Inhibitors & Agonists

Peptides

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Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128062

LIMK1 inhibitor BMS-4	LIM Kinase (LIMK)	Cancer
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells ^[1] .

HY-RS07662

LIMK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LIMK1 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LIMK1 Human Pre-designed siRNA Set A LIMK1 Human Pre-designed siRNA Set A

HY-RS07663

Limk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Limk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Limk1 Mouse Pre-designed siRNA Set A Limk1 Mouse Pre-designed siRNA Set A

HY-RS07664

Limk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Limk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Limk1 Rat Pre-designed siRNA Set A Limk1 Rat Pre-designed siRNA Set A

HY-123345

CRT 0105446

LIM Kinase (LIMK) Cancer

CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC₅₀ of 8 nM ^[1].

CRT 0105446	LIM Kinase (LIMK)	Cancer
CRT 0105446 (compound 22d) is a *LIMK1* inhibitor, with an IC₅₀ of 8 nM ^[1].

HY-19353

SR7826 1 Publications Verification	LIM Kinase (LIMK)	Neurological Disease Cancer
SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC₅₀ of 43 nM for *LIMK1. SR7826 is >100-fold more selective for LIMK1* than ROCK and JNK kinases ^[1].

HY-120025

CRT0105950	LIM Kinase (LIMK)	Cancer
CRT0105950 is a potent *LIMK* inhibitor, with IC₅₀s of 0.3 nM and 1 nM for *LIMK1* and *LIMK2* respectively. CRT0105950 can be used for the research of cancer ^[1].

HY-135843

TH-263

Others Cancer

TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257 ^[1].

TH-263	Others	Cancer
TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257 ^[1].

HY-122630

TH-257	LIM Kinase (LIMK)	Cancer
TH-257 is a potent inhibitor of *LIMK1* and *LIMK2* with IC₅₀ values of 84 nM and 39 nM for *LIMK1* and *LIMK2, respectively, and it can be used as a chemical probe for LIMK1* and *LIMK2*. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM ^[1].

HY-151539

TH470	LIM Kinase (LIMK)	Neurological Disease
TH470 is a highly selective *LIMK1/2* (LIM kinase1/2) inhibitor (LIMK1 IC₅₀=9.8 nM; LIMK2 IC₅₀=13 nM), and can be used in orphan disease research ^[1].

HY-18304

BMS-3

3 Publications Verification

LIM Kinase (LIMK) Cancer

BMS-3 is a potent LIMK inhibitor with IC₅₀s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
HY-18305

BMS-5

2 Publications Verification

LIMKi 3
LIM Kinase (LIMK) Cancer

BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC₅₀s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.

BMS-3 3 Publications Verification	LIM Kinase (LIMK)	Cancer
BMS-3 is a potent *LIMK* inhibitor with IC₅₀s of 5 nM and 6 nM for *LIMK1* and *LIMK2*, respectively.

BMS-5 2 Publications Verification LIMKi 3	LIM Kinase (LIMK)	Cancer
BMS-5 (LIMKi 3) is a potent *LIMK* inhibitor with IC₅₀s of 7 nM and 8 nM for *LIMK1* and *LIMK2*, respectively.

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

HY-12659

LX7101 2 Publications Verification	ROCK	Others
LX7101 is a potent inhibitor of *LIMK* and ROCK2 with IC₅₀ values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC₅₀ less than 1 nM.

HY-120097

R-10015	LIM Kinase (LIMK) Reverse Transcriptase	Infection
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC₅₀ of 38 nM for human LIMK1 ^[1].

HY-14227

LIMK-IN-1	LIM Kinase (LIMK) ROCK	Others
LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC₅₀s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research ^[1].

HY-136848

SM1-71	MAP3K Src FGFR Ribosomal S6 Kinase (RSK) LIM Kinase (LIMK)	Cancer
SM1-71 (compound 5) is a potent *TAK1* inhibitor, with a K_i of 160 nM, it also can covalently inhibit MKNK2, *MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1* and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines ^[1] .

HY-N10868

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	LIM Kinase (LIMK)	Cancer
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has *anti-LIMK1* activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility ^[1].

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Others
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants	LIM Kinase (LIMK)
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has *anti-LIMK1* activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility ^[1].

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701792

	LIMK1 Protein, Human (Sf9) LIMK1; LIM domain kinase 1; LIMK-1	Human	Sf9 insect cells
	The LIMK1 protein is an important serine/threonine protein kinase that controls actin dynamics downstream of Rho GTPases. Activation of ROCK1, PAK1, and PAK4 phosphorylates LIMK1, allowing it to phosphorylate and inhibit actin depolymerizing factors, including cofilin-1/CFL1 and destrin/DSTN. LIMK1 Protein, Human (Sf9) is the recombinant human-derived LIMK1 protein, expressed by Sf9 insect cells , with tag free. The total length of LIMK1 Protein, Human (Sf9) is 310 a.a., .

HY-P701793

	LIMK1 Protein, Human (Sf9, His) LIMK1; LIM domain kinase 1; LIMK-1	Human	Sf9 insect cells
	The LIMK1 protein is an important serine/threonine protein kinase that controls actin dynamics downstream of Rho GTPases. Activation of ROCK1, PAK1, and PAK4 phosphorylates LIMK1, allowing it to phosphorylate and inhibit actin depolymerizing factors, including cofilin-1/CFL1 and destrin/DSTN. LIMK1 Protein, Human (Sf9, His) is the recombinant human-derived LIMK1 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of LIMK1 Protein, Human (Sf9, His) is 310 a.a., .


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HY-P81941

LIM Kinase 1 Antibody (YA1686)

LIMK1; LIMK; LIM domain kinase 1; LIMK-1
WB Human, Mouse

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