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Results for "

Leishmaniasis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (7) Bacterial (7) Bcl-2 Family (1) Caspase (1) Fungal (5) Isotope-Labeled Compounds (1) Parasite (23) PARP (1) Phosphatase (5) Proteasome (1) Pyroptosis (1) Reactive Oxygen Species (2) Topoisomerase (4)
By Research Areas:	Cancer (6) Infection (26) Inflammation/Immunology (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121241

Dehydroemetine

Parasite Infection

Dehydroemetine, a synthetic analogue of emetine dihydrochloride, is used for visceral leishmaniasis. Dehydroemetine used for anti-parasites .

Dehydroemetine	Parasite	Infection
Dehydroemetine, a synthetic analogue of emetine dihydrochloride, is used for visceral leishmaniasis. Dehydroemetine used for anti-parasites .

HY-U00128

PPA-904	Parasite	Infection Inflammation/Immunology
PPA-904 is a specific phenothiazine photosensitizer in photodynamic research (PDT) research, especially topical application for cutaneous leishmaniasis in vivo .

HY-W077028

N-(2-Hydroxypropyl)methacrylamide	Others	Others
N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .

HY-W159102

8CN

Parasite Infection

8CN, a 2-amino-thiophene derivative, has anti-leishmanial activity. 8CN can be used in research of Leishmaniasis .

8CN	Parasite	Infection
8CN, a 2-amino-thiophene derivative, has anti-leishmanial activity. 8CN can be used in research of Leishmaniasis .

HY-N6054

Niranthin	Parasite Topoisomerase	Infection Inflammation/Immunology
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.

HY-120060

GNF6702	Parasite	Infection
GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis .

HY-131350

LXE408	Proteasome Parasite	Infection
LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 has an IC₅₀ of 0.04 μM for *L. donovani* proteasome and an EC₅₀ of 0.04 μM for L. donovani. LXE408 has a low propensity to cross the blood brain barrier. LXE408 has the potential for visceral leishmaniasis (VL) research .

HY-18351

Indotecan LMP-400; NSC-724998	Topoisomerase	Infection Cancer
Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC₅₀s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis .

HY-146166

PT4	Parasite Reactive Oxygen Species	Infection Inflammation/Immunology
PT4 is a therapeutic agent against Cutaneous leishmaniasis (CL). PT4 is effective against both species of Leishmania, with IC₅₀s of 125.18 and 233.18 μM for L. amazonensis and L. braziliensis, respectively. PT4 decreases of mitochondrial membrane potential and increases production of reactive oxygen species, which leads to parasite death. PT4 has a potent in vivo anti-inflammatory activity .

HY-139854

DNDI-6148

Parasite Infection

DNDI-6148 is a novel preclinical candidate for the research of visceral leishmaniasis.
HY-N9263

Diacetylpiptocarphol

Others Infection

Diacetylpiptocarphol (compound 4) is a sesquiterpene lactone compound. Diacetylpiptocarphol has anti-leishmaniasis activity .

DNDI-6148	Parasite	Infection
DNDI-6148 is a novel preclinical candidate for the research of visceral leishmaniasis.

Diacetylpiptocarphol	Others	Infection
Diacetylpiptocarphol (compound 4) is a sesquiterpene lactone compound. Diacetylpiptocarphol has anti-leishmaniasis activity .

HY-B0956

Paromomycin sulfate 1 Publications Verification Aminosidine sulfate	Antibiotic Parasite Bacterial	Infection
Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections .

HY-B0621

Triclabendazole 4 Publications Verification CGA89317	Parasite Caspase Bcl-2 Family PARP Pyroptosis	Infection
Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-151149

Trypanothione synthetase-IN-4	Parasite	Infection
Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC₅₀ value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis .

HY-146744

Antileishmanial agent-4

Parasite Infection

Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent .

Antileishmanial agent-4	Parasite	Infection
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent .

HY-147536

Antileishmanial agent-8	Parasite	Infection
Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC₅₀=73.9 μM) .

HY-147537

Antileishmanial agent-9	Parasite	Infection
Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC₅₀ = 40.1 μM) .

HY-149834

Antileishmanial agent-18	Parasite	Infection
Antileishmanial agent-18 (Compound 1e) is an antileishmanial agent. Antileishmanial agent-18 effectively inhibits growth of L. donovani promastigotes. Antileishmanial agent-18 is safe for host cells .

HY-156464

Topoisomerase I inhibitor 10	Topoisomerase	Infection
Topoisomerase I inhibitor 10 (compound 13) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 10 has antileishmanial activity against L. donovani promastigotes, with the IC₅₀ of 27.91 μM .

HY-156462

Topoisomerase I inhibitor 9	Topoisomerase	Infection
Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC₅₀ of 34.81μM .

HY-B0537

Pentamidine MP-601205	Parasite Fungal Phosphatase Bacterial Antibiotic	Infection Cancer
Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-B0537A

Pentamidine dihydrochloride MP-601205 dihydrochloride	Parasite Fungal Phosphatase Bacterial Antibiotic	Infection Cancer
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-B0537C

Pentamidine dimesylate MP-601205 dimesylate	Antibiotic Parasite Fungal Phosphatase Bacterial	Infection Cancer
Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dimesylate inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine dimesylate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dimesylate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-146745

Antileishmanial agent-5	Parasite	Inflammation/Immunology
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent. Antileishmanial agent-4 is against L.infantum and T.cruzi with EC₅₀ values of 0.68 μM and 0.83 μM, respectively .

HY-P1957

Dihydrocyclosporin A	Parasite	Infection
Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic .

HY-B0537B

Pentamidine isethionate Maximum Cited Publications 7 Publications Verification MP-601205 isethionate	Parasite Fungal Phosphatase Bacterial Antibiotic	Infection Cancer
Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC₅₀ of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .

HY-B0537AS

Pentamidine-d4 dihydrochloride MP-601205-d₄(dihydrochloride)	Isotope-Labeled Compounds Parasite Fungal Phosphatase Bacterial Antibiotic	Infection Cancer
Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

HY-B0688

Dapsone 4,4′-Diaminodiphenyl sulfone; DDS	Antibiotic Parasite Bacterial Reactive Oxygen Species	Infection Inflammation/Immunology
Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

Dihydrocyclosporin A	Parasite	Infection
Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0956

Paromomycin sulfate 1 Publications Verification Aminosidine sulfate	Structural Classification Classification of Application Fields Source classification Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields	Antibiotic Parasite Bacterial
Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections .

HY-N6054

Niranthin	Infection Classification of Application Fields Phyllanthus amarus chumacher & Thonning Source classification Lignans Euphorbiaceae Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Parasite Topoisomerase
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.

HY-N9263

Diacetylpiptocarphol	Source classification Plants Compositae Cyrtocymura cincta var. cincta	Others
Diacetylpiptocarphol (compound 4) is a sesquiterpene lactone compound. Diacetylpiptocarphol has anti-leishmaniasis activity .

Cat. No.	Product Name	Chemical Structure

HY-B0537AS

Pentamidine-d4 dihydrochloride
Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

Pentamidine-d4 dihydrochloride

Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

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