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Results for "

Leptin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (1) Casein Kinase (1) Cholecystokinin Receptor (1) DNA-PK (1) Epigenetic Reader Domain (1) Glucocorticoid Receptor (1) iGluR (1) Neuropeptide Y Receptor (6) PD-1/PD-L1 (1) Phosphatase (2) PI3K (1) PKA (1) PPAR (1)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (2) Metabolic Disease (9) Neurological Disease (8)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1304

CART(55-102)(human)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(human) is an endogenous satiety factor with potent appetite-suppressing activity. CART(55-102)(human) is closely associated with leptin and neuropeptide Y .

HY-P1305

CART(55-102)(rat)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior .

HY-P3340

Leptin (116-130)	iGluR	Neurological Disease
Leptin (116-130) is a bioactive leptin fragment. Leptin (116-130) promotes AMPA receptor trafficking to synapses and facilitate activity-dependent hippocampal synaptic plasticity. Leptin (116-130) prevents hippocampal synaptic disruption and neuronal cell death in models of amyloid toxicity. Leptin (116-130) has the potential for the research of Alzheimer's disease (AD) .

HY-P1304A

CART(55-102)(human) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(human) TFA is a human satiety factor with potent appetite-suppressing activity. CART(55-102)(human) TFA is closely associated with leptin and neuropeptide Y .

HY-P1305A

CART(55-102)(rat) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) TFA is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) TFA is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) TFA can induces anxiety and stress-related behavior .

HY-P3692

CART (55-76), rat	Neuropeptide Y Receptor	Neurological Disease
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior .

HY-P3691

CART (1-39), Human, Rat	Neuropeptide Y Receptor	Neurological Disease
CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior .

HY-120327

KY-226 1 Publications Verification	Phosphatase	Neurological Disease Metabolic Disease
KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury .

HY-101764

Lintitript SR 27897	Cholecystokinin Receptor	Metabolic Disease
Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC₅₀ of 6 nM and a K_i of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC₅₀ value of 200 nM). Lintitript increases plasma concentration of leptin and food intake as well as plasma concentration of insulin .

HY-B0283

Acipimox 1 Publications Verification K-9321	Others	Metabolic Disease
Acipimox (K-9321), a nicotinic acid analogue, is an antilipolytic compound. Acipimox stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity .

HY-B0283A

Acipimox sodium K-9321 sodium	Others	Metabolic Disease
Acipimox (K-9321) sodium, a nicotinic acid analogue, is an antilipolytic compound. Acipimox sodium stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity .

HY-121515

DPM-1001	Phosphatase	Metabolic Disease
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property .

HY-151963

PPARγ/GR modulator 1	PPAR Glucocorticoid Receptor	Metabolic Disease
PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with K_is of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes .

HY-110218

CW 008	PKA Epigenetic Reader Domain	Others
CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion .

HY-P3342

[D-Leu-4]-OB3	PD-1/PD-L1 Apoptosis	Inflammation/Immunology
[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes .

HY-10108

LY294002 Maximum Cited Publications 686 Publications Verification	PI3K Casein Kinase DNA-PK Apoptosis Autophagy	Infection Cancer
LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively . LY294002 also inhibits CK2 with an IC₅₀ of 98 nM . LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4 μM. LY294002 is an apoptosis activator .

Cat. No.	Product Name	Target	Research Area

HY-P1523

Leptin (22-56), human

Peptides Metabolic Disease

Leptin (22-56), human is the fragment of leptin, mediated via several isoforms of receptors (Ob-Rs).

Leptin (22-56), human	Peptides	Metabolic Disease
Leptin (22-56), human is the fragment of leptin, mediated via several isoforms of receptors (Ob-Rs).

HY-P2540

Leptin (93-105), human	Peptides	Metabolic Disease
Leptin (93-105), human, is the amino acids 93 to 105 fragment of human leptin. Leptin is a 167-residue peptide hormone mainly produced by adipocytes and acts in the central nervous system to primarily coordinate the metabolic adaptations to fasting .

HY-P1304

CART(55-102)(human)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(human) is an endogenous satiety factor with potent appetite-suppressing activity. CART(55-102)(human) is closely associated with leptin and neuropeptide Y .

HY-P3340

Leptin (116-130)	iGluR	Neurological Disease
Leptin (116-130) is a bioactive leptin fragment. Leptin (116-130) promotes AMPA receptor trafficking to synapses and facilitate activity-dependent hippocampal synaptic plasticity. Leptin (116-130) prevents hippocampal synaptic disruption and neuronal cell death in models of amyloid toxicity. Leptin (116-130) has the potential for the research of Alzheimer's disease (AD) .

HY-P4736

Leptin (116-130) (human)	Peptides	Others
Leptin (116-130) (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P1304A

CART(55-102)(human) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(human) TFA is a human satiety factor with potent appetite-suppressing activity. CART(55-102)(human) TFA is closely associated with leptin and neuropeptide Y .

HY-P1305

CART(55-102)(rat)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior .

HY-P1305A

CART(55-102)(rat) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) TFA is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) TFA is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) TFA can induces anxiety and stress-related behavior .

HY-P3692

CART (55-76), rat	Neuropeptide Y Receptor	Neurological Disease
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior .

HY-P3212

Allo-aca 1 Publications Verification	Peptides	Cancer
Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models .

HY-P3212A

Allo-aca TFA	Peptides	Cancer
Allo-aca TFA, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca TFA blocks leptin signaling and action in numerous in vitro and in vivo models .

HY-P3691

CART (1-39), Human, Rat	Neuropeptide Y Receptor	Neurological Disease
CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior .

HY-P3341

OB3	Peptides	Metabolic Disease Inflammation/Immunology Cancer
OB3, a derivative of Leptin, show more effective than leptin in reducing obesity and diabetes in mouse models. OB3 can reduce Leptin-related inflammation and proliferation in hepatocellular carcinoma cells .

HY-P1027

LEP(116-130)(mouse)

1 Publications Verification

Peptides Others

LEP(116-130)(mouse) is a synthetic leptin peptide fragment.

LEP(116-130)(mouse) 1 Publications Verification	Peptides	Others
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.

HY-P3342

[D-Leu-4]-OB3	PD-1/PD-L1 Apoptosis	Inflammation/Immunology
[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes .

Recombinant Proteins Recommended:

Leptin

Species:	Human (4) Mouse (3) Rat (2)
Tag:	His (7) Tag Free (3) Fc (1)
Source:	HEK293 (3) P. pastoris (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P70704

	Leptin Protein, Mouse 1 Publications Verification Leptin; Obese Protein; Obesity Factor; LEP; OB; OBS	Mouse	E. coli
	Leptin Protein, Mouse is a hormone secreted by fat cells that helps to regulate energy balance by inhibiting feeding and increase thermogenesis.

HY-P70181

	Leptin Protein, Carassius auratus (P.pastoris, His) rCaLeptin, His; Leptin; Obese Protein; Obesity Factor; LEP; OB; OBS	Others	P. pastoris
	Leptin protein plays a pivotal role in regulating energy balance and body weight. It binds to its receptor, LEPR, in various tissues, activating signaling pathways that regulate energy homeostasis. Leptin Protein, Carassius auratus (P.pastoris, His) is the recombinant Leptin protein, expressed by P. pastoris , with N-8*His labeled tag. The total length of Leptin Protein, Carassius auratus (P.pastoris, His) is 150 a.a., with molecular weight of ~17.0 kDa.

HY-P7232

	Leptin Protein, Human rHuLeptin; Obesity protein; OB	Human	E. coli
	Leptin Protein, Human is a hormone secreted by fat cells that helps to regulate energy balance by inhibiting feeding and increase thermogenesis.

HY-P70704A

	Leptin Protein, Mouse (His) Leptin; Obese Protein; Obesity Factor; LEP; OB; OBS	Mouse	E. coli
	Leptin is a key regulator of energy balance and body weight and binds to LEPR receptors in multiple tissues. It controls appetite in the hypothalamus and affects bone mass, hormone regulation, and reproductive function. Leptin Protein, Mouse (His) is the recombinant mouse-derived Leptin protein, expressed by E. coli , with N-6*His labeled tag. The total length of Leptin Protein, Mouse (His) is 146 a.a., with molecular weight of ~17 kDa.

HY-P7233

	Leptin Protein, Rat rRtLeptin; Obesity protein (OB)	Rat	E. coli
	Leptin Protein, Rat is a hormone secreted by fat cells that helps to regulate energy balance by inhibiting feeding and increase thermogenesis.

HY-P73273

	Leptin R/LEPR Protein, Human (HEK293, His-Fc) Leptin receptor; LEP-R; HuB219; OB-R; CD295; DB	Human	HEK293
	PSAP/prosaposin protein is a multifunctional protein involved in various cellular processes. It serves as a precursor to four different saponin proteins involved in lipid metabolism and lysosomal function. Leptin R/LEPR Protein, Human (HEK293, His-Fc) is the recombinant human-derived Leptin R/LEPR protein, expressed by HEK293 , with C-hFc, C-8*His labeled tag. The total length of Leptin R/LEPR Protein, Human (HEK293, His-Fc) is 818 a.a., with molecular weight of 130-180 kDa.

HY-P7232A

	Leptin Protein, Human (His) rHuLeptin; Obesity protein; OB	Human	E. coli
	Leptin is an important energy regulator that regulates appetite, metabolism, and immune responses through its central receptor LEPR. In the hypothalamus, it reduces food intake, affects neuropeptides, and affects bone mass and reproductive function. Leptin Protein, Human (His) is the recombinant human-derived Leptin protein, expressed by E. coli , with N-6*His labeled tag. The total length of Leptin Protein, Human (His) is 146 a.a., with molecular weight of ~17 kDa.

HY-P7233A

	Leptin Protein, Rat (His) rRtLeptin; Obesity protein (OB)	Rat	E. coli
	Leptin Protein, Rat is a hormone secreted by fat cells that helps to regulate energy balance by inhibiting feeding and increase thermogenesis.

HY-P72523

	Leptin R/LEPR Protein, Mouse (HEK293, His) Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR	Mouse	HEK293
	Leptin R/LEPR protein, as a receptor for the hormone LEP/leptin, mediates central and peripheral effects by activating various signaling pathways (such as JAK2/STAT3 and MAPK cascade/FOS). In the hypothalamus, it regulates appetite, energy expenditure, bone mass, and hormone secretion. Leptin R/LEPR Protein, Mouse (HEK293, His) is the recombinant mouse-derived Leptin R/LEPR protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Leptin R/LEPR Protein, Mouse (HEK293, His) is 818 a.a., with molecular weight of 120-150 kDa.

HY-P72524

	Leptin R/LEPR Protein, Human (HEK293, His) Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR	Human	HEK293
	Leptin R/LEPR protein, as the receptor of LEP/leptin, plays a key role in mediating central and peripheral effects through multiple signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, it regulates appetite, influencing orexigenic factors and inhibiting orexigenic neuropeptides. Leptin R/LEPR Protein, Human (HEK293, His) is the recombinant human-derived Leptin R/LEPR protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Leptin R/LEPR Protein, Human (HEK293, His) is 818 a.a., with molecular weight of 100-130 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81241

Leptin Antibody LEP; Leptin Murine Obesity Homolog; Leptin Precursor Obesity Factor; OB; Obese Protein; Obesity; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog Leptin; OBS; LEP_HUMAN.	WB; ELISA; IHC-P; IHC-F; IF;	Human, Mouse, Rat, Pig, Sheep

HY-P82748

Leptin Receptor Antibody (YA2493)

Leptin receptor; LEP-R; HuB219 OB receptor; OB-R; CD295; LEPR; DB; OBR
WB Human, Mouse, Rat

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