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Lucidum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (4) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) AP-1 (1) Apoptosis (8) Bacterial (3) Bcl-2 Family (1) c-Myc (1) Caspase (1) CaSR (2) Cholinesterase (ChE) (2) COX (1) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Intermediate (1) EBV (3) Endogenous Metabolite (4) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (1) Glycosidase (1) HIV (1) HIV Protease (4) HMG-CoA Reductase (HMGCR) (3) HSV (1) Influenza Virus (2) Interleukin Related (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mixed Lineage Kinase (2) MMP (4) NF-κB (3) NO Synthase (4) P-glycoprotein (1) p38 MAPK (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (6) RIP kinase (2) RSV (1) Sirtuin (2) Survivin (1) TGF-beta/Smad (2) TNF Receptor (1) Toll-like Receptor (TLR) (2) Tyrosinase (1) Wnt (2) β-catenin (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (5) Endocrinology (2) Infection (12) Inflammation/Immunology (22) Metabolic Disease (10) Neurological Disease (6)

By Targets:

Aldose Reductase (4)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (2)

AP-1 (1)

Apoptosis (8)

Bacterial (3)

Bcl-2 Family (1)

c-Myc (1)

Caspase (1)

CaSR (2)

Cholinesterase (ChE) (2)

COX (1)

DNA/RNA Synthesis (1)

Drug Derivative (2)

Drug Intermediate (1)

EBV (3)

Endogenous Metabolite (4)

Epigenetic Reader Domain (1)

Eukaryotic Initiation Factor (eIF) (1)

Glycosidase (1)

HIV (1)

HIV Protease (4)

HMG-CoA Reductase (HMGCR) (3)

HSV (1)

Influenza Virus (2)

Interleukin Related (2)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

Mixed Lineage Kinase (2)

MMP (4)

NF-κB (3)

NO Synthase (4)

P-glycoprotein (1)

p38 MAPK (1)

PI3K (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (6)

RIP kinase (2)

RSV (1)

Sirtuin (2)

Survivin (1)

TGF-beta/Smad (2)

TNF Receptor (1)

Toll-like Receptor (TLR) (2)

Tyrosinase (1)

Wnt (2)

β-catenin (1)

By Research Areas:

Cancer (31)

Cardiovascular Disease (5)

Endocrinology (2)

Infection (12)

Inflammation/Immunology (22)

Metabolic Disease (10)

Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1511

Ganoderic acid D 2 Publications Verification	Sirtuin Apoptosis	Cancer
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-N0546

Ligustroflavone 2 Publications Verification Nuezhenoside	CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

HY-107260

Lucidenic acid D Lucidenic acid D2	NO Synthase COX	Infection Inflammation/Immunology Cancer
Lucidenic acid D is a highly oxidized triterpenoid with anti-inflammatory and antiviral activities. Lucidenic acid D attenuates lipopolysaccharide-induced release of proinflammatory cytokines and nitric oxide, reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and inhibits skin inflammation. Lucidenic acid D suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of Epstein-Barr virus (EBV) early antigen and maintains the viability of Raji cells. Lucidenic acid D can be used in studies of cancer chemoprevention .

HY-N2458

Ganoderic acid G	Others	Others
Ganoderic acid G is a highly oxidized lanostane-type triterpenoid compound. Ganoderic acid G can be isolated from the fungus Ganoderma lucidum .

HY-N1517

Ganoderic acid C2	Aldose Reductase	Inflammation/Immunology Cancer
Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 is the inhibitor for aldose reductase with an IC₅₀ of 43.8 µM .

HY-N2006

Ganoderic acid B	EBV HIV Protease	Infection Inflammation/Immunology
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-N0665

Specnuezhenide 1 Publications Verification (8E)-Nuezhenide	NF-κB Wnt	Inflammation/Immunology
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

HY-120140

Ganoderic acid DM 1 Publications Verification	Apoptosis PI3K	Metabolic Disease Inflammation/Immunology Cancer
Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis .

HY-N1513

Ganoderic acid H	AP-1 NF-κB	Cancer
Ganoderic acid H is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderic acid H suppresses growth and invasive behavior of breast cancer cells through the inhibition of transcription factors AP-1 and NF-kappaB signaling .

HY-159059

*Ganoderma Lucidum/Reishi Extract*	c-Myc Bcl-2 Family Eukaryotic Initiation Factor (eIF) Survivin β-catenin MMP Interleukin Related	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Ganoderma Lucidum/Reishi Extract is a Ganoderma lucidum extract. Ganoderma Lucidum/Reishi Extract reduces the expression of c-Myc, BCL-2, BCL-XL, TERT, PDGFB, eIF4G, Survivin, β-catenin, and eIF4E. Ganoderma Lucidum/Reishi Extract downregulates the gene expression of MMP-9. Ganoderma Lucidum/Reishi Extract upregulates the expression of IL8. Ganoderma Lucidum/Reishi Extract is applicable to the research of inflammatory breast cancer. Ganoderma Lucidum is used in the research of various diseases, such as allergy, arthritis, hypertension, neurasthenia, inflammation, and cancer .

HY-N6862

Lucideric acid A	MMP	Cancer
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells .

HY-N2996

Ganodermanondiol	HIV Protease	Infection
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-N2999

Ganoderic acid I	Drug Intermediate	Others
Ganoderic acid I is a lanostane-type triterpenoid compound present in Ganoderma lucidum .

HY-N11591

Ganoderic acid T	Apoptosis DNA/RNA Synthesis Mitochondrial Metabolism	Cancer
Ganoderic acid T is a lanostane triterpenoid. Ganoderic acid T is isolated from Ganoderma lucidum mycelia. Ganoderic acid T induces Mitochondria-mediated Apoptosis and inhibits DNA synthesis. Ganoderic acid T exhibits anticancer activity against cervical cancer, liver cancer and lung cancer .

HY-N2221

Ganoderal A	Others	Metabolic Disease
Ganoderal A, an oxygenated sterol from G. lucidum, is a cholesterol synthesis inhibitor .

HY-N3501

Deacetyl Ganoderic Acid F	Others	Metabolic Disease
Deacetyl Ganoderic Acid F is a 7-anostane triterpenoid from Ganoderma lucidum.

HY-N6055

Nuezhenidic acid	Influenza Virus	Infection
Nuezhenidic acid can be isolated from the fruits of Ligustrum lucidum, posseses inhibitory activities against influenza A virus .

HY-N9312

Ganoderic acid J	Others	Inflammation/Immunology
Ganoderic acid J is a natural terpenoid isolated from the Fungus Ganoderma lucidum. Ganoderic acid J possesses anti-inflammatory anti-inflammatory activity .

HY-N1516

Ganoderenic acid D	Apoptosis	Cancer
Ganoderenic acid D is a triterpene identified from the effective compounds of Ganoderma lucidum extract (GLE). Ganoderenic acid D inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis .

HY-N1506

Ganodermanontriol	Epigenetic Reader Domain p38 MAPK	Cancer
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity .

HY-N1514

Ganoderenic acid B	P-glycoprotein	Cancer
Ganoderenic acid B is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid B exhibits potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to Doxorubicin .

HY-N6861

Lucidenic acid B	Apoptosis	Cancer
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells .

HY-N3844

Ergosta-7,22-dien-3-one	Others Toll-like Receptor (TLR)	Others
Ergosta-7,22-dien-3-on is a lanosterane isolated from the fruiting bodies of Ganoderma lucidum. ent-16-Kaurene-3b,15b,18-triol inhibits platelet aggregation . Ergosta-7,22-dien-3-on is able to stimulate nitric oxide production, induce the expression of genes, and induce the production of TLRs, cytokines, chemokines, and cellular adhesion molecules in vitro .

HY-125361

Ganosporeric acid A	Others	Others
Ganosporeric acid A, a natural product, is isolated from the ether-soluble fraction of the spores of Ganoderma lucidum. Ganosporeric acid A can be used for the research of liver injury .

HY-N1512

Ganoderic acid E	Others	Others
Ganoderic acid E is a triterpenoid found in Ganoderma lucidum .

HY-N6874

Ligustrosidic acid	Others	Others
Ligustrosidic acid is a natural compound isolated from ligustrum japonicum and ligustrum lucidum .

HY-123100

Ganoderic acid N	Others	Others
Ganoderic acid N is a natural terpenoid isolated from the Fungus Ganoderma lucidum .

HY-N3500

Ganoderic acid D2	Endogenous Metabolite	Inflammation/Immunology Cancer
Ganoderic acid D2 (compound 27) is a triterpenoid isolated from Ganoderma lucidum. Ganoderic acid D2 has anticancer, anti-inflammatory and antioxidative activity .

HY-N6860

Lucidenic acid C	MMP	Cancer
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells .

HY-N8039

Ganoderic acid T-Q Ganodermic acid T-Q	Microtubule/Tubulin	Cancer
Ganoderic acid T-Q (Ganodermic acid T-Q) (compound 1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid T-Q stimulates tubulin polymerization .

HY-N11637

Ganoderenic acid K	HMG-CoA Reductase (HMGCR)	Inflammation/Immunology
Ganoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum. Ganoderenic acid K shows strong inhibitory activity against HMG-CoA reductase (HMGCR) with IC₅₀ of 16.5 μM .

HY-113898

Ganoderic acid K	Angiotensin-converting Enzyme (ACE) Toll-like Receptor (TLR) Interleukin Related	Cardiovascular Disease Neurological Disease
Ganoderic acid K is a triterpenoid compound. Ganoderic acid K can be isolated from Ganoderma lucidum. Ganoderic acid K inhibits ACE activity with an IC₅₀ of 2.6×10 ^-5 M. Ganoderic acid K exhibits direct, high-affinity binding to recombinant MD2 protein, with a K_d value of 0.47 μM. It potently inhibits LPS-induced release of TNF-α and IL-6. It reduces cerebral infarction volume and ameliorates neurological dysfunction in mice with ischemic stroke in the tMCAO model. Ganoderic acid K can be used in studies related to hypertension and ischemic stroke .

HY-N8819

Methyl ganoderate H	NO Synthase	Others
Methyl ganoderate H is a natural product that can be isolated from Ganoderma lucidum. Methyl ganoderate H has moderate inhibitory effect to NO production .

HY-N11641

Methyl ganoderate A acetonide	Cholinesterase (ChE)	Neurological Disease
Methyl ganoderate A acetonide, a lanostane triterpene, is a natural product that could be isolated from the fruiting bodies of Ganoderma lucidum. Methyl ganoderate A acetonide is a potent AChE inhibitor with an IC₅₀ value of 18.35 μM. Methyl ganoderate A acetonide can be used in research of Alzheimer’s disease (AD) .

HY-125443

Lucialdehyde A	Others	Cancer
Lucialdehydes A is a lanostante-type triterpene aldehydes, isolated from the fruiting bodies of Ganoderma lucidum. Lucialdehydes A shows cytotoxic effects on tumor cells, including Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines .

HY-N8106

7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid	Others	Cancer
7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid is one of the ganoderma triterpenoids which have been recognised as an important bioactive ingredient in Ganoderma Lucidum Karst. 7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid can be used for the research of various etiologies .

HY-N2223

Ganoderol B Ganodermadiol	Glycosidase	Metabolic Disease
Ganoderol B is a potent α-glucosidase inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC₅₀ of 48.5 μg/mL (119.8 μM) .

HY-N3923

Ganoderic acid S1	Others	Others
Ganoderic acid S1 (compound 4) is a natural product that can be found in ganoderma lucidum .

HY-N3925

Ganoderol A	Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ganoderol A is a terpenoid extracted from Ganoderma lucidum with antimicrobial activities. Ganoderol A inhibits cholesterol synthesis pathway and has significant anti-inflammatory activity and protection against ultraviolet A (UVA) damage .

HY-N7346

Lucidadiol	HSV Cholinesterase (ChE)	Infection
Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC₅₀ values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1 .

HY-N2277

3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone	Bacterial	Infection Inflammation/Immunology
3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone is a natural compound that could be isolated from G. lucidum with antimycobacterial activity.

HY-118736

Ganodermic acid S	Others	Cardiovascular Disease
Ganodermic acid S is an oxygenated triterpenoid, that can be isolated from the Chinese medicinal fungus Ganoderma lucidum (Fr.) Karst (Polyporaceae). Ganodermic acid S exerts a concentration dependent inhibition on the response of human gel-filtered platelets (GFP) to U-46619 (HY-108566), a thromboxane (TX) A2 mimetic .

HY-N12777

Coixenolide	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
Coixenolide can be isolated from coix seeds, and exhibits anti-inflammatory, anti-tumor and pain-reducing activities. Coixenolide stimulates the lung, heart, striated and smooth muscles at low doses, while inhibits at high doses. Coixenolide dilates pulmonary veins and improves pulmonary blood circulation. Coixenolide can also be used as nutraceuticals and functional foods. Coixenolide enhances the prodcutionof mycelia biomass and polysaccharides when added to the media of submerged culture of G. lucidum. Coixenolide affects the synthesis level of phosphoglucose isomerase and α-phosphoglucomutase .

HY-N11636

Ganoderic acid S	Apoptosis	Cancer
Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway .

HY-N13148

Ganodermatriol	Others	Others
Ganodermatriol is a lanostane type triterpenoid compound derived from Ganoderma lucidum. These compounds have been reported to possess various biological activities, such as inhibiting histamine release from rat mast cells and exhibiting anti-hepatoma cell activity in vitro .

HY-107265

Lucidenic acid E	HMG-CoA Reductase (HMGCR)	Cancer
Lucidenic acid E is a terpenoid from Ganoderma lucidum .

HY-129151

Ganoderic acid C1	TNF Receptor	Inflammation/Immunology
Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells) .

HY-N11637A

(Z)-Ganoderenic acid K	HMG-CoA Reductase (HMGCR)	Inflammation/Immunology
(Z)-Ganoderenic acid K is a triterpene acid that can be isolated from the basidiocarp of Ganoderma lucidum. Ganoderenic acid K (HY-N11637), the isomer of (Z)-Ganoderenic acid K, is a HMG-CoA reductase (HMGCR) inhibitor with an IC₅₀ of 16.5 μM .

HY-125664

Lucialdehyde B	Antibiotic	Cancer
Lucialdehyde B is a tetracyclic triterpene isolated from the substrates of Ganoderma lucidum with antiviral and cytotoxic activities. Lucialdehyde B has cytotoxic effects against Lewis lung cancer (LLC), T-47D, Sarcoma 180 and Meth-A tumor cell lines .

HY-N0546R

Ligustroflavone (Standard) Nuezhenoside (Standard)	Reference Standards CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Ligustroflavone (Standard) is the analytical standard of Ligustroflavone (HY-N0546). This product is intended for research and analytical applications. Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

Cat. No.	Product Name	Type

HY-159059

Ganoderma Lucidum/Reishi Extract

Biochemical Assay Reagents

Ganoderma Lucidum/Reishi Extract is a Ganoderma lucidum extract. Ganoderma Lucidum/Reishi Extract reduces the expression of c-Myc, BCL-2, BCL-XL, TERT, PDGFB, eIF4G, Survivin, β-catenin, and eIF4E. Ganoderma Lucidum/Reishi Extract downregulates the gene expression of MMP-9. Ganoderma Lucidum/Reishi Extract upregulates the expression of IL8. Ganoderma Lucidum/Reishi Extract is applicable to the research of inflammatory breast cancer. Ganoderma Lucidum is used in the research of various diseases, such as allergy, arthritis, hypertension, neurasthenia, inflammation, and cancer .

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