M3 | MedChemExpress (MCE) Life Science Reagents

By Targets:	5-HT Receptor (3) Adrenergic Receptor (7) Bacterial (1) Biochemical Assay Reagents (1) c-Met/HGFR (1) Calcium Channel (2) Cholinesterase (ChE) (1) Fluorescent Dye (1) Histamine Receptor (1) Influenza Virus (1) Isotope-Labeled Compounds (9) mAChR (87) MicroRNA (8) NF-κB (2) Phosphodiesterase (PDE) (2) Sodium Channel (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (5) Endocrinology (2) Infection (3) Inflammation/Immunology (16) Metabolic Disease (9) Neurological Disease (66)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19619

m-3M3FBS 4 Publications Verification
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis ^[3].

HY-N6669

Methyl 3-O-methylgallate 1 Publications Verification M3OMG	Others	Neurological Disease
Methyl 3-O-methylgallate (M3OMG) possesses antioxidant effect and can protect neuronal cells from oxidative damage .

HY-155819

M3/PDE4 modulator-1	mAChR Phosphodiesterase (PDE)	Inflammation/Immunology
M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PDE4 modulator-1 (10-1000 nM/kg; iv) reduces cysteine eosinophil influx in the OVA rat model .

HY-P5900

m3-Huwentoxin IV M3-HwTx-IV	Sodium Channel	Neurological Disease
m3-Huwentoxin IV (m3-HwTx-IV) is a potent Na_V inhibitor with IC₅₀s of 3.3, 6.8, 7.2, 8.4, 11.9 and 369 nM against hNa_V1.7, hNa_V1.6, hNa_V1.3, hNa_V1.1, hNa_V1.2 and hNa_V1.4, respectively in QPatch assay. m3-Huwentoxin IV dose-dependently suppresses spontaneous pain induced by the Na_V1.7 activator OD1 in a rodent pain model .

HY-148526

β2AR/M3-receptor agonist-1	Adrenergic Receptor mAChR	Metabolic Disease
β2AR/M3-receptor agonist-1 (example 9) is a potent β2AR and M3 receptor agonist. β2AR/M3-receptor agonist-1 shows M3 receptor affinity with a pIC₅₀ value of 9.3. β2AR/M3-receptor agonist-1 has the potential for the research of respiratory tract disorders .

HY-U00302

CHF5407	mAChR	Inflammation/Immunology
CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity .

HY-B0726

Pilocarpine Hydrochloride Maximum Cited Publications 21 Publications Verification	mAChR	Neurological Disease
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B0726A

Pilocarpine Maximum Cited Publications 21 Publications Verification	mAChR	Neurological Disease
Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B1006

Pilocarpine nitrate Maximum Cited Publications 21 Publications Verification	mAChR	Neurological Disease Cancer
Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-107649

Zamifenacin fumarate UK-76654 fumarate	mAChR	Metabolic Disease
Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome .

HY-123337

Zamifenacin UK-76654	mAChR	Metabolic Disease
Zamifenacin (UK-76654) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome .

HY-100234

DREADD agonist 21

1 Publications Verification

mAChR Neurological Disease

DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

DREADD agonist 21 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

HY-100234A

DREADD agonist 21 dihydrochloride 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

HY-B0726S

Pilocarpine-d3 hydrochloride	Isotope-Labeled Compounds mAChR	Neurological Disease
Pilocarpine-d₃ (hydrochloride) is deuterium labeled Pilocarpine (Hydrochloride). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-122761

Quifenadine	mAChR	Neurological Disease
Quifenadine (Compound 3a), the hydroxyl-(diphenyl)methyl quinuclidine derivative, is a M3 receptor antagonist with an IC₅₀ value > 1000 nM. Quifenadine can be used for the research of neurological disease .

HY-U00104

YM-46303

mAChR Endocrinology

YM-46303 is an mAChR antagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.

YM-46303	mAChR	Endocrinology
YM-46303 is an mAChR antagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.

HY-114933

VU0119498	mAChR	Metabolic Disease
VU0119498 is a pan G_q mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC₅₀s of 6.04, 6.38, and 4.08 µM, respectively. VU0119498 has antidiabetic activity ^[3].

HY-109013

Sofpironium bromide BBI 4000	mAChR	Neurological Disease
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes .

HY-107653

J 104129 fumarate	mAChR	Neurological Disease
J 104129 fumarate is a selective and orally active muscarinic M3 antagonist with K_i values of 4.2 nM and 490 nM for M3 and M2, respectively. J 104129 fumarate antagonized ACh-induced bronchoconstriction. J 104129 fumarate has the potential for the research of obstructive airway disease .

HY-22437

(±)-Darifenacin

(±)-UK-88525
mAChR Neurological Disease Cancer

(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist .

(±)-Darifenacin (±)-UK-88525	mAChR	Neurological Disease Cancer
(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist .

HY-B0662A

Imidafenacin hydrochloride KRP-197 hydrochloride; ONO-8025 hydrochloride	mAChR	Neurological Disease
Imidafenacin hydrochloride is a potent and selective inhibitor of M3 receptors with a K_b of 0.317 nM .

HY-101586

Alvameline

Lu 25-109
mAChR Neurological Disease

Alvameline (Lu25-109) is a partial M1 agonist and M2/M3 antagonist.
HY-P4156

VLVNTFCDSCIPKTYWNLGY TFA

mAChR Neurological Disease

VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of M3 muscarinic receptor (M3R). VLVNTFCDSCIPKTYWNLGY TFA can be used in ELISA .
HY-U00030

Rispenzepine

mAChR Neurological Disease

Rispenzepine is a novel antimuscarinic compound with a preferential action at M₁, and M₃ receptor subtypes.
HY-A0033

Darifenacin

5 Publications Verification

UK-88525
mAChR Neurological Disease Cancer

Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
HY-B0662

Imidafenacin

KRP-197; ONO-8025
mAChR Neurological Disease

Imidafenacin (KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors.

Alvameline Lu 25-109	mAChR	Neurological Disease
Alvameline (Lu25-109) is a partial M1 agonist and *M2/M3* antagonist.

VLVNTFCDSCIPKTYWNLGY TFA	mAChR	Neurological Disease
VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of M3 muscarinic receptor (M3R). VLVNTFCDSCIPKTYWNLGY TFA can be used in ELISA .

Rispenzepine	mAChR	Neurological Disease
Rispenzepine is a novel antimuscarinic compound with a preferential action at M₁, and M₃ receptor subtypes.

Darifenacin 5 Publications Verification UK-88525	mAChR	Neurological Disease Cancer
Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.

Imidafenacin KRP-197; ONO-8025	mAChR	Neurological Disease
Imidafenacin (KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors.

HY-137976

Penehyclidine hydrochloride Penequinine hydrochloride	mAChR NF-κB	Inflammation/Immunology
Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation .

HY-142119

Penehyclidine	mAChR NF-κB	Inflammation/Immunology
Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation .

HY-A0012

Darifenacin hydrobromide 5 Publications Verification UK-88525 hydrobromide	mAChR	Neurological Disease Cancer
Darifenacin hydrobromide (UK-88525 hydrobromide) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.

HY-108030

Bencycloquidium bromide	mAChR	Neurological Disease Inflammation/Immunology Cancer
Bencycloquidium bromide, a *muscarinic M(3) receptor* antagonist, is an anticholinergic compound that acts as an anticholinergic bronchodilator. Bencycloquidium bromide can be used in the study for rhinitis .

HY-16489A

Terodiline hydrochloride	mAChR Calcium Channel	Neurological Disease
Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with K_bs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca ²⁺ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence .

HY-15851

Revefenacin TD-4208; GSK1160724	mAChR	Cardiovascular Disease Inflammation/Immunology
Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a K_i of 0.18 nM.

HY-32067AS

Aceclidine-d3 hydrochloride	Isotope-Labeled Compounds	Others
Aceclidine-d₃ hydrochloride is a deuterated version of Aceclidine (HY-32067). Aceclidine is a modulator of the M3 muscarinic acetylcholine receptor.

HY-100958

4-DAMP

1 Publications Verification

4-DAMP methiodide

4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor .

4-DAMP 1 Publications Verification 4-DAMP methiodide
4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor .

HY-22437S

(±)-Darifenacin-d4 (±)-UK-88525-d₄	Isotope-Labeled Compounds mAChR	Neurological Disease Cancer
(±)-Darifenacin-d₄ is deuterium labeled (±)-Darifenacin. (±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist[1].

HY-120802

Navafenterol AZD-8871; LAS191351	mAChR Adrenergic Receptor	Inflammation/Immunology
Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC₅₀ is 9.5 for human M3 receptor, and the pEC₅₀ is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile .

HY-A0030

Fesoterodine fumarate	mAChR	Neurological Disease Metabolic Disease
Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB) .

HY-70053

Fesoterodine	mAChR	Neurological Disease Metabolic Disease
Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB) .

HY-22437S1

(±)-Darifenacin-d4 hydrobromide (±)-UK-88525-d₄ hydrobromide	Isotope-Labeled Compounds mAChR	Neurological Disease Cancer
(±)-Darifenacin-d₄ (hydrobromide) is deuterium labeled (±)-Darifenacin. (±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist[1].

HY-107645

DAU 5884 hydrochloride	mAChR	Neurological Disease
DAU 5884 hydrochloride is a potent muscarinic M3 receptor antagonist. DAU 5884 hydrochloride inhibits methacholine-dependent effects on cell proliferation and muscle contractility .

HY-120802A

Navafenterol saccharinate AZD-8871 saccharinate; LAS191351 saccharinate	mAChR Adrenergic Receptor	Infection Inflammation/Immunology
Navafenterol (AZD-8871) saccharinate is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC₅₀ is 9.5 for human M3 receptor, and the pEC₅₀ is 9.5 for β2-adrenoceptor. Navafenterol saccharinate can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile .

HY-14825

Tarafenacin

SVT-40776
mAChR Neurological Disease

Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.

Tarafenacin SVT-40776	mAChR	Neurological Disease
Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.

HY-I0230

Solifenacin hydrochloride 2 Publications Verification YM905 hydrochloride	mAChR	Neurological Disease Cancer
Solifenacin hydrochloride (YM905 hydrochloride) is a muscarinic receptor antagonist, with pK_is of 7.6, 6.9 and 8.0 for M₁, M₂ and M₃ receptors, respectively.

HY-129826

J-104129

mAChR Others

J-104129 is a selective and orally active muscarinic M3 receptor antagonist (K_i = 4.2 nM). J-104129 is effective in promoting bronchodilation .

J-104129	mAChR	Others
J-104129 is a selective and orally active muscarinic M3 receptor antagonist (K_i = 4.2 nM). J-104129 is effective in promoting bronchodilation .

HY-70053A

Fesoterodine L-mandelate	mAChR	Neurological Disease Metabolic Disease
Fesoterodine L-mandelate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-mandelate is used for the overactive bladder (OAB) .

HY-32067

Aceclidine Quinuclidin-3-yl acetate	mAChR	Neurological Disease
Aceclidine (Quinuclidin-3-yl acetate) is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC₅₀: 40 μM). Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia ^[3].

HY-32067A

Aceclidine hydrochloride Quinuclidin-3-yl acetate hydrochloride	mAChR	Neurological Disease
Aceclidine (Quinuclidin-3-yl acetate) hydrochloride is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC₅₀: 40 μM). Aceclidine hydrochloride is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine hydrochloride has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia ^[3].

HY-A0002

Solifenacin Succinate 2 Publications Verification YM905	mAChR	Neurological Disease
Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pK_is of 7.6, 6.9 and 8.0 for M₁, M₂ and M₃ receptors, respectively.

HY-155367

mAChR antagonist 1	mAChR	Neurological Disease
mAChR antagonist 1 (compound 4a) is a mAChR antagonist with K_i values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively .

HY-107647

(S)-(+)-Dimethindene maleate	mAChR Histamine Receptor	Inflammation/Immunology
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M₂-selective muscarinic receptor antagonist (pA₂ = 7.86/7.74; pK_i = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M₁ (pA₂ = 6.83/6.36; pK_i = 7.08), the M₃ (pA₂ = 6.92/6.96; pK_i = 6.70) and the M₄ receptors (pK_i = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H₁ receptor antagonist (pA₂ = 7.48) .

Cat. No.	Product Name	Type

HY-D0153

Tetramethylrhodamine-5-isothiocyanate	Fluorescent Dyes/Probes
Tetramethylrhodamine-5-isothiocyanate is a potent fluorescent dye. Tetramethylrhodamine-5-isothiocyanate can be used for label PG-M3 antibody for rapid diagnosis of acute promyelocytic leukemia (APL). Tetramethylrhodamine-5-isothiocyanate can be used as probe to quantify in vivo the biodistribution of PLGA (poly(lactic-co-glycolic) acid) and PLGA/chitosan nanoparticles .

Cat. No.	Product Name	Type

HY-157881

2-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O) β-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O)	Buffer Reagents
2-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O) is a biochemical reagent that can be used for protein sequence analysis .

Cat. No.	Product Name	Target	Research Area

HY-P5900

m3-Huwentoxin IV M3-HwTx-IV	Sodium Channel	Neurological Disease
m3-Huwentoxin IV (m3-HwTx-IV) is a potent Na_V inhibitor with IC₅₀s of 3.3, 6.8, 7.2, 8.4, 11.9 and 369 nM against hNa_V1.7, hNa_V1.6, hNa_V1.3, hNa_V1.1, hNa_V1.2 and hNa_V1.4, respectively in QPatch assay. m3-Huwentoxin IV dose-dependently suppresses spontaneous pain induced by the Na_V1.7 activator OD1 in a rodent pain model .

HY-P10089

TREM-1 inhibitory peptide M3	Peptides	Inflammation/Immunology
TREM-1 inhibitory peptide M3 is a ligand-dependent TREM-1 antagonist. TREM-1 inhibitory peptide M3 can inhibit systemic and pulmonary pro-inflammatory cytokine and chemokine production and attenuate acute lung injury .

HY-P4156

VLVNTFCDSCIPKTYWNLGY TFA

mAChR Neurological Disease

VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of M3 muscarinic receptor (M3R). VLVNTFCDSCIPKTYWNLGY TFA can be used in ELISA .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6669

Methyl 3-O-methylgallate 1 Publications Verification M3OMG	Sanguisorba officinalis Linn. Source classification Rosaceae Phenols Polyphenols Plants	Others
Methyl 3-O-methylgallate (M3OMG) possesses antioxidant effect and can protect neuronal cells from oxidative damage .

HY-B0726

Pilocarpine Hydrochloride Maximum Cited Publications 21 Publications Verification	Alkaloids other families Source classification Plants	mAChR
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B1006

Pilocarpine nitrate Maximum Cited Publications 21 Publications Verification	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	mAChR
Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-N7535

Chlorovaltrate K	Structural Classification Valeriana jatamansi Jones Iridoids Terpenoids Source classification Plants Valerianaceae	Others
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

HY-N12589

8-epi-Helenalin	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Piptanthus nepalensis (Hook.) D. Don	Others
8-epi-Helenalin is a semitterpene lactone with anti-tumor activity that can be isolated from Inula britannicaL. var. chinensis (Rupr.) Reg. and the ED₅₀ values of 8-epi-Helenalin for HL-60, A549, MCF7, HCT-15, SK-OV-3 and Malme-3M are 12.2 μM, 53.8 μM, 9.1 μM, 8.7 μM, 18.7 μM and 8.3 μM, respectively. 8-epi-Helenalin can be used for anti-tumor studies .

Species:	Human (3) Cynomolgus (1)
Tag:	SUMO (1) His (2) Tag Free (1)
Source:	HEK293 (2) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72234

	HNRNPM Protein, Human (His-SUMO) CEA receptor; CEAR; Heterogeneous nuclear ribonucleoprotein M; Heterogenous nuclear ribonucleoprotein M4; hnRNA binding protein M4; hnRNP M; Hnrnpm; HNRNPM4; HNRPM; HNRPM_HUMAN; HNRPM4; HTGR1; M3; M4; M4 protein; N-acetylglucosamine receptor 1; NAGR1	Human	E. coli
	The HNRNPM protein is a key pre-mRNA binding protein that exhibits strong affinity for poly(G) and poly(U) RNA homopolymers. It is central to the splicing process, complexly regulates RNA maturation, and serves as a receptor for carcinoembryonic antigen in Kupffer cells. HNRNPM Protein, Human (His-SUMO) is the recombinant human-derived HNRNPM protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HNRNPM Protein, Human (His-SUMO) is 729 a.a., with molecular weight of ~93.4 kDa.

HY-P700837

TM4SF1 Protein-VLP, Human (HEK293)

M3S1; TAAL6; H-L6; L6
Human HEK293

TM4SF1 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay.

HY-P702595

	TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) M3S1; TAAL6; H-L6; L6	Cynomolgus	HEK293
	TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.

HY-P701329

	TM4SF1 Protein,Human (N-His) M3S1; Membrane component chromosome 3 surface marker 1; T4S1_HUMAN; TAAL6; Tm4sf1; Transmembrane 4 L6 family member 1; Tumor-associated antigen L6	Human	P. pastoris
	TM4SF1 protein-VLP is present in tumor cells and can form high molecular weight complexes, indicating its involvement in complex cellular processes in malignant tumors. It interacts with SDCBP2, emphasizing its association with specific molecular pathways, suggesting a role in cell signaling or regulatory mechanisms. TM4SF1 Protein,Human (N-His) is the recombinant human-derived TM4SF1 protein,Human, expressed by P. pastoris , with N-His labeled tag. The total length of TM4SF1 Protein,Human (N-His) is 47 a.a., with molecular weight of 7.3 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0726S

Pilocarpine-d3 hydrochloride
Pilocarpine-d₃ (hydrochloride) is deuterium labeled Pilocarpine (Hydrochloride). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-32067AS

Aceclidine-d3 hydrochloride

Aceclidine-d₃ hydrochloride is a deuterated version of Aceclidine (HY-32067). Aceclidine is a modulator of the M3 muscarinic acetylcholine receptor.

HY-22437S

(±)-Darifenacin-d4
(±)-Darifenacin-d₄ is deuterium labeled (±)-Darifenacin. (±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist[1].

HY-22437S1

(±)-Darifenacin-d4 hydrobromide
(±)-Darifenacin-d₄ (hydrobromide) is deuterium labeled (±)-Darifenacin. (±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist[1].

HY-I0230S

Solifenacin-d7 hydrochloride
Solifenacin-d₇ (hydrochloride) is the deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride (YM905 hydrochloride) is a muscarinic receptor antagonist, with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.

HY-A0033S1

Darifenacin-d4

Darifenacin-d₄ is the deuterium labeled Darifenacin[1]. Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. IC50 value: 8.9 (pKi)[2].

HY-A0002S

Solifenacin-d5 succinate
Solifenacin-d₅ (succinate) is deuterium labeled Solifenacin (Succinate). Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.

HY-50683S

JNJ-38877605-d1
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .

HY-B0461S

Trospium-d8 chloride
Trospium-d₈ (chloride) is the deuterium labeled Trospium chloride. Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors[1][2].

HY-B0406AS

Bethanechol-d6 chloride
Bethanechol-d₆ (chloride) is the deuterium labeled Bethanechol chloride. Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system[1].

HY-135329S

(1R,3S-)Solifenacin-d5 hydrochloride
(1R,3S-)Solifenacin-d₅ (hydrochloride) is the deuterium labeled Solifenacin D5 hydrochloride. Solifenacin D5 hydrochloride is a deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride is a muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively[1].

HY-B0241S

Ipratropium-d3 bromide
Ipratropium-d₃ (bromide) is the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].

HY-B0241S1

Ipratropium-d7 bromide
Ipratropium-d₇ (bromide)eis the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].

HY-A0030S

Fesoterodine-d7 fumarate
Fesoterodine-d₇ (fumarate) is the deuterium labeled Fesoterodine fumarate[1]. Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB)[2][3].

HY-76570S

(Rac)-5-Hydroxymethyl Tolterodine-d14

(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

HY-76570S1

5-Hydroxymethyl Tolterodine-d14 formate

5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

HY-10564S

Sarpogrelate-d3 hydrochloride

Sarpogrelate-d₃ (hydrochloride) is the deuterium labeled Sarpogrelate hydrochloride. Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis[1][2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P81142

Muscarinic Acetylcholine receptor M3 Antibody Muscarinic Acetylcholine receptor M3; cholinergic receptor, muscarinic 3; CHRM 3; CHRM3; HM 3; HM3; HM3; EGBRS; M3 muscarinic receptor; muscarinic 3; M3 muscarinic acetylcholine receptor; ACM3_HUMAN; muscarinic receptor M3; muscarinic cholinergic M3 receptor; muscarinic M3 receptor; Acetylcholine receptor(M3).	WB; ELISA; IHC-P; IHC-F; IF	Human(predicted: Mouse, Rat)
Muscarinic Acetylcholine receptor M3 Antibody is an unconjugated, approximately 65 kDa, rabbit-derived, anti-Muscarinic Acetylcholine receptor M3 polyclonal antibody. Muscarinic Acetylcholine receptor M3 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, and predicted: mouse, rat background without labeling.

Cat. No.	Product Name		Classification

HY-128855

Talsaclidine		Alkynes
Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes ^[3] . Talsaclidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


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