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Results for "

M5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Biochemical Assay Reagents (4) Cholinesterase (ChE) (1) Fluorescent Dye (2) Influenza Virus (1) Isotope-Labeled Compounds (4) mAChR (29) MicroRNA (4) Nucleoside Antimetabolite/Analog (1) Phosphatase (1) Reactive Oxygen Species (2)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (3) Metabolic Disease (5) Neurological Disease (22)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132578

M5N36	Phosphatase	Cancer
M5N36 is a potent and selective Cdc25C inhibitor with IC₅₀ values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2 .

HY-12439

ML380 1 Publications Verification	mAChR	Neurological Disease
ML380 is a potent, subtype-selective, and brain-penetrant positive allosteric modulator (PAM) of M5 mAChR, with EC₅₀s of 190 and 610 nM for human and rat M5, respectively. ML380 exhibits moderate selectivity versus the M1 and M3 mAChR subtypes. ML380 could increase the affinity of ACh for the M5 mAChR .

HY-N7922

Urolithin M5 Decarboxyellagic acid	Influenza Virus	Infection
Urolithin M5 is a neuraminidase inhibitor that can be isolated from Ganlanye. Urolithin M5 has antiviral activity in vitro and in vivo by inhibiting the activity of viral NA. Urolithin M5 can increase the survival rate and improve pulmonary edema in pr8-infected mouse models. Urolithin M5 can be used in anti-influenza research .

HY-108226S

Regorafenib N-oxide and N-desmethyl (M5)-d3	Isotope-Labeled Compounds	Others
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-108226S1

Regorafenib N-oxide and N-desmethyl (M5)-13C6	Isotope-Labeled Compounds	Others
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5)[1].

HY-12567

ML375 VU0483253	mAChR	Neurological Disease
ML375 (VU0483253) is a potent, highly selective, brain-penetrant and orally active M5 mAChR negative allosteric modulator (NAM) with IC₅₀s of 300 nM and 790 nM for human and rat M5, respectively. ML375 is inactive at human and rat M1-M4 .

HY-101281

VU 6008667

VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC₅₀s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration .

VU 6008667
VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC₅₀s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration .

HY-114933

VU0119498	mAChR	Metabolic Disease
VU0119498 is a pan G_q mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC₅₀s of 6.04, 6.38, and 4.08 µM, respectively. VU0119498 has antidiabetic activity .

HY-12100

Umeclidinium bromide 1 Publications Verification GSK573719A	mAChR	Inflammation/Immunology Cancer
Umeclidinium bromide is a novel mAChR antagonist. The affinity (K_i) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-12157

VU 0238429 1 Publications Verification	mAChR	Others
VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC₅₀ of 1.16 μM.

HY-100958

4-DAMP

1 Publications Verification

4-DAMP methiodide

4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor .

4-DAMP 1 Publications Verification 4-DAMP methiodide
4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor .

HY-A0030

Fesoterodine fumarate	mAChR	Neurological Disease Metabolic Disease
Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB) .

HY-70053

Fesoterodine	mAChR	Neurological Disease Metabolic Disease
Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB) .

HY-101281B

(R)-VU 6008667

Others Neurological Disease

(R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC₅₀>10 μM) .

(R)-VU 6008667	Others	Neurological Disease
(R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC₅₀>10 μM) .

HY-148502

VU6019650	mAChR	Neurological Disease
VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR (IC₅₀=36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopaminergic reward circuitry. VU6019650 blocks Oxotremorine M iodide (HY-101372A) induced increases of neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area (VTA) .

HY-70053A

Fesoterodine L-mandelate	mAChR	Neurological Disease Metabolic Disease
Fesoterodine L-mandelate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pK_i values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-mandelate is used for the overactive bladder (OAB) .

HY-155367

mAChR antagonist 1	mAChR	Neurological Disease
mAChR antagonist 1 (compound 4a) is a mAChR antagonist with K_i values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively .

HY-12100S

Umeclidinium-d5 bromide GSK573719A-d₅	Isotope-Labeled Compounds mAChR	Inflammation/Immunology
Umeclidinium-d₅ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-12100S1

Umeclidinium-d10 bromide GSK573719A-d₁₀	mAChR	Inflammation/Immunology
Umeclidinium-d₁₀ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-B0406A

Bethanechol chloride 1 Publications Verification Carbamyl-β-methylcholine chloride	mAChR	Neurological Disease
Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system .

HY-B0406

Bethanechol Carbamyl-β-methylcholine	mAChR	Neurological Disease Cancer
Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system .

HY-12567A

(R)-ML375

(R)-VU0483253
Others Others

(R)-ML375 ((R)-VU0483253) is an enantiomer of ML375 (HY-12567). (R)-ML375 is devoid of M₅ mAChR activity (hM₅, IC₅₀>30 μM) .

(R)-ML375 (R)-VU0483253	Others	Others
(R)-ML375 ((R)-VU0483253) is an enantiomer of ML375 (HY-12567). (R)-ML375 is devoid of M₅ mAChR activity (hM₅, IC₅₀>30 μM) .

HY-101839

ML381 VU0488130	mAChR	Neurological Disease
ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC₅₀ = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies .

HY-B0406AS

Bethanechol-d6 chloride Carbamyl-β-methylcholine-d₆ (chloride)	mAChR	Neurological Disease
Bethanechol-d₆ (chloride) is the deuterium labeled Bethanechol chloride. Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system[1].

HY-107651

VU 0365114 1 Publications Verification	mAChR	Metabolic Disease
VU 0365114 is a selective mAChR M₅ positive allosteric modulator, with an EC₅₀ of 2.7 μM, and >30 μM for M1, M2, M3 and M4 receptors. VU 0365114 increases insulin secretion stimulated by ACh in human β-cells .

HY-107646

PD 102807	mAChR	Neurological Disease
PD 102807 is a M4 muscarinic receptor antagonist with an IC₅₀ of 90.7 nM. PD 102807 inhibits M1, M2, M3, M5 muscarinic receptor with IC₅₀s of 6558.7, 3440.7, 950.0, and 7411.7 nM, respectively . Antidyskinetic effect.

HY-19752A

VU0357017 hydrochloride CID-25010775	mAChR	Neurological Disease
VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M₁ muscarinic acetylcholine receptor, with an EC₅₀ of 477 nM. VU0357017 hydrochloride is highly selective for M₁ and has no activity at M₂-M₅ up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia .

HY-12158

VU0238441	mAChR	Neurological Disease
VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC₅₀s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively .

HY-109013

Sofpironium bromide BBI 4000	mAChR	Neurological Disease
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes .

HY-107656

PTAC oxalate	mAChR	Neurological Disease
PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (K_i values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects .

HY-76570

(Rac)-5-Hydroxymethyl Tolterodine (Rac)-Desfesoterodine; (Rac)-PNU-200577	mAChR	Neurological Disease
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (K_i values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .

HY-76570A

(Rac)-5-Hydroxymethyl Tolterodine hydrochloride (Rac)-Desfesoterodine hydrochloride; (Rac)-PNU-200577 hydrochloride	mAChR	Neurological Disease
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (K_i values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research .

HY-A0030S

Fesoterodine-d7 fumarate	mAChR
Fesoterodine-d₇ (fumarate) is the deuterium labeled Fesoterodine fumarate[1]. Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB)[2][3].

HY-122203

PCS1055 dihydrochloride	mAChR Cholinesterase (ChE)	Neurological Disease
PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC₅₀ of 18.1 nM and a K_d of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [ ³H]-NMS binding to the M4 receptor with a K_i of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC₅₀ s of 22 nM and 120 nM for electric eel and human AChE, respectively .

HY-148527

LAS190792 AZD8999	Adrenergic Receptor mAChR	Others
LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC₅₀ 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilator .

HY-76570S

(Rac)-5-Hydroxymethyl Tolterodine-d14 (Rac)-Desfesoterodine-d₁₄; (Rac)-PNU-200577-d₁₄	mAChR	Neurological Disease
(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

HY-76570S1

5-Hydroxymethyl Tolterodine-d14 formate	Isotope-Labeled Compounds mAChR	Neurological Disease
5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

HY-R03188

mmu-miR-466m-5p mimic	MicroRNA	Cancer
mmu-miR-466m-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-466m-5p mimic mmu-miR-466m-5p mimic

HY-148506

5'-ODMT cEt m5U Phosphoramidite (Amidite)	Nucleoside Antimetabolite/Analog	Others
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity .

HY-RI03188

mmu-miR-466m-5p inhibitor	MicroRNA
mmu-miR-466m-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-466m-5p inhibitor mmu-miR-466m-5p inhibitor

HY-R03188A

mmu-miR-466m-5p agomir	MicroRNA
mmu-miR-466m-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-466m-5p agomir mmu-miR-466m-5p agomir

HY-RI03188A

mmu-miR-466m-5p antagomir	MicroRNA
mmu-miR-466m-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-466m-5p antagomir mmu-miR-466m-5p antagomir

HY-147412

Ultevursen QR-421a	Others	Others
Ultevursen (QR-421a) is a single-stranded RNA based oligonucleotide that is designed to skip exon 13 in the RNA with the aim to stop vision loss in people that have retinitis pigmentosa due to a mutation in exon 13 of the USH2A gene (encoding usherin). Ultevursen sequence: (P-thio)[2′-O-(2-methoxyethyl)](A-G-m ⁵C-m ⁵U-m ⁵U-m ⁵C-G-G-A-G-A-A-A-m ⁵U-m ⁵U-m ⁵U-A-A-A-m ⁵U-m ⁵C) .

HY-D1156

HKSOX-1m (5/6-mixture)	Reactive Oxygen Species Fluorescent Dye	Others
HKSOX-1m (5/6-mixture) is a O₂ fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O₂ over a broad range of pH, strong oxidants, and abundant reductants found in cells .

HY-D1156A

HKSOX-1m (5/6-mixture) (hydrobromide)	Reactive Oxygen Species Fluorescent Dye	Others
HKSOX-1m (5/6-mixture) hydrobromide is a O₂ fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O₂ over a broad range of pH, strong oxidants, and abundant reductants found in cells .

HY-B1610J

Sodium Citrate Buffer, 0.5M, pH 5.0	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 5.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 5.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 5.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.5M, pH 5.0 is used as solution for captisol in animal tumor models .

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. .

HY-B1610M

Sodium Citrate Buffer, 0.5M, pH 6.5	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .

HY-B1610L

Sodium Citrate Buffer, 0.5M, pH 6.0	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .

HY-101261

ATPA
ATPA is a selective glutamate receptor *GluR5* activator with EC₅₀s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7922

Urolithin M5 Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Source classification Phenols Polyphenols Plants Burseraceae	Influenza Virus
Urolithin M5 is a neuraminidase inhibitor that can be isolated from Ganlanye. Urolithin M5 has antiviral activity in vitro and in vivo by inhibiting the activity of viral NA. Urolithin M5 can increase the survival rate and improve pulmonary edema in pr8-infected mouse models. Urolithin M5 can be used in anti-influenza research .

Cat. No.	Product Name	Chemical Structure

HY-12100S1

Umeclidinium-d10 bromide
Umeclidinium-d₁₀ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-108226S

Regorafenib N-oxide and N-desmethyl (M5)-d3

Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).
HY-108226S1

Regorafenib N-oxide and N-desmethyl (M5)-13C6

Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5)[1].

HY-12100S

Umeclidinium-d5 bromide
Umeclidinium-d₅ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-B0406AS

Bethanechol-d6 chloride
Bethanechol-d₆ (chloride) is the deuterium labeled Bethanechol chloride. Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system[1].

HY-A0030S

Fesoterodine-d7 fumarate
Fesoterodine-d₇ (fumarate) is the deuterium labeled Fesoterodine fumarate[1]. Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB)[2][3].

HY-76570S

(Rac)-5-Hydroxymethyl Tolterodine-d14

(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

HY-76570S1

5-Hydroxymethyl Tolterodine-d14 formate

5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

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