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Isoforms Recommended:	MAO-A

Results for "

MAO-A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Monoamine Oxidase (68) 5-HT Receptor (2) Amyloid-β (1) Apoptosis (2) Autophagy (1) Bcl-2 Family (1) Caspase (1) Cholinesterase (ChE) (7) COMT (6) Cytochrome P450 (1) DYRK (1) Endogenous Metabolite (2) Enterovirus (2) Guanylate Cyclase (2) HDAC (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (8) HSP (2) HSV (1) IAP (1) Isotope-Labeled Compounds (1) mGluR (2) Microtubule/Tubulin (2) NO Synthase (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (24) Cardiovascular Disease (5) Endocrinology (1) Infection (6) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (54)
Click Chemistry:	Alkynes (6)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

MAO-A inhibitor 2	Monoamine Oxidase	Neurological Disease
MAO-A inhibitor 2 (compound HT4) is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 14.3 µM. MAO-A inhibitor 2 shows a less effect on MAO-B (IC₅₀ of 106 µM) and shows almost ineffective on xanthine oxidase (XO). MAO-A inhibitor 2 can be used for the neurodegenerative disorders and oxidative stress research .

MAO-A inhibitor 1	Monoamine Oxidase	Cancer
MAO-A inhibitor 1 (compound VIII) is a *MAO-A* inhibitor, with an IC₅₀ of 100 μM .

MAOA-IN-1	Monoamine Oxidase	Cancer
MAOA-IN-1 (compound 15) is an orally active MAOA inhibitor with cytotoxicity against prostate cancer cells. MAOA-IN-1 has Caco-2 permeability and lower CNS permeability. MAOA-IN-1 can be further used in the research of anti-cancer and anti-inflammatory indications .

MAOA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAOA Human Pre-designed siRNA Set A contains three designed siRNAs for MAOA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Maoa Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Maoa Mouse Pre-designed siRNA Set A contains three designed siRNAs for Maoa gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Maoa Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Maoa Rat Pre-designed siRNA Set A contains three designed siRNAs for Maoa gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAO-A/5-HT2AR-IN-1	Monoamine Oxidase 5-HT Receptor	Neurological Disease
MAO-A/5-HT2AR-IN-1 (compound I14) is a potent *MAO-A* and 5-HT2AR dual inhibitor, with IC₅₀ values of 0.004 and 0.014 μM, respectively. MAO-A/5-HT2AR-IN-1 is a potential antidepressant agent .

MAO-A/B-IN-2	Monoamine Oxidase	Neurological Disease
MAO-A/B-IN-2 (compound 30) is a *MAO-A/B* inhibitor with IC₅₀ values of 17.8 and 15.8 μM for *MAO-A* and *MAO-B, respectively. MAO*-A/B-IN-2 can be used in the study of neurological disorders .

MAO A/HDAC-IN-1	Monoamine Oxidase HDAC	Cancer
MAO A/HDAC-IN-1 is a dual?inhibitor?of *monoamine oxidase A (MAO* A) and HDAC*. MAO* A/HDAC-IN-1 can be used for glioma research . MAO A/HDAC-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

MAO A/HSP90-IN-2	Monoamine Oxidase HSP	Cancer
MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC₅₀ values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape ^[1].

MAO A/HSP90-IN-1	Monoamine Oxidase HSP	Cancer
MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC₅₀ value of 1.77 μM and 0.019 μM in Glioblastoma (GBM) GL26 cells and HSP90α, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research .

AnnH31	Monoamine Oxidase DYRK	Neurological Disease Cancer
AnnH31 is a Dyrk1A inhibitor (IC₅₀: 81 nM). AnnH31 also inhibits *MAO-A* with an IC₅₀ of 3.2 μM .

ASS234	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
ASS234 is a potent monoamino oxidase (MAO) inhibitor with IC₅₀s of 5.2 nM and 43 nM for MAO-A and MAO-B, respectively. ASS234 also inhibits AChE and BuChE with IC₅₀s of 350 nM and 460 nM, respectively .

MAO-IN-4	Monoamine Oxidase	Neurological Disease
MAO-IN-4 (Compound 2l) is a monoamine oxidase (MAO) inhibitor, with IC₅₀ values of 0.07 and 0.75 μM for MAO-A and MAO-B Enzymes, respectively. MAO-IN-4 can be used for the research of depression and Parkinson’s disease (PD) .

AChE-IN-60	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE-IN-60 (compound 6k) is a potant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with IC₅₀s of 27 nM and 43 nM, respectively. AChE-IN-60 also inhibits monoamine oxidase (MAO)-A and *MAO-B* with IC₅₀s of 353 nM and 716 nM, respectively .

Moclobemide N-Oxide Ro 12-5637	Monoamine Oxidase	Neurological Disease
Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain *MAO-A* (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm .

2-PAT	Monoamine Oxidase	Neurological Disease
2-PAT, an analogue of Rasagiline and Selegiline, a reversible *MAO-A* inhibitor with an IC₅₀ of 0.721 µM. 2-PAT is an inactivator of MAO-B with an IC₅₀ of 14.6 µM. 2-PAT has the potential for Parkinson’s disease and depression research .

Moclobemide Ro111163	Monoamine Oxidase	Neurological Disease
Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC₅₀ of 6.061 μM for hMAO-A .Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HIF-1α-IN-5	HIF/HIF Prolyl-Hydroxylase Monoamine Oxidase	Cancer
HIF-1α-IN-5 is a HIF-1α inhibitor with an IC₅₀ value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer .

OG-L002 1 Publications Verification	Histone Demethylase Monoamine Oxidase HSV	Infection
OG-L002 is a potent and highly selective LSD1 inhibitor with an IC₅₀ of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC₅₀s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes .

1-Methyl-2-undecyl-4(1H)-quinolone	Monoamine Oxidase	Neurological Disease
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of *MAO-B* activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS .

RS 8359	Monoamine Oxidase	Neurological Disease
RS 8359 is a selective and reversible *MAO-A* inhibitor, with antidepressant activity.

*AChE/MAO-IN-1*	Cholinesterase (ChE) Monoamine Oxidase Amyloid-β	Neurological Disease
AChE/MAO-IN-1 (Compound D28) is a potent AChE, *MAO-A* and *MAO-B* inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively .

Minaprine	Monoamine Oxidase	Neurological Disease
Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

Minaprine dihydrochloride	Monoamine Oxidase	Neurological Disease
Minaprine dihydrochloride is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

Toloxatone MD 69276	Monoamine Oxidase	Neurological Disease
Toloxatone (MD 69276) is a reversible monoamine oxidase A (MAO_A) inhibitor . Antidepressant .

Brofaromine CGP 11305A	Monoamine Oxidase	Neurological Disease
Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC₅₀ of 0.2 μM for *MAO-A*.

CX-157	Monoamine Oxidase	Neurological Disease
CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC₅₀ of 19.3 ng/mL.

Mofegiline hydrochloride MDL72974A	Monoamine Oxidase	Neurological Disease
Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of *MAO-B, with marked selectivity on the MAO-B* over *MAO-A* with IC₅₀s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride is also an inhibitor of semicarbazide-sensitive amine oxidase (SSAO) .

Clorgyline hydrochloride 4 Publications Verification	Monoamine Oxidase	Metabolic Disease
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline.

(±)-Amiflamine FLA 336	Monoamine Oxidase	Neurological Disease
(±)-Amiflamine (FLA 336) is a potent monoamine oxidase-A (MAO-A) inhibitor with a pIC₅₀ of 5.57 .

Azure B Azure B chloride	Monoamine Oxidase	Neurological Disease
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC₅₀s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

ETAP	Monoamine Oxidase	Neurological Disease
ETAP is a *MAO-A* and *MAO-B* inhibitor. ETAP has antidepressant-like effect. ETAP can be used for research of major depressive disorder .

Paeonol 4 Publications Verification	Monoamine Oxidase Autophagy	Neurological Disease Cancer
Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits *MAO-A* and *MAO-B* with IC₅₀ of 54.6 μM and 42.5 μM, respectively.

Pirlindole	Monoamine Oxidase Enterovirus	Infection Neurological Disease
Pirlindole is a selective and reversible *MAO-A* inhibitor . Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3) .

Pirlindole mesylate	Monoamine Oxidase Enterovirus	Infection Endocrinology
Pirlindole mesylate is a selective and reversible *MAO-A* inhibitor. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3) .

MAO-B-IN-25	Monoamine Oxidase	Neurological Disease
MAO-B-IN-25 (compound 92) is a selective *MAO-B* inhibitor with IC₅₀s of 0.5 nM and 240 nM for MAO-A and MAO-B, respectively .

Cimoxatone MD 780515	Monoamine Oxidase	Metabolic Disease
Cimoxatone (MD 780515) is a reversible, selectively and orally active type A monoamine oxidase (MAO-A) inhibitor. Cimoxatone enhances the anorectic action of Serotonin (HY-B1473A) .

MAO-IN-5	Monoamine Oxidase	Neurological Disease
MAO-IN-5 (Compound ZINC000016952895) is a monoamine oxidase (MAO) inhibitor. According to the prediction of Swiss ADME, MAO-IN-5 can inhibit the CYP enzyme family, has blood-brain barrier (BBB) permeability, and has a high gastrointestinal absorption rate. MAO-IN-5 can be used in the study of neurological diseases .

Rosmarinic acid 5+ Cited Publications Labiatenic acid	Monoamine Oxidase COMT Apoptosis Endogenous Metabolite	Cancer
Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits *MAO-A, MAO-B* and COMT enzymes with IC₅₀s of 50.1, 184.6 and 26.7 μM, respectively.

Desoxypeganine Deoxypeganine; Deoxyvasicine	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective *MAO-A* inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research .

BChE-IN-28	Cholinesterase (ChE)	Neurological Disease
BChE-IN-28 (compound 6J) is a selective butyrylcholinesterase (BChE) inhibitor with an IC₅₀ of 8 nM and a K_i of 12.16 nM. BChE-IN-28 shows the lower inhibition against AChE, MAO-A and MAO-B .

PSB-1491	Monoamine Oxidase	Neurological Disease
PSB-1491 is a selective and competitive monoamine oxidase B (MAO-B) inhibitor with an IC₅₀ of 0.386 nM for hMAO-B. PSB-1491 shows >25000-fold selective versus MAO-A .

Befloxatone MD-370503	Monoamine Oxidase	Neurological Disease
Befloxatone (MD-370503) is an orally active, selective and reversible inhibitor of Monoamine Oxidase A (MAO-A) (IC₅₀=4 nM). Befloxatone increases the tissue level of monoamine, striatal dopamine and cortical norepinephrine. Befloxatone has antidepressant potential .

LSD1-IN-12	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-12 (compound 2) is a potent LSD1 inhibitor, with K_i values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively .

WAY-620147	Monoamine Oxidase	Neurological Disease
WAY-620147 (compound 6) is an N-(2-morpholinoethyl)nicotinamide derivative that inhibits monoamine oxidase (Monoamine Oxidase). WAY-620147 inhibits MAO-A and MAO-B with IC50s of 26 μM and 55 μM, respectively .

Cat. No.	Product Name	Chemical Structure

HY-B0534S1

Moclobemide-d4
Moclobemide-d₄ is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-14280S

Entacapone-d10

Entacapone-d₁₀ is the deuterium labeled Entacapone. Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 µM). Entacapone can be used for the research of Parkinson's disease[1]. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders[2].

HY-70057S1

Safinamide-d4-1

Safinamide-d₄-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].

HY-14280S2

(E)-Entacapone-d10

(E)-Entacapone-d₁₀ is the deuterium labeled Entacapone. Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 µM). Entacapone can be used for the research of Parkinson's disease[1]. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders[2].

Cat. No.	Product Name		Classification

HY-A0091

Pargyline hydrochloride 2 Publications Verification		Alkynes
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for *MAO-A* and *MAO-B*, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities . Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0091A

Pargyline 2 Publications Verification		Alkynes
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for *MAO-A* and *MAO-B*, respectively. Pargyline has antihypertensive and anticancer activities . Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-142706

MAO A/HDAC-IN-1		Alkynes
MAO A/HDAC-IN-1 is a dual?inhibitor?of *monoamine oxidase A (MAO* A) and HDAC*. MAO* A/HDAC-IN-1 can be used for glioma research . MAO A/HDAC-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-121072

ASS234		Alkynes
ASS234 is a potent monoamino oxidase (MAO) inhibitor with IC₅₀s of 5.2 nM and 43 nM for MAO-A and MAO-B, respectively. ASS234 also inhibits AChE and BuChE with IC₅₀s of 350 nM and 460 nM, respectively .

HY-145259

HDAC6-IN-3		Alkynes
HDAC6-IN-3 (Compound 14), an antiprostate cancer agent, is a potent, orally active HDAC6 inhibitor with IC₅₀s ranging from 0.02-1.54 μM for HDAC1/2/3/6/8/10. HDAC6-IN-3 is also an effective *MAO-A* (IC₅₀=0.79 μM) and LSD1 inhibitor . HDAC6-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131036

MAO-IN-M30 dihydrochloride		Alkynes
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible *MAO-A* (IC₅₀=37 nM) and *MAO-B* (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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