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Results for "

MC3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) Cholinesterase (ChE) (1) Drug-Linker Conjugates for ADC (1) GnRH Receptor (1) Isotope-Labeled Compounds (1) Liposome (1) Melanocortin Receptor (20) PD-1/PD-L1 (1) Small Interfering RNA (siRNA) (3) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (3) Infection (1) Inflammation/Immunology (6) Metabolic Disease (7) Neurological Disease (7)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

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Isotope-Labeled Compounds

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112251

D-Lin-MC3-DMA

Maximum Cited Publications

45 Publications Verification

Liposome Cancer

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

*D-Lin-MC3-DMA* Maximum Cited Publications 45 Publications Verification	Liposome	Cancer
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

HY-RS08206

MC3R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MC3R Human Pre-designed siRNA Set A contains three designed siRNAs for MC3R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MC3R Human Pre-designed siRNA Set A MC3R Human Pre-designed siRNA Set A

HY-RS08208

Mc3r Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mc3r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc3r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mc3r Rat Pre-designed siRNA Set A Mc3r Rat Pre-designed siRNA Set A

HY-RS08207

Mc3r Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mc3r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc3r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mc3r Mouse Pre-designed siRNA Set A Mc3r Mouse Pre-designed siRNA Set A

HY-112251S

*D-Lin-MC3-DMA-13C3*	Isotope-Labeled Compounds	Others
D-Lin-MC3-DMA- ¹³C₃ is the ¹³C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle[1][2].

HY-P1214

γ1-MSH	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH is a *melanocortin MC3* receptor agonist, with a K_i** of 34 nM for the rat MC3 receptor. γ1-MSH displays ~40-fold selectivity over MC4 (K_i=1318 nM) .

HY-P1214A

γ1-MSH TFA	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH TFA is a *melanocortin MC3* receptor agonist, with a K_i** of 34 nM for the rat MC3 receptor. γ1-MSH TFA displays ~40-fold selectivity over MC4 (K_i=1318 nM) .

HY-P1217

[D-Trp8]-γ-MSH	Melanocortin Receptor	Inflammation/Immunology
[D-Trp8]-γ-MSH is a potent and selective agonist of *melanocortin 3 (MC3) receptor, with IC₅₀s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4* and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis .

HY-P1217A

[D-Trp8]-γ-MSH TFA	Melanocortin Receptor	Inflammation/Immunology
[D-Trp8]-γ-MSH TFA is a potent and selective agonist of *melanocortin 3 (MC3) receptor, with IC₅₀s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4* and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH TFA could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis .

HY-P0227

SHU 9119 1 Publications Verification	Melanocortin Receptor	Metabolic Disease
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC₅₀ values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

HY-P1531

γ-1-Melanocyte Stimulating Hormone (MSH), amide	Melanocortin Receptor	Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na ⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-P1215

HS024	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-P1215A

HS024 TFA	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-P3605

GnRH Associated Peptide (25-53), human GAP (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-147301

Resomelagon AP1189	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology
Resomelagon (AP1189) is a potent, orally active melanocortin receptor (MR) agonist about MC₁ and MC₃. Resomelagon induces ERK1/2 phosphorylation and Ca ²⁺ mobilization. Resomelagon has anti-inflammatory activity. Resomelagon can be used for obesity and chronic inflammation research .

HY-147301A

Resomelagon acetate AP1189 acetate	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology
Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC₁ and MC₃. Resomelagon acetate induces ERK1/2 phosphorylation and Ca ²⁺ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research .

HY-P1216A

HS014 TFA	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA increases food intake in free-feeding rats .

HY-P1213A

JKC363 TFA	Melanocortin Receptor	Neurological Disease
JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect .

HY-P1213

JKC363	Melanocortin Receptor	Neurological Disease
JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect .

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats ^[3].

HY-P1726A

MSG606 TFA	Melanocortin Receptor
MSG606 TFA is a potent human MC1 receptor antagonist (IC₅₀=17 nM). MSG606 TFA also partial agonist at human MC3 and MC5 receptors (EC₅₀ values are 59 and 1300 nM, respectively). MSG606 TFA exhibits binding affinity for A375 melanoma cells in vitro. MSG606 TFA reverses the induced hyperalgesia in female mice, with no effect in male mice.

HY-151738

Fmoc-Aeg(N3)-OH	ADC Linker	Others
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-N11038

Drynachromoside A

Others Others

Drynachromoside A is a chromone glycoside. Drynachromoside A has biochemical effects on the osteoblastic (MC3T3-E1 cells) proliferation activities .

Drynachromoside A	Others	Others
Drynachromoside A is a chromone glycoside. Drynachromoside A has biochemical effects on the osteoblastic (MC3T3-E1 cells) proliferation activities .

HY-N4119

Neoeriocitrin	Cholinesterase (ChE)	Neurological Disease
Neoeriocitrin, isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor .

HY-P0252B

α-MSH free acid α-Melanocyte-Stimulating Hormone free acid	Melanocortin Receptor	Neurological Disease
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an *MC3R* and MC4R agonist with EC₅₀s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R .

HY-115644

BMS-470539 dihydrochloride	Melanocortin Receptor	Inflammation/Immunology
BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC₅₀ of 120 nM, an EC₅₀ of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties ^[3].

HY-18678A

Bremelanotide Acetate 1 Publications Verification PT-141 Acetate	Melanocortin Receptor	Endocrinology
Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction .

HY-N0123

Aloin 5+ Cited Publications Aloin-A; Barbaloin-A	Others	Cancer
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) ^[3] .

HY-144497

HE-S2	PD-1/PD-L1 Toll-like Receptor (TLR) Drug-Linker Conjugates for ADC	Infection Cancer
HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity .

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects ^[3].

HY-10624

THIQ 1 Publications Verification	Melanocortin Receptor	Metabolic Disease
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC₅₀=1.2 nM, EC₅₀=2.1 nM) and rMC4R (IC₅₀=0.6 nM, EC₅₀=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .

*D-Lin-MC3-DMA* 40+ Cited Publications	Drug Delivery
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Cat. No.	Product Name	Target	Research Area