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Results for "

MCF7

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (293) Cardiovascular Disease (2) Endocrinology (8) Infection (15) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (4)
Click Chemistry:	Azide (1)

330

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137099A

Genistein 7-sulfate sodium	Others	Endocrinology
Genistein 7-sulfate sodium is a metabolite of genistein that can reduce the activity of estrogen agonists in MCF-7 cells. Genistein 7-sulfate sodium can promote the growth of MCF-7 cells at concentrations of 10 μM and above .

HY-146162

Colletotrichalactones A

Others Cancer

Colletotrichalactones A is a polyketide that display moderate-to-potent cytotoxic activities against MCF7 cells with an IC₅₀ of 35.06 µM .

Colletotrichalactones A	Others	Cancer
Colletotrichalactones A is a polyketide that display moderate-to-potent cytotoxic activities against MCF7 cells with an IC₅₀ of 35.06 µM .

HY-137099

Genistein 7-sulfate	Others	Endocrinology
Genistein 7-sulfate is a metabolite of genistein that can reduce the activity of estrogen agonists in MCF-7 cells. Genistein 7-sulfate can promote the growth of MCF-7 cells at concentrations of 10 μM and above .

HY-160563

PROTAC ERα Degrader-8

PROTACs Estrogen Receptor/ERR Cancer

PROTAC ERα Degrader-8 (compound ii-56) is a potent PROTAC degrader of Erα, with DC₅₀ of 0.000006 μM in MCF7 cells .

PROTAC ERα Degrader-8	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERα Degrader-8 (compound ii-56) is a potent PROTAC degrader of Erα, with DC₅₀ of 0.000006 μM in MCF7 cells .

HY-N11973

5,7-Dimethoxy-2,3-phenanthrenediol	Others	Cancer
5,7-Dimethoxy-2,3-phenanthrenediol is a compound with estrogenic activity. 5,7-Dimethoxy-2,3-phenanthrenediol increases the proliferation of MCF-7 cell and the expression of ERβ in the MCF-7 cell line .

HY-W179181

MSNBA	GLUT	Metabolic Disease
MSNBA is a specific inhibitor of GLUT5 fructose transport in proteoliposomes. MSNBA competitively inhibits GLUT5 fructose uptake with a K_I of 3.2±0.4?μM in MCF7 cells .

HY-153700

Estrogen receptor modulator 8	Estrogen Receptor/ERR	Endocrinology
Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC₅₀=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC₅₀ value of 0.1 nM .

HY-151564

Anticancer agent 85	Others	Cancer
Anticancer agent 85 (compound 6j) is an anticancer agent that shows good cytotoxicity against MCF7 cells. Anticancer agent 85 can be used in breast cancer and other cancer studies .

HY-144637

Autophagy inducer 2	Apoptosis Autophagy	Cancer
Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC₅₀ value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer .

HY-N10871

Neocryptomerin

Others Cancer

Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell .
HY-156452

T-1-MCPAB

VEGFR Cancer

T-1-MCPAB is a VEGFR-2 inhibitor (IC₅₀=0.135 µM) that effectively inhibits MCF7 migration. T-1-MCPAB can be used in cancer research .
HY-157960

VEGFR-2-IN-42

VEGFR Cancer

VEGFR-2-IN-42 (compound 8c) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-42 shows anti-proliferative effect against MCF7 cells with the IC₅₀ of 25 µM .

Neocryptomerin	Others	Cancer
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell .

T-1-MCPAB	VEGFR	Cancer
T-1-MCPAB is a VEGFR-2 inhibitor (IC₅₀=0.135 µM) that effectively inhibits MCF7 migration. T-1-MCPAB can be used in cancer research .

VEGFR-2-IN-42	VEGFR	Cancer
VEGFR-2-IN-42 (compound 8c) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-42 shows anti-proliferative effect against MCF7 cells with the IC₅₀ of 25 µM .

HY-144306

ERα degrader 4	Estrogen Receptor/ERR Apoptosis	Cancer
ERα degrader 4 is an excellent and selective estrogen receptor α (ERα) degrader (IC₅₀ of 0.31, 0.41 and 0.48 μM in MDA-MB-231, MCF-7 and MCF-7/ADR cells, respectively). ERα degrader 4 has potent inhibitory activity against MCF-7 cell lines. ERα degrader 4 is a potential SERDs candidate for the research of breast cancer .

HY-163434

PRMT5/EGFR-IN-1	EGFR Histone Methyltransferase	Cancer
PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual PRMT5/EGFR inhibitor, with IC₅₀s of 15.47 and 19.31 μM, respectively. PRMT5/EGFR-IN-1 exhibits antiproliferative activity against A549, MCF7, HeLa, and MDA-MB-231 cell lines. PRMT5/EGFR-IN-1 has favorable in vivo PK and PD properties. PRMT5/EGFR-IN-1 can significantly inhibit the growth of MCF7 orthotopic xenograft tumors .

HY-161267

Mitochondrial respiration-IN-4	Mitochondrial Metabolism Reactive Oxygen Species	Cancer
Mitochondrial respiration-IN-4 (Compound TC11) is a potent mitochondrial respiration inhibitor. Mitochondrial respiration-IN-4 impairs Reactive Oxygen Species (ROS) in and induces apoptosis in MCF7 cells .

HY-145866

Antiproliferative agent-3

Others Cancer

Antiproliferative agent-3 (comp 4) shows the highest potency for MCF-7 cells (IC₅₀ = 0.19 nM) .
HY-153469

Benzyl DC-81

ADC Cytotoxin Cancer

Benzyl DC-81 (Compound 6a) is an anticancer agent with antiproliferative activity against A375 and MCF-7 cells .

Antiproliferative agent-3	Others	Cancer
Antiproliferative agent-3 (comp 4) shows the highest potency for MCF-7 cells (IC₅₀ = 0.19 nM) .

Benzyl DC-81	ADC Cytotoxin	Cancer
Benzyl DC-81 (Compound 6a) is an anticancer agent with antiproliferative activity against A375 and MCF-7 cells .

HY-155841

Tubulin polymerization-IN-46	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC₅₀ of 10 nM .

HY-163126

AChE-IN-52	Cholinesterase (ChE)	Cancer
AChE-IN-52 (compound A6) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-52 shows antitumor efficacy, especially against breast cancer MCF-7 cells. AChE-IN-52 significantly disrupts the amino acid metabolism and inhibits migration of MCF-7. AChE-IN-52 plays anticancer role by regulating Best1 and HIST1H2BJ .

HY-134964

CTB 3 Publications Verification	Histone Acetyltransferase Apoptosis	Neurological Disease Cancer
CTB is a potent p300 histone acetyltransferase activator . CTB can effectively induce apoptosis in MCF-7 cells .

HY-163281

FSY-OSO2F	Fluorescent Dye	Cancer
FSY-OSO2F is used as an amino acid tracer for subsutaneous MCF-7 tumors after labeling with isotope ¹⁸F. FSY-OSO2F shows an uptake in MCF-7 cells through the regulation of L-Tyr, ASC, and ASC2 transporters. FSY-OSO2F visualizes the U78MG glioma labeled with ¹⁸F .

HY-N5103

Genistein 7,4'-di-O-β-D-glucoside

Others Endocrinology

Genistein 7,4'-di-O-β-D-glucoside is a natural product with significantly estrogenic proliferative effect in MCF-7 cells .
HY-147967

EGFR-IN-63

EGFR Cancer

EGFR-IN-63 is an EGFR inhibition (IC₅₀: 0.096 μM) and it has anticancer activity in MCF-7 cells (IC₅₀: 2.49 μM).

Genistein 7,4'-di-O-β-D-glucoside	Others	Endocrinology
Genistein 7,4'-di-O-β-D-glucoside is a natural product with significantly estrogenic proliferative effect in MCF-7 cells .

EGFR-IN-63	EGFR	Cancer
EGFR-IN-63 is an EGFR inhibition (IC₅₀: 0.096 μM) and it has anticancer activity in MCF-7 cells (IC₅₀: 2.49 μM).

HY-N3042

Platyphyllonol Platyphyllone	Others	Cancer
Platyphyllonol (Platyphyllone) can be isolated from A. japonica. Platyphyllonol shows cytotoxic effects on MCF-7 cells with IC₅₀ values of 46.9 μg/mL .

HY-153588

HSP90-IN-22	HSP	Cancer
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC₅₀ values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.

HY-13668

Lomeguatrib 5+ Cited Publications PaTrin-2	DNA Methyltransferase	Cancer
Lomeguatrib is a O ⁶-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC₅₀s of 9 nM in cell-free assay and ∼6 nM in MCF-7 cells.

HY-N4010

Iriflophenone

Others Cancer

Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation .
HY-132247B

(S)-ErSO

Others Cancer

(S)-ErSO is the dextrorotatory enantiomer of ErSO. (S)-ErSO is inactive in MCF-7 cells (from patent WO2020009958A1, compound (s)-105) .
HY-N8679

Physalin C

Endogenous Metabolite Cancer

Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

Iriflophenone	Others	Cancer
Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation .

(S)-ErSO	Others	Cancer
(S)-ErSO is the dextrorotatory enantiomer of ErSO. (S)-ErSO is inactive in MCF-7 cells (from patent WO2020009958A1, compound (s)-105) .

Physalin C	Endogenous Metabolite	Cancer
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-103452

RU58668	Estrogen Receptor/ERR	Endocrinology
RU58668 is a steroidal antiestrogen that can be used as a potent antiproliferative agent on MCF-7 cells. RU58668 has the potential for the breast cancer research .

HY-132294A

(1S,3R)-GNE-502	Estrogen Receptor/ERR	Cancer
(1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC₅₀ value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor .

HY-13686

PQ401 2 Publications Verification	IGF-1R Apoptosis	Cancer
PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC₅₀ of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC₅₀, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis .

HY-N12208

Neohelmanthicin B	Others	Cancer
Neohelmanthicin B is a phenylpropanoid that can be isolated from Thapsia garganica. Neohelmanthicin B exhibits cytotoxicity against EL4, S180 and MCF7 cell lines with IC₅₀s of 10, 5 and12 μM, respectively .

HY-N2887

Araliadiol	Others	Cancer
Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC₅₀ value of 6.41 µg/mL .

HY-156879

Antiproliferative agent-40

Others Cancer

Antiproliferative agent-40 (Compound 9) inhibits proliferation of HT1080 and MCF-7 with IC₅₀s of 52 and 8.2 μM respectively .

Antiproliferative agent-40	Others	Cancer
Antiproliferative agent-40 (Compound 9) inhibits proliferation of HT1080 and MCF-7 with IC₅₀s of 52 and 8.2 μM respectively .

HY-151573

EGFR/CDK2-IN-1	EGFR CDK	Cancer
EGFR/CDK2-IN-1 (Compound 3b) is an EGFR/CDK2 inhibitor. EGFR/CDK2-IN-1 shows good cytotoxicity against MCF7 and HepG2 cells. EGFR/CDK2-IN-1 can be used in cancer research .

HY-147710

PIN1 inhibitor 2	MicroRNA	Cancer
PIN1 inhibitor 2 (compound 12) is a potent PIN1 inhibitor. PIN1 inhibitor 2 shows antitumor activity with an IC₅₀ of 9.55 µM for MCF7 cells. PIN1 inhibitor 2 has the potential for the research of breast cancer .

HY-N7340

Withaperuvin C	Others	Cancer
Withaperuvin C is a withanolide that can be isolated from Physalis Minima. Withaperuvin C has moderate cytotoxicity against cancer cells such as HepG2, SK-LU-1, and MCF7 cells (IC₅₀: 19.5, 14.65, 11.74 μg/mL) .

HY-N2198

Podocarpusflavone A
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents .

HY-N10305

Clionamine B	Autophagy	Cancer
Clionamine B is an autophagy stimulating aminosteroid isolated from the sponge Cliona celata. Clionamine B strongly stimulates autophagy in human breast cancer MCF-7 cells .

HY-156114

EGFR/CDK2-IN-2	EGFR CDK	Cancer
EGFR/CDK2-IN-2 (compound 6a) is a dual inhibitor of EGFR and CDK-2 with IC₅₀s of 19.6 and 87.9 nM, respectively. EGFR/CDK2-IN-2 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-2 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC₅₀ of 0.39 μM .

HY-156115

EGFR/CDK2-IN-3	EGFR CDK	Cancer
EGFR/CDK2-IN-3 (compound 4b) is a dual inhibitor of EGFR and CDK-2 with IC₅₀s of 71.7 and 113.7 nM, respectively. EGFR/CDK2-IN-3 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-3 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC₅₀ of 3.16 μM .

HY-156116

EGFR/CDK2-IN-4	EGFR CDK	Cancer
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor of EGFR and CDK-2 with IC₅₀s of 89.6 and 165.4 nM, respectively. EGFR/CDK2-IN-4 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-4 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC₅₀ of 2.74 μM .

HY-146238

EGFR/HER2/TS-IN-1	EGFR Thymidylate Synthase Apoptosis	Cancer
EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC₅₀ values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis .

HY-N2863

Goniothalenol	Others	Cancer
Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines .

HY-N7464

Jolkinolide E	Others	Others
Jolkinolide E is a casbane diterpenoid from the roots of Euphorbia rapulum. Jolkinolide E shows weak selective activity against HepG2, MCF-7, and C6 cell lines .

HY-N6990

Anhydrosecoisolariciresinol	Others	Cancer
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-147887

Tubulin inhibitor 28	Microtubule/Tubulin	Cancer
Tubulin inhibitor 28 (compound 2g) is a potent tubulin inhibitor with an IC₅₀ value of 1.2 µM. Tubulin inhibitor 28 shows anti-proliferative activity for MCF-7 cells .

HY-N7589

Demethylcarolignan E Carolignan M	Others	Cancer
Demethylcarolignan E is a phenylpropanoid ester that can be isolated from the stems of Hibiscus taiwanensi. Demethylcarolignan E has cytotoxicity against human cancer lines A549 and MCF-7 (IC₅₀: <10 μg/mL) .

HY-14307

Necrocide 1	Others	Cancer
Necrocide 1 (compound (S)-38) a potent anticancer agent. Necrocide 1 has antiproliferative activity with an IC₅₀ value of 0.48 and 2 nM for MCF-7 and PC3, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4010

Iriflophenone	Iridaceae Classification of Application Fields Thymelaeaceae Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Aquilaria sinensis (Lour.) Spreng. Cancer	Others
Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation .

HY-N11973

5,7-Dimethoxy-2,3-phenanthrenediol	Structural Classification Dioscorea polystachya Turczaninow Source classification Phenols Polyphenols Plants Dioscoreaceae	Others
5,7-Dimethoxy-2,3-phenanthrenediol is a compound with estrogenic activity. 5,7-Dimethoxy-2,3-phenanthrenediol increases the proliferation of MCF-7 cell and the expression of ERβ in the MCF-7 cell line .

HY-N10871

Neocryptomerin	Structural Classification Flavonoids Source classification Taxodiaceae Plants Cunninghamia lanceolata var. konishii Biflavones	Others
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell .

HY-N5103

Genistein 7,4'-di-O-β-D-glucoside	Flavonoids Monophenols Classification of Application Fields Leguminosae Source classification Ammopiptanthus nanus (M. Pop.) Cheng f. Phenols Plants Disease Research Fields Endocrinology Isoflavones	Others
Genistein 7,4'-di-O-β-D-glucoside is a natural product with significantly estrogenic proliferative effect in MCF-7 cells .

HY-N3042

Platyphyllonol Platyphyllone	Structural Classification Source classification Phenols Polyphenols Lepidoziaceae Bazzania serrulatioides Horik. Plants	Others
Platyphyllonol (Platyphyllone) can be isolated from A. japonica. Platyphyllonol shows cytotoxic effects on MCF-7 cells with IC₅₀ values of 46.9 μg/mL .

HY-N8679

Physalin C	Structural Classification Cardiacglycosides Source classification Physalis angulata L. Plants Solanaceae Steroids	Endogenous Metabolite
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-N12208

Neohelmanthicin B	Structural Classification Natural Products Source classification Plants Umbelliferae	Others
Neohelmanthicin B is a phenylpropanoid that can be isolated from Thapsia garganica. Neohelmanthicin B exhibits cytotoxicity against EL4, S180 and MCF7 cell lines with IC₅₀s of 10, 5 and12 μM, respectively .

HY-N2887

Araliadiol	Structural Classification Natural Products Classification of Application Fields Aralia cordata Thunb. Source classification Plants Disease Research Fields Araliaceae Cancer	Others
Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC₅₀ value of 6.41 µg/mL .

HY-N7340

Withaperuvin C	Structural Classification Physalis minima Linn. Source classification Plants Solanaceae Steroids	Others
Withaperuvin C is a withanolide that can be isolated from Physalis Minima. Withaperuvin C has moderate cytotoxicity against cancer cells such as HepG2, SK-LU-1, and MCF7 cells (IC₅₀: 19.5, 14.65, 11.74 μg/mL) .

HY-N10305

Clionamine B	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Autophagy
Clionamine B is an autophagy stimulating aminosteroid isolated from the sponge Cliona celata. Clionamine B strongly stimulates autophagy in human breast cancer MCF-7 cells .

HY-N2863

Goniothalenol	Goniothalamus calvicarpus Craib Structural Classification Natural Products Source classification Plants Annonaceae	Others
Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines .

HY-N7464

Jolkinolide E	Structural Classification Terpenoids Source classification Euphorbia rapulum Kar. et Kir. Diterpenoids Euphorbiaceae Plants	Others
Jolkinolide E is a casbane diterpenoid from the roots of Euphorbia rapulum. Jolkinolide E shows weak selective activity against HepG2, MCF-7, and C6 cell lines .

HY-N6990

Anhydrosecoisolariciresinol	other families Classification of Application Fields Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Others
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-N7589

Demethylcarolignan E Carolignan M	Structural Classification Caprifoliaceae Source classification Phenols Polyphenols Sambucus williamsii Hance Plants	Others
Demethylcarolignan E is a phenylpropanoid ester that can be isolated from the stems of Hibiscus taiwanensi. Demethylcarolignan E has cytotoxicity against human cancer lines A549 and MCF-7 (IC₅₀: <10 μg/mL) .

HY-N3722

O-Demethylmurrayanine	Structural Classification Monophenols Clausena lansium (Lour.) Skeels Source classification Rutaceae Phenols Plants	Others
O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC₅₀ values in the range 4.42-7.59 μg/mL .

HY-22024

5-Hydroxyflavone	Flavonoids Monophenols other families Classification of Application Fields Flavones Source classification Phenols Plants Disease Research Fields Cancer	Others
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .

HY-N8859

Isoiridogermanal 16-Hydroxyiridal	Structural Classification Natural Products Source classification Lridaceae Plants	Others
Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against *MCF-7* and C32 cell lines.

HY-119539

Limocitrin	Structural Classification Flavonols Flavonoids Source classification Plants Platanaceae Platanus orientalis L.	Phosphatase
Limocitrin is a natural product that can be isolated from the buds of P. acerifolia and P. orientalis. Limocitrin suppresses estradiol-dependent proliferation of MCF7 cells weakly but estradiol-induced AlkP (alkaline phosphatase) expression only marginally .

HY-N9391

7,3′,5′-Trihydroxyflavanone	Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Dalbergia sissoo Plants Disease Research Fields Cancer	Apoptosis
7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, induces the apoptotic cell death of MCF-7 cells by increasing Bax expression level. 7,3′,5′-Trihydroxyflavanone also exhibits antioxidant activity .

HY-N10846

Neotriptonoterpene	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.	Others
Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC₅₀ values of 65.80, 35.45 and 64.80 µM respectively .

HY-N11438

3'-Hydroxymirificin	Structural Classification Flavonoids Flavones Leguminosae Source classification Pueraria montana (Loureiro) Merrill Plants	Estrogen Receptor/ERR
3'-Hydroxymirificin (compound 3) is a naural compound that can be isolated from Pueraria lobata roots. 3'-Hydroxymirificin (compound 3) possesses estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-N3443

Jolkinol A	Structural Classification Terpenoids Source classification Euphorbia peplus Linn. Diterpenoids Euphorbiaceae Plants	Others
Jolkinol A is a natural product that can be found in Euphorbia pubescens. Jolkinol A inhibits cell growth with GI₅₀s of 95.3, 57.3, >100 µM for MCF-7, NCI-460, SF-268 cells, respectively .

HY-N3261

Methyllinderone	Structural Classification Flavonoids Source classification Lindera erythrocarpa Makino Plants Lauraceae Other Flavonoids	AP-1 ERK STAT
Methyllinderone is an inhibitor of AP-1/STAT/ERK. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis .

HY-N11919

Anticancer agent 149	Structural Classification Source classification Phenols Polyphenols Plants Dioscorea membranacea Pierre ex Prain & Burkill Dioscoreaceae	Others
Anticancer agent 149 (compound 3) is an anticancer agent isolated from the rhizome of Dioscorea dioscorea (DM). Anticancer agent 149 exhibits selective cytotoxic activity against MCF-7 cells (IC₅₀=31.41 μM) .

HY-N7302

Anthracophyllone	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Anthracophyllone is an aristolane sesquiterpene that can be isolated from the mushroom Anthracophyllum. Anthracophyllone has cytotoxicity against MCF-7, KB, NCI-H187, Vero cells (IC₅₀: 32.97, 18.02, 15.17, 18.06 μM) .

HY-N3000

6-Methoxydihydrosanguinarine	Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Papaveraceae Cancer	Others
6-Methoxydihydrosanguinarine is an lkaloid isolated from the fruits of M.cordata. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC₅₀ values of 0.61 μM and 0.54 μM, respectively .

HY-N10959

4,15-Isoatriplicolide methylacrylate	Structural Classification Terpenoids Helianthus tuberosus L. Sesquiterpenes Source classification Plants Compositae	Others
4,15-Isoatriplicolide methylacrylate is a germacrane-type sesquiterpene lactone. 4,15-Isoatriplicolide methylacrylate also is a cytotoxic agent. 4,15-Isoatriplicolide methylacrylate has cytotoxic activity for MCF-7 human breast cancer cell line .

HY-N12209

Neohelmanthicin A	Structural Classification Natural Products Source classification Plants Umbelliferae	Others
Neohelmanthicin A (compound 3A) is a phenylpropanoid compound with antitumor activity. The IC₅₀s of Neohelmanthicin A for inhibiting leukemia cell line EL4, breast cancer cell line S180 and breast cancer cell line MCF7 are 0.13 μM, 7 μM and 23 μM respectively .

HY-N7654

(-)-Epipodophyllotoxin	Structural Classification other families Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI₅₀s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro .

HY-N6885

Puerarin-4'-O-β-D-glucopyranoside	Flavonoids Monophenols Classification of Application Fields Leguminosae Source classification Phenols Pueraria montana (Loureiro) Merrill Plants Disease Research Fields Isoflavones Cancer	Others
Puerarin-4'-O-β-D-glucopyranoside (compound 8) is a isoflavone from Pueraria lobata root (PLR). Puerarin-4'-O-β-D-glucopyranoside has estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-N3316

Martynoside	Simple Phenylpropanols Labiatae Source classification Phenols Polyphenols Ligularia muliensis Hand.-Mazz. Phenylpropanoids Plants	Others
Martynoside protects ex vivo bone marrow cells from 5-fluorouracil (5-FU)-induced cell death and inflammation response by down-regulating the TNF signaling pathway .Martynoside is a potent antiestrogen in MCF-7 cells, increasing IGFBP3 levels

HY-N3615

Confluentin	Structural Classification Natural Products Rhododendron simsii Planch. Source classification Plants Ericaceae	Others
Confluentin can be isolated from Rhododendron dauricum. Confluentin shows weak cytotoxicity against human tumor cells (IC₅₀: 15.05, 17.08, 18.48, and 23.01 μM for HL-60, SMMC-7712, A-549, and MCF-7) .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-N12299

Parthenosin Quercetin 3-O-β-D-glucuronide butyl ester	Structural Classification Flavonoids Flavones Polygonaceae Source classification Phenols Polyphenols Plants Calligonum aphyllum (Pall.) Gurke	Others
Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester) is a flavonoid, that can be isolated from the aerial parts of Calligoum polygonoides. Parthenosin shows cytotoxic activity against HepG2 and MCF-7 cell lines with IC₅₀ values of 60.46 and 61.4 μg/mL, respectively .

HY-N12607

Garcilatelic acid	Structural Classification Flavonoids Guttiferae Source classification Garcinia lateriflora Blume Plants Other Flavonoids	Others
Garcilatelic acid (Compound 5) is a compound that can be isolated from Garcinia lateriflora. Garcilatelic acid has antiproliferative activity against tumor cell lines (A549, MDA-MB-231, MCF-7, KB and KB-VIN), with IC₅₀ values of 0.5-1.3 μM .

HY-N10777

1-Ketoaethiopinone	Structural Classification Ardisia crenata Sims Terpenoids Source classification Diterpenoids Plants Myrsinaceae	Others
1-Ketoaethiopinone is an abietane-diterpenoid. 1-Ketoaethiopinone has an α, β-unsaturated carbonyl function. 1-Ketoaethiopinone shows cytotoxic activity against human cancer cell lines MOLT-4 (human lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma) .

HY-N11928

Changnanic acid	Structural Classification Kadsura heteroclita (Roxb.) Craib Ketones, Aldehydes, Acids Source classification Plants Schisandraceae	Others
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC₅₀s of 100 μM, 100 μM and 50.51 μM respectively .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Phenols Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-N10023

Physalin O	Structural Classification Physalis minima Linn. Cardiacglycosides Source classification Plants Solanaceae Steroids	NO Synthase
Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC₅₀ values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities .

HY-113319

β-D-Fructose	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Endogenous Metabolite
β-D-Fructose is a β-fruit sugar that can be produced by the hydrolysis of sucrose. β-D-Fructose can be used as a sweetness potentiator. β-D-Fructose can be designed as a units of antiproliferative agents against breast (MCF-7) and colon (MDST8) cancer cell lines .

HY-N9505

Schisanlactone E Kadsulactone acid	Triterpenes Structural Classification Kadsura heteroclita (Roxb.) Craib Terpenoids Source classification Plants Schisandraceae	Others
Schisanlactone E is a triterpenoids that can be isolated from Kadsura heteroclita. Schisanlactone E exhibits moderate cytotoxic activity against Bel-7402, BGC-823, MCF-7 and HL-60 cell line with IC₅₀s of 68.33, 100, >100, 73.37 μM,respectively .

HY-134008

Protoapigenone	Structural Classification Flavonoids Flavones Source classification Plants Macrothelypteris torresiana (Gaud.) Ching Thelypteridaceae	Others
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .

HY-135453

(-)-Pinocembrin	Structural Classification Flavonoids Flavones Polygonaceae Source classification Persicaria glabra (Willd.) M. Gomez Plants	Bacterial
(-)-Pinocembrin exhibits anti-mycobacterium activity against mycobacteriuum tuberculosis H37Ra with an IC₅₀ value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent antiproliferative activity with IC₅₀ values of 1.88-11.00 mg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines .

HY-119358

Traumatic Acid	Structural Classification Classification of Application Fields Source classification Plants Phaseolus vulgaris Linn. Cytokinin Agricultural Research Microorganisms Leguminosae Ketones, Aldehydes, Acids Phytohormone Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species Apoptosis
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis .

HY-N2741

Vitexin B-1	Structural Classification Monophenols Verbenaceae Source classification Phenols Plants Vitex negundo Linn.	Bcl-2 Family
Vitexin B-1 is an inhibitor of Bcl-2 and the agonist of Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC₅₀s of 3.2, 2.1, 1.8 and 0.39 μM, respectively .

HY-N12586

Pheophytin a	Suaeda vermiculata Forssk. ex J.F.Gmel. Structural Classification Alkaloids Other Alkaloids Source classification Amaranthaceae Plants	Reactive Oxygen Species
Pheophytin a is a chlorophyll that can be isolated from S. vermiculata extracts. Pheophytin a has antioxidant activity with IC₅₀ values of? 200.5 and 137.7 μg/mL for SOD, and NO respectively. Pheophytin a has reducing power with an IC₅₀ value of 4.2 μg/mL . Pheophytin a has a cytotoxic effect on the MCF-7 cell line(IC₅₀= 35.9 μg/mL)^[1].

HY-138210

N,O-Diacetyltyramine	Structural Classification Natural Products Microorganisms Source classification	Fungal
N,O-Diacetyltyramine is a compound with antibacterial activity and cytotoxicity that can be isolated from the actinomycete Pseudonocardia endophytica VUK-10. N,O-Diacetyltyramine has antibacterial activity against Gram-positive and Gram-negative bacteria and fungi. N,O-Diacetyltyramine is cytotoxic to MDA-MB-231, HeLa, MCF-7 and OAW-42 cells .

HY-50936

Trabectedin 3 Publications Verification Ecteinascidin 743; ET-743	Alkaloids Structural Classification Classification of Application Fields Animals Source classification Marine natural products Other marine organisms Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species Apoptosis
Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research .

HY-N3210

Nb-Demethylechitamine	Apocynaceae Structural Classification Alkaloids Source classification Plants Indole Alkaloids Alstonia rostrata C. E. C. Fischer	Others
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Steroids	Others
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

Cat. No.	Product Name	Chemical Structure

HY-13636S

Fulvestrant-d3
Fulvestrant-d₃ is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].

HY-50936S

Trabectedin-d3

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

HY-19822S2

Elacestrant-d10
Elacestrant-d₁₀ is the deuterium labeled of Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also inhibits growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

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