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Results for "

MCT1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Mitochondrial Metabolism (2) Monocarboxylate Transporter (9) P-glycoprotein (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Inflammation/Immunology (2) Neurological Disease (1)

13

Inhibitors & Agonists

1

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18974

MCT1-IN-2

MCT1-IN-2 is a potent monocarboxylate transporter 1 (MCT1) inhibitor. MCT1-IN-2 has anti-cancer activity ^[1] .

BAY-8002 3 Publications Verification	Monocarboxylate Transporter	Cancer
BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC₅₀ of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity ^[1].

AZD3965 Maximum Cited Publications 37 Publications Verification	Monocarboxylate Transporter	Cancer
AZD3965 is a selective *MCT1* inhibitor with a K_i of 1.6 nM, showing 6-fold selectivity over MCT2.

MCT1-IN-3	Monocarboxylate Transporter P-glycoprotein	Cancer
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC₅₀ value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter *ABCB1. MCT1*-IN-3 can be used for the research of cancer ^[1].

AR-C141990	Others	Inflammation/Immunology
AR-C141990 (Compound 30) is a potent blocker of the monocarboxylate transporter MCT1 with a K_i of 4.8 nM. AR-C141990 (Compound 30) inhibits CYP3A4 and CYP2C9 with IC₅₀ values of 16 μM ^[1].

AR-C155858 30+ Cited Publications	Monocarboxylate Transporter	Others
AR-C155858 is a selective monocarboxylate transporter *MCT1* and *MCT2* inhibitor with K_is of 2.3 nM and 10 nM, respectively.

GW604714X	Mitochondrial Metabolism	Neurological Disease
GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a K_i <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC ^[1].

AR-C141990 hydrochloride	Monocarboxylate Transporter	Inflammation/Immunology
AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pK_i values of 7.6, 6.6 for MCT-1 and MCT-2, respectively ^[1]. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response .

Syrosingopine 3 Publications Verification Su 3118	Monocarboxylate Transporter	Cardiovascular Disease Cancer
Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine ^[1] .

7ACC1 5+ Cited Publications DEAC; Coumarin D 1421; D 1421	Monocarboxylate Transporter	Cancer
7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.

VB124	Monocarboxylate Transporter	Cardiovascular Disease
VB124 is an orally active, potent, and selective *MCT4* inhibitor. VB124 can specifically inhibit lactate efflux with IC₅₀s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism ^[1].

MCTS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MCTS1 Human Pre-designed siRNA Set A contains three designed siRNAs for MCTS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCTS1 Human Pre-designed siRNA Set A MCTS1 Human Pre-designed siRNA Set A

7ACC2 5 Publications Verification	Monocarboxylate Transporter Mitochondrial Metabolism	Cancer
7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC₅₀ of 11 nM for inhibition of [ ¹⁴C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux ^[1] .

Cat. No.	Compare	Product Name	Species	Source

	Chymase/CMA1 Protein, Human (sf9, His) Alpha-chymase; Mast cell chymase 1; Mast cell protease 5; mMCP-5	Human	Sf9 insect cells
	Chymase/CMA1 Protein, a secreted protease from mast cells, plays a significant role in generating vasoactive peptides, degrading the extracellular matrix, and regulating gland secretion. Chymase/CMA1 Protein, Human (sf9, His) is the recombinant human-derived Chymase/CMA1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Chymase/CMA1 Protein, Human (sf9, His) is 247 a.a., with molecular weight of ~33 kDa.

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