MD-2

By Targets:	Apoptosis (1) Bcl-2 Family (1) Caspase (1) COX (1) Interleukin Related (1) MMP (1) NF-κB (2) NOD-like Receptor (NLR) (1) PARP (1) Reactive Oxygen Species (1) TNF Receptor (1) Toll-like Receptor (TLR) (10)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103483

MD2-IN-1 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).

HY-128598

MD2-TLR4-IN-1	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC₅₀ values of 0.89 μM and 0.53 μM, respectively .

HY-W082785A

L6H21	TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species	Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K_D value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC₅₀ values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research ^[2] .

HY-N0774

Isofraxidin 1 Publications Verification	COX MMP Toll-like Receptor (TLR)	Inflammation/Immunology
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of *ERK1/2* in hepatoma cells . Isofraxidin attenuates the expression of iNOS and *COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2*) complex formation ^[2].

HY-161026

JM-9	Toll-like Receptor (TLR)	Inflammation/Immunology
JM-9 is a inhibitor of *MD2. JM-9 suppresses high glucose and palmitic acid -induced inflammation in MPMs. JM-9 improves diabetic kidney disease by inhibiting MD2*-mediated inflammation .

HY-149248

NF-κB-IN-8	NF-κB	Inflammation/Immunology
NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. NF-κB-IN-8 reduces the expression of inflammatory factors by binding to MD-2. NF-κB-IN-8 also inhibits ALP activity. NF-κB-IN-8 can be used for the research of inflammation such as acute lung injury (ALI) .

HY-126154

L48H37	Toll-like Receptor (TLR)	Inflammation/Immunology
L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment .

HY-108708

GeA-69	PARP	Cancer
GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2 (MD2), with a K_d value of 2.1 µM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage ^[2].

HY-N9347

Stepharine 1 Publications Verification	Toll-like Receptor (TLR)	Cardiovascular Disease Inflammation/Immunology
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects .

HY-P5117

TAT-CIRP	Toll-like Receptor (TLR)	Neurological Disease
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .

HY-N0795

Procyanidin B1 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to *TLR4/MD-2* complex, and has anti-inflammatory activity.

HY-U00435

Neoseptin 3 2 Publications Verification	Toll-like Receptor (TLR)	Cancer
Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC₅₀ of 18.5 μM.

Cat. No.	Product Name	Target	Research Area

HY-P5117

TAT-CIRP	Toll-like Receptor (TLR)	Neurological Disease
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0774

Isofraxidin 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae	COX MMP Toll-like Receptor (TLR)
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of *ERK1/2* in hepatoma cells . Isofraxidin attenuates the expression of iNOS and *COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2*) complex formation ^[2].

HY-N9347

Stepharine 1 Publications Verification	Cardiovascular Disease Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Toll-like Receptor (TLR)
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects .

HY-N0795

Procyanidin B1 3 Publications Verification	Flavonoids other families Classification of Application Fields Functional Molecules Source classification Research of Health Products Phenols Polyphenols Plants Biflavones Disease Research Fields Inflammation/Immunology	Toll-like Receptor (TLR)
Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to *TLR4/MD-2* complex, and has anti-inflammatory activity.

Species:	Human (2) Mouse (1) Cynomolgus (1)
Tag:	His (3) SUMO (1) Fc (1)
Source:	HEK293 (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701067

	MD2 Protein, Human (His) Lymphocyte antigen 96; LY96; Ly-96; ESOP1; ESOP-1; MD-2	Human	E. coli
	MD2 protein binds bacterial lipopolysaccharide (LPS) and collaborates with TLR4 in the innate immune response to LPS. It also interacts with TLR2 in the response to cell wall components from bacteria. MD2 enhances TLR4-dependent NF-kappa-B activation and forms a heterogeneous homomer, participating in a multi-protein complex with CD14 and TLR4. Ligand binding induces complex oligomerization, crucial for the cellular response to LPS. MD2 Protein, Human (His) is the recombinant human-derived MD2 protein, expressed by E. coli , with C-His labeled tag. The total length of MD2 Protein, Human (His) is 142 a.a., with molecular weight of 18.07 kDa.

HY-P77081

	MD-2/LY96 Protein, Mouse (HEK293, Fc) Lymphocyte antigen 96; Ly-96; ESOP-1	Mouse	HEK293
	MD-2/LY96 Protein, acting as a monomer, robustly and specifically binds to interleukin-13 (IL13), distinguishing it from interleukin-4 (IL4) with which it does not interact. This selective binding highlights MD-2/LY96's pivotal role in mediating cellular responses to IL13, underscoring its significance in IL13-related biological activities. MD-2/LY96 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived MD-2/LY96 protein, expressed by HEK293, with C-hFc labeled tag. The total length of MD-2/LY96 Protein, Mouse (HEK293, Fc) is 142 a.a., with molecular weight of ~47 kDa.

HY-P71540

	MAD2L1 Protein, Human (His-SUMO) HsMAD2; MAD 2; MAD2 like 1; MAD2 mitotic arrest deficient like 1; MAD2-like protein 1; Mad2l1; MD2L1_HUMAN; Mitotic arrest deficient 2-like protein 1; Mitotic spindle assembly checkpoint protein MAD2A; REV7	Human	E. coli
	MAD2L1 is a critical spindle assembly checkpoint component that delays anaphase until correct chromosome alignment. During prophase, it forms a heterotetrameric complex with MAD1L1 at unattached kinetochores, recruiting O-MAD2 and aiding transformation. MAD2L1 Protein, Human (His-SUMO) is the recombinant human-derived MAD2L1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of MAD2L1 Protein, Human (His-SUMO) is 204 a.a., with molecular weight of ~39.4 kDa.

HY-P701066

	MD2 Protein, Cynomolgus (His) Lymphocyte antigen 96; LY96; ESOP1; ESOP-1; MD-2	Cynomolgus	E. coli
	MD2 protein binds bacterial lipopolysaccharide (LPS) and collaborates with TLR4 in the innate immune response to LPS. It also interacts with TLR2 in the response to cell wall components from bacteria. MD2 enhances TLR4-dependent NF-kappa-B activation and forms a heterogeneous homomer, participating in a multi-protein complex with CD14 and TLR4. Ligand binding induces complex oligomerization, crucial for the cellular response to LPS. MD2 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived MD2 protein, expressed by E. coli , with C-His labeled tag. The total length of MD2 Protein, Cynomolgus (His) is 142 a.a., with molecular weight of 17.97 kDa.


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