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Results for "

ME-1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

4

Peptides

1

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124861
    Malic enzyme inhibitor ME1
    2 Publications Verification

    ME1

    		 Others Metabolic Disease Cancer
    Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM [1] .
    Malic enzyme inhibitor <em>ME1</em>
  • HY-150621
    AS1134900

    		Others Cancer
    AS1134900 is a highly selective, allosteric and uncompetitive NADP +-dependent malic enzyme 1 (ME1) inhibitor [1].
    AS1134900
  • HY-138617
    AI-10-47

    		Others Cancer
    AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM [1].
    AI-10-47
  • HY-RS08270
    ME1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ME1 Human Pre-designed siRNA Set A contains three designed siRNAs for ME1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ME1 Human Pre-designed siRNA Set A
    ME1 Human Pre-designed siRNA Set A
  • HY-D0858S
    MES-13d

    		Isotope-Labeled Compounds Others
    MES-d13 is the deuterium labeled MES[1]. MES (2-Morpholinoethanesulphonic acid) is a buffering agent in biology and biochemistry. MES is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments[2][3].
    MES-13d
  • HY-128912
    Arborinine

    		Histone Demethylase Cancer
    Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1] .
    Arborinine
  • HY-149677
    ZK53

    		Mitochondrial Metabolism Cancer
    ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37?μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model [1].
    ZK53
  • HY-149091
    KDM5B-IN-4

    		Others Cancer
    KDM5B-IN-4 (compound 11ad) is a lysine demethylase 5B (KDM5B) inhibitor with an IC50 of 0.025 μM KDM5B-IN-4 increases substrate H3K4me1/2/3 level by inhibiting KDM5B in PC-3 cells. KDM5B-IN-4 downregulates PI3K/AKT. KDM5B-IN-4 reduces tumor volume in mice and shows less toxic to organs [1].
    KDM5B-IN-4

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