Search Result

Results for "

MERS-CoV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (25) Apoptosis (1) Autophagy (2) Bcr-Abl (2) c-Kit (2) Calcium Channel (1) Cathepsin (1) DNA/RNA Synthesis (7) Drug Metabolite (3) Filovirus (2) Influenza Virus (2) PDGFR (2) Virus Protease (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (21) Inflammation/Immunology (1) Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: SARS-CoV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139908

MERS-CoV-IN-1	SARS-CoV	Infection
MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus. MERS-CoV-IN-1 is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS) (extracted from patent WO2018174442A1, compound 1) .

HY-N2949

Bonducellpin D	SARS-CoV	Infection Cancer
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M ^pro and MERS-CoV M ^pro, with an K_i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .

HY-104077S

Remdesivir-d5 2 Publications Verification GS-5734-d₅	DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir-d₅ is a deuterium labeled Remdesivir. Remdesivir (GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of 2019-nCoV (COVID-19) infection in vitro[1][2].

HY-44358

Remdesivir nucleoside monophosphate 2 Publications Verification	DNA/RNA Synthesis SARS-CoV Drug Metabolite	Infection
Remdesivir nucleoside monophosphate is a metabolite of Remdesivir . Remdesivir is a nucleoside analogue with effective antiviral activity against SARS-CoV and MERS-CoV .

HY-148072

MM3122	SARS-CoV	Infection
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC₅₀ value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .

HY-100229

Aloxistatin 45+ Cited Publications E64d; E64c ethyl ester	Cathepsin SARS-CoV	Neurological Disease
Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV.

HY-149535

WU-04	SARS-CoV	Infection
WU-04 is a non-covalent inhibitor of SARS-CoV-2, targeting the 3CLpro protein. WU-04 has high inhibitory effect on the 3CLpro protein of 6 SARS-CoV-2 variants (Alpha, Beta, Gamma, Delta, Lambda and Omicron) and 2 coronaviruses (SARS-CoV and MERS-CoV) .

HY-N0360

Dihydrotanshinone I 3 Publications Verification	SARS-CoV	Cardiovascular Disease
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-100227

E 64c 2 Publications Verification
E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV.

HY-155136

NSC89641	SARS-CoV	Infection
NSC89641 inhibits MERS-CoV M ^pro, with an IC₅₀ value < 3.5 μM. NSC89641 exhibits the high inhibitory potency against SARS-CoV-2 M ^pro enzymatic activity, with an IC₅₀ of 3.05 μM .

HY-13433

Thapsigargin 50+ Cited Publications	Calcium Channel SARS-CoV Apoptosis	Infection Cancer
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-135860

SARS-CoV-2-IN-1	Virus Protease SARS-CoV	Infection
SARS-CoV-2-IN-1 is a potent Mpro inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC₅₀s of 0.67, 0.90 and 0.58 μM, respectively .

HY-P9805

*Anti-MERS-3A1 mAb* MERS-3A1; MERS Antibody-3A1	SARS-CoV	Infection
Anti-MERS-3A1 mAb (MERS-3A1) is a human monoclonal IgG1 antibody with the high binding affinity produced in CHO cells. Anti-MERS-3A1 mAb bocks the binding of MERS-CoV spike protein to DPP4 receptor .

HY-135853

Molnupiravir 35+ Cited Publications EIDD-2801; MK-4482	SARS-CoV Influenza Virus	Infection
Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, *MERS-CoV, SARS-CoV*. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .

HY-P9806

*Anti-MERS-D12 mAb* MERS-D12; MERS Antibody-D12	SARS-CoV	Infection
Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal IgG1. Anti-MERS-D12 mAb binds directly to the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD) and effect neutralization by directly blocking receptor binding .

HY-145949

Remdesivir de(ethylbutyl 2-aminopropanoate)	Drug Metabolite	Infection
Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC₅₀s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro .

HY-15463

Imatinib 65+ Cited Publications STI571; CGP-57148B	Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy	Cancer
Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and *MERS-CoV* .

HY-104077S1

Remdesivir-d4 GS-5734-d₄	DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir-d₄ is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

HY-135853S

Molnupiravir-d7 EIDD-2801-d₇; MK-4482-d₇	SARS-CoV Influenza Virus	Inflammation/Immunology
Molnupiravir-d₇ is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza[1][2].

HY-15463S2

Imatinib-d3 hydrochloride STI571-d₃ hydrochloride; CGP-57148B-d₃ hydrochloride	Autophagy Bcr-Abl c-Kit SARS-CoV PDGFR	Cancer
Imatinib-d₃ (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

HY-131275

Imatinib Impurity E	Drug Metabolite	Others
Imatinib Impurity E is the impurity of Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and *MERS-CoV* .

HY-104077S2

Remdesivir impurity 9-d4	DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir impurity 9-d₄ is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

HY-18649

Galidesivir hydrochloride 5+ Cited Publications BCX4430 hydrochloride; Immucillin-A hydrochloride	DNA/RNA Synthesis SARS-CoV Filovirus	Infection
Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC₅₀s ranging from ~3 to ~68 μM .

HY-18649A

Galidesivir 5+ Cited Publications BCX4430; Immucillin-A	DNA/RNA Synthesis SARS-CoV Filovirus	Infection
Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC₅₀s ranging from ~3 to ~68 μM .

HY-136149A

Mpro inhibitor N3 hemihydrate	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC₅₀ of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC₅₀ of 4.0 μM, 8.8 μM, and 2.7 μM, respectively .

HY-151990

*SARS-CoV-2/MERS* Mpro-IN-1**	SARS-CoV	Infection
SARS-CoV-2/MERS Mpro-IN-1 (compound 9c) is a potent SARS-CoV-2 and MERS main protease inhibitor with IC₅₀ values of 0.10, 0.06 µM, respectively .

HY-151991

*SARS-CoV-2/MERS* Mpro-IN-2**	SARS-CoV	Infection
SARS-CoV-2/MERS Mpro-IN-2 (compound 9d) is a potent SARS-CoV-2 and MERS main protease inhibitor with IC₅₀ values of 0.21, 0.07 µM, respectively .

HY-104077

Remdesivir Maximum Cited Publications 145 Publications Verification GS-5734	DNA/RNA Synthesis SARS-CoV	Infection
Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC₅₀s of 3.3 μM, 4.7 μM, 32 μM, 3.7 μM and 9.2 μM for SARS-CoV-2 and its variants alpha, beta, gamma and delta, respectively. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro .

*Anti-MERS-3A1 mAb* MERS-3A1; MERS Antibody-3A1	SARS-CoV	Infection
Anti-MERS-3A1 mAb (MERS-3A1) is a human monoclonal IgG1 antibody with the high binding affinity produced in CHO cells. Anti-MERS-3A1 mAb bocks the binding of MERS-CoV spike protein to DPP4 receptor .

*Anti-MERS-D12 mAb* MERS-D12; MERS Antibody-D12	SARS-CoV	Infection
Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal IgG1. Anti-MERS-D12 mAb binds directly to the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD) and effect neutralization by directly blocking receptor binding .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2949

Bonducellpin D	Other Terpenoids Infection Caesalpinia minax Hance Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields	SARS-CoV
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M ^pro and MERS-CoV M ^pro, with an K_i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .

HY-N0360

Dihydrotanshinone I 3 Publications Verification	Cardiovascular Disease Quinones Structural Classification Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Plants Phenanthrenequinones Disease Research Fields	SARS-CoV
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-13433

Thapsigargin 50+ Cited Publications	Infection Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Umbelliferae Disease Research Fields Cancer Thapsia garganica L.	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

Species:	Virus (8)
Tag:	His (7) Fc (1)
Source:	HEK293 (1) Sf9 insect cells (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P74754

	MERS-CoV Nucleoprotein/NP Protein (sf9, His) MERS-CoV coronavirus NP Protein; MERS-CoV coronavirus Nucleocapsid Protein	Virus	Sf9 insect cells
	MERS-CoV Nucleoprotein/NP Protein is a phosphorylated basic protein and the second largest structural protein of MERS-CoV, containing 413 amino acid residues. The Nucleoprotein combines with the RNA genome to form a nucleocapsid, which is important in viral replication and assembly. In addition, Nucleoprotein plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. MERS-CoV Nucleoprotein/NP Protein (sf9, His) is the recombinant Virus-derived MERS-CoV Nucleoprotein/NP protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of MERS-CoV Nucleoprotein/NP Protein (sf9, His) is 413 a.a., with molecular weight of ~46.51 kDa.

HY-P74751

	MERS-CoV Spike/S1 Protein (HEK293, His) Spike glycoprotein; S glycoprotein; E2; Peplomer protein; S	Virus	HEK293
	The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. The engagement of the MERS-CoV spike protein S1 with CD26 (also known as dipeptidyl peptidase 4, DPP4) mediates viral attachment to host cells and virus鈥揷ell fusion, thereby initiating infection. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein and S2' is unmasked following S2 cleavage occurring upon virus endocytosis. MERS-CoV Spike/S1 Protein (HEK293, His) is the recombinant Virus-derived MERS-CoV Spike/S1 protein, expressed by HEK293 , with C-His labeled tag. The total length of MERS-CoV Spike/S1 Protein (HEK293, His) is 725 a.a., with molecular weight of ~94 kDa.

HY-P74750

	MERS-CoV Spike/S2 Protein (sf9, His) Spike glycoprotein; S glycoprotein; E2; Peplomer protein; S	Virus	Sf9 insect cells
	The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. The engagement of the MERS-CoV spike protein S1 with CD26 (also known as dipeptidyl peptidase 4, DPP4) mediates viral attachment to host cells and virus鈥揷ell fusion, thereby initiating infection. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein and S2' is unmasked following S2 cleavage occurring upon virus endocytosis. MERS-CoV Spike/S2 Protein (sf9, His) is the recombinant Virus-derived MERS-CoV Spike/S2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of MERS-CoV Spike/S2 Protein (sf9, His) is 571 a.a., with molecular weight of ~63.84 kDa.

HY-P74752

	MERS-CoV Spike/S Protein RBD (sf9, Fc) Spike glycoprotein; S glycoprotein; E2; Peplomer protein; S	Virus	Sf9 insect cells
	The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. The engagement of the MERS-CoV spike protein S1 with CD26 (also known as dipeptidyl peptidase 4, DPP4) mediates viral attachment to host cells and virus鈥揷ell fusion, thereby initiating infection. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein and S2' is unmasked following S2 cleavage occurring upon virus endocytosis. MERS-CoV Spike/S Protein RBD (sf9, Fc) is the recombinant Virus-derived MERS-CoV Spike/S protein RBD, expressed by Sf9 insect cells , with C-rFc labeled tag. The total length of MERS-CoV Spike/S Protein RBD (sf9, Fc) is 240 a.a., with molecular weight of ~51.5 kDa.

HY-P75924

	MERS-CoV Spike/S Protein RBD (sf9, His) Spike glycoprotein; S glycoprotein; E2; Peplomer protein; S	Virus	Sf9 insect cells
	The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. The engagement of the MERS-CoV spike protein S1 with CD26 (also known as dipeptidyl peptidase 4, DPP4) mediates viral attachment to host cells and virus鈥揷ell fusion, thereby initiating infection. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein and S2' is unmasked following S2 cleavage occurring upon virus endocytosis. MERS-CoV Spike/S Protein RBD (sf9, His) is the recombinant Virus-derived MERS-CoV Spike/S protein RBD, expressed by Sf9 insect cells , with C-His labeled tag. The total length of MERS-CoV Spike/S Protein RBD (sf9, His) is 240 a.a., with molecular weight of ~33.7 kDa.

HY-P73290

	MERS-CoV Spike/S1 Protein (1297a.a, sf9, His) SARS-CoV-2; Spike S1 Subunit	Virus	Sf9 insect cells
	The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. The engagement of the MERS-CoV spike protein S1 with CD26 (also known as dipeptidyl peptidase 4, DPP4) mediates viral attachment to host cells and virus鈥揷ell fusion, thereby initiating infection. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein and S2' is unmasked following S2 cleavage occurring upon virus endocytosis. MERS-CoV Spike/S1 Protein (1297a.a, sf9, His) is the recombinant Virus-derived MERS-CoV Spike/S1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of MERS-CoV Spike/S1 Protein (1297a.a, sf9, His) is 1297 a.a., with molecular weight of ~142.52 kDa.

HY-P73291

	MERS-CoV Spike/S1 Protein (725a.a, sf9, His) SARS-CoV-2; Spike S1 Subunit	Virus	Sf9 insect cells
	The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. The engagement of the MERS-CoV spike protein S1 with CD26 (also known as dipeptidyl peptidase 4, DPP4) mediates viral attachment to host cells and virus鈥揷ell fusion, thereby initiating infection. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein and S2' is unmasked following S2 cleavage occurring upon virus endocytosis. MERS-CoV Spike/S1 Protein (725a.a, sf9, His) is the recombinant Virus-derived MERS-CoV Spike/S1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of MERS-CoV Spike/S1 Protein (725a.a, sf9, His) is 725 a.a., with molecular weight of ~94 kDa.

HY-P74753

	MERS-CoV Spike/S Protein RBD (Biotinylated, sf9, His) Spike glycoprotein; S glycoprotein; E2; Peplomer protein; S	Virus	Sf9 insect cells
	The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. The engagement of the MERS-CoV spike protein S1 with CD26 (also known as dipeptidyl peptidase 4, DPP4) mediates viral attachment to host cells and virus鈥揷ell fusion, thereby initiating infection. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein and S2' is unmasked following S2 cleavage occurring upon virus endocytosis. MERS-CoV Spike/S Protein RBD (Biotinylated, sf9, His) is the recombinant Virus-derived MERS-CoV Spike/S protein RBD, expressed by Sf9 insect cells , with C-His labeled tag. The total length of MERS-CoV Spike/S Protein RBD (Biotinylated, sf9, His) is 240 a.a., with molecular weight of ~27.7 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-104077S

Remdesivir-d5 2 Publications Verification
Remdesivir-d₅ is a deuterium labeled Remdesivir. Remdesivir (GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of 2019-nCoV (COVID-19) infection in vitro[1][2].

HY-135853S

Molnupiravir-d7

Molnupiravir-d₇ is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza[1][2].

HY-15463S2

Imatinib-d3 hydrochloride

Imatinib-d₃ (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.